GREMLIN Database
GLRK - Sensor histidine kinase GlrK
UniProt: P52101 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13461
Length: 475 (424)
Sequences: 43329 (37360)
Seq/√Len: 1814.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
402_I463_C3.9971.00
403_N407_P3.8671.00
325_V360_A3.5451.00
442_R446_R3.5251.00
396_R467_E3.4741.00
453_Y465_R3.3191.00
272_T294_L3.1831.00
400_D463_C3.0961.00
413_R456_D2.8511.00
360_A448_M2.7891.00
398_Y467_E2.7671.00
389_R400_D2.7531.00
350_D387_C2.7061.00
400_D465_R2.6711.00
380_G404_T2.6441.00
385_N404_T2.6391.00
391_S398_Y2.6201.00
269_R299_R2.5981.00
398_Y465_R2.5681.00
324_N359_L2.5611.00
441_A452_L2.5401.00
454_L464_F2.5351.00
350_D385_N2.5171.00
276_A295_D2.5061.00
457_E460_Q2.5041.00
387_C402_I2.4891.00
409_P412_E2.4751.00
368_V445_I2.4421.00
276_A292_S2.4281.00
391_S400_D2.3771.00
352_D389_R2.3681.00
324_N357_A2.3541.00
417_F452_L2.3361.00
455_V465_R2.3321.00
455_V463_C2.3261.00
389_R402_I2.3191.00
445_I450_G2.2911.00
413_R454_L2.2781.00
408_I416_I2.2541.00
326_E329_P2.1951.00
227_S230_R2.1741.00
451_E467_E2.1241.00
333_T366_M2.1221.00
456_D462_V2.1191.00
445_I466_I2.0751.00
412_E415_M2.0701.00
284_T287_Q2.0551.00
269_R298_S2.0541.00
338_H370_D2.0511.00
323_E362_P2.0401.00
348_H385_N1.9981.00
352_D387_C1.9961.00
368_V444_C1.9141.00
415_M418_E1.9011.00
360_A365_L1.8731.00
410_Q413_R1.8571.00
380_G384_G1.8531.00
384_G404_T1.8121.00
322_L359_L1.8101.00
393_H398_Y1.8041.00
368_V441_A1.7991.00
453_Y467_E1.7981.00
269_R302_Q1.7821.00
252_Q256_H1.7671.00
302_Q306_E1.7601.00
408_I412_E1.7571.00
342_A377_V1.7551.00
374_S378_H1.7431.00
283_L287_Q1.7261.00
225_G230_R1.7141.00
247_E250_R1.7091.00
412_E421_F1.6871.00
415_M421_F1.6861.00
226_P230_R1.6841.00
246_L250_R1.6841.00
444_C448_M1.6731.00
369_L399_I1.6641.00
446_R451_E1.6411.00
408_I462_V1.6381.00
272_T295_D1.6291.00
210_R215_R1.6271.00
273_E295_D1.6161.00
283_L286_E1.6111.00
399_I466_I1.6061.00
361_E364_L1.5971.00
47_V50_T1.5831.00
248_S252_Q1.5761.00
371_N441_A1.5741.00
240_S244_S1.5481.00
387_C404_T1.5481.00
276_A288_K1.5401.00
412_E423_G1.5121.00
205_E231_S1.4971.00
328_A332_E1.4961.00
417_F454_L1.4481.00
403_N461_D1.4471.00
275_L291_V1.4361.00
295_D299_R1.4251.00
215_R218_G1.4201.00
271_G290_V1.4191.00
268_M298_S1.4171.00
247_E251_H1.4091.00
364_L367_S1.4021.00
239_L243_L1.3951.00
456_D460_Q1.3941.00
379_Y422_Q1.3931.00
380_G386_I1.3851.00
190_V194_T1.3781.00
240_S243_L1.3701.00
260_E367_S1.3641.00
445_I452_L1.3581.00
368_V466_I1.3531.00
326_E357_A1.3471.00
362_P366_M1.3451.00
253_F257_L1.3441.00
333_T362_P1.3361.00
413_R417_F1.3331.00
339_S343_R1.3311.00
237_L240_S1.3301.00
409_P458_S1.3291.00
320_V361_E1.3271.00
418_E421_F1.3231.00
267_S271_G1.3191.00
328_A390_S1.3181.00
364_L444_C1.3101.00
205_E209_N1.3101.00
456_D459_G1.3081.00
268_M294_L1.3081.00
208_I211_L1.3041.00
337_A366_M1.2891.00
32_Q36_S1.2811.00
236_I239_L1.2741.00
341_P344_A1.2721.00
210_R219_N1.2631.00
443_D446_R1.2621.00
250_R254_L1.2601.00
332_E351_V1.2581.00
450_G468_L1.2541.00
335_V351_V1.2451.00
278_Q287_Q1.2411.00
269_R295_D1.2351.00
364_L447_R1.2291.00
256_H419_P1.2191.00
417_F464_F1.2091.00
267_S297_S1.2081.00
229_L233_G1.1881.00
330_L334_V1.1871.00
454_L462_V1.1841.00
233_G237_L1.1681.00
208_I212_G1.1611.00
202_K205_E1.1441.00
292_S296_S1.1351.00
211_L240_S1.1331.00
245_W249_Q1.1281.00
328_A353_L1.1241.00
402_I457_E1.1161.00
396_R451_E1.1141.00
416_I454_L1.1041.00
353_L390_S1.1031.00
284_T288_K1.0961.00
334_V370_D1.0911.00
356_T397_V1.0841.00
275_L287_Q1.0821.00
403_N462_V1.0821.00
303_K363_M1.0811.00
331_V390_S1.0811.00
417_F442_R1.0791.00
173_Q177_W1.0791.00
365_L448_M1.0781.00
86_V90_Q1.0761.00
207_M221_V1.0711.00
410_Q456_D1.0671.00
225_G229_L1.0621.00
39_A43_Q1.0601.00
38_N41_S1.0581.00
248_S251_H1.0551.00
272_T276_A1.0551.00
252_Q419_P1.0541.00
272_T298_S1.0521.00
376_A386_I1.0511.00
141_A144_S1.0501.00
204_I208_I1.0441.00
422_Q431_V1.0401.00
225_G233_G1.0371.00
169_A173_Q1.0371.00
195_R199_G1.0311.00
194_T198_I1.0301.00
270_E274_L1.0301.00
334_V338_H1.0261.00
272_T291_V1.0241.00
271_G293_I1.0201.00
371_N374_S1.0141.00
95_S99_D1.0131.00
262_K306_E1.0121.00
34_W38_N1.0111.00
86_V91_R1.0091.00
306_E310_D1.0051.00
187_L191_L1.0031.00
320_V364_L0.9961.00
325_V330_L0.9931.00
91_R95_S0.9891.00
288_K292_S0.9861.00
88_Q92_K0.9851.00
436_L440_I0.9851.00
64_A68_M0.9841.00
307_Q364_L0.9841.00
244_S248_S0.9821.00
140_E143_A0.9811.00
220_S241_E0.9811.00
267_S270_E0.9791.00
197_I200_P0.9721.00
322_L448_M0.9711.00
334_V366_M0.9701.00
408_I454_L0.9701.00
54_D57_R0.9661.00
205_E208_I0.9661.00
226_P229_L0.9651.00
229_L232_V0.9641.00
208_I235_R0.9631.00
372_L464_F0.9621.00
369_L401_V0.9591.00
48_N51_T0.9551.00
144_S148_E0.9461.00
354_K391_S0.9451.00
419_P443_D0.9441.00
309_L312_N0.9441.00
96_E100_A0.9381.00
69_E73_R0.9321.00
140_E144_S0.9301.00
408_I413_R0.9261.00
14_L227_S0.9251.00
289_E293_I0.9231.00
94_Y98_L0.9221.00
235_R238_W0.9191.00
209_N231_S0.9181.00
246_L249_Q0.9151.00
188_V192_L0.9141.00
215_R219_N0.9141.00
208_I236_I0.9111.00
356_T392_L0.9071.00
36_S39_A0.9061.00
33_A37_L0.9041.00
205_E235_R0.9001.00
218_G244_S0.8991.00
338_H373_Y0.8981.00
379_Y406_T0.8971.00
369_L373_Y0.8941.00
373_Y388_L0.8921.00
303_K307_Q0.8901.00
296_S333_T0.8901.00
372_L452_L0.8891.00
293_I297_S0.8881.00
58_S62_T0.8861.00
393_H396_R0.8851.00
381_A384_G0.8811.00
327_L399_I0.8801.00
161_G165_Q0.8791.00
407_P462_V0.8791.00
294_L298_S0.8791.00
329_P333_T0.8761.00
416_I464_F0.8751.00
103_G106_P0.8731.00
139_L143_A0.8731.00
269_R273_E0.8701.00
341_P374_S0.8691.00
62_T66_L0.8671.00
337_A370_D0.8631.00
31_W35_Q0.8631.00
99_D102_A0.8621.00
242_R245_W0.8621.00
260_E371_N0.8621.00
445_I468_L0.8611.00
65_A69_E0.8601.00
12_R195_R0.8571.00
192_L196_M0.8551.00
209_N213_E0.8541.00
238_W242_R0.8531.00
372_L466_I0.8531.00
223_F234_Q0.8521.00
441_A445_I0.8491.00
366_M370_D0.8481.00
330_L360_A0.8471.00
370_D374_S0.8471.00
347_M380_G0.8461.00
372_L441_A0.8451.00
297_S300_N0.8421.00
393_H467_E0.8381.00
93_R96_E0.8341.00
363_M366_M0.8331.00
45_A49_R0.8321.00
36_S40_L0.8321.00
335_V339_S0.8311.00
322_L449_Q0.8291.00
46_L49_R0.8281.00
282_P287_Q0.8281.00
90_Q93_R0.8241.00
443_D447_R0.8211.00
408_I414_A0.8201.00
334_V373_Y0.8181.00
285_P288_K0.8161.00
33_A36_S0.8161.00
230_R234_Q0.8151.00
450_G466_I0.8151.00
64_A67_E0.8141.00
92_K95_S0.8131.00
331_V369_L0.8111.00
148_E152_A0.8111.00
220_S244_S0.8101.00
153_T157_V0.8061.00
92_K96_E0.8061.00
346_M383_S0.8061.00
338_H374_S0.8051.00
57_R60_A0.8051.00
368_V448_M0.8011.00
254_L257_L0.8001.00
60_A64_A0.7991.00
259_H371_N0.7981.00
274_L278_Q0.7971.00
61_M65_A0.7941.00
292_S295_D0.7941.00
191_L195_R0.7931.00
97_M101_H0.7911.00
321_E361_E0.7891.00
200_P204_I0.7881.00
50_T54_D0.7841.00
241_E245_W0.7841.00
84_A88_Q0.7841.00
93_R97_M0.7841.00
51_T55_A0.7821.00
172_G176_G0.7811.00
144_S147_T0.7791.00
322_L360_A0.7761.00
149_M153_T0.7751.00
225_G228_E0.7751.00
66_L69_E0.7751.00
211_L239_L0.7741.00
139_L144_S0.7741.00
332_E336_S0.7731.00
176_G180_L0.7711.00
210_R214_G0.7701.00
289_E292_S0.7701.00
232_V236_I0.7691.00
95_S98_L0.7671.00
226_P233_G0.7651.00
260_E264_P0.7631.00
261_L301_L0.7621.00
101_H105_L0.7601.00
311_Y439_S0.7601.00
263_T267_S0.7581.00
442_R451_E0.7581.00
259_H263_T0.7571.00
299_R302_Q0.7571.00
154_R158_F0.7551.00
209_N235_R0.7531.00
348_H351_V0.7531.00
206_R210_R0.7531.00
406_T431_V0.7491.00
99_D103_G0.7481.00
254_L258_S0.7461.00
194_T197_I0.7451.00
222_S237_L0.7451.00
326_E356_T0.7421.00
40_L43_Q0.7391.00
328_A355_A0.7391.00
207_M219_N0.7391.00
196_M199_G0.7381.00
88_Q91_R0.7371.00
367_S444_C0.7361.00
310_D367_S0.7361.00
287_Q290_V0.7351.00
231_S234_Q0.7351.00
413_R455_V0.7341.00
403_N406_T0.7341.00
143_A146_N0.7311.00
257_L308_L0.7291.00
155_T160_R0.7291.00
265_L305_I0.7251.00
422_Q433_G0.7251.00
328_A356_T0.7241.00
298_S302_Q0.7241.00
388_L401_V0.7221.00
307_Q367_S0.7211.00
325_V362_P0.7211.00
253_F260_E0.7181.00
342_A349_T0.7171.00
262_K302_Q0.7161.00
278_Q282_P0.7161.00
346_M382_E0.7151.00
51_T54_D0.7141.00
220_S240_S0.7131.00
53_I56_R0.7131.00
340_L344_A0.7131.00
22_I26_L0.7131.00
271_G294_L0.7121.00
320_V447_R0.7101.00
408_I456_D0.7081.00
39_A42_D0.7061.00
332_E335_V0.7061.00
230_R233_G0.7051.00
342_A386_I0.7011.00
390_S397_V0.7011.00
85_K89_S0.6971.00
378_H431_V0.6971.00
68_M72_Y0.6961.00
65_A68_M0.6941.00
202_K206_R0.6931.00
408_I464_F0.6911.00
241_E244_S0.6901.00
327_L397_V0.6891.00
266_A270_E0.6891.00
145_A148_E0.6881.00
54_D58_S0.6881.00
343_R346_M0.6881.00
331_V388_L0.6881.00
341_P345_K0.6881.00
410_Q414_A0.6871.00
400_D455_V0.6861.00
148_E151_Q0.6821.00
97_M102_A0.6821.00
412_E425_H0.6801.00
293_I296_S0.6801.00
106_P109_K0.6781.00
150_V153_T0.6771.00
233_G236_I0.6771.00
409_P423_G0.6761.00
392_L397_V0.6761.00
335_V349_T0.6761.00
97_M100_A0.6741.00
173_Q176_G0.6721.00
203_N206_R0.6711.00
333_T337_A0.6711.00
106_P110_L0.6711.00
364_L368_V0.6701.00
276_A291_V0.6701.00
220_S237_L0.6691.00
47_V51_T0.6691.00
232_V235_R0.6681.00
271_G297_S0.6681.00
450_G469_P0.6671.00
100_A103_G0.6651.00
364_L448_M0.6641.00
221_V233_G0.6631.00
49_R53_I0.6621.00
342_A345_K0.6611.00
410_Q457_E0.6611.00
336_S339_S0.6581.00
208_I232_V0.6571.00
345_K382_E0.6561.00
209_N212_G0.6541.00
142_F145_A0.6531.00
225_G232_V0.6531.00
290_V294_L0.6531.00
418_E442_R0.6511.00
332_E353_L0.6511.00
83_L86_V0.6501.00
53_I57_R0.6501.00
38_N42_D0.6491.00
210_R213_E0.6471.00
372_L445_I0.6471.00
91_R97_M0.6451.00
342_A347_M0.6441.00
59_E62_T0.6441.00
45_A48_N0.6431.00
35_Q38_N0.6431.00
245_W248_S0.6421.00
211_L214_G0.6421.00
300_N366_M0.6421.00
85_K88_Q0.6411.00
347_M377_V0.6401.00
35_Q172_G0.6361.00
376_A401_V0.6321.00
267_S293_I0.6321.00
301_L305_I0.6311.00
334_V337_A0.6311.00
204_I233_G0.6301.00
228_E232_V0.6301.00
255_R258_S0.6301.00
32_Q35_Q0.6291.00
63_N67_E0.6271.00
212_G238_W0.6261.00
57_R65_A0.6241.00
340_L343_R0.6231.00
402_I459_G0.6231.00
325_V359_L0.6221.00
440_I444_C0.6221.00
186_S190_V0.6201.00
60_A63_N0.6191.00
453_Y466_I0.6151.00
107_D110_L0.6131.00
390_S399_I0.6121.00
174_Y177_W0.6101.00
274_L290_V0.6091.00
335_V388_L0.6091.00
356_T390_S0.6091.00
327_L358_C0.6091.00
378_H433_G0.6091.00
217_L221_V0.6071.00
203_N207_M0.6051.00
310_D364_L0.6051.00
352_D391_S0.6051.00
398_Y453_Y0.6031.00
102_A106_P0.6031.00
219_N223_F0.6021.00
96_E102_A0.6021.00
329_P362_P0.6011.00
82_T85_K0.6011.00
413_R464_F0.6001.00
168_I172_G0.5991.00
105_L108_D0.5991.00
40_L44_A0.5981.00
56_R60_A0.5971.00
315_Q419_P0.5971.00
260_E440_I0.5941.00
196_M200_P0.5931.00
266_A269_R0.5931.00
37_L41_S0.5931.00
441_A444_C0.5921.00
89_S93_R0.5891.00
98_L104_V0.5881.00
271_G275_L0.5881.00
101_H104_V0.5861.00
290_V293_I0.5851.00
253_F258_S0.5841.00
207_M210_R0.5821.00
256_H260_E0.5821.00
330_L365_L0.5811.00
336_S340_L0.5801.00
169_A172_G0.5781.00
147_T150_V0.5771.00
365_L468_L0.5761.00
104_V108_D0.5761.00
219_N222_S0.5751.00
396_R469_P0.5751.00
416_I439_S0.5751.00
381_A406_T0.5741.00
347_M351_V0.5731.00
67_E70_R0.5691.00
140_E145_A0.5691.00
144_S152_A0.5681.00
102_A105_L0.5681.00
416_I421_F0.5671.00
86_V97_M0.5661.00
81_P84_A0.5651.00
165_Q169_A0.5651.00
139_L142_F0.5641.00
386_I401_V0.5621.00
49_R52_L0.5611.00
170_E174_Y0.5611.00
392_L396_R0.5611.00
297_S337_A0.5601.00
373_Y386_I0.5601.00
100_A104_V0.5601.00
338_H377_V0.5581.00
252_Q443_D0.5571.00
199_G203_N0.5571.00
35_Q39_A0.5561.00
59_E63_N0.5531.00
180_L184_L0.5521.00
308_L312_N0.5521.00
261_L264_P0.5511.00
320_V448_M0.5511.00
236_I240_S0.5501.00
89_S92_K0.5501.00
98_L101_H0.5491.00
223_F233_G0.5461.00
413_R462_V0.5461.00
231_S235_R0.5461.00
201_V232_V0.5461.00
302_Q305_I0.5451.00
206_R209_N0.5431.00
103_G107_D0.5431.00
309_L313_R0.5411.00
63_N66_L0.5411.00
223_F230_R0.5391.00
237_L241_E0.5391.00
96_E99_D0.5381.00
330_L366_M0.5381.00
452_L464_F0.5371.00
12_R202_K0.5371.00
203_N222_S0.5371.00
311_Y419_P0.5361.00
414_A418_E0.5361.00
275_L294_L0.5341.00
271_G298_S0.5341.00
367_S370_D0.5341.00
260_E304_L0.5341.00
409_P413_R0.5321.00
19_F190_V0.5311.00
439_S443_D0.5311.00
260_E263_T0.5291.00
251_H315_Q0.5291.00
295_D298_S0.5291.00
30_A34_W0.5291.00
201_V205_E0.5281.00
21_L24_L0.5281.00
311_Y443_D0.5281.00
356_T359_L0.5281.00
208_I239_L0.5261.00
268_M272_T0.5261.00
286_E290_V0.5261.00
253_F420_F0.5261.00
43_Q47_V0.5241.00
200_P227_S0.5231.00
67_E71_S0.5221.00
55_A58_S0.5211.00
422_Q432_K0.5211.00
204_I207_M0.5201.00
149_M155_T0.5201.00
299_R303_K0.5201.00
243_L246_L0.5161.00
166_R170_E0.5151.00
342_A346_M0.5141.00
104_V107_D0.5141.00
43_Q46_L0.5131.00
208_I214_G0.5131.00
68_M73_R0.5111.00
98_L102_A0.5101.00
325_V365_L0.5101.00
68_M71_S0.5091.00
329_P332_E0.5071.00
424_S432_K0.5071.00
201_V204_I0.5061.00
141_A149_M0.5041.00
273_E276_A0.5041.00
12_R16_M0.5041.00
28_V32_Q0.5041.00
358_C397_V0.5041.00
291_V295_D0.5031.00
147_T152_A0.5031.00
270_E298_S0.5021.00
25_P28_V0.5021.00
17_L20_L0.5011.00
445_I451_E0.5011.00
23_L26_L0.5011.00
84_A91_R0.5001.00
278_Q290_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5705 100 0.329 Contact Map
4bixA 2 0.4779 100 0.362 Contact Map
4ctiA 2 0.48 100 0.398 Contact Map
4q20A 2 0.48 100 0.449 Contact Map
4mpcA 2 0.6295 100 0.463 Contact Map
3jz3A 2 0.3347 100 0.467 Contact Map
2c2aA 2 0.4905 100 0.47 Contact Map
2q8gA 2 0.6358 100 0.472 Contact Map
3d36A 2 0.4653 100 0.474 Contact Map
2e0aA 2 0.6526 100 0.48 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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