GLRK - ECOLI - GREMLIN Contacts

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GLRK - Sensor histidine kinase GlrK

UniProt:	P52101	Sequences: MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEMERSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPDDKLYQALRQDLHNLAQLQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADSAVELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSKNTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13461
Length:	475 (424)
Sequences:	43329 (37360)
Seq/√Len:	1814.4

ECOLI - GLRK BARA BAES TORS PHOQ CUSS CREC ENVZ YEDV QSEC CPXA RSTB ATOS RCSD RCSC ZRAS NARX NARQ BASS DCUS ARCB DPIB EVGS PHOR KDPD YPDA NTRB UHPB
BACSU - YCLK YKOH YYCG RESE CSSS YVRG PHOR YVCQ KINB KIND YRKQ DCTS YXDK CITS YCBM MALK BCES KINE YESM KINA GLNK KINC LIAS LYTS YBDK YWPD COMP NATK YFIJ YDFH DEGS YHCY YXJM
HALSA - Q9HQ15 Q9HQE9 Q9HQG5 Q9HQ16 Q9HRE4 O51970 Q9HR10 Q9HRG1 Q9HNM2 BAT Q9HNA6 Q9HQB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
402_I	463_C	3.997	1.00
403_N	407_P	3.867	1.00
325_V	360_A	3.545	1.00
442_R	446_R	3.525	1.00
396_R	467_E	3.474	1.00
453_Y	465_R	3.319	1.00
272_T	294_L	3.183	1.00
400_D	463_C	3.096	1.00
413_R	456_D	2.851	1.00
360_A	448_M	2.789	1.00
398_Y	467_E	2.767	1.00
389_R	400_D	2.753	1.00
350_D	387_C	2.706	1.00
400_D	465_R	2.671	1.00
380_G	404_T	2.644	1.00
385_N	404_T	2.639	1.00
391_S	398_Y	2.620	1.00
269_R	299_R	2.598	1.00
398_Y	465_R	2.568	1.00
324_N	359_L	2.561	1.00
441_A	452_L	2.540	1.00
454_L	464_F	2.535	1.00
350_D	385_N	2.517	1.00
276_A	295_D	2.506	1.00
457_E	460_Q	2.504	1.00
387_C	402_I	2.489	1.00
409_P	412_E	2.475	1.00
368_V	445_I	2.442	1.00
276_A	292_S	2.428	1.00
391_S	400_D	2.377	1.00
352_D	389_R	2.368	1.00
324_N	357_A	2.354	1.00
417_F	452_L	2.336	1.00
455_V	465_R	2.332	1.00
455_V	463_C	2.326	1.00
389_R	402_I	2.319	1.00
445_I	450_G	2.291	1.00
413_R	454_L	2.278	1.00
408_I	416_I	2.254	1.00
326_E	329_P	2.195	1.00
227_S	230_R	2.174	1.00
451_E	467_E	2.124	1.00
333_T	366_M	2.122	1.00
456_D	462_V	2.119	1.00
445_I	466_I	2.075	1.00
412_E	415_M	2.070	1.00
284_T	287_Q	2.055	1.00
269_R	298_S	2.054	1.00
338_H	370_D	2.051	1.00
323_E	362_P	2.040	1.00
348_H	385_N	1.998	1.00
352_D	387_C	1.996	1.00
368_V	444_C	1.914	1.00
415_M	418_E	1.901	1.00
360_A	365_L	1.873	1.00
410_Q	413_R	1.857	1.00
380_G	384_G	1.853	1.00
384_G	404_T	1.812	1.00
322_L	359_L	1.810	1.00
393_H	398_Y	1.804	1.00
368_V	441_A	1.799	1.00
453_Y	467_E	1.798	1.00
269_R	302_Q	1.782	1.00
252_Q	256_H	1.767	1.00
302_Q	306_E	1.760	1.00
408_I	412_E	1.757	1.00
342_A	377_V	1.755	1.00
374_S	378_H	1.743	1.00
283_L	287_Q	1.726	1.00
225_G	230_R	1.714	1.00
247_E	250_R	1.709	1.00
412_E	421_F	1.687	1.00
415_M	421_F	1.686	1.00
226_P	230_R	1.684	1.00
246_L	250_R	1.684	1.00
444_C	448_M	1.673	1.00
369_L	399_I	1.664	1.00
446_R	451_E	1.641	1.00
408_I	462_V	1.638	1.00
272_T	295_D	1.629	1.00
210_R	215_R	1.627	1.00
273_E	295_D	1.616	1.00
283_L	286_E	1.611	1.00
399_I	466_I	1.606	1.00
361_E	364_L	1.597	1.00
47_V	50_T	1.583	1.00
248_S	252_Q	1.576	1.00
371_N	441_A	1.574	1.00
240_S	244_S	1.548	1.00
387_C	404_T	1.548	1.00
276_A	288_K	1.540	1.00
412_E	423_G	1.512	1.00
205_E	231_S	1.497	1.00
328_A	332_E	1.496	1.00
417_F	454_L	1.448	1.00
403_N	461_D	1.447	1.00
275_L	291_V	1.436	1.00
295_D	299_R	1.425	1.00
215_R	218_G	1.420	1.00
271_G	290_V	1.419	1.00
268_M	298_S	1.417	1.00
247_E	251_H	1.409	1.00
364_L	367_S	1.402	1.00
239_L	243_L	1.395	1.00
456_D	460_Q	1.394	1.00
379_Y	422_Q	1.393	1.00
380_G	386_I	1.385	1.00
190_V	194_T	1.378	1.00
240_S	243_L	1.370	1.00
260_E	367_S	1.364	1.00
445_I	452_L	1.358	1.00
368_V	466_I	1.353	1.00
326_E	357_A	1.347	1.00
362_P	366_M	1.345	1.00
253_F	257_L	1.344	1.00
333_T	362_P	1.336	1.00
413_R	417_F	1.333	1.00
339_S	343_R	1.331	1.00
237_L	240_S	1.330	1.00
409_P	458_S	1.329	1.00
320_V	361_E	1.327	1.00
418_E	421_F	1.323	1.00
267_S	271_G	1.319	1.00
328_A	390_S	1.318	1.00
364_L	444_C	1.310	1.00
205_E	209_N	1.310	1.00
456_D	459_G	1.308	1.00
268_M	294_L	1.308	1.00
208_I	211_L	1.304	1.00
337_A	366_M	1.289	1.00
32_Q	36_S	1.281	1.00
236_I	239_L	1.274	1.00
341_P	344_A	1.272	1.00
210_R	219_N	1.263	1.00
443_D	446_R	1.262	1.00
250_R	254_L	1.260	1.00
332_E	351_V	1.258	1.00
450_G	468_L	1.254	1.00
335_V	351_V	1.245	1.00
278_Q	287_Q	1.241	1.00
269_R	295_D	1.235	1.00
364_L	447_R	1.229	1.00
256_H	419_P	1.219	1.00
417_F	464_F	1.209	1.00
267_S	297_S	1.208	1.00
229_L	233_G	1.188	1.00
330_L	334_V	1.187	1.00
454_L	462_V	1.184	1.00
233_G	237_L	1.168	1.00
208_I	212_G	1.161	1.00
202_K	205_E	1.144	1.00
292_S	296_S	1.135	1.00
211_L	240_S	1.133	1.00
245_W	249_Q	1.128	1.00
328_A	353_L	1.124	1.00
402_I	457_E	1.116	1.00
396_R	451_E	1.114	1.00
416_I	454_L	1.104	1.00
353_L	390_S	1.103	1.00
284_T	288_K	1.096	1.00
334_V	370_D	1.091	1.00
356_T	397_V	1.084	1.00
275_L	287_Q	1.082	1.00
403_N	462_V	1.082	1.00
303_K	363_M	1.081	1.00
331_V	390_S	1.081	1.00
417_F	442_R	1.079	1.00
173_Q	177_W	1.079	1.00
365_L	448_M	1.078	1.00
86_V	90_Q	1.076	1.00
207_M	221_V	1.071	1.00
410_Q	456_D	1.067	1.00
225_G	229_L	1.062	1.00
39_A	43_Q	1.060	1.00
38_N	41_S	1.058	1.00
248_S	251_H	1.055	1.00
272_T	276_A	1.055	1.00
252_Q	419_P	1.054	1.00
272_T	298_S	1.052	1.00
376_A	386_I	1.051	1.00
141_A	144_S	1.050	1.00
204_I	208_I	1.044	1.00
422_Q	431_V	1.040	1.00
225_G	233_G	1.037	1.00
169_A	173_Q	1.037	1.00
195_R	199_G	1.031	1.00
194_T	198_I	1.030	1.00
270_E	274_L	1.030	1.00
334_V	338_H	1.026	1.00
272_T	291_V	1.024	1.00
271_G	293_I	1.020	1.00
371_N	374_S	1.014	1.00
95_S	99_D	1.013	1.00
262_K	306_E	1.012	1.00
34_W	38_N	1.011	1.00
86_V	91_R	1.009	1.00
306_E	310_D	1.005	1.00
187_L	191_L	1.003	1.00
320_V	364_L	0.996	1.00
325_V	330_L	0.993	1.00
91_R	95_S	0.989	1.00
288_K	292_S	0.986	1.00
88_Q	92_K	0.985	1.00
436_L	440_I	0.985	1.00
64_A	68_M	0.984	1.00
307_Q	364_L	0.984	1.00
244_S	248_S	0.982	1.00
140_E	143_A	0.981	1.00
220_S	241_E	0.981	1.00
267_S	270_E	0.979	1.00
197_I	200_P	0.972	1.00
322_L	448_M	0.971	1.00
334_V	366_M	0.970	1.00
408_I	454_L	0.970	1.00
54_D	57_R	0.966	1.00
205_E	208_I	0.966	1.00
226_P	229_L	0.965	1.00
229_L	232_V	0.964	1.00
208_I	235_R	0.963	1.00
372_L	464_F	0.962	1.00
369_L	401_V	0.959	1.00
48_N	51_T	0.955	1.00
144_S	148_E	0.946	1.00
354_K	391_S	0.945	1.00
419_P	443_D	0.944	1.00
309_L	312_N	0.944	1.00
96_E	100_A	0.938	1.00
69_E	73_R	0.932	1.00
140_E	144_S	0.930	1.00
408_I	413_R	0.926	1.00
14_L	227_S	0.925	1.00
289_E	293_I	0.923	1.00
94_Y	98_L	0.922	1.00
235_R	238_W	0.919	1.00
209_N	231_S	0.918	1.00
246_L	249_Q	0.915	1.00
188_V	192_L	0.914	1.00
215_R	219_N	0.914	1.00
208_I	236_I	0.911	1.00
356_T	392_L	0.907	1.00
36_S	39_A	0.906	1.00
33_A	37_L	0.904	1.00
205_E	235_R	0.900	1.00
218_G	244_S	0.899	1.00
338_H	373_Y	0.898	1.00
379_Y	406_T	0.897	1.00
369_L	373_Y	0.894	1.00
373_Y	388_L	0.892	1.00
303_K	307_Q	0.890	1.00
296_S	333_T	0.890	1.00
372_L	452_L	0.889	1.00
293_I	297_S	0.888	1.00
58_S	62_T	0.886	1.00
393_H	396_R	0.885	1.00
381_A	384_G	0.881	1.00
327_L	399_I	0.880	1.00
161_G	165_Q	0.879	1.00
407_P	462_V	0.879	1.00
294_L	298_S	0.879	1.00
329_P	333_T	0.876	1.00
416_I	464_F	0.875	1.00
103_G	106_P	0.873	1.00
139_L	143_A	0.873	1.00
269_R	273_E	0.870	1.00
341_P	374_S	0.869	1.00
62_T	66_L	0.867	1.00
337_A	370_D	0.863	1.00
31_W	35_Q	0.863	1.00
99_D	102_A	0.862	1.00
242_R	245_W	0.862	1.00
260_E	371_N	0.862	1.00
445_I	468_L	0.861	1.00
65_A	69_E	0.860	1.00
12_R	195_R	0.857	1.00
192_L	196_M	0.855	1.00
209_N	213_E	0.854	1.00
238_W	242_R	0.853	1.00
372_L	466_I	0.853	1.00
223_F	234_Q	0.852	1.00
441_A	445_I	0.849	1.00
366_M	370_D	0.848	1.00
330_L	360_A	0.847	1.00
370_D	374_S	0.847	1.00
347_M	380_G	0.846	1.00
372_L	441_A	0.845	1.00
297_S	300_N	0.842	1.00
393_H	467_E	0.838	1.00
93_R	96_E	0.834	1.00
363_M	366_M	0.833	1.00
45_A	49_R	0.832	1.00
36_S	40_L	0.832	1.00
335_V	339_S	0.831	1.00
322_L	449_Q	0.829	1.00
46_L	49_R	0.828	1.00
282_P	287_Q	0.828	1.00
90_Q	93_R	0.824	1.00
443_D	447_R	0.821	1.00
408_I	414_A	0.820	1.00
334_V	373_Y	0.818	1.00
285_P	288_K	0.816	1.00
33_A	36_S	0.816	1.00
230_R	234_Q	0.815	1.00
450_G	466_I	0.815	1.00
64_A	67_E	0.814	1.00
92_K	95_S	0.813	1.00
331_V	369_L	0.811	1.00
148_E	152_A	0.811	1.00
220_S	244_S	0.810	1.00
153_T	157_V	0.806	1.00
92_K	96_E	0.806	1.00
346_M	383_S	0.806	1.00
338_H	374_S	0.805	1.00
57_R	60_A	0.805	1.00
368_V	448_M	0.801	1.00
254_L	257_L	0.800	1.00
60_A	64_A	0.799	1.00
259_H	371_N	0.798	1.00
274_L	278_Q	0.797	1.00
61_M	65_A	0.794	1.00
292_S	295_D	0.794	1.00
191_L	195_R	0.793	1.00
97_M	101_H	0.791	1.00
321_E	361_E	0.789	1.00
200_P	204_I	0.788	1.00
50_T	54_D	0.784	1.00
241_E	245_W	0.784	1.00
84_A	88_Q	0.784	1.00
93_R	97_M	0.784	1.00
51_T	55_A	0.782	1.00
172_G	176_G	0.781	1.00
144_S	147_T	0.779	1.00
322_L	360_A	0.776	1.00
149_M	153_T	0.775	1.00
225_G	228_E	0.775	1.00
66_L	69_E	0.775	1.00
211_L	239_L	0.774	1.00
139_L	144_S	0.774	1.00
332_E	336_S	0.773	1.00
176_G	180_L	0.771	1.00
210_R	214_G	0.770	1.00
289_E	292_S	0.770	1.00
232_V	236_I	0.769	1.00
95_S	98_L	0.767	1.00
226_P	233_G	0.765	1.00
260_E	264_P	0.763	1.00
261_L	301_L	0.762	1.00
101_H	105_L	0.760	1.00
311_Y	439_S	0.760	1.00
263_T	267_S	0.758	1.00
442_R	451_E	0.758	1.00
259_H	263_T	0.757	1.00
299_R	302_Q	0.757	1.00
154_R	158_F	0.755	1.00
209_N	235_R	0.753	1.00
348_H	351_V	0.753	1.00
206_R	210_R	0.753	1.00
406_T	431_V	0.749	1.00
99_D	103_G	0.748	1.00
254_L	258_S	0.746	1.00
194_T	197_I	0.745	1.00
222_S	237_L	0.745	1.00
326_E	356_T	0.742	1.00
40_L	43_Q	0.739	1.00
328_A	355_A	0.739	1.00
207_M	219_N	0.739	1.00
196_M	199_G	0.738	1.00
88_Q	91_R	0.737	1.00
367_S	444_C	0.736	1.00
310_D	367_S	0.736	1.00
287_Q	290_V	0.735	1.00
231_S	234_Q	0.735	1.00
413_R	455_V	0.734	1.00
403_N	406_T	0.734	1.00
143_A	146_N	0.731	1.00
257_L	308_L	0.729	1.00
155_T	160_R	0.729	1.00
265_L	305_I	0.725	1.00
422_Q	433_G	0.725	1.00
328_A	356_T	0.724	1.00
298_S	302_Q	0.724	1.00
388_L	401_V	0.722	1.00
307_Q	367_S	0.721	1.00
325_V	362_P	0.721	1.00
253_F	260_E	0.718	1.00
342_A	349_T	0.717	1.00
262_K	302_Q	0.716	1.00
278_Q	282_P	0.716	1.00
346_M	382_E	0.715	1.00
51_T	54_D	0.714	1.00
220_S	240_S	0.713	1.00
53_I	56_R	0.713	1.00
340_L	344_A	0.713	1.00
22_I	26_L	0.713	1.00
271_G	294_L	0.712	1.00
320_V	447_R	0.710	1.00
408_I	456_D	0.708	1.00
39_A	42_D	0.706	1.00
332_E	335_V	0.706	1.00
230_R	233_G	0.705	1.00
342_A	386_I	0.701	1.00
390_S	397_V	0.701	1.00
85_K	89_S	0.697	1.00
378_H	431_V	0.697	1.00
68_M	72_Y	0.696	1.00
65_A	68_M	0.694	1.00
202_K	206_R	0.693	1.00
408_I	464_F	0.691	1.00
241_E	244_S	0.690	1.00
327_L	397_V	0.689	1.00
266_A	270_E	0.689	1.00
145_A	148_E	0.688	1.00
54_D	58_S	0.688	1.00
343_R	346_M	0.688	1.00
331_V	388_L	0.688	1.00
341_P	345_K	0.688	1.00
410_Q	414_A	0.687	1.00
400_D	455_V	0.686	1.00
148_E	151_Q	0.682	1.00
97_M	102_A	0.682	1.00
412_E	425_H	0.680	1.00
293_I	296_S	0.680	1.00
106_P	109_K	0.678	1.00
150_V	153_T	0.677	1.00
233_G	236_I	0.677	1.00
409_P	423_G	0.676	1.00
392_L	397_V	0.676	1.00
335_V	349_T	0.676	1.00
97_M	100_A	0.674	1.00
173_Q	176_G	0.672	1.00
203_N	206_R	0.671	1.00
333_T	337_A	0.671	1.00
106_P	110_L	0.671	1.00
364_L	368_V	0.670	1.00
276_A	291_V	0.670	1.00
220_S	237_L	0.669	1.00
47_V	51_T	0.669	1.00
232_V	235_R	0.668	1.00
271_G	297_S	0.668	1.00
450_G	469_P	0.667	1.00
100_A	103_G	0.665	1.00
364_L	448_M	0.664	1.00
221_V	233_G	0.663	1.00
49_R	53_I	0.662	1.00
342_A	345_K	0.661	1.00
410_Q	457_E	0.661	1.00
336_S	339_S	0.658	1.00
208_I	232_V	0.657	1.00
345_K	382_E	0.656	1.00
209_N	212_G	0.654	1.00
142_F	145_A	0.653	1.00
225_G	232_V	0.653	1.00
290_V	294_L	0.653	1.00
418_E	442_R	0.651	1.00
332_E	353_L	0.651	1.00
83_L	86_V	0.650	1.00
53_I	57_R	0.650	1.00
38_N	42_D	0.649	1.00
210_R	213_E	0.647	1.00
372_L	445_I	0.647	1.00
91_R	97_M	0.645	1.00
342_A	347_M	0.644	1.00
59_E	62_T	0.644	1.00
45_A	48_N	0.643	1.00
35_Q	38_N	0.643	1.00
245_W	248_S	0.642	1.00
211_L	214_G	0.642	1.00
300_N	366_M	0.642	1.00
85_K	88_Q	0.641	1.00
347_M	377_V	0.640	1.00
35_Q	172_G	0.636	1.00
376_A	401_V	0.632	1.00
267_S	293_I	0.632	1.00
301_L	305_I	0.631	1.00
334_V	337_A	0.631	1.00
204_I	233_G	0.630	1.00
228_E	232_V	0.630	1.00
255_R	258_S	0.630	1.00
32_Q	35_Q	0.629	1.00
63_N	67_E	0.627	1.00
212_G	238_W	0.626	1.00
57_R	65_A	0.624	1.00
340_L	343_R	0.623	1.00
402_I	459_G	0.623	1.00
325_V	359_L	0.622	1.00
440_I	444_C	0.622	1.00
186_S	190_V	0.620	1.00
60_A	63_N	0.619	1.00
453_Y	466_I	0.615	1.00
107_D	110_L	0.613	1.00
390_S	399_I	0.612	1.00
174_Y	177_W	0.610	1.00
274_L	290_V	0.609	1.00
335_V	388_L	0.609	1.00
356_T	390_S	0.609	1.00
327_L	358_C	0.609	1.00
378_H	433_G	0.609	1.00
217_L	221_V	0.607	1.00
203_N	207_M	0.605	1.00
310_D	364_L	0.605	1.00
352_D	391_S	0.605	1.00
398_Y	453_Y	0.603	1.00
102_A	106_P	0.603	1.00
219_N	223_F	0.602	1.00
96_E	102_A	0.602	1.00
329_P	362_P	0.601	1.00
82_T	85_K	0.601	1.00
413_R	464_F	0.600	1.00
168_I	172_G	0.599	1.00
105_L	108_D	0.599	1.00
40_L	44_A	0.598	1.00
56_R	60_A	0.597	1.00
315_Q	419_P	0.597	1.00
260_E	440_I	0.594	1.00
196_M	200_P	0.593	1.00
266_A	269_R	0.593	1.00
37_L	41_S	0.593	1.00
441_A	444_C	0.592	1.00
89_S	93_R	0.589	1.00
98_L	104_V	0.588	1.00
271_G	275_L	0.588	1.00
101_H	104_V	0.586	1.00
290_V	293_I	0.585	1.00
253_F	258_S	0.584	1.00
207_M	210_R	0.582	1.00
256_H	260_E	0.582	1.00
330_L	365_L	0.581	1.00
336_S	340_L	0.580	1.00
169_A	172_G	0.578	1.00
147_T	150_V	0.577	1.00
365_L	468_L	0.576	1.00
104_V	108_D	0.576	1.00
219_N	222_S	0.575	1.00
396_R	469_P	0.575	1.00
416_I	439_S	0.575	1.00
381_A	406_T	0.574	1.00
347_M	351_V	0.573	1.00
67_E	70_R	0.569	1.00
140_E	145_A	0.569	1.00
144_S	152_A	0.568	1.00
102_A	105_L	0.568	1.00
416_I	421_F	0.567	1.00
86_V	97_M	0.566	1.00
81_P	84_A	0.565	1.00
165_Q	169_A	0.565	1.00
139_L	142_F	0.564	1.00
386_I	401_V	0.562	1.00
49_R	52_L	0.561	1.00
170_E	174_Y	0.561	1.00
392_L	396_R	0.561	1.00
297_S	337_A	0.560	1.00
373_Y	386_I	0.560	1.00
100_A	104_V	0.560	1.00
338_H	377_V	0.558	1.00
252_Q	443_D	0.557	1.00
199_G	203_N	0.557	1.00
35_Q	39_A	0.556	1.00
59_E	63_N	0.553	1.00
180_L	184_L	0.552	1.00
308_L	312_N	0.552	1.00
261_L	264_P	0.551	1.00
320_V	448_M	0.551	1.00
236_I	240_S	0.550	1.00
89_S	92_K	0.550	1.00
98_L	101_H	0.549	1.00
223_F	233_G	0.546	1.00
413_R	462_V	0.546	1.00
231_S	235_R	0.546	1.00
201_V	232_V	0.546	1.00
302_Q	305_I	0.545	1.00
206_R	209_N	0.543	1.00
103_G	107_D	0.543	1.00
309_L	313_R	0.541	1.00
63_N	66_L	0.541	1.00
223_F	230_R	0.539	1.00
237_L	241_E	0.539	1.00
96_E	99_D	0.538	1.00
330_L	366_M	0.538	1.00
452_L	464_F	0.537	1.00
12_R	202_K	0.537	1.00
203_N	222_S	0.537	1.00
311_Y	419_P	0.536	1.00
414_A	418_E	0.536	1.00
275_L	294_L	0.534	1.00
271_G	298_S	0.534	1.00
367_S	370_D	0.534	1.00
260_E	304_L	0.534	1.00
409_P	413_R	0.532	1.00
19_F	190_V	0.531	1.00
439_S	443_D	0.531	1.00
260_E	263_T	0.529	1.00
251_H	315_Q	0.529	1.00
295_D	298_S	0.529	1.00
30_A	34_W	0.529	1.00
201_V	205_E	0.528	1.00
21_L	24_L	0.528	1.00
311_Y	443_D	0.528	1.00
356_T	359_L	0.528	1.00
208_I	239_L	0.526	1.00
268_M	272_T	0.526	1.00
286_E	290_V	0.526	1.00
253_F	420_F	0.526	1.00
43_Q	47_V	0.524	1.00
200_P	227_S	0.523	1.00
67_E	71_S	0.522	1.00
55_A	58_S	0.521	1.00
422_Q	432_K	0.521	1.00
204_I	207_M	0.520	1.00
149_M	155_T	0.520	1.00
299_R	303_K	0.520	1.00
243_L	246_L	0.516	1.00
166_R	170_E	0.515	1.00
342_A	346_M	0.514	1.00
104_V	107_D	0.514	1.00
43_Q	46_L	0.513	1.00
208_I	214_G	0.513	1.00
68_M	73_R	0.511	1.00
98_L	102_A	0.510	1.00
325_V	365_L	0.510	1.00
68_M	71_S	0.509	1.00
329_P	332_E	0.507	1.00
424_S	432_K	0.507	1.00
201_V	204_I	0.506	1.00
141_A	149_M	0.504	1.00
273_E	276_A	0.504	1.00
12_R	16_M	0.504	1.00
28_V	32_Q	0.504	1.00
358_C	397_V	0.504	1.00
291_V	295_D	0.503	1.00
147_T	152_A	0.503	1.00
270_E	298_S	0.502	1.00
25_P	28_V	0.502	1.00
17_L	20_L	0.501	1.00
445_I	451_E	0.501	1.00
23_L	26_L	0.501	1.00
84_A	91_R	0.500	1.00
278_Q	290_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.5705	100	0.329	Contact Map
4bixA	2	0.4779	100	0.362	Contact Map
4ctiA	2	0.48	100	0.398	Contact Map
4q20A	2	0.48	100	0.449	Contact Map
4mpcA	2	0.6295	100	0.463	Contact Map
3jz3A	2	0.3347	100	0.467	Contact Map
2c2aA	2	0.4905	100	0.47	Contact Map
2q8gA	2	0.6358	100	0.472	Contact Map
3d36A	2	0.4653	100	0.474	Contact Map
2e0aA	2	0.6526	100	0.48	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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