GREMLIN Database
TILS - tRNA(Ile)-lysidine synthase
UniProt: P52097 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13220
Length: 432 (393)
Sequences: 3177 (2753)
Seq/√Len: 138.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_T67_V3.7531.00
56_N178_E3.6401.00
50_H58_D3.6161.00
183_D193_R3.4511.00
27_V167_A3.1861.00
183_D192_L2.8371.00
46_A68_C2.7161.00
78_E103_R2.7141.00
199_Q206_A2.6641.00
45_R76_V2.6161.00
160_R164_V2.5961.00
61_V65_E2.5651.00
46_A73_V2.5321.00
118_D206_A2.5251.00
47_I100_A2.4891.00
52_G79_R2.4571.00
50_H57_A2.4011.00
50_H61_V2.3981.00
375_R383_E2.3741.00
61_V77_V2.3691.00
121_C209_T2.3611.00
30_H166_W2.3361.00
105_L111_L2.3361.00
19_F64_C2.3271.00
19_F46_A2.3261.00
23_L167_A2.3231.00
254_R279_W2.2981.00
176_E181_Q2.2831.00
29_L46_A2.2601.00
218_E255_A2.2201.00
126_L186_D2.1271.00
65_E69_Q2.1211.00
53_L89_I2.0771.00
14_Q43_A2.0731.00
225_E250_S2.0151.00
124_F213_A1.9971.00
15_I112_V1.9831.00
30_H170_Y1.9571.00
212_S216_C1.9101.00
19_F26_T1.8931.00
18_A101_F1.8921.00
365_L368_I1.8701.00
68_C75_L1.8671.00
17_V32_L1.8611.00
60_W175_I1.8241.00
23_L163_L1.8201.00
45_R108_G1.8091.00
67_V71_W1.8021.00
112_V152_I1.7821.00
23_L27_V1.7811.00
90_E179_S1.7401.00
13_R110_V1.7331.00
23_L176_E1.7291.00
120_Q140_M1.7121.00
31_Q155_L1.6961.00
381_W394_T1.6861.00
226_L229_D1.6841.00
26_T172_L1.6781.00
30_H71_W1.6771.00
14_Q45_R1.6681.00
17_V28_L1.6671.00
242_Q245_P1.6581.00
91_A95_Q1.6581.00
113_T151_L1.6561.00
30_H172_L1.6531.00
124_F209_T1.6521.00
358_V397_L1.6461.00
62_T65_E1.6351.00
59_A175_I1.5981.00
240_T306_Q1.5951.00
228_A260_R1.5831.00
128_L212_S1.5741.00
33_V73_V1.5721.00
398_F403_L1.5701.00
219_Q256_A1.5681.00
61_V79_R1.5671.00
66_N70_Q1.5671.00
54_S178_E1.5601.00
135_A220_E1.5581.00
19_F67_V1.5531.00
189_F201_R1.5521.00
399_Y402_T1.5521.00
129_K198_L1.5491.00
378_K382_Q1.5431.00
361_K392_D1.5361.00
16_L45_R1.5251.00
365_L374_G1.5241.00
13_R109_E1.5211.00
222_L226_L1.5161.00
32_L112_V1.5111.00
29_L68_C1.5051.00
47_I104_T1.5021.00
121_C195_V1.4841.00
58_D79_R1.4831.00
129_K202_W1.4721.00
396_L403_L1.4581.00
30_H34_Q1.4381.00
18_A113_T1.4321.00
33_V71_W1.4271.00
134_P216_C1.4201.00
31_Q35_W1.4161.00
124_F139_A1.4131.00
159_T162_E1.4081.00
190_L194_V1.4081.00
220_E224_D1.4041.00
98_Y113_T1.4031.00
165_Q169_Q1.3951.00
193_R197_L1.3941.00
398_F401_E1.3881.00
230_D253_R1.3861.00
49_V80_V1.3821.00
16_L104_T1.3761.00
68_C73_V1.3681.00
49_V78_E1.3651.00
47_I101_F1.3361.00
377_L381_W1.3361.00
121_C213_A1.3291.00
105_L149_T1.3281.00
27_V166_W1.3141.00
164_V168_R1.3041.00
62_T66_N1.2911.00
143_V150_R1.2881.00
117_L210_A1.2801.00
55_A60_W1.2801.00
95_Q99_Q1.2701.00
244_V305_S1.2591.00
65_E75_L1.2591.00
133_G136_G1.2451.00
231_L235_Q1.2411.00
359_R398_F1.2391.00
16_L47_I1.2251.00
23_L164_V1.2231.00
102_A105_L1.2211.00
215_L272_R1.2211.00
167_A172_L1.2031.00
50_H79_R1.2011.00
88_G91_A1.1951.00
76_V107_P1.1941.00
366_L380_I1.1931.00
379_K382_Q1.1921.00
167_A174_W1.1911.00
137_L212_S1.1901.00
380_I406_A1.1901.00
141_A144_S1.1851.00
90_E185_Y1.1781.00
82_L96_A1.1761.00
377_L406_A1.1680.99
227_L257_I1.1680.99
90_E182_D1.1630.99
88_G92_Q1.1530.99
361_K364_G1.1520.99
348_R352_A1.1490.99
134_P219_Q1.1440.99
80_V96_A1.1440.99
394_T409_V1.1420.99
26_T174_W1.1410.99
63_H175_I1.1410.99
348_R351_R1.1410.99
205_F209_T1.1410.99
87_L95_Q1.1390.99
46_A75_L1.1360.99
26_T63_H1.1350.99
396_L406_A1.1340.99
161_G199_Q1.1320.99
300_I309_W1.1300.99
258_I278_I1.1280.99
132_S136_G1.1220.99
118_D199_Q1.1210.99
65_E77_V1.1160.99
34_Q170_Y1.1160.99
121_C206_A1.1140.99
230_D249_M1.1100.99
204_H208_A1.1000.99
399_Y404_I1.0990.99
78_E100_A1.0950.99
117_L206_A1.0910.99
116_H163_L1.0910.99
89_I185_Y1.0900.99
242_Q305_S1.0820.99
215_L219_Q1.0800.99
54_S60_W1.0800.99
360_F395_P1.0770.99
223_L256_A1.0720.99
380_I409_V1.0720.99
361_K378_K1.0720.99
243_I302_R1.0540.99
367_H374_G1.0530.99
194_V198_L1.0500.99
49_V100_A1.0490.99
166_W170_Y1.0480.99
155_L158_R1.0380.99
164_V176_E1.0370.99
52_G58_D1.0370.99
59_A178_E1.0360.99
144_S149_T1.0360.99
59_A62_T1.0360.99
117_L159_T1.0360.99
208_A211_R1.0320.99
138_S141_A1.0250.99
17_V44_L1.0240.99
278_I300_I1.0240.99
142_E157_A1.0240.99
82_L92_Q1.0230.99
330_L333_P1.0220.99
292_C299_E1.0220.99
193_R200_Q1.0220.99
23_L174_W1.0160.99
31_Q158_R1.0130.99
161_G165_Q1.0120.99
304_Q385_G1.0080.98
124_F132_S1.0020.98
103_R107_P0.9980.98
110_V152_I0.9970.98
277_R281_E0.9960.98
87_L92_Q0.9940.98
395_P407_A0.9900.98
23_L160_R0.9870.98
124_F128_L0.9860.98
14_Q109_E0.9780.98
289_A294_R0.9760.98
379_K383_E0.9740.98
204_H207_E0.9700.98
194_V202_W0.9690.98
365_L369_V0.9650.98
66_N69_Q0.9630.98
96_A99_Q0.9610.98
116_H160_R0.9610.98
99_Q103_R0.9600.98
249_M257_I0.9590.98
221_S250_S0.9580.98
359_R365_L0.9570.98
274_A294_R0.9560.98
32_L44_L0.9520.98
299_E310_I0.9520.98
102_A150_R0.9480.98
33_V36_R0.9480.98
333_P336_L0.9470.98
64_C75_L0.9460.98
27_V163_L0.9430.98
121_C210_A0.9420.98
198_L202_W0.9420.98
48_H61_V0.9410.98
16_L76_V0.9370.98
246_M254_R0.9360.98
159_T206_A0.9340.97
365_L370_G0.9310.97
219_Q223_L0.9240.97
63_H174_W0.9200.97
113_T140_M0.9180.97
347_I404_I0.9180.97
230_D234_C0.9180.97
384_L410_F0.9150.97
332_L335_G0.9140.97
368_I371_R0.9130.97
198_L205_F0.9100.97
29_L44_L0.9080.97
229_D233_H0.9070.97
129_K209_T0.9050.97
47_I78_E0.9000.97
35_W42_V0.8970.97
387_P390_L0.8960.97
46_A64_C0.8900.97
206_A210_A0.8890.97
194_V197_L0.8890.97
36_R42_V0.8880.97
366_L370_G0.8840.96
251_D254_R0.8830.96
179_S182_D0.8800.96
90_E184_S0.8790.96
361_K396_L0.8700.96
125_L190_L0.8650.96
227_L260_R0.8640.96
132_S212_S0.8640.96
78_E104_T0.8640.96
210_A213_A0.8630.96
17_V46_A0.8630.96
179_S188_N0.8570.96
380_I410_F0.8560.96
182_D185_Y0.8530.96
211_R215_L0.8490.96
76_V104_T0.8490.96
333_P337_G0.8490.96
16_L108_G0.8480.96
89_I93_A0.8460.95
255_A276_V0.8450.95
199_Q205_F0.8390.95
380_I384_L0.8250.95
189_F192_L0.8220.95
26_T64_C0.8210.95
354_E399_Y0.8200.95
224_D260_R0.8190.95
301_R310_I0.8170.95
195_V209_T0.8160.95
15_I152_I0.8160.95
352_A399_Y0.8160.95
56_N59_A0.8150.94
125_L213_A0.8140.94
226_L230_D0.8120.94
126_L190_L0.8110.94
274_A277_R0.8100.94
357_S398_F0.8080.94
26_T71_W0.8050.94
302_R305_S0.8040.94
15_I32_L0.8030.94
234_C245_P0.8020.94
347_I350_P0.8020.94
182_D192_L0.7970.94
197_L201_R0.7940.94
205_F208_A0.7940.94
127_A132_S0.7920.94
140_M156_L0.7910.94
352_A355_A0.7910.94
260_R264_G0.7860.93
332_L337_G0.7840.93
102_A149_T0.7820.93
186_D189_F0.7810.93
15_I110_V0.7780.93
30_H33_V0.7760.93
277_R280_Q0.7760.93
57_A61_V0.7740.93
160_R163_L0.7740.93
252_A256_A0.7720.93
394_T407_A0.7710.93
140_M144_S0.7710.93
356_V404_I0.7670.92
50_H178_E0.7670.92
45_R74_P0.7640.92
390_L393_T0.7630.92
124_F137_L0.7610.92
28_L32_L0.7550.92
218_E251_D0.7500.92
298_F309_W0.7490.92
63_H67_V0.7490.92
197_L200_Q0.7440.91
80_V100_A0.7420.91
21_G64_C0.7400.91
101_F113_T0.7380.91
365_L371_R0.7370.91
358_V395_P0.7350.91
158_R163_L0.7350.91
405_A408_G0.7340.91
220_E223_L0.7330.91
170_Y173_R0.7300.91
241_L261_W0.7270.90
48_H75_L0.7250.90
384_L409_V0.7250.90
67_V70_Q0.7250.90
101_F105_L0.7230.90
19_F63_H0.7230.90
262_L267_A0.7230.90
356_V399_Y0.7230.90
271_S274_A0.7210.90
227_L256_A0.7190.90
303_Y389_W0.7180.90
262_L270_P0.7180.90
186_D201_R0.7180.90
27_V172_L0.7180.90
124_F216_C0.7170.90
111_L151_L0.7150.90
168_R174_W0.7110.89
138_S217_A0.7110.89
227_L230_D0.7100.89
242_Q306_Q0.7090.89
118_D161_G0.7090.89
228_A232_A0.7080.89
105_L150_R0.7070.89
361_K377_L0.7050.89
120_Q156_L0.7050.89
229_D232_A0.7000.89
87_L91_A0.6980.88
243_I307_L0.6980.88
27_V155_L0.6970.88
386_V391_R0.6970.88
92_Q96_A0.6940.88
18_A98_Y0.6910.88
256_A260_R0.6880.88
376_K379_K0.6870.88
36_R40_P0.6860.88
382_Q385_G0.6860.88
288_D293_L0.6850.88
179_S184_S0.6850.88
22_G25_S0.6840.87
52_G82_L0.6830.87
125_L195_V0.6820.87
116_H155_L0.6820.87
56_N60_W0.6810.87
120_Q127_A0.6800.87
18_A57_A0.6800.87
304_Q391_R0.6790.87
101_F111_L0.6790.87
60_W64_C0.6790.87
323_W330_L0.6780.87
223_L227_L0.6760.87
231_L260_R0.6760.87
118_D160_R0.6760.87
276_V280_Q0.6750.87
27_V30_H0.6750.87
20_S24_D0.6740.87
376_K382_Q0.6720.87
29_L67_V0.6720.87
349_P352_A0.6710.86
347_I411_V0.6710.86
61_V75_L0.6700.86
366_L369_V0.6690.86
129_K194_V0.6690.86
357_S401_E0.6650.86
183_D189_F0.6640.86
249_M253_R0.6630.86
141_A217_A0.6630.86
219_Q252_A0.6630.86
360_F396_L0.6610.86
117_L207_E0.6600.86
48_H60_W0.6580.85
338_S341_L0.6570.85
370_G373_G0.6560.85
129_K205_F0.6560.85
386_V409_V0.6560.85
405_A411_V0.6560.85
367_H413_Q0.6560.85
98_Y151_L0.6540.85
189_F197_L0.6540.85
20_S25_S0.6520.85
102_A111_L0.6520.85
26_T173_R0.6520.85
260_R263_A0.6510.85
214_A272_R0.6500.85
287_E304_Q0.6480.85
280_Q284_L0.6470.84
138_S216_C0.6470.84
299_E312_S0.6460.84
381_W406_A0.6460.84
381_W396_L0.6440.84
32_L36_R0.6430.84
297_A312_S0.6420.84
253_R256_A0.6410.84
386_V394_T0.6400.84
36_R41_G0.6400.84
251_D255_A0.6380.84
354_E400_G0.6370.84
138_S220_E0.6370.84
14_Q108_G0.6370.84
17_V29_L0.6350.83
323_W328_Q0.6350.83
250_S253_R0.6350.83
223_L226_L0.6330.83
133_G137_L0.6300.83
291_P294_R0.6290.83
279_W283_A0.6290.83
80_V92_Q0.6270.83
127_A212_S0.6260.82
19_F29_L0.6240.82
133_G215_L0.6230.82
29_L73_V0.6210.82
281_E291_P0.6200.82
352_A404_I0.6170.82
105_L108_G0.6170.82
120_Q139_A0.6170.82
121_C124_F0.6150.81
230_D256_A0.6140.81
67_V172_L0.6110.81
234_C242_Q0.6110.81
381_W395_P0.6090.81
361_K382_Q0.6080.81
165_Q168_R0.6060.80
227_L253_R0.6060.80
105_L109_E0.6050.80
224_D227_L0.6030.80
124_F212_S0.6020.80
347_I352_A0.6020.80
155_L163_L0.6000.80
179_S185_Y0.5990.80
34_Q166_W0.5980.80
373_G383_E0.5980.80
245_P248_A0.5960.79
82_L88_G0.5960.79
255_A279_W0.5950.79
243_I247_L0.5950.79
58_D62_T0.5940.79
98_Y144_S0.5940.79
19_F75_L0.5940.79
129_K190_L0.5930.79
63_H173_R0.5930.79
55_A175_I0.5930.79
272_R276_V0.5910.79
402_T412_T0.5910.79
54_S57_A0.5900.79
366_L412_T0.5880.78
405_A410_F0.5880.78
336_L341_L0.5880.78
222_L250_S0.5870.78
258_I279_W0.5870.78
121_C205_F0.5870.78
49_V96_A0.5840.78
273_D277_R0.5810.78
30_H167_A0.5800.77
135_A224_D0.5800.77
63_H172_L0.5790.77
27_V170_Y0.5790.77
227_L231_L0.5790.77
49_V101_F0.5790.77
186_D190_L0.5780.77
26_T167_A0.5770.77
104_T107_P0.5770.77
367_H370_G0.5770.77
45_R109_E0.5760.77
21_G24_D0.5750.77
301_R389_W0.5740.77
327_L330_L0.5720.76
121_C125_L0.5700.76
129_K201_R0.5690.76
371_R379_K0.5680.76
251_D276_V0.5670.76
137_L216_C0.5670.76
27_V116_H0.5670.76
406_A409_V0.5670.76
93_A101_F0.5640.75
334_A337_G0.5630.75
397_L407_A0.5620.75
98_Y153_R0.5620.75
261_W309_W0.5610.75
128_L216_C0.5580.75
398_F404_I0.5550.74
21_G25_S0.5540.74
353_D400_G0.5530.74
226_L253_R0.5530.74
16_L101_F0.5520.74
189_F198_L0.5490.74
16_L105_L0.5480.73
124_F210_A0.5480.73
194_V201_R0.5480.73
53_L88_G0.5460.73
366_L377_L0.5440.73
189_F200_Q0.5440.73
342_N345_G0.5430.73
52_G80_V0.5420.73
53_L90_E0.5420.73
133_G259_R0.5410.72
233_H245_P0.5410.72
82_L93_A0.5390.72
208_A216_C0.5380.72
166_W172_L0.5370.72
304_Q383_E0.5350.72
26_T30_H0.5330.71
144_S254_R0.5330.71
236_S240_T0.5330.71
78_E101_F0.5310.71
55_A178_E0.5310.71
33_V172_L0.5300.71
244_V247_L0.5290.71
261_W265_Q0.5290.71
218_E252_A0.5280.71
23_L60_W0.5270.70
222_L227_L0.5250.70
60_W63_H0.5250.70
331_E334_A0.5220.70
289_A292_C0.5210.70
19_F90_E0.5210.70
254_R283_A0.5210.70
57_A93_A0.5190.69
55_A59_A0.5190.69
167_A176_E0.5190.69
60_W179_S0.5180.69
164_V174_W0.5180.69
30_H67_V0.5170.69
236_S242_Q0.5170.69
359_R364_G0.5160.69
51_H100_A0.5160.69
231_L261_W0.5150.69
190_L195_V0.5140.69
162_E165_Q0.5110.68
304_Q382_Q0.5110.68
80_V93_A0.5110.68
43_A74_P0.5110.68
359_R385_G0.5100.68
330_L335_G0.5080.68
366_L371_R0.5080.68
214_A217_A0.5080.68
282_V307_L0.5080.68
395_P398_F0.5070.68
298_F311_K0.5050.67
214_A218_E0.5050.67
290_S293_L0.5050.67
353_D399_Y0.5040.67
18_A151_L0.5030.67
246_M307_L0.5030.67
117_L120_Q0.5030.67
111_L149_T0.5010.67
18_A76_V0.5000.67
96_A127_A0.5000.67
190_L205_F0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a2kA 1 0.9907 100 0.214 Contact Map
1ni5A 2 0.9931 100 0.232 Contact Map
1wy5A 4 0.6759 100 0.432 Contact Map
3vrhA 2 0.5787 100 0.64 Contact Map
2vxoA 2 0.6875 100 0.733 Contact Map
3rjzA 2 0.4653 100 0.735 Contact Map
3uowA 2 0.5949 100 0.737 Contact Map
2dplA 2 0.5741 100 0.741 Contact Map
3k32A 2 0.4259 100 0.742 Contact Map
1surA 2 0.3889 100 0.747 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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