GREMLIN Database
YAER - Uncharacterized protein YaeR
UniProt: P52096 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13224
Length: 129 (119)
Sequences: 3590 (1936)
Seq/√Len: 177.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_A26_D5.8781.00
91_A95_S3.8761.00
85_D88_A3.1071.00
92_H96_H2.6381.00
32_L35_E2.3901.00
99_K117_N2.3631.00
17_Y46_G2.1531.00
93_L98_V2.0261.00
16_D19_V2.0081.00
112_R128_E1.9561.00
32_L46_G1.8581.00
90_V94_E1.8511.00
22_A27_I1.8051.00
36_V108_Y1.7981.00
30_F50_L1.7741.00
70_R73_A1.7521.00
42_D63_F1.7131.00
20_S58_L1.6961.00
33_Q49_A1.6811.00
87_D112_R1.6801.00
94_E100_C1.5901.00
37_Y44_W1.5661.00
90_V114_T1.5651.00
6_Q82_S1.5521.00
89_A92_H1.5301.00
25_C31_T1.4631.00
117_N121_G1.4491.00
15_T64_P1.4351.00
64_P74_C1.4171.00
27_I96_H1.3831.00
115_F125_E1.3671.00
26_D96_H1.3421.00
81_F124_L1.3041.00
117_N123_P1.2881.00
87_D91_A1.2801.00
19_V22_A1.2761.00
19_V120_D1.2671.00
21_K48_L1.2231.00
39_E42_D1.2131.00
8_H82_S1.2111.00
114_T126_L1.1941.00
42_D62_P1.1831.00
18_A22_A1.1731.00
113_F127_Y1.1711.00
94_E102_T1.1531.00
79_L124_L1.1411.00
31_T49_A1.1201.00
44_W62_P1.1081.00
78_H125_E1.1041.00
31_T51_N1.0991.00
101_E117_N1.0941.00
52_G55_V1.0881.00
14_A17_Y1.0851.00
30_F81_F1.0831.00
37_Y42_D1.0751.00
20_S120_D1.0731.00
15_T66_E1.0731.00
15_T65_P1.0671.00
88_A92_H1.0561.00
20_S24_Y1.0501.00
38_R43_S1.0381.00
88_A91_A1.0280.99
50_L81_F1.0240.99
93_L126_L1.0230.99
116_F124_L1.0140.99
101_E123_P1.0020.99
37_Y62_P0.9940.99
9_H80_A0.9870.99
91_A94_E0.9410.99
28_L116_F0.9360.99
86_I112_R0.9120.99
86_I90_V0.9040.99
92_H95_S0.9010.99
27_I93_L0.8980.99
35_E44_W0.8910.98
83_V89_A0.8880.98
8_H127_Y0.8700.98
35_E46_G0.8660.98
9_H57_E0.8540.98
43_S61_F0.8500.98
38_R41_R0.8490.98
24_Y118_D0.8430.98
76_L79_L0.8430.98
15_T19_V0.8360.98
78_H115_F0.8330.98
102_T114_T0.8290.98
28_L126_L0.8270.98
11_A59_F0.8190.97
11_A77_R0.8150.97
46_G60_S0.8150.97
56_I79_L0.8100.97
15_T120_D0.7980.97
10_I54_Y0.7980.97
36_V45_K0.7910.97
27_I98_V0.7770.96
9_H78_H0.7750.96
50_L53_Q0.7740.96
98_V116_F0.7710.96
14_A46_G0.7670.96
90_V100_C0.7610.96
17_Y60_S0.7520.96
51_N54_Y0.7370.95
45_K59_F0.7270.95
64_P70_R0.7230.95
63_F66_E0.7230.95
38_R42_D0.7200.95
13_I122_L0.7200.95
72_E75_G0.7180.94
116_F126_L0.7090.94
10_I79_L0.7080.94
6_Q53_Q0.7040.94
93_L114_T0.7020.94
31_T52_G0.6980.94
104_R107_P0.6800.93
44_W60_S0.6780.93
13_I61_F0.6780.93
18_A35_E0.6760.92
22_A96_H0.6730.92
31_T99_K0.6730.92
106_D109_T0.6570.91
14_A22_A0.6520.91
20_S119_P0.6500.91
12_I24_Y0.6490.91
107_P110_Q0.6490.91
90_V99_K0.6420.90
43_S106_D0.6400.90
26_D92_H0.6390.90
70_R117_N0.6370.90
107_P111_K0.6300.90
25_C32_L0.6280.89
7_V10_I0.6270.89
25_C48_L0.6260.89
39_E62_P0.6160.89
32_L44_W0.6150.89
6_Q52_G0.6100.88
100_C116_F0.6050.88
66_E71_P0.6000.87
37_Y60_S0.5970.87
43_S113_F0.5920.87
12_I79_L0.5840.86
66_E74_C0.5830.86
71_P74_C0.5790.85
49_A53_Q0.5770.85
60_S64_P0.5750.85
22_A25_C0.5700.84
86_I113_F0.5690.84
43_S59_F0.5670.84
11_A61_F0.5660.84
57_E61_F0.5600.83
70_R80_A0.5590.83
7_V54_Y0.5590.83
80_A125_E0.5580.83
49_A54_Y0.5550.83
82_S127_Y0.5540.83
8_H80_A0.5530.83
104_R109_T0.5530.83
41_R44_W0.5510.82
31_T34_S0.5470.82
14_A60_S0.5440.82
80_A115_F0.5430.82
94_E97_N0.5410.81
30_F74_C0.5400.81
72_E76_L0.5400.81
10_I124_L0.5340.80
105_V108_Y0.5270.80
108_Y111_K0.5270.80
105_V110_Q0.5270.80
118_D122_L0.5260.79
38_R45_K0.5240.79
21_K46_G0.5150.78
45_K57_E0.5140.78
102_T109_T0.5130.78
51_N55_V0.5130.78
26_D84_D0.5120.78
21_K25_C0.5100.77
61_F76_L0.5050.77
14_A30_F0.5030.76
20_S118_D0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c21A 2 0.9225 99.9 0.364 Contact Map
2p25A 2 0.9767 99.9 0.365 Contact Map
1ss4A 4 0.9922 99.9 0.367 Contact Map
3l7tA 2 0.969 99.9 0.372 Contact Map
3w0tA 2 0.9922 99.9 0.374 Contact Map
3hdpA 2 0.9845 99.9 0.384 Contact Map
1jc4A 2 1 99.9 0.395 Contact Map
4mtsA 2 0.9457 99.9 0.398 Contact Map
3gm5A 2 0.9767 99.8 0.399 Contact Map
3kolA 2 0.9845 99.8 0.401 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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