GREMLIN Database
HISQ - Histidine transport system permease protein HisQ
UniProt: P52094 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12125
Length: 228 (204)
Sequences: 17647 (10476)
Seq/√Len: 733.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_G212_L3.2561.00
189_E192_Y3.1921.00
26_L101_G3.1451.00
96_G168_V3.0581.00
127_A137_V2.8411.00
180_T197_C2.8271.00
133_T136_Q2.6811.00
14_L18_E2.6041.00
37_G49_F2.5541.00
123_H145_S2.4751.00
34_G109_T2.3741.00
59_V64_L2.2951.00
124_I137_V2.2441.00
34_G105_G2.0561.00
44_L48_I2.0431.00
135_G139_R2.0271.00
210_G214_F2.0161.00
128_T137_V1.9531.00
44_L47_L1.9211.00
38_K50_E1.8481.00
124_I128_T1.8341.00
178_K182_L1.8211.00
115_A150_A1.7781.00
118_A149_Y1.7531.00
30_I105_G1.7401.00
91_D94_V1.7341.00
43_R47_L1.7321.00
19_L168_V1.7251.00
20_A162_L1.7231.00
202_L206_T1.7191.00
35_A112_F1.7161.00
10_L14_L1.7071.00
15_V18_E1.7061.00
53_T109_T1.6741.00
13_A204_F1.6741.00
22_S97_I1.6651.00
184_G190_P1.6641.00
133_T137_V1.6351.00
180_T193_F1.6351.00
18_E93_M1.6201.00
206_T210_G1.6191.00
39_L117_M1.5941.00
214_F217_R1.5921.00
68_I99_T1.5641.00
110_E113_R1.5461.00
108_F154_I1.5371.00
27_A104_Y1.5321.00
11_Q14_L1.5221.00
210_G213_L1.5191.00
34_G49_F1.5071.00
134_R138_F1.4311.00
15_V173_L1.4081.00
43_R46_G1.4051.00
24_V158_W1.4011.00
211_V214_F1.3911.00
136_Q139_R1.3701.00
32_L112_F1.3701.00
20_A165_T1.3621.00
42_N47_L1.3331.00
33_I37_G1.3181.00
136_Q140_R1.3151.00
64_L103_I1.3141.00
93_M97_I1.2921.00
8_V11_Q1.2861.00
128_T134_R1.2661.00
56_I102_F1.2581.00
112_F150_A1.2461.00
132_F136_Q1.2401.00
22_S101_G1.2301.00
59_V103_I1.2101.00
124_I142_M1.1981.00
108_F157_N1.1901.00
184_G194_A1.1801.00
38_K110_E1.1641.00
92_P172_G1.1611.00
42_N45_S1.1581.00
47_L51_G1.1531.00
37_G40_S1.1381.00
46_G50_E1.1351.00
6_S10_L1.1331.00
29_I33_I1.1311.00
65_M99_T1.1301.00
127_A141_I1.1171.00
111_T157_N1.1131.00
26_L97_I1.1091.00
39_L116_F1.1001.00
8_V179_A1.0981.00
178_K181_Q1.0971.00
116_F142_M1.0881.00
179_A182_L1.0791.00
48_I51_G1.0781.00
214_F218_R1.0761.00
48_I52_Y1.0721.00
174_E178_K1.0661.00
162_L204_F1.0601.00
54_T206_T1.0501.00
18_E22_S1.0501.00
31_G108_F1.0441.00
138_F143_F1.0411.00
113_R117_M1.0341.00
93_M173_L1.0291.00
11_Q15_V1.0271.00
64_L68_I1.0261.00
97_I101_G1.0251.00
65_M168_V1.0231.00
168_V175_D1.0211.00
49_F109_T0.9921.00
111_T153_G0.9881.00
183_A193_F0.9881.00
68_I95_A0.9861.00
94_V97_I0.9771.00
16_T162_L0.9611.00
211_V215_L0.9561.00
51_G54_T0.9521.00
213_L217_R0.9501.00
119_V146_M0.9491.00
160_V164_S0.9471.00
71_G75_A0.9461.00
54_T202_L0.9451.00
119_V149_Y0.9351.00
65_M167_L0.9281.00
192_Y195_I0.9281.00
162_L208_S0.9251.00
37_G45_S0.9201.00
213_L216_E0.9141.00
166_A201_Y0.9121.00
41_Q46_G0.9121.00
20_A158_W0.9111.00
122_G126_A0.9111.00
182_L186_S0.9051.00
181_Q184_G0.9031.00
56_I106_A0.8981.00
23_S101_G0.8971.00
132_F140_R0.8921.00
52_Y105_G0.8911.00
24_V161_I0.8771.00
134_R137_V0.8771.00
94_V98_I0.8731.00
7_G11_Q0.8691.00
22_S26_L0.8671.00
162_L205_T0.8661.00
28_V154_I0.8521.00
207_V211_V0.8511.00
61_D103_I0.8511.00
52_Y56_I0.8451.00
42_N46_G0.8451.00
38_K53_T0.8441.00
13_A200_I0.8421.00
187_T190_P0.8371.00
138_F142_M0.8351.00
12_G179_A0.8331.00
104_Y157_N0.8311.00
87_Q90_I0.8271.00
92_P173_L0.8261.00
35_A39_L0.8171.00
25_V29_I0.8111.00
96_G171_L0.8081.00
100_L165_T0.8071.00
69_F95_A0.8051.00
149_Y153_G0.7991.00
17_L21_I0.7951.00
40_S49_F0.7931.00
21_I25_V0.7931.00
35_A116_F0.7921.00
47_L50_E0.7911.00
38_K46_G0.7901.00
52_Y106_A0.7901.00
61_D164_S0.7891.00
66_L70_Y0.7891.00
203_V207_V0.7891.00
67_L71_G0.7831.00
69_F171_L0.7761.00
122_G125_E0.7681.00
40_S134_R0.7681.00
104_Y164_S0.7661.00
168_V173_L0.7581.00
124_I134_R0.7571.00
180_T184_G0.7551.00
13_A176_V0.7541.00
42_N48_I0.7511.00
64_L99_T0.7501.00
177_V201_Y0.7451.00
108_F112_F0.7401.00
170_L174_E0.7401.00
174_E179_A0.7381.00
121_K125_E0.7351.00
16_T20_A0.7311.00
7_G10_L0.7271.00
30_I101_G0.7271.00
16_T201_Y0.7221.00
22_S93_M0.7201.00
50_E54_T0.7151.00
22_S25_V0.7151.00
177_V194_A0.7131.00
15_V175_D0.7121.00
19_L165_T0.7091.00
65_M171_L0.7031.00
195_I199_V0.6991.00
30_I34_G0.6981.00
116_F146_M0.6971.00
32_L143_F0.6901.00
176_V200_I0.6901.00
67_L195_I0.6891.00
36_G138_F0.6881.00
194_A197_C0.6851.00
38_K41_Q0.6841.00
71_G74_I0.6791.00
23_S161_I0.6761.00
115_A149_Y0.6761.00
27_A108_F0.6741.00
184_G193_F0.6741.00
169_S178_K0.6731.00
100_L161_I0.6721.00
166_A177_V0.6701.00
121_K124_I0.6661.00
19_L96_G0.6611.00
19_L173_L0.6601.00
199_V203_V0.6581.00
62_L170_L0.6541.00
166_A169_S0.6521.00
177_V197_C0.6521.00
34_G37_G0.6491.00
196_V200_I0.6481.00
112_F116_F0.6471.00
215_L219_Y0.6441.00
92_P171_L0.6441.00
119_V142_M0.6431.00
193_F197_C0.6401.00
90_I94_V0.6381.00
103_I164_S0.6351.00
45_S48_I0.6351.00
169_S172_G0.6331.00
32_L147_M0.6331.00
19_L23_S0.6291.00
104_Y161_I0.6261.00
15_V93_M0.6261.00
104_Y108_F0.6231.00
152_P216_E0.6231.00
151_L215_L0.6211.00
37_G48_I0.6161.00
157_N160_V0.6131.00
103_I157_N0.6121.00
116_F138_F0.6111.00
26_L30_I0.6091.00
125_E140_R0.6081.00
191_F195_I0.6071.00
28_V112_F0.6001.00
202_L205_T0.5991.00
26_L29_I0.5971.00
12_G15_V0.5961.00
18_E94_V0.5951.00
133_T140_R0.5901.00
101_G105_G0.5901.00
41_Q134_R0.5901.00
41_Q44_L0.5891.00
186_S189_E0.5861.00
69_F92_P0.5851.00
38_K109_T0.5841.00
51_G55_L0.5831.00
159_Q208_S0.5821.00
100_L168_V0.5801.00
9_I200_I0.5781.00
29_I101_G0.5771.00
158_W208_S0.5751.00
58_G163_K0.5741.00
151_L219_Y0.5711.00
209_N213_L0.5701.00
208_S212_L0.5591.00
197_C200_I0.5591.00
121_K128_T0.5591.00
142_M145_S0.5581.00
153_G156_N0.5571.00
127_A132_F0.5561.00
23_S100_L0.5511.00
179_A183_A0.5501.00
124_I138_F0.5481.00
50_E53_T0.5471.00
207_V214_F0.5441.00
34_G52_Y0.5421.00
62_L66_L0.5421.00
148_R219_Y0.5401.00
14_L17_L0.5361.00
62_L167_L0.5331.00
10_L13_A0.5321.00
137_V142_M0.5321.00
90_I95_A0.5321.00
40_S46_G0.5311.00
183_A187_T0.5311.00
194_A198_G0.5291.00
207_V210_G0.5291.00
56_I64_L0.5281.00
9_I183_A0.5281.00
30_I33_I0.5261.00
9_I180_T0.5241.00
41_Q45_S0.5211.00
8_V12_G0.5201.00
55_L59_V0.5161.00
49_F53_T0.5161.00
114_G153_G0.5151.00
45_S49_F0.5151.00
29_I32_L0.5081.00
37_G42_N0.5071.00
107_Y164_S0.5061.00
159_Q205_T0.5041.00
96_G173_L0.5020.99
8_V182_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9167 100 0.554 Contact Map
3tuiA 2 0.9167 99.9 0.618 Contact Map
2onkC 2 0.9386 99.9 0.633 Contact Map
3rlfF 1 0.9211 99.9 0.64 Contact Map
3d31C 2 0.9298 99.9 0.642 Contact Map
4tquM 1 0.9693 99.9 0.661 Contact Map
3rlfG 1 0.9605 99.8 0.671 Contact Map
4tquN 1 0.8991 99.7 0.71 Contact Map
3j9pD 4 0.6711 6.3 0.963 Contact Map
4h33A 3 0.3202 6.2 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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