GREMLIN Database
COBC - Adenosylcobalamin/alpha-ribazole phosphatase
UniProt: P52086 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13240
Length: 203 (186)
Sequences: 14520 (10294)
Seq/√Len: 754.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Q75_I2.9601.00
78_E134_R2.7791.00
54_E80_N2.7511.00
86_D117_N2.7161.00
32_I60_H2.7111.00
2_R180_A2.6351.00
129_E159_R2.5941.00
128_V152_V2.5091.00
2_R143_N2.3361.00
78_E130_R2.2441.00
78_E131_F2.1941.00
10_E30_R2.1841.00
49_L74_Q2.1111.00
79_L131_F1.9901.00
36_Q64_L1.9871.00
32_I64_L1.9721.00
6_I38_L1.9551.00
26_P60_H1.9471.00
148_S152_V1.9401.00
2_R182_D1.8661.00
60_H63_R1.7631.00
22_H80_N1.7601.00
47_F145_L1.7551.00
10_E28_T1.7471.00
26_P56_E1.6991.00
12_Q28_T1.6711.00
76_I134_R1.6531.00
119_E127_R1.6211.00
76_I131_F1.6121.00
120_G123_A1.5891.00
50_V66_L1.5871.00
52_C75_I1.5801.00
6_I65_V1.5751.00
90_R98_E1.5661.00
48_D142_Q1.5451.00
50_V62_A1.5431.00
4_W143_N1.5421.00
148_S153_L1.5391.00
59_Q63_R1.5261.00
22_H83_F1.5201.00
6_I145_L1.5011.00
4_W47_F1.4991.00
54_E77_P1.4831.00
12_Q16_D1.4601.00
10_E15_I1.4581.00
114_I123_A1.4511.00
33_E36_Q1.4461.00
40_T68_D1.4381.00
33_E37_N1.4361.00
129_E133_A1.4211.00
48_D143_N1.4131.00
30_R34_Q1.4091.00
4_W180_A1.4051.00
91_H94_D1.3911.00
65_V147_V1.3911.00
30_R33_E1.3821.00
153_L173_V1.3751.00
32_I36_Q1.3671.00
109_D112_H1.3571.00
183_I188_A1.3351.00
13_A25_T1.3311.00
35_A61_T1.3251.00
90_R94_D1.3001.00
128_V156_L1.2961.00
56_E60_H1.2551.00
29_A32_I1.2521.00
13_A18_L1.2251.00
51_L131_F1.2191.00
122_Q126_Q1.2131.00
125_S129_E1.1911.00
49_L142_Q1.1861.00
99_D102_N1.1771.00
112_H122_Q1.1281.00
52_C73_V1.1281.00
63_R67_S1.1101.00
62_A147_V1.1081.00
5_L153_L1.1051.00
51_L76_I1.1031.00
123_A126_Q1.1021.00
167_A170_H1.1011.00
66_L73_V1.1011.00
55_L80_N1.0951.00
104_S108_N1.0901.00
37_N40_T1.0831.00
13_A20_S1.0781.00
124_F152_V1.0731.00
40_T43_H1.0681.00
49_L144_I1.0641.00
125_S159_R1.0531.00
64_L67_S1.0531.00
77_P80_N1.0301.00
23_A88_E1.0261.00
47_F143_N1.0261.00
62_A73_V1.0181.00
83_F88_E1.0181.00
53_S58_A1.0151.00
139_Q142_Q1.0141.00
79_L146_V1.0131.00
10_E34_Q1.0061.00
52_C59_Q1.0021.00
24_P56_E0.9961.00
4_W45_V0.9931.00
14_N175_Q0.9901.00
36_Q67_S0.9871.00
131_F135_L0.9861.00
86_D116_T0.9841.00
28_T31_G0.9801.00
184_N187_F0.9801.00
63_R73_V0.9761.00
135_L146_V0.9591.00
131_F146_V0.9501.00
43_H68_D0.9441.00
5_L156_L0.9431.00
132_I156_L0.9301.00
49_L138_F0.9271.00
53_S149_H0.9251.00
50_V71_L0.9221.00
52_C58_A0.9201.00
125_S155_L0.9201.00
124_F128_V0.9181.00
90_R95_L0.9171.00
4_W178_W0.9161.00
54_E75_I0.9081.00
102_N105_A0.9041.00
174_D177_C0.9041.00
157_I161_I0.9011.00
164_P167_A0.9011.00
124_F155_L0.8961.00
173_V179_S0.8951.00
20_S25_T0.8881.00
135_L144_I0.8811.00
93_R96_M0.8801.00
87_W95_L0.8771.00
18_L91_H0.8701.00
29_A33_E0.8701.00
163_M167_A0.8681.00
51_L74_Q0.8651.00
126_Q130_R0.8611.00
56_E59_Q0.8581.00
74_Q138_F0.8481.00
134_R138_F0.8481.00
22_H54_E0.8461.00
94_D97_Q0.8441.00
161_I171_F0.8431.00
45_V143_N0.8401.00
58_A149_H0.8381.00
133_A136_S0.8371.00
36_Q68_D0.8301.00
60_H64_L0.8291.00
39_H64_L0.8241.00
161_I181_I0.8211.00
51_L139_Q0.8191.00
15_I30_R0.8181.00
157_I179_S0.8081.00
11_T20_S0.8051.00
25_T28_T0.8011.00
51_L144_I0.8001.00
39_H68_D0.7971.00
51_L135_L0.7931.00
11_T175_Q0.7781.00
173_V177_C0.7781.00
12_Q26_P0.7771.00
12_Q15_I0.7721.00
51_L138_F0.7721.00
38_L176_G0.7671.00
93_R97_Q0.7611.00
13_A23_A0.7571.00
82_M124_F0.7511.00
6_I147_V0.7511.00
64_L68_D0.7481.00
157_I181_I0.7461.00
22_H55_L0.7441.00
105_A108_N0.7341.00
105_A109_D0.7341.00
131_F134_R0.7311.00
21_G88_E0.7311.00
121_F155_L0.7241.00
52_C62_A0.7231.00
34_Q175_Q0.7191.00
81_E150_Q0.7111.00
9_G61_T0.7111.00
35_A39_H0.7081.00
158_A168_M0.7061.00
3_L132_I0.7001.00
96_M103_Y0.6971.00
160_L181_I0.6941.00
153_L179_S0.6931.00
41_L178_W0.6921.00
84_F88_E0.6901.00
35_A64_L0.6881.00
136_S183_I0.6871.00
35_A176_G0.6851.00
66_L69_R0.6781.00
158_A163_M0.6661.00
94_D98_E0.6651.00
36_Q39_H0.6621.00
181_I188_A0.6601.00
36_Q40_T0.6601.00
11_T28_T0.6581.00
6_I178_W0.6571.00
81_E151_G0.6551.00
46_S143_N0.6521.00
79_L135_L0.6501.00
9_G27_L0.6491.00
27_L35_A0.6491.00
50_V69_R0.6481.00
50_V145_L0.6381.00
158_A165_A0.6331.00
114_I120_G0.6331.00
103_Y107_C0.6321.00
45_V180_A0.6301.00
26_P32_I0.6281.00
5_L181_I0.6261.00
130_R134_R0.6221.00
92_H96_M0.6201.00
168_M171_F0.6191.00
23_A89_M0.6161.00
39_H43_H0.6151.00
133_A137_E0.6131.00
87_W115_P0.6111.00
11_T14_N0.6081.00
14_N20_S0.6051.00
129_E156_L0.6041.00
126_Q129_E0.6031.00
24_P55_L0.6021.00
66_L71_L0.6021.00
12_Q25_T0.6001.00
49_L139_Q0.6001.00
101_E104_S0.5971.00
104_S107_C0.5971.00
163_M171_F0.5901.00
15_I28_T0.5871.00
124_F151_G0.5841.00
128_V159_R0.5831.00
27_L31_G0.5791.00
101_E105_A0.5781.00
55_L58_A0.5711.00
38_L178_W0.5681.00
66_L70_Q0.5661.00
46_S69_R0.5661.00
133_A159_R0.5641.00
136_S188_A0.5641.00
82_M121_F0.5641.00
9_G34_Q0.5641.00
34_Q37_N0.5621.00
17_G93_R0.5611.00
45_V69_R0.5591.00
96_M100_A0.5581.00
5_L146_V0.5581.00
111_Q122_Q0.5531.00
31_G35_A0.5531.00
62_A66_L0.5491.00
9_G176_G0.5491.00
37_N41_L0.5471.00
17_G92_H0.5451.00
44_G69_R0.5421.00
125_S128_V0.5411.00
8_H81_E0.5331.00
4_W42_L0.5301.00
47_F69_R0.5291.00
122_Q125_S0.5261.00
90_R99_D0.5241.00
75_I80_N0.5231.00
23_A83_F0.5211.00
111_Q166_E0.5191.00
138_F142_Q0.5191.00
17_G20_S0.5171.00
11_T25_T0.5161.00
17_G91_H0.5151.00
9_G31_G0.5141.00
113_A116_T0.5081.00
121_F168_M0.5061.00
63_R75_I0.5051.00
96_M101_E0.5031.00
25_T56_E0.5031.00
31_G34_Q0.5021.00
34_Q176_G0.5011.00
154_S158_A0.5011.00
76_I79_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h2eA 1 1 100 0.115 Contact Map
4pzaA 2 0.9803 100 0.119 Contact Map
4ij5A 2 1 100 0.12 Contact Map
3gp3A 1 0.9606 100 0.143 Contact Map
1e58A 2 1 100 0.145 Contact Map
3kkkA 3 0.9557 100 0.147 Contact Map
3d8hA 2 0.9606 100 0.153 Contact Map
3r7aA 1 0.9704 100 0.159 Contact Map
2hhjA 2 1 100 0.159 Contact Map
4embA 2 1 100 0.16 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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