COBC - ECOLI - GREMLIN Contacts

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COBC - Adenosylcobalamin/alpha-ribazole phosphatase

UniProt:	P52086	Sequences: MRLWLIRHGETQANIDGLYSGHAPTPLTARGIEQAQNLHTLLHGVSFDLVLCSELERAQHTARLVLSDRQLPVQIIPELNEMFFGDWEMRHHRDLMQEDAENYSAWCNDWQHAIPTNGEGFQAFSQRVERFIARLSEFQHYQNILVVSHQGVLSLLIARLIGMPAEAMWHFRVDQGCWSAIDINQKFATLRVLNSRAIGVENA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13240
Length:	203 (186)
Sequences:	14520 (10294)
Seq/√Len:	754.8

ECOLI - COBC GPMB GPMA SIXA
BACSU - PHOE
SULSO - Q97WI1 Q97YV8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_Q	75_I	2.960	1.00
78_E	134_R	2.779	1.00
54_E	80_N	2.751	1.00
86_D	117_N	2.716	1.00
32_I	60_H	2.711	1.00
2_R	180_A	2.635	1.00
129_E	159_R	2.594	1.00
128_V	152_V	2.509	1.00
2_R	143_N	2.336	1.00
78_E	130_R	2.244	1.00
78_E	131_F	2.194	1.00
10_E	30_R	2.184	1.00
49_L	74_Q	2.111	1.00
79_L	131_F	1.990	1.00
36_Q	64_L	1.987	1.00
32_I	64_L	1.972	1.00
6_I	38_L	1.955	1.00
26_P	60_H	1.947	1.00
148_S	152_V	1.940	1.00
2_R	182_D	1.866	1.00
60_H	63_R	1.763	1.00
22_H	80_N	1.760	1.00
47_F	145_L	1.755	1.00
10_E	28_T	1.747	1.00
26_P	56_E	1.699	1.00
12_Q	28_T	1.671	1.00
76_I	134_R	1.653	1.00
119_E	127_R	1.621	1.00
76_I	131_F	1.612	1.00
120_G	123_A	1.589	1.00
50_V	66_L	1.587	1.00
52_C	75_I	1.580	1.00
6_I	65_V	1.575	1.00
90_R	98_E	1.566	1.00
48_D	142_Q	1.545	1.00
50_V	62_A	1.543	1.00
4_W	143_N	1.542	1.00
148_S	153_L	1.539	1.00
59_Q	63_R	1.526	1.00
22_H	83_F	1.520	1.00
6_I	145_L	1.501	1.00
4_W	47_F	1.499	1.00
54_E	77_P	1.483	1.00
12_Q	16_D	1.460	1.00
10_E	15_I	1.458	1.00
114_I	123_A	1.451	1.00
33_E	36_Q	1.446	1.00
40_T	68_D	1.438	1.00
33_E	37_N	1.436	1.00
129_E	133_A	1.421	1.00
48_D	143_N	1.413	1.00
30_R	34_Q	1.409	1.00
4_W	180_A	1.405	1.00
91_H	94_D	1.391	1.00
65_V	147_V	1.391	1.00
30_R	33_E	1.382	1.00
153_L	173_V	1.375	1.00
32_I	36_Q	1.367	1.00
109_D	112_H	1.357	1.00
183_I	188_A	1.335	1.00
13_A	25_T	1.331	1.00
35_A	61_T	1.325	1.00
90_R	94_D	1.300	1.00
128_V	156_L	1.296	1.00
56_E	60_H	1.255	1.00
29_A	32_I	1.252	1.00
13_A	18_L	1.225	1.00
51_L	131_F	1.219	1.00
122_Q	126_Q	1.213	1.00
125_S	129_E	1.191	1.00
49_L	142_Q	1.186	1.00
99_D	102_N	1.177	1.00
112_H	122_Q	1.128	1.00
52_C	73_V	1.128	1.00
63_R	67_S	1.110	1.00
62_A	147_V	1.108	1.00
5_L	153_L	1.105	1.00
51_L	76_I	1.103	1.00
123_A	126_Q	1.102	1.00
167_A	170_H	1.101	1.00
66_L	73_V	1.101	1.00
55_L	80_N	1.095	1.00
104_S	108_N	1.090	1.00
37_N	40_T	1.083	1.00
13_A	20_S	1.078	1.00
124_F	152_V	1.073	1.00
40_T	43_H	1.068	1.00
49_L	144_I	1.064	1.00
125_S	159_R	1.053	1.00
64_L	67_S	1.053	1.00
77_P	80_N	1.030	1.00
23_A	88_E	1.026	1.00
47_F	143_N	1.026	1.00
62_A	73_V	1.018	1.00
83_F	88_E	1.018	1.00
53_S	58_A	1.015	1.00
139_Q	142_Q	1.014	1.00
79_L	146_V	1.013	1.00
10_E	34_Q	1.006	1.00
52_C	59_Q	1.002	1.00
24_P	56_E	0.996	1.00
4_W	45_V	0.993	1.00
14_N	175_Q	0.990	1.00
36_Q	67_S	0.987	1.00
131_F	135_L	0.986	1.00
86_D	116_T	0.984	1.00
28_T	31_G	0.980	1.00
184_N	187_F	0.980	1.00
63_R	73_V	0.976	1.00
135_L	146_V	0.959	1.00
131_F	146_V	0.950	1.00
43_H	68_D	0.944	1.00
5_L	156_L	0.943	1.00
132_I	156_L	0.930	1.00
49_L	138_F	0.927	1.00
53_S	149_H	0.925	1.00
50_V	71_L	0.922	1.00
52_C	58_A	0.920	1.00
125_S	155_L	0.920	1.00
124_F	128_V	0.918	1.00
90_R	95_L	0.917	1.00
4_W	178_W	0.916	1.00
54_E	75_I	0.908	1.00
102_N	105_A	0.904	1.00
174_D	177_C	0.904	1.00
157_I	161_I	0.901	1.00
164_P	167_A	0.901	1.00
124_F	155_L	0.896	1.00
173_V	179_S	0.895	1.00
20_S	25_T	0.888	1.00
135_L	144_I	0.881	1.00
93_R	96_M	0.880	1.00
87_W	95_L	0.877	1.00
18_L	91_H	0.870	1.00
29_A	33_E	0.870	1.00
163_M	167_A	0.868	1.00
51_L	74_Q	0.865	1.00
126_Q	130_R	0.861	1.00
56_E	59_Q	0.858	1.00
74_Q	138_F	0.848	1.00
134_R	138_F	0.848	1.00
22_H	54_E	0.846	1.00
94_D	97_Q	0.844	1.00
161_I	171_F	0.843	1.00
45_V	143_N	0.840	1.00
58_A	149_H	0.838	1.00
133_A	136_S	0.837	1.00
36_Q	68_D	0.830	1.00
60_H	64_L	0.829	1.00
39_H	64_L	0.824	1.00
161_I	181_I	0.821	1.00
51_L	139_Q	0.819	1.00
15_I	30_R	0.818	1.00
157_I	179_S	0.808	1.00
11_T	20_S	0.805	1.00
25_T	28_T	0.801	1.00
51_L	144_I	0.800	1.00
39_H	68_D	0.797	1.00
51_L	135_L	0.793	1.00
11_T	175_Q	0.778	1.00
173_V	177_C	0.778	1.00
12_Q	26_P	0.777	1.00
12_Q	15_I	0.772	1.00
51_L	138_F	0.772	1.00
38_L	176_G	0.767	1.00
93_R	97_Q	0.761	1.00
13_A	23_A	0.757	1.00
82_M	124_F	0.751	1.00
6_I	147_V	0.751	1.00
64_L	68_D	0.748	1.00
157_I	181_I	0.746	1.00
22_H	55_L	0.744	1.00
105_A	108_N	0.734	1.00
105_A	109_D	0.734	1.00
131_F	134_R	0.731	1.00
21_G	88_E	0.731	1.00
121_F	155_L	0.724	1.00
52_C	62_A	0.723	1.00
34_Q	175_Q	0.719	1.00
81_E	150_Q	0.711	1.00
9_G	61_T	0.711	1.00
35_A	39_H	0.708	1.00
158_A	168_M	0.706	1.00
3_L	132_I	0.700	1.00
96_M	103_Y	0.697	1.00
160_L	181_I	0.694	1.00
153_L	179_S	0.693	1.00
41_L	178_W	0.692	1.00
84_F	88_E	0.690	1.00
35_A	64_L	0.688	1.00
136_S	183_I	0.687	1.00
35_A	176_G	0.685	1.00
66_L	69_R	0.678	1.00
158_A	163_M	0.666	1.00
94_D	98_E	0.665	1.00
36_Q	39_H	0.662	1.00
181_I	188_A	0.660	1.00
36_Q	40_T	0.660	1.00
11_T	28_T	0.658	1.00
6_I	178_W	0.657	1.00
81_E	151_G	0.655	1.00
46_S	143_N	0.652	1.00
79_L	135_L	0.650	1.00
9_G	27_L	0.649	1.00
27_L	35_A	0.649	1.00
50_V	69_R	0.648	1.00
50_V	145_L	0.638	1.00
158_A	165_A	0.633	1.00
114_I	120_G	0.633	1.00
103_Y	107_C	0.632	1.00
45_V	180_A	0.630	1.00
26_P	32_I	0.628	1.00
5_L	181_I	0.626	1.00
130_R	134_R	0.622	1.00
92_H	96_M	0.620	1.00
168_M	171_F	0.619	1.00
23_A	89_M	0.616	1.00
39_H	43_H	0.615	1.00
133_A	137_E	0.613	1.00
87_W	115_P	0.611	1.00
11_T	14_N	0.608	1.00
14_N	20_S	0.605	1.00
129_E	156_L	0.604	1.00
126_Q	129_E	0.603	1.00
24_P	55_L	0.602	1.00
66_L	71_L	0.602	1.00
12_Q	25_T	0.600	1.00
49_L	139_Q	0.600	1.00
101_E	104_S	0.597	1.00
104_S	107_C	0.597	1.00
163_M	171_F	0.590	1.00
15_I	28_T	0.587	1.00
124_F	151_G	0.584	1.00
128_V	159_R	0.583	1.00
27_L	31_G	0.579	1.00
101_E	105_A	0.578	1.00
55_L	58_A	0.571	1.00
38_L	178_W	0.568	1.00
66_L	70_Q	0.566	1.00
46_S	69_R	0.566	1.00
133_A	159_R	0.564	1.00
136_S	188_A	0.564	1.00
82_M	121_F	0.564	1.00
9_G	34_Q	0.564	1.00
34_Q	37_N	0.562	1.00
17_G	93_R	0.561	1.00
45_V	69_R	0.559	1.00
96_M	100_A	0.558	1.00
5_L	146_V	0.558	1.00
111_Q	122_Q	0.553	1.00
31_G	35_A	0.553	1.00
62_A	66_L	0.549	1.00
9_G	176_G	0.549	1.00
37_N	41_L	0.547	1.00
17_G	92_H	0.545	1.00
44_G	69_R	0.542	1.00
125_S	128_V	0.541	1.00
8_H	81_E	0.533	1.00
4_W	42_L	0.530	1.00
47_F	69_R	0.529	1.00
122_Q	125_S	0.526	1.00
90_R	99_D	0.524	1.00
75_I	80_N	0.523	1.00
23_A	83_F	0.521	1.00
111_Q	166_E	0.519	1.00
138_F	142_Q	0.519	1.00
17_G	20_S	0.517	1.00
11_T	25_T	0.516	1.00
17_G	91_H	0.515	1.00
9_G	31_G	0.514	1.00
113_A	116_T	0.508	1.00
121_F	168_M	0.506	1.00
63_R	75_I	0.505	1.00
96_M	101_E	0.503	1.00
25_T	56_E	0.503	1.00
31_G	34_Q	0.502	1.00
34_Q	176_G	0.501	1.00
154_S	158_A	0.501	1.00
76_I	79_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1h2eA	1	1	100	0.115	Contact Map
4pzaA	2	0.9803	100	0.119	Contact Map
4ij5A	2	1	100	0.12	Contact Map
3gp3A	1	0.9606	100	0.143	Contact Map
1e58A	2	1	100	0.145	Contact Map
3kkkA	3	0.9557	100	0.147	Contact Map
3d8hA	2	0.9606	100	0.153	Contact Map
3r7aA	1	0.9704	100	0.159	Contact Map
2hhjA	2	1	100	0.159	Contact Map
4embA	2	1	100	0.16	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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