GREMLIN Database
GLCF - Glycolate oxidase iron-sulfur subunit
UniProt: P52074 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13291
Length: 407 (373)
Sequences: 5865 (3970)
Seq/√Len: 205.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
301_K330_T5.0351.00
394_R402_Q4.9641.00
191_R401_E4.7831.00
169_R199_S4.3561.00
188_A398_E4.2311.00
282_L397_I3.7701.00
301_K332_T3.6561.00
280_V288_E3.4771.00
287_R322_K3.3501.00
208_C251_C2.8861.00
321_E333_D2.8851.00
218_A221_K2.7461.00
189_T247_T2.7331.00
300_K373_M2.7261.00
375_V399_I2.6151.00
184_N398_E2.3861.00
176_C208_C2.3501.00
178_Q186_N2.3211.00
90_R93_N2.2941.00
209_C251_C2.2821.00
125_R128_V2.2561.00
136_G140_R2.1741.00
303_A334_V2.1721.00
306_C321_E2.1631.00
334_V366_L2.1391.00
168_R198_I2.1171.00
302_L399_I2.0991.00
227_R231_D2.0971.00
246_Q252_G2.0871.00
373_M394_R2.0841.00
172_M247_T2.0591.00
322_K325_L2.0191.00
226_A258_Y2.0061.00
223_L227_R1.9951.00
352_P356_R1.9921.00
207_G228_N1.9911.00
198_I285_L1.9901.00
185_T398_E1.9711.00
300_K372_E1.9341.00
196_L404_L1.8931.00
126_P130_R1.8921.00
176_C251_C1.8691.00
192_V400_V1.8341.00
136_G139_L1.8251.00
284_E288_E1.8241.00
169_R201_M1.8101.00
321_E325_L1.7381.00
195_R401_E1.7351.00
29_G49_R1.7201.00
189_T193_L1.6971.00
40_L357_Q1.6851.00
281_D285_L1.6841.00
311_Q317_N1.6531.00
82_E90_R1.6411.00
190_A200_V1.6411.00
144_P147_V1.6381.00
176_C209_C1.6281.00
303_A369_G1.6281.00
275_V279_A1.6031.00
256_K284_E1.5971.00
301_K372_E1.5961.00
324_L375_V1.5851.00
188_A401_E1.5801.00
302_L329_F1.5601.00
273_R277_E1.4971.00
280_V284_E1.4781.00
356_R388_A1.4641.00
170_V245_L1.4631.00
63_E67_K1.4371.00
142_F145_E1.4271.00
234_W238_E1.4221.00
382_Q393_V1.4201.00
151_L154_E1.4161.00
392_S402_Q1.4121.00
123_V126_P1.4061.00
245_L285_L1.4041.00
211_A250_G1.4031.00
170_V200_V1.3951.00
302_L373_M1.3921.00
282_L286_L1.3811.00
359_R363_M1.3791.00
360_D367_E1.3701.00
127_A130_R1.3671.00
259_G276_S1.3561.00
359_R388_A1.3531.00
213_D221_K1.3531.00
189_T282_L1.3481.00
364_N368_S1.3471.00
134_Q137_L1.3431.00
44_E49_R1.3401.00
231_D234_W1.3391.00
394_R398_E1.3371.00
171_L241_A1.3281.00
214_Y254_F1.3201.00
302_L375_V1.3191.00
122_V126_P1.3161.00
167_K199_S1.3151.00
192_V404_L1.3091.00
194_D200_V1.3071.00
120_R123_V1.3031.00
165_R199_S1.3001.00
307_P376_T1.2981.00
276_S281_D1.2951.00
100_D219_Q1.2881.00
137_L140_R1.2861.00
135_V139_L1.2821.00
248_A378_N1.2781.00
366_L374_I1.2781.00
139_L142_F1.2771.00
286_L323_V1.2751.00
298_G403_A1.2611.00
93_N260_Q1.2531.00
374_I385_L1.2531.00
360_D364_N1.2471.00
57_Q60_E1.2441.00
225_R229_N1.2351.00
377_A396_W1.2331.00
203_A206_A1.2271.00
140_R143_L1.2221.00
277_E281_D1.1971.00
191_R195_R1.1961.00
119_L123_V1.1901.00
175_G248_A1.1831.00
277_E280_V1.1831.00
299_D330_T1.1831.00
98_G102_V1.1811.00
284_E319_E1.1791.00
280_V285_L1.1791.00
318_G322_K1.1781.00
151_L155_T1.1771.00
304_F320_V1.1701.00
50_G54_L1.1661.00
246_Q255_V1.1651.00
229_N258_Y1.1651.00
359_R384_H1.1651.00
110_L113_R1.1631.00
192_V397_I1.1611.00
318_G321_E1.1611.00
79_R82_E1.1601.00
300_K402_Q1.1571.00
57_Q61_G1.1561.00
252_G314_Q1.1491.00
170_V285_L1.1411.00
338_H362_K1.1351.00
190_A194_D1.1331.00
140_R147_V1.1331.00
100_D104_Q1.1321.00
152_P156_V1.1311.00
274_Q278_L1.1301.00
366_L385_L1.1281.00
144_P148_R1.1271.00
394_R399_I1.1251.00
341_C381_C1.1171.00
189_T397_I1.1131.00
149_A154_E1.1121.00
274_Q277_E1.1051.00
174_E186_N1.0971.00
192_V401_E1.0931.00
34_T84_T1.0911.00
192_V323_V1.0901.00
69_Q102_V1.0851.00
137_L141_P1.0771.00
46_D74_R1.0751.00
352_P387_S1.0721.00
104_Q220_E1.0611.00
165_R168_R1.0611.00
82_E92_H1.0571.00
32_T38_Y1.0551.00
32_T47_G1.0551.00
291_L294_L1.0551.00
259_G273_R1.0511.00
121_Q125_R1.0501.00
37_T51_R1.0461.00
286_L400_V1.0451.00
278_L281_D1.0441.00
195_R404_L1.0341.00
367_E389_G1.0261.00
306_C333_D1.0261.00
155_T158_A1.0231.00
121_Q130_R1.0231.00
214_Y222_G1.0231.00
322_K326_R1.0211.00
319_E322_K1.0201.00
298_G329_F1.0181.00
343_S348_A1.0061.00
187_A191_R1.0041.00
147_V150_K1.0041.00
211_A215_H1.0011.00
185_T188_A0.9901.00
150_K153_A0.9901.00
143_L146_Q0.9901.00
143_L148_R0.9891.00
316_L319_E0.9881.00
149_A152_P0.9861.00
353_D357_Q0.9851.00
187_A190_A0.9841.00
262_L265_D0.9821.00
122_V125_R0.9821.00
172_M189_T0.9791.00
182_S379_I0.9781.00
53_Y56_K0.9761.00
69_Q73_D0.9751.00
225_R228_N0.9721.00
182_S185_T0.9691.00
323_V400_V0.9691.00
214_Y219_Q0.9681.00
145_E148_R0.9651.00
327_L400_V0.9641.00
166_H199_S0.9621.00
103_E108_R0.9621.00
373_M402_Q0.9610.99
324_L329_F0.9610.99
145_E149_A0.9600.99
109_P112_E0.9580.99
243_A285_L0.9570.99
150_K155_T0.9570.99
276_S280_V0.9570.99
193_L198_I0.9540.99
140_R146_Q0.9500.99
191_R194_D0.9490.99
290_P294_L0.9490.99
287_R326_R0.9440.99
364_N367_E0.9440.99
228_N231_D0.9430.99
327_L403_A0.9410.99
139_L143_L0.9380.99
26_V32_T0.9360.99
118_G121_Q0.9360.99
40_L361_N0.9290.99
44_E50_G0.9280.99
213_D225_R0.9270.99
119_L122_V0.9260.99
169_R241_A0.9250.99
32_T44_E0.9230.99
40_L354_L0.9220.99
215_H250_G0.9220.99
47_G50_G0.9210.99
135_V138_V0.9160.99
221_K224_A0.9150.99
39_Q361_N0.9130.99
375_V396_W0.9110.99
306_C317_N0.9050.99
303_A374_I0.9040.99
118_G123_V0.9020.99
119_L127_A0.9010.99
134_Q140_R0.8980.99
238_E274_Q0.8870.99
101_I105_K0.8840.99
346_T350_T0.8820.99
174_E206_A0.8810.99
190_A202_P0.8790.99
141_P147_V0.8770.99
47_G51_R0.8760.99
172_M178_Q0.8760.99
54_L71_H0.8690.99
127_A131_A0.8660.99
196_L285_L0.8660.99
138_V141_P0.8600.99
363_M367_E0.8580.99
401_E404_L0.8550.99
311_Q338_H0.8540.99
227_R265_D0.8530.99
38_Y42_G0.8520.99
56_K60_E0.8490.99
80_N84_T0.8490.99
229_N232_A0.8470.99
123_V127_A0.8440.99
307_P378_N0.8430.99
357_Q360_D0.8370.99
193_L245_L0.8350.99
189_T245_L0.8340.99
299_D328_G0.8300.99
367_E390_R0.8280.99
243_A280_V0.8260.98
355_A384_H0.8250.98
222_G254_F0.8210.98
43_D46_D0.8200.98
325_L331_L0.8200.98
142_F146_Q0.8170.98
118_G125_R0.8170.98
183_P187_A0.8140.98
283_V287_R0.8120.98
238_E241_A0.8100.98
121_Q126_P0.8090.98
174_E202_P0.8070.98
186_N190_A0.8050.98
120_R125_R0.8050.98
304_F331_L0.8020.98
91_Y95_L0.8010.98
125_R129_F0.8000.98
306_C320_V0.7980.98
282_L400_V0.7930.98
112_E116_R0.7920.98
205_E239_A0.7920.98
134_Q138_V0.7900.98
303_A366_L0.7880.98
244_I275_V0.7870.98
74_R354_L0.7830.98
170_V243_A0.7820.98
76_L358_L0.7820.98
250_G378_N0.7820.98
138_V142_F0.7810.98
102_V106_V0.7810.98
133_T136_G0.7810.98
126_P129_F0.7810.98
77_T309_T0.7800.98
52_I94_L0.7790.98
303_A371_P0.7760.98
249_S307_P0.7740.98
108_R218_A0.7730.98
252_G256_K0.7720.98
234_W274_Q0.7720.98
146_Q149_A0.7720.98
356_R360_D0.7710.98
253_A313_A0.7690.98
226_A261_M0.7680.98
299_D329_F0.7660.98
230_I234_W0.7650.97
118_G127_A0.7640.97
125_R130_R0.7640.97
170_V281_D0.7590.97
133_T140_R0.7580.97
216_L346_T0.7570.97
133_T137_L0.7540.97
66_L69_Q0.7520.97
376_T382_Q0.7500.97
39_Q339_L0.7500.97
163_P166_H0.7490.97
169_R243_A0.7480.97
178_Q247_T0.7470.97
122_V128_V0.7460.97
121_Q124_P0.7440.97
158_A179_P0.7360.97
226_A262_L0.7360.97
334_V369_G0.7350.97
297_R329_F0.7300.97
143_L147_V0.7300.97
120_R126_P0.7300.97
308_C340_C0.7290.97
44_E51_R0.7290.97
283_V322_K0.7280.97
198_I289_E0.7270.97
49_R54_L0.7270.97
48_P55_I0.7260.97
224_A227_R0.7230.96
113_R117_E0.7210.96
304_F317_N0.7190.96
169_R239_A0.7180.96
101_I104_Q0.7170.96
201_M204_N0.7170.96
276_S285_L0.7160.96
318_G325_L0.7150.96
21_I24_A0.7140.96
25_C31_C0.7130.96
97_I101_I0.7120.96
27_H56_K0.7120.96
216_L350_T0.7090.96
244_I255_V0.7040.96
26_V87_S0.7020.96
229_N255_V0.6980.96
147_V154_E0.6980.96
332_T371_P0.6970.96
27_H89_V0.6950.96
172_M186_N0.6940.96
122_V129_F0.6940.96
46_D71_H0.6940.96
398_E401_E0.6920.95
173_L209_C0.6910.95
298_G327_L0.6900.95
97_I100_D0.6890.95
224_A228_N0.6870.95
343_S384_H0.6870.95
250_G309_T0.6850.95
182_S398_E0.6840.95
147_V151_L0.6840.95
142_F147_V0.6840.95
220_E223_L0.6830.95
156_V159_K0.6790.95
173_L229_N0.6730.95
52_I91_Y0.6720.95
150_K154_E0.6720.95
160_P163_P0.6710.95
48_P51_R0.6700.95
58_V63_E0.6680.95
161_R199_S0.6650.94
79_R92_H0.6640.94
385_L388_A0.6600.94
256_K314_Q0.6600.94
219_Q223_L0.6590.94
121_Q127_A0.6590.94
77_T95_L0.6580.94
274_Q284_E0.6570.94
231_D274_Q0.6550.94
141_P144_P0.6550.94
231_D238_E0.6530.94
323_V327_L0.6520.94
273_R276_S0.6510.94
144_P149_A0.6510.94
202_P206_A0.6510.94
309_T379_I0.6490.94
48_P56_K0.6480.94
279_A282_L0.6470.94
184_N187_A0.6460.94
310_L316_L0.6460.94
213_D218_A0.6450.93
31_C35_C0.6450.93
289_E294_L0.6440.93
392_S398_E0.6440.93
292_E326_R0.6440.93
49_R53_Y0.6410.93
285_L289_E0.6390.93
140_R148_R0.6380.93
173_L255_V0.6370.93
298_G301_K0.6360.93
188_A192_V0.6350.93
139_L148_R0.6350.93
367_E371_P0.6350.93
208_C212_V0.6330.93
366_L369_G0.6330.93
182_S382_Q0.6320.93
51_R56_K0.6320.93
159_K162_P0.6310.93
291_L295_A0.6290.93
290_P326_R0.6280.93
222_G261_M0.6250.92
118_G124_P0.6250.92
306_C311_Q0.6230.92
51_R378_N0.6210.92
307_P377_A0.6170.92
248_A251_C0.6160.92
117_E121_Q0.6150.92
295_A326_R0.6140.92
304_F377_A0.6110.92
292_E295_A0.6100.91
49_R91_Y0.6090.91
283_V377_A0.6080.91
53_Y57_Q0.6080.91
385_L389_G0.6050.91
162_P166_H0.6050.91
361_N365_A0.6030.91
72_L98_G0.6030.91
110_L114_I0.6010.91
141_P150_K0.5960.91
347_Y351_H0.5960.91
161_R164_L0.5960.91
147_V152_P0.5960.91
143_L151_L0.5940.90
221_K225_R0.5930.90
363_M385_L0.5910.90
233_W244_I0.5900.90
304_F321_E0.5900.90
231_D265_D0.5880.90
176_C248_A0.5860.90
28_C31_C0.5860.90
172_M200_V0.5830.90
161_R166_H0.5830.90
212_V248_A0.5830.90
356_R387_S0.5820.89
181_L382_Q0.5820.89
182_S383_T0.5780.89
184_N188_A0.5780.89
37_T378_N0.5770.89
232_A238_E0.5770.89
220_E224_A0.5770.89
120_R127_A0.5770.89
288_E319_E0.5750.89
301_K392_S0.5750.89
54_L58_V0.5750.89
353_D356_R0.5740.89
303_A331_L0.5730.89
111_P114_I0.5730.89
146_Q150_K0.5720.89
170_V198_I0.5700.88
118_G126_P0.5690.88
233_W241_A0.5680.88
96_D214_Y0.5650.88
324_L331_L0.5630.88
207_G232_A0.5630.88
49_R52_I0.5600.88
127_A132_L0.5580.87
82_E93_N0.5580.87
243_A274_Q0.5580.87
25_C28_C0.5580.87
175_G251_C0.5570.87
119_L124_P0.5570.87
362_K365_A0.5570.87
134_Q139_L0.5570.87
276_S284_E0.5560.87
113_R116_R0.5560.87
100_D103_E0.5550.87
154_E158_A0.5530.87
25_C35_C0.5530.87
300_K329_F0.5520.87
48_P52_I0.5520.87
162_P194_D0.5520.87
50_G53_Y0.5520.87
33_A49_R0.5510.87
265_D273_R0.5510.87
256_K316_L0.5510.87
316_L320_V0.5500.87
192_V282_L0.5490.87
68_T72_L0.5480.87
32_T49_R0.5470.86
348_A380_G0.5460.86
32_T84_T0.5460.86
49_R76_L0.5460.86
148_R152_P0.5450.86
125_R131_A0.5450.86
171_L233_W0.5450.86
122_V130_R0.5430.86
68_T71_H0.5400.86
50_G61_G0.5400.86
296_I300_K0.5390.86
296_I299_D0.5380.86
124_P128_V0.5370.85
76_L89_V0.5370.85
302_L331_L0.5360.85
303_A332_T0.5360.85
126_P131_A0.5340.85
278_L285_L0.5330.85
373_M399_I0.5330.85
69_Q106_V0.5320.85
301_K370_K0.5320.85
279_A283_V0.5310.85
193_L282_L0.5310.85
331_L396_W0.5300.85
152_P155_T0.5290.85
275_V278_L0.5280.84
140_R144_P0.5280.84
118_G122_V0.5250.84
253_A257_E0.5220.84
195_R295_A0.5200.84
23_R53_Y0.5200.84
170_V193_L0.5190.83
171_L203_A0.5180.83
386_A392_S0.5180.83
263_K273_R0.5180.83
211_A380_G0.5170.83
296_I403_A0.5160.83
36_P76_L0.5150.83
135_V142_F0.5140.83
150_K157_K0.5120.83
252_G279_A0.5120.83
301_K371_P0.5120.83
252_G281_D0.5090.82
33_A84_T0.5090.82
45_L70_E0.5080.82
41_L354_L0.5080.82
298_G373_M0.5080.82
50_G76_L0.5080.82
168_R194_D0.5060.82
127_A133_T0.5060.82
41_L46_D0.5040.82
34_T339_L0.5040.82
285_L290_P0.5040.82
248_A379_I0.5040.82
142_F148_R0.5030.82
36_P89_V0.5020.81
79_R90_R0.5010.81
168_R289_E0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8501 100 0.45 Contact Map
3cf4A 2 0.8231 100 0.573 Contact Map
3c8yA 1 0.7985 99.8 0.792 Contact Map
2h88B 1 0.2604 99.4 0.846 Contact Map
2wdqB 1 0.2629 99.4 0.849 Contact Map
1kf6B 1 0.2776 99.4 0.849 Contact Map
4ysxB 1 0.2899 99.4 0.85 Contact Map
2bs2B 1 0.258 99.2 0.86 Contact Map
4p6vA 1 0.1794 99 0.874 Contact Map
1hfeL 2 0.7518 98.4 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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