GREMLIN Database
GLCE - Glycolate oxidase subunit GlcE
UniProt: P52073 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12996
Length: 350 (334)
Sequences: 18664 (14044)
Seq/√Len: 768.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_R165_E4.0721.00
8_S125_R3.6451.00
19_I338_C3.6441.00
102_V166_I3.3211.00
122_L169_K3.1581.00
52_G66_R3.1091.00
125_R135_R2.9371.00
64_T167_S2.9271.00
64_T165_E2.8641.00
51_R73_T2.8141.00
22_K338_C2.7921.00
77_A80_S2.7291.00
57_D60_E2.6891.00
83_Q170_V2.6161.00
185_S188_E2.5981.00
126_I153_M2.5891.00
128_T132_K2.4231.00
3_R14_Q2.4021.00
123_G135_R2.3871.00
11_L164_T2.3741.00
123_G167_S2.3221.00
12_L133_H2.2231.00
6_D49_C2.1511.00
66_R165_E2.1421.00
69_T74_I2.1381.00
17_Q21_D2.1021.00
79_E173_R2.0621.00
58_P81_A2.0611.00
129_G341_F2.0271.00
15_V25_L2.0081.00
70_P73_T1.9831.00
72_V76_A1.9781.00
128_T134_L1.9491.00
63_I74_I1.9351.00
53_I69_T1.9051.00
123_G137_G1.8941.00
55_N64_T1.8871.00
8_S12_L1.8831.00
78_L170_V1.8761.00
8_S133_H1.8721.00
125_R133_H1.8551.00
298_R302_N1.8431.00
4_E49_C1.8281.00
9_Q12_L1.8281.00
11_L162_V1.8081.00
299_I302_N1.8071.00
124_T153_M1.8061.00
126_I161_G1.8021.00
62_V167_S1.7941.00
8_S164_T1.7801.00
12_L16_N1.7671.00
62_V122_L1.7471.00
47_V162_V1.7381.00
65_A98_W1.7291.00
28_Q31_N1.7251.00
50_H66_R1.7211.00
317_F322_A1.7191.00
9_Q13_E1.7071.00
61_L83_Q1.6821.00
152_L331_L1.6531.00
61_L172_P1.6441.00
27_I162_V1.6411.00
229_E233_G1.6371.00
333_Q339_G1.6011.00
56_Y77_A1.5821.00
7_Y10_A1.5741.00
102_V121_V1.5731.00
330_Q334_Q1.5571.00
15_V341_F1.5551.00
326_R330_Q1.5491.00
6_D10_A1.5491.00
13_E16_N1.5331.00
77_A81_A1.5321.00
127_I164_T1.5251.00
294_N298_R1.5101.00
101_M117_V1.5041.00
45_L162_V1.4981.00
73_T76_A1.4881.00
125_R164_T1.4751.00
16_N19_I1.4721.00
103_A163_L1.4541.00
195_E199_Q1.4411.00
53_I77_A1.4401.00
326_R329_Q1.4351.00
103_A156_S1.4311.00
66_R69_T1.4291.00
321_S324_L1.4261.00
102_V168_M1.4231.00
120_F171_L1.4191.00
137_G145_A1.4101.00
329_Q333_Q1.4081.00
63_I168_M1.4071.00
18_A43_Q1.3761.00
153_M161_G1.3751.00
47_V50_H1.3681.00
17_Q23_T1.3561.00
57_D62_V1.3521.00
121_V124_T1.3491.00
242_Q246_E1.3461.00
322_A326_R1.3431.00
136_F146_G1.3331.00
65_A168_M1.3231.00
11_L127_I1.3211.00
316_G320_L1.3191.00
188_E191_S1.3091.00
327_Y330_Q1.3091.00
289_S293_D1.2841.00
308_T311_S1.2831.00
129_G335_L1.2791.00
86_P120_F1.2771.00
191_S195_E1.2721.00
332_K339_G1.2671.00
51_R66_R1.2451.00
133_H164_T1.2421.00
16_N20_S1.2371.00
136_F150_S1.2341.00
15_V19_I1.2231.00
96_A101_M1.2091.00
15_V162_V1.1921.00
316_G321_S1.1861.00
3_R43_Q1.1851.00
65_A74_I1.1831.00
4_E46_D1.1671.00
324_L327_Y1.1661.00
187_Q191_S1.1591.00
5_C14_Q1.1501.00
12_L127_I1.1481.00
295_Q298_R1.1421.00
18_A25_L1.1421.00
325_F329_Q1.1371.00
28_Q44_T1.1371.00
56_Y83_Q1.1301.00
134_L146_G1.1261.00
76_A80_S1.1261.00
115_G119_D1.1231.00
11_L45_L1.1111.00
10_A13_E1.1111.00
52_G69_T1.1101.00
204_S207_C1.1061.00
330_Q333_Q1.1041.00
15_V127_I1.1011.00
225_K229_E1.1011.00
5_C10_A1.0961.00
63_I170_V1.0891.00
19_I340_V1.0881.00
317_F321_S1.0851.00
102_V117_V1.0771.00
299_I303_A1.0771.00
305_G309_R1.0721.00
127_I133_H1.0651.00
311_S314_D1.0651.00
275_E278_I1.0641.00
24_P42_G1.0531.00
56_Y63_I1.0451.00
121_V154_V1.0441.00
192_E195_E1.0421.00
14_Q43_Q1.0361.00
216_R219_G1.0341.00
264_P267_A1.0271.00
4_E48_R1.0221.00
128_T335_L1.0201.00
99_G166_I1.0171.00
151_R327_Y1.0161.00
203_I207_C1.0121.00
14_Q45_L1.0121.00
75_E87_C1.0111.00
252_F256_G1.0101.00
308_T313_G1.0061.00
22_K340_V1.0051.00
221_E225_K1.0041.00
126_I134_L1.0021.00
63_I78_L0.9901.00
29_G97_T0.9811.00
290_T293_D0.9791.00
124_T150_S0.9761.00
98_W168_M0.9751.00
310_F313_G0.9721.00
297_H301_R0.9681.00
249_L252_F0.9671.00
307_A312_A0.9591.00
317_F325_F0.9581.00
306_H309_R0.9571.00
195_E198_L0.9521.00
248_Q252_F0.9501.00
86_P171_L0.9491.00
148_D151_R0.9471.00
203_I206_L0.9471.00
73_T77_A0.9461.00
47_V67_V0.9401.00
226_A229_E0.9381.00
28_Q46_D0.9381.00
236_V239_Q0.9321.00
223_S226_A0.9281.00
304_G309_R0.9281.00
25_L45_L0.9221.00
72_V94_E0.9191.00
235_E239_Q0.9181.00
234_E238_G0.9171.00
298_R318_A0.9131.00
135_R167_S0.9101.00
194_A198_L0.9091.00
13_E17_Q0.9081.00
24_P342_N0.8981.00
317_F320_L0.8931.00
29_G47_V0.8931.00
230_L233_G0.8911.00
295_Q299_I0.8901.00
309_R312_A0.8861.00
11_L50_H0.8821.00
72_V95_E0.8771.00
8_S66_R0.8741.00
83_Q172_P0.8741.00
33_K37_G0.8691.00
153_M163_L0.8651.00
23_T43_Q0.8641.00
307_A310_F0.8581.00
25_L340_V0.8561.00
71_L101_M0.8491.00
316_G319_P0.8481.00
8_S127_I0.8481.00
30_S97_T0.8461.00
271_D274_G0.8451.00
203_I208_Y0.8411.00
5_C47_V0.8391.00
16_N132_K0.8371.00
275_E280_W0.8371.00
298_R301_R0.8361.00
124_T166_I0.8351.00
62_V169_K0.8341.00
244_L247_Q0.8341.00
26_V42_G0.8331.00
316_G322_A0.8301.00
121_V166_I0.8231.00
274_G279_D0.8181.00
239_Q242_Q0.8101.00
259_W262_S0.8101.00
242_Q245_R0.8081.00
215_I218_E0.8061.00
241_W244_L0.8061.00
260_R265_S0.8041.00
152_L160_L0.8031.00
148_D334_Q0.8011.00
296_I299_I0.7991.00
163_L166_I0.7991.00
227_A230_L0.7971.00
135_R165_E0.7961.00
130_A134_L0.7951.00
29_G67_V0.7941.00
136_F153_M0.7921.00
205_G208_Y0.7921.00
258_L262_S0.7911.00
11_L47_V0.7901.00
51_R69_T0.7871.00
200_P203_I0.7871.00
260_R264_P0.7861.00
234_E237_A0.7841.00
156_S160_L0.7831.00
316_G325_F0.7811.00
229_E232_G0.7771.00
273_P276_Q0.7761.00
224_V228_R0.7751.00
120_F169_K0.7721.00
261_I265_S0.7701.00
252_F255_P0.7701.00
27_I47_V0.7701.00
99_G103_A0.7681.00
67_V166_I0.7641.00
202_P205_G0.7641.00
246_E249_L0.7601.00
200_P207_C0.7591.00
71_L74_I0.7551.00
300_A304_G0.7551.00
190_M194_A0.7551.00
251_F255_P0.7511.00
69_T73_T0.7511.00
308_T312_A0.7481.00
204_S208_Y0.7441.00
276_Q279_D0.7431.00
309_R314_D0.7431.00
122_L167_S0.7431.00
274_G277_L0.7421.00
205_G209_F0.7371.00
309_R313_G0.7371.00
284_L288_K0.7341.00
269_M303_A0.7311.00
283_A288_K0.7311.00
71_L87_C0.7281.00
202_P207_C0.7261.00
258_L265_S0.7251.00
258_L261_I0.7231.00
50_H164_T0.7191.00
299_I304_G0.7191.00
33_K38_R0.7181.00
240_F244_L0.7161.00
204_S209_F0.7161.00
82_G173_R0.7161.00
307_A313_G0.7151.00
214_W218_E0.7131.00
129_G340_V0.7121.00
276_Q280_W0.7101.00
201_L204_S0.7081.00
283_A287_L0.7041.00
241_W245_R0.7031.00
151_R154_V0.7031.00
137_G146_G0.7031.00
8_S11_L0.7021.00
239_Q243_Q0.7011.00
124_T163_L0.7011.00
147_Y159_C0.7001.00
57_D64_T0.6991.00
63_I77_A0.6991.00
320_L324_L0.6991.00
306_H311_S0.6981.00
249_L253_S0.6971.00
257_T260_R0.6941.00
181_R184_I0.6931.00
227_A231_L0.6921.00
223_S227_A0.6911.00
301_R306_H0.6901.00
243_Q246_E0.6891.00
189_A193_I0.6881.00
267_A303_A0.6881.00
307_A311_S0.6871.00
15_V129_G0.6871.00
263_L266_D0.6871.00
48_R70_P0.6861.00
48_R97_T0.6841.00
98_W166_I0.6841.00
201_L207_C0.6821.00
226_A230_L0.6811.00
331_L335_L0.6791.00
304_G311_S0.6791.00
305_G308_T0.6761.00
116_S119_D0.6761.00
203_I209_F0.6741.00
304_G308_T0.6721.00
55_N139_E0.6711.00
5_C49_C0.6701.00
308_T314_D0.6701.00
332_K342_N0.6661.00
217_L224_V0.6651.00
259_W264_P0.6641.00
146_G335_L0.6631.00
71_L96_A0.6621.00
218_E221_E0.6611.00
108_G111_R0.6591.00
222_G225_K0.6591.00
228_R232_G0.6591.00
123_G165_E0.6571.00
282_G286_W0.6561.00
60_E266_D0.6551.00
8_S50_H0.6541.00
150_S154_V0.6531.00
19_I130_A0.6501.00
251_F256_G0.6491.00
193_I197_Q0.6481.00
278_I281_G0.6471.00
237_A240_F0.6471.00
84_M173_R0.6451.00
206_L209_F0.6451.00
74_I98_W0.6411.00
318_A322_A0.6401.00
304_G307_A0.6391.00
243_Q248_Q0.6391.00
339_G342_N0.6341.00
184_I192_E0.6321.00
202_P206_L0.6301.00
204_S218_E0.6291.00
220_G223_S0.6281.00
124_T136_F0.6281.00
191_S194_A0.6271.00
135_R145_A0.6271.00
202_P209_F0.6261.00
248_Q253_S0.6241.00
148_D331_L0.6241.00
275_E279_D0.6241.00
301_R304_G0.6231.00
236_V241_W0.6191.00
263_L270_M0.6181.00
74_I85_L0.6181.00
284_L287_L0.6171.00
283_A286_W0.6161.00
9_Q133_H0.6141.00
194_A197_Q0.6131.00
227_A232_G0.6121.00
260_R263_L0.6111.00
139_E145_A0.6111.00
58_P61_L0.6111.00
53_I66_R0.6111.00
250_P255_P0.6101.00
261_I264_P0.6081.00
250_P256_G0.6061.00
273_P278_I0.6061.00
262_S265_S0.6061.00
310_F314_D0.6051.00
251_F254_L0.6051.00
238_G242_Q0.6041.00
263_L267_A0.6021.00
271_D278_I0.6021.00
160_L331_L0.6011.00
245_R252_F0.6011.00
299_I305_G0.5981.00
213_L216_R0.5981.00
78_L81_A0.5971.00
306_H314_D0.5951.00
213_L218_E0.5931.00
61_L169_K0.5921.00
56_Y81_A0.5911.00
57_D61_L0.5911.00
297_H307_A0.5911.00
240_F243_Q0.5911.00
24_P343_P0.5841.00
244_L252_F0.5841.00
244_L254_L0.5831.00
71_L98_W0.5811.00
5_C50_H0.5811.00
250_P254_L0.5781.00
282_G287_L0.5781.00
306_H313_G0.5771.00
214_W219_G0.5771.00
243_Q249_L0.5761.00
185_S189_A0.5751.00
85_L168_M0.5751.00
180_L184_I0.5741.00
249_L255_P0.5741.00
279_D282_G0.5721.00
30_S70_P0.5721.00
244_L249_L0.5701.00
305_G310_F0.5681.00
294_N297_H0.5621.00
216_R220_G0.5621.00
235_E238_G0.5611.00
304_G310_F0.5601.00
8_S165_E0.5591.00
245_R248_Q0.5591.00
326_R333_Q0.5591.00
180_L183_E0.5581.00
55_N58_P0.5581.00
277_L288_K0.5581.00
10_A14_Q0.5581.00
259_W263_L0.5581.00
253_S256_G0.5571.00
281_G284_L0.5571.00
260_R268_P0.5571.00
248_Q251_F0.5551.00
2_L44_T0.5541.00
85_L170_V0.5521.00
277_L280_W0.5511.00
12_L15_V0.5501.00
138_G150_S0.5481.00
70_P97_T0.5461.00
178_L225_K0.5451.00
260_R266_D0.5451.00
159_C332_K0.5441.00
296_I300_A0.5431.00
56_Y170_V0.5431.00
53_I65_A0.5431.00
105_G116_S0.5401.00
321_S326_R0.5401.00
102_V163_L0.5391.00
259_W265_S0.5351.00
126_I136_F0.5351.00
306_H310_F0.5331.00
75_E173_R0.5331.00
258_L268_P0.5291.00
217_L220_G0.5291.00
244_L248_Q0.5271.00
76_A79_E0.5271.00
205_G210_D0.5261.00
219_G223_S0.5261.00
240_F245_R0.5251.00
139_E146_G0.5251.00
225_K232_G0.5251.00
111_R116_S0.5241.00
323_P326_R0.5241.00
226_A233_G0.5221.00
201_L205_G0.5211.00
114_S171_L0.5201.00
138_G154_V0.5201.00
187_Q269_M0.5191.00
281_G285_R0.5191.00
318_A321_S0.5191.00
201_L209_F0.5191.00
52_G55_N0.5191.00
137_G147_Y0.5181.00
274_G278_I0.5181.00
244_L251_F0.5161.00
225_K228_R0.5161.00
280_W283_A0.5161.00
289_S292_E0.5151.00
261_I267_A0.5151.00
243_Q247_Q0.5141.00
302_N305_G0.5131.00
238_G245_R0.5071.00
29_G99_G0.5071.00
190_M193_I0.5061.00
300_A303_A0.5061.00
273_P277_L0.5041.00
285_R288_K0.5031.00
218_E224_V0.5021.00
217_L227_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9886 100 0.278 Contact Map
2uuuA 2 0.9343 100 0.303 Contact Map
1f0xA 1 0.9771 100 0.327 Contact Map
4bbyA 2 0.9829 100 0.34 Contact Map
4xloA 2 0.9657 100 0.349 Contact Map
2exrA 1 0.9686 100 0.35 Contact Map
4mlaA 1 0.9543 100 0.352 Contact Map
1w1oA 1 0.9486 100 0.358 Contact Map
4ud8A 1 0.9714 100 0.36 Contact Map
2bvfA 1 0.9629 100 0.36 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.