GLCE - ECOLI - GREMLIN Contacts

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GLCE - Glycolate oxidase subunit GlcE

UniProt:	P52073	Sequences: MLRECDYSQALLEQVNQAISDKTPLVIQGSNSKAFLGRPVTGQTLDVRCHRGIVNYDPTELVITARVGTPLVTIEAALESAGQMLPCEPPHYGEEATWGGMVACGLAGPRRPWSGSVRDFVLGTRIITGAGKHLRFGGEVMKNVAGYDLSRLMVGSYGCLGVLTEISMKVLPRPRASLSLRREISLQEAMSEIAEWQLQPLPISGLCYFDNALWIRLEGGEGSVKAARELLGGEEVAGQFWQQLREQQLPFFSLPGTLWRISLPSDAPMMDLPGEQLIDWGGALRWLKSTAEDNQIHRIARNAGGHATRFSAGDGGFAPLSAPLFRYHQQLKQQLDPCGVFNPGRMYAEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12996
Length:	350 (334)
Sequences:	18664 (14044)
Seq/√Len:	768.4

ECOLI - GLCE GLCD YGCU YDIJ
BACSU - GLCD YVDP YGAK YITY
HALSA - Q9HMR2
SULSO - Q97U60 Q97U59 Q97Y18 Q7LX43 Q97ZB9 Q7LXI5 Q97Z67

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
125_R	165_E	4.072	1.00
8_S	125_R	3.645	1.00
19_I	338_C	3.644	1.00
102_V	166_I	3.321	1.00
122_L	169_K	3.158	1.00
52_G	66_R	3.109	1.00
125_R	135_R	2.937	1.00
64_T	167_S	2.927	1.00
64_T	165_E	2.864	1.00
51_R	73_T	2.814	1.00
22_K	338_C	2.792	1.00
77_A	80_S	2.729	1.00
57_D	60_E	2.689	1.00
83_Q	170_V	2.616	1.00
185_S	188_E	2.598	1.00
126_I	153_M	2.589	1.00
128_T	132_K	2.423	1.00
3_R	14_Q	2.402	1.00
123_G	135_R	2.387	1.00
11_L	164_T	2.374	1.00
123_G	167_S	2.322	1.00
12_L	133_H	2.223	1.00
6_D	49_C	2.151	1.00
66_R	165_E	2.142	1.00
69_T	74_I	2.138	1.00
17_Q	21_D	2.102	1.00
79_E	173_R	2.062	1.00
58_P	81_A	2.061	1.00
129_G	341_F	2.027	1.00
15_V	25_L	2.008	1.00
70_P	73_T	1.983	1.00
72_V	76_A	1.978	1.00
128_T	134_L	1.949	1.00
63_I	74_I	1.935	1.00
53_I	69_T	1.905	1.00
123_G	137_G	1.894	1.00
55_N	64_T	1.887	1.00
8_S	12_L	1.883	1.00
78_L	170_V	1.876	1.00
8_S	133_H	1.872	1.00
125_R	133_H	1.855	1.00
298_R	302_N	1.843	1.00
4_E	49_C	1.828	1.00
9_Q	12_L	1.828	1.00
11_L	162_V	1.808	1.00
299_I	302_N	1.807	1.00
124_T	153_M	1.806	1.00
126_I	161_G	1.802	1.00
62_V	167_S	1.794	1.00
8_S	164_T	1.780	1.00
12_L	16_N	1.767	1.00
62_V	122_L	1.747	1.00
47_V	162_V	1.738	1.00
65_A	98_W	1.729	1.00
28_Q	31_N	1.725	1.00
50_H	66_R	1.721	1.00
317_F	322_A	1.719	1.00
9_Q	13_E	1.707	1.00
61_L	83_Q	1.682	1.00
152_L	331_L	1.653	1.00
61_L	172_P	1.644	1.00
27_I	162_V	1.641	1.00
229_E	233_G	1.637	1.00
333_Q	339_G	1.601	1.00
56_Y	77_A	1.582	1.00
7_Y	10_A	1.574	1.00
102_V	121_V	1.573	1.00
330_Q	334_Q	1.557	1.00
15_V	341_F	1.555	1.00
326_R	330_Q	1.549	1.00
6_D	10_A	1.549	1.00
13_E	16_N	1.533	1.00
77_A	81_A	1.532	1.00
127_I	164_T	1.525	1.00
294_N	298_R	1.510	1.00
101_M	117_V	1.504	1.00
45_L	162_V	1.498	1.00
73_T	76_A	1.488	1.00
125_R	164_T	1.475	1.00
16_N	19_I	1.472	1.00
103_A	163_L	1.454	1.00
195_E	199_Q	1.441	1.00
53_I	77_A	1.440	1.00
326_R	329_Q	1.435	1.00
103_A	156_S	1.431	1.00
66_R	69_T	1.429	1.00
321_S	324_L	1.426	1.00
102_V	168_M	1.423	1.00
120_F	171_L	1.419	1.00
137_G	145_A	1.410	1.00
329_Q	333_Q	1.408	1.00
63_I	168_M	1.407	1.00
18_A	43_Q	1.376	1.00
153_M	161_G	1.375	1.00
47_V	50_H	1.368	1.00
17_Q	23_T	1.356	1.00
57_D	62_V	1.352	1.00
121_V	124_T	1.349	1.00
242_Q	246_E	1.346	1.00
322_A	326_R	1.343	1.00
136_F	146_G	1.333	1.00
65_A	168_M	1.323	1.00
11_L	127_I	1.321	1.00
316_G	320_L	1.319	1.00
188_E	191_S	1.309	1.00
327_Y	330_Q	1.309	1.00
289_S	293_D	1.284	1.00
308_T	311_S	1.283	1.00
129_G	335_L	1.279	1.00
86_P	120_F	1.277	1.00
191_S	195_E	1.272	1.00
332_K	339_G	1.267	1.00
51_R	66_R	1.245	1.00
133_H	164_T	1.242	1.00
16_N	20_S	1.237	1.00
136_F	150_S	1.234	1.00
15_V	19_I	1.223	1.00
96_A	101_M	1.209	1.00
15_V	162_V	1.192	1.00
316_G	321_S	1.186	1.00
3_R	43_Q	1.185	1.00
65_A	74_I	1.183	1.00
4_E	46_D	1.167	1.00
324_L	327_Y	1.166	1.00
187_Q	191_S	1.159	1.00
5_C	14_Q	1.150	1.00
12_L	127_I	1.148	1.00
295_Q	298_R	1.142	1.00
18_A	25_L	1.142	1.00
325_F	329_Q	1.137	1.00
28_Q	44_T	1.137	1.00
56_Y	83_Q	1.130	1.00
134_L	146_G	1.126	1.00
76_A	80_S	1.126	1.00
115_G	119_D	1.123	1.00
11_L	45_L	1.111	1.00
10_A	13_E	1.111	1.00
52_G	69_T	1.110	1.00
204_S	207_C	1.106	1.00
330_Q	333_Q	1.104	1.00
15_V	127_I	1.101	1.00
225_K	229_E	1.101	1.00
5_C	10_A	1.096	1.00
63_I	170_V	1.089	1.00
19_I	340_V	1.088	1.00
317_F	321_S	1.085	1.00
102_V	117_V	1.077	1.00
299_I	303_A	1.077	1.00
305_G	309_R	1.072	1.00
127_I	133_H	1.065	1.00
311_S	314_D	1.065	1.00
275_E	278_I	1.064	1.00
24_P	42_G	1.053	1.00
56_Y	63_I	1.045	1.00
121_V	154_V	1.044	1.00
192_E	195_E	1.042	1.00
14_Q	43_Q	1.036	1.00
216_R	219_G	1.034	1.00
264_P	267_A	1.027	1.00
4_E	48_R	1.022	1.00
128_T	335_L	1.020	1.00
99_G	166_I	1.017	1.00
151_R	327_Y	1.016	1.00
203_I	207_C	1.012	1.00
14_Q	45_L	1.012	1.00
75_E	87_C	1.011	1.00
252_F	256_G	1.010	1.00
308_T	313_G	1.006	1.00
22_K	340_V	1.005	1.00
221_E	225_K	1.004	1.00
126_I	134_L	1.002	1.00
63_I	78_L	0.990	1.00
29_G	97_T	0.981	1.00
290_T	293_D	0.979	1.00
124_T	150_S	0.976	1.00
98_W	168_M	0.975	1.00
310_F	313_G	0.972	1.00
297_H	301_R	0.968	1.00
249_L	252_F	0.967	1.00
307_A	312_A	0.959	1.00
317_F	325_F	0.958	1.00
306_H	309_R	0.957	1.00
195_E	198_L	0.952	1.00
248_Q	252_F	0.950	1.00
86_P	171_L	0.949	1.00
148_D	151_R	0.947	1.00
203_I	206_L	0.947	1.00
73_T	77_A	0.946	1.00
47_V	67_V	0.940	1.00
226_A	229_E	0.938	1.00
28_Q	46_D	0.938	1.00
236_V	239_Q	0.932	1.00
223_S	226_A	0.928	1.00
304_G	309_R	0.928	1.00
25_L	45_L	0.922	1.00
72_V	94_E	0.919	1.00
235_E	239_Q	0.918	1.00
234_E	238_G	0.917	1.00
298_R	318_A	0.913	1.00
135_R	167_S	0.910	1.00
194_A	198_L	0.909	1.00
13_E	17_Q	0.908	1.00
24_P	342_N	0.898	1.00
317_F	320_L	0.893	1.00
29_G	47_V	0.893	1.00
230_L	233_G	0.891	1.00
295_Q	299_I	0.890	1.00
309_R	312_A	0.886	1.00
11_L	50_H	0.882	1.00
72_V	95_E	0.877	1.00
8_S	66_R	0.874	1.00
83_Q	172_P	0.874	1.00
33_K	37_G	0.869	1.00
153_M	163_L	0.865	1.00
23_T	43_Q	0.864	1.00
307_A	310_F	0.858	1.00
25_L	340_V	0.856	1.00
71_L	101_M	0.849	1.00
316_G	319_P	0.848	1.00
8_S	127_I	0.848	1.00
30_S	97_T	0.846	1.00
271_D	274_G	0.845	1.00
203_I	208_Y	0.841	1.00
5_C	47_V	0.839	1.00
16_N	132_K	0.837	1.00
275_E	280_W	0.837	1.00
298_R	301_R	0.836	1.00
124_T	166_I	0.835	1.00
62_V	169_K	0.834	1.00
244_L	247_Q	0.834	1.00
26_V	42_G	0.833	1.00
316_G	322_A	0.830	1.00
121_V	166_I	0.823	1.00
274_G	279_D	0.818	1.00
239_Q	242_Q	0.810	1.00
259_W	262_S	0.810	1.00
242_Q	245_R	0.808	1.00
215_I	218_E	0.806	1.00
241_W	244_L	0.806	1.00
260_R	265_S	0.804	1.00
152_L	160_L	0.803	1.00
148_D	334_Q	0.801	1.00
296_I	299_I	0.799	1.00
163_L	166_I	0.799	1.00
227_A	230_L	0.797	1.00
135_R	165_E	0.796	1.00
130_A	134_L	0.795	1.00
29_G	67_V	0.794	1.00
136_F	153_M	0.792	1.00
205_G	208_Y	0.792	1.00
258_L	262_S	0.791	1.00
11_L	47_V	0.790	1.00
51_R	69_T	0.787	1.00
200_P	203_I	0.787	1.00
260_R	264_P	0.786	1.00
234_E	237_A	0.784	1.00
156_S	160_L	0.783	1.00
316_G	325_F	0.781	1.00
229_E	232_G	0.777	1.00
273_P	276_Q	0.776	1.00
224_V	228_R	0.775	1.00
120_F	169_K	0.772	1.00
261_I	265_S	0.770	1.00
252_F	255_P	0.770	1.00
27_I	47_V	0.770	1.00
99_G	103_A	0.768	1.00
67_V	166_I	0.764	1.00
202_P	205_G	0.764	1.00
246_E	249_L	0.760	1.00
200_P	207_C	0.759	1.00
71_L	74_I	0.755	1.00
300_A	304_G	0.755	1.00
190_M	194_A	0.755	1.00
251_F	255_P	0.751	1.00
69_T	73_T	0.751	1.00
308_T	312_A	0.748	1.00
204_S	208_Y	0.744	1.00
276_Q	279_D	0.743	1.00
309_R	314_D	0.743	1.00
122_L	167_S	0.743	1.00
274_G	277_L	0.742	1.00
205_G	209_F	0.737	1.00
309_R	313_G	0.737	1.00
284_L	288_K	0.734	1.00
269_M	303_A	0.731	1.00
283_A	288_K	0.731	1.00
71_L	87_C	0.728	1.00
202_P	207_C	0.726	1.00
258_L	265_S	0.725	1.00
258_L	261_I	0.723	1.00
50_H	164_T	0.719	1.00
299_I	304_G	0.719	1.00
33_K	38_R	0.718	1.00
240_F	244_L	0.716	1.00
204_S	209_F	0.716	1.00
82_G	173_R	0.716	1.00
307_A	313_G	0.715	1.00
214_W	218_E	0.713	1.00
129_G	340_V	0.712	1.00
276_Q	280_W	0.710	1.00
201_L	204_S	0.708	1.00
283_A	287_L	0.704	1.00
241_W	245_R	0.703	1.00
151_R	154_V	0.703	1.00
137_G	146_G	0.703	1.00
8_S	11_L	0.702	1.00
239_Q	243_Q	0.701	1.00
124_T	163_L	0.701	1.00
147_Y	159_C	0.700	1.00
57_D	64_T	0.699	1.00
63_I	77_A	0.699	1.00
320_L	324_L	0.699	1.00
306_H	311_S	0.698	1.00
249_L	253_S	0.697	1.00
257_T	260_R	0.694	1.00
181_R	184_I	0.693	1.00
227_A	231_L	0.692	1.00
223_S	227_A	0.691	1.00
301_R	306_H	0.690	1.00
243_Q	246_E	0.689	1.00
189_A	193_I	0.688	1.00
267_A	303_A	0.688	1.00
307_A	311_S	0.687	1.00
15_V	129_G	0.687	1.00
263_L	266_D	0.687	1.00
48_R	70_P	0.686	1.00
48_R	97_T	0.684	1.00
98_W	166_I	0.684	1.00
201_L	207_C	0.682	1.00
226_A	230_L	0.681	1.00
331_L	335_L	0.679	1.00
304_G	311_S	0.679	1.00
305_G	308_T	0.676	1.00
116_S	119_D	0.676	1.00
203_I	209_F	0.674	1.00
304_G	308_T	0.672	1.00
55_N	139_E	0.671	1.00
5_C	49_C	0.670	1.00
308_T	314_D	0.670	1.00
332_K	342_N	0.666	1.00
217_L	224_V	0.665	1.00
259_W	264_P	0.664	1.00
146_G	335_L	0.663	1.00
71_L	96_A	0.662	1.00
218_E	221_E	0.661	1.00
108_G	111_R	0.659	1.00
222_G	225_K	0.659	1.00
228_R	232_G	0.659	1.00
123_G	165_E	0.657	1.00
282_G	286_W	0.656	1.00
60_E	266_D	0.655	1.00
8_S	50_H	0.654	1.00
150_S	154_V	0.653	1.00
19_I	130_A	0.650	1.00
251_F	256_G	0.649	1.00
193_I	197_Q	0.648	1.00
278_I	281_G	0.647	1.00
237_A	240_F	0.647	1.00
84_M	173_R	0.645	1.00
206_L	209_F	0.645	1.00
74_I	98_W	0.641	1.00
318_A	322_A	0.640	1.00
304_G	307_A	0.639	1.00
243_Q	248_Q	0.639	1.00
339_G	342_N	0.634	1.00
184_I	192_E	0.632	1.00
202_P	206_L	0.630	1.00
204_S	218_E	0.629	1.00
220_G	223_S	0.628	1.00
124_T	136_F	0.628	1.00
191_S	194_A	0.627	1.00
135_R	145_A	0.627	1.00
202_P	209_F	0.626	1.00
248_Q	253_S	0.624	1.00
148_D	331_L	0.624	1.00
275_E	279_D	0.624	1.00
301_R	304_G	0.623	1.00
236_V	241_W	0.619	1.00
263_L	270_M	0.618	1.00
74_I	85_L	0.618	1.00
284_L	287_L	0.617	1.00
283_A	286_W	0.616	1.00
9_Q	133_H	0.614	1.00
194_A	197_Q	0.613	1.00
227_A	232_G	0.612	1.00
260_R	263_L	0.611	1.00
139_E	145_A	0.611	1.00
58_P	61_L	0.611	1.00
53_I	66_R	0.611	1.00
250_P	255_P	0.610	1.00
261_I	264_P	0.608	1.00
250_P	256_G	0.606	1.00
273_P	278_I	0.606	1.00
262_S	265_S	0.606	1.00
310_F	314_D	0.605	1.00
251_F	254_L	0.605	1.00
238_G	242_Q	0.604	1.00
263_L	267_A	0.602	1.00
271_D	278_I	0.602	1.00
160_L	331_L	0.601	1.00
245_R	252_F	0.601	1.00
299_I	305_G	0.598	1.00
213_L	216_R	0.598	1.00
78_L	81_A	0.597	1.00
306_H	314_D	0.595	1.00
213_L	218_E	0.593	1.00
61_L	169_K	0.592	1.00
56_Y	81_A	0.591	1.00
57_D	61_L	0.591	1.00
297_H	307_A	0.591	1.00
240_F	243_Q	0.591	1.00
24_P	343_P	0.584	1.00
244_L	252_F	0.584	1.00
244_L	254_L	0.583	1.00
71_L	98_W	0.581	1.00
5_C	50_H	0.581	1.00
250_P	254_L	0.578	1.00
282_G	287_L	0.578	1.00
306_H	313_G	0.577	1.00
214_W	219_G	0.577	1.00
243_Q	249_L	0.576	1.00
185_S	189_A	0.575	1.00
85_L	168_M	0.575	1.00
180_L	184_I	0.574	1.00
249_L	255_P	0.574	1.00
279_D	282_G	0.572	1.00
30_S	70_P	0.572	1.00
244_L	249_L	0.570	1.00
305_G	310_F	0.568	1.00
294_N	297_H	0.562	1.00
216_R	220_G	0.562	1.00
235_E	238_G	0.561	1.00
304_G	310_F	0.560	1.00
8_S	165_E	0.559	1.00
245_R	248_Q	0.559	1.00
326_R	333_Q	0.559	1.00
180_L	183_E	0.558	1.00
55_N	58_P	0.558	1.00
277_L	288_K	0.558	1.00
10_A	14_Q	0.558	1.00
259_W	263_L	0.558	1.00
253_S	256_G	0.557	1.00
281_G	284_L	0.557	1.00
260_R	268_P	0.557	1.00
248_Q	251_F	0.555	1.00
2_L	44_T	0.554	1.00
85_L	170_V	0.552	1.00
277_L	280_W	0.551	1.00
12_L	15_V	0.550	1.00
138_G	150_S	0.548	1.00
70_P	97_T	0.546	1.00
178_L	225_K	0.545	1.00
260_R	266_D	0.545	1.00
159_C	332_K	0.544	1.00
296_I	300_A	0.543	1.00
56_Y	170_V	0.543	1.00
53_I	65_A	0.543	1.00
105_G	116_S	0.540	1.00
321_S	326_R	0.540	1.00
102_V	163_L	0.539	1.00
259_W	265_S	0.535	1.00
126_I	136_F	0.535	1.00
306_H	310_F	0.533	1.00
75_E	173_R	0.533	1.00
258_L	268_P	0.529	1.00
217_L	220_G	0.529	1.00
244_L	248_Q	0.527	1.00
76_A	79_E	0.527	1.00
205_G	210_D	0.526	1.00
219_G	223_S	0.526	1.00
240_F	245_R	0.525	1.00
139_E	146_G	0.525	1.00
225_K	232_G	0.525	1.00
111_R	116_S	0.524	1.00
323_P	326_R	0.524	1.00
226_A	233_G	0.522	1.00
201_L	205_G	0.521	1.00
114_S	171_L	0.520	1.00
138_G	154_V	0.520	1.00
187_Q	269_M	0.519	1.00
281_G	285_R	0.519	1.00
318_A	321_S	0.519	1.00
201_L	209_F	0.519	1.00
52_G	55_N	0.519	1.00
137_G	147_Y	0.518	1.00
274_G	278_I	0.518	1.00
244_L	251_F	0.516	1.00
225_K	228_R	0.516	1.00
280_W	283_A	0.516	1.00
289_S	292_E	0.515	1.00
261_I	267_A	0.515	1.00
243_Q	247_Q	0.514	1.00
302_N	305_G	0.513	1.00
238_G	245_R	0.507	1.00
29_G	99_G	0.507	1.00
190_M	193_I	0.506	1.00
300_A	303_A	0.506	1.00
273_P	277_L	0.504	1.00
285_R	288_K	0.503	1.00
218_E	224_V	0.502	1.00
217_L	227_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pm9A	5	0.9886	100	0.278	Contact Map
2uuuA	2	0.9343	100	0.303	Contact Map
1f0xA	1	0.9771	100	0.327	Contact Map
4bbyA	2	0.9829	100	0.34	Contact Map
4xloA	2	0.9657	100	0.349	Contact Map
2exrA	1	0.9686	100	0.35	Contact Map
4mlaA	1	0.9543	100	0.352	Contact Map
1w1oA	1	0.9486	100	0.358	Contact Map
4ud8A	1	0.9714	100	0.36	Contact Map
2bvfA	1	0.9629	100	0.36	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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