GREMLIN Database
YGGW - Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW
UniProt: P52062 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12983
Length: 378 (367)
Sequences: 6966 (4972)
Seq/√Len: 259.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_L83_G3.9491.00
181_R227_L3.1701.00
44_L79_T3.0581.00
177_L223_Q2.8611.00
187_N243_K2.8441.00
141_G144_E2.7771.00
41_Q79_T2.7721.00
48_D83_G2.7431.00
153_S189_P2.7401.00
48_D87_R2.5551.00
352_T359_Q2.4141.00
361_T364_G2.3641.00
37_D76_A2.3581.00
146_K182_Q2.2671.00
90_L94_A2.2461.00
184_I231_A2.2221.00
107_A154_G2.2171.00
42_H288_R2.2051.00
78_Q82_D2.1901.00
73_S76_A2.1381.00
121_I152_A2.1141.00
130_E142_P2.0961.00
150_K154_G2.0681.00
129_S175_E2.0461.00
303_E306_D2.0361.00
78_Q115_R2.0241.00
283_K286_H1.9941.00
19_K27_S1.9711.00
182_Q185_E1.9701.00
8_S253_N1.9681.00
177_L227_L1.9661.00
213_D216_A1.9571.00
128_F183_A1.9361.00
39_Y265_C1.9261.00
324_R353_E1.9161.00
143_Q147_R1.8841.00
125_V145_A1.8781.00
37_D79_T1.8761.00
176_A224_G1.8611.00
40_V44_L1.8351.00
178_G182_Q1.8221.00
47_L263_I1.8181.00
226_Q230_A1.8161.00
130_E143_Q1.8111.00
159_S246_Y1.7911.00
11_I84_V1.7741.00
287_P290_F1.7681.00
345_A371_L1.7631.00
147_R150_K1.7611.00
38_D292_Q1.7481.00
184_I227_L1.7311.00
9_L59_V1.7021.00
131_E175_E1.6901.00
345_A374_L1.6891.00
227_L231_A1.6891.00
173_L223_Q1.6851.00
174_E177_L1.6731.00
110_F152_A1.6581.00
193_W224_G1.6261.00
107_A151_L1.6231.00
177_L181_R1.6151.00
144_E147_R1.5991.00
346_I353_E1.5951.00
13_I72_L1.5881.00
40_V80_L1.5881.00
42_H292_Q1.5861.00
146_K150_K1.5841.00
74_G112_D1.5581.00
173_L219_D1.5531.00
132_K175_E1.5501.00
111_V155_L1.5481.00
98_M118_V1.5431.00
343_D347_A1.5421.00
223_Q226_Q1.5391.00
43_L263_I1.5341.00
225_H241_Y1.5341.00
114_Q157_L1.5321.00
178_G181_R1.5311.00
269_G278_I1.5211.00
167_G217_L1.5191.00
180_L227_L1.5101.00
142_P146_K1.5041.00
130_E134_K1.4921.00
162_L183_A1.4801.00
128_F182_Q1.4711.00
47_L84_V1.4641.00
323_P326_E1.4531.00
45_N48_D1.4431.00
191_L228_L1.4331.00
129_S132_K1.4261.00
308_P327_F1.4231.00
78_Q116_A1.4191.00
229_T362_E1.4071.00
112_D116_A1.4041.00
46_D280_R1.3981.00
324_R357_Y1.3971.00
181_R185_E1.3961.00
325_V356_D1.3811.00
111_V115_R1.3711.00
234_Q247_Q1.3691.00
323_P356_D1.3681.00
58_E91_A1.3681.00
252_L318_L1.3661.00
188_P233_Y1.3361.00
173_L216_A1.3331.00
360_I368_L1.3131.00
343_D346_I1.3111.00
153_S187_N1.3111.00
172_S175_E1.3071.00
324_R335_E1.3071.00
129_S178_G1.3061.00
189_P246_Y1.3061.00
319_L365_K1.3051.00
131_E134_K1.2991.00
36_H73_S1.2961.00
281_T290_F1.2931.00
268_H279_L1.2921.00
344_E374_L1.2911.00
40_V76_A1.2871.00
280_R287_P1.2871.00
228_L233_Y1.2851.00
107_A111_V1.2831.00
234_Q244_P1.2831.00
47_L87_R1.2741.00
125_V128_F1.2701.00
256_R320_E1.2671.00
262_G267_A1.2531.00
344_E348_Q1.2481.00
123_I152_A1.2471.00
284_T288_R1.2401.00
285_R289_G1.2371.00
36_H76_A1.2191.00
58_E89_P1.2171.00
132_K179_D1.2171.00
103_G139_I1.2131.00
339_R343_D1.2111.00
142_P182_Q1.2061.00
354_C359_Q1.2021.00
9_L263_I1.1971.00
49_N291_M1.1951.00
131_E170_D1.1901.00
312_F322_A1.1851.00
189_P233_Y1.1811.00
64_I77_M1.1771.00
84_V90_L1.1751.00
253_N258_G1.1701.00
222_E366_L1.1701.00
26_N266_G1.1661.00
159_S189_P1.1641.00
149_A186_L1.1631.00
223_Q227_L1.1621.00
44_L48_D1.1561.00
147_R151_L1.1541.00
62_I90_L1.1521.00
160_F189_P1.1481.00
50_D263_I1.1461.00
311_F331_T1.1441.00
72_L76_A1.1421.00
195_Q217_L1.1411.00
82_D86_A1.1201.00
280_R290_F1.1201.00
276_G299_Q1.1161.00
107_A155_L1.1161.00
151_L154_G1.1141.00
98_M113_Y1.1141.00
136_L168_L1.1061.00
173_L220_I1.1051.00
247_Q320_E1.1051.00
83_G86_A1.1011.00
100_A105_V1.0991.00
64_I80_L1.0971.00
348_Q363_H1.0961.00
256_R318_L1.0961.00
227_L230_A1.0951.00
226_Q362_E1.0941.00
70_S100_A1.0921.00
152_A160_F1.0921.00
13_I265_C1.0851.00
40_V72_L1.0811.00
216_A219_D1.0791.00
326_E330_Y1.0741.00
149_A160_F1.0741.00
110_F155_L1.0721.00
286_H289_G1.0681.00
109_R113_Y1.0671.00
40_V83_G1.0671.00
173_L177_L1.0671.00
74_G109_R1.0611.00
135_R170_D1.0581.00
49_N295_Y1.0571.00
360_I371_L1.0501.00
121_I157_L1.0491.00
45_N292_Q1.0461.00
244_P247_Q1.0431.00
203_L207_R1.0391.00
259_D270_K1.0391.00
153_S160_F1.0321.00
281_T286_H1.0281.00
70_S113_Y1.0261.00
308_P337_V1.0221.00
323_P357_Y1.0211.00
37_D41_Q1.0181.00
311_F315_R1.0181.00
311_F330_Y1.0171.00
70_S98_M1.0161.00
108_D112_D1.0141.00
81_L96_I1.0091.00
164_L179_D1.0071.00
74_G108_D1.0011.00
127_S132_K1.0011.00
6_P60_K0.9971.00
85_R90_L0.9851.00
78_Q112_D0.9811.00
60_K91_A0.9811.00
282_T287_P0.9801.00
41_Q44_L0.9801.00
232_G244_P0.9801.00
146_K186_L0.9751.00
281_T297_E0.9741.00
284_T287_P0.9731.00
286_H290_F0.9721.00
149_A188_P0.9711.00
112_D115_R0.9651.00
279_L298_S0.9641.00
76_A79_T0.9611.00
304_A307_K0.9571.00
106_E109_R0.9551.00
368_L372_L0.9551.00
7_L57_R0.9521.00
321_A359_Q0.9471.00
48_D86_A0.9461.00
149_A153_S0.9451.00
158_R246_Y0.9441.00
315_R319_L0.9411.00
225_H229_T0.9401.00
265_C284_T0.9351.00
9_L84_V0.9341.00
57_R259_D0.9341.00
42_H45_N0.9331.00
225_H235_Q0.9281.00
315_R322_A0.9281.00
354_C357_Y0.9281.00
93_D249_Q0.9271.00
306_D309_F0.9231.00
170_D210_V0.9231.00
60_K249_Q0.9131.00
91_A94_A0.9121.00
348_Q374_L0.9091.00
288_R291_M0.9041.00
81_L84_V0.9011.00
287_P291_M0.9011.00
45_N49_N0.8981.00
325_V329_A0.8971.00
300_R306_D0.8971.00
60_K253_N0.8951.00
183_A191_L0.8931.00
35_P38_D0.8921.00
97_T248_C0.8891.00
171_Q220_I0.8841.00
324_R356_D0.8811.00
259_D272_T0.8791.00
198_I204_F0.8771.00
26_N265_C0.8741.00
108_D111_V0.8741.00
114_Q158_R0.8711.00
184_I228_L0.8701.00
321_A357_Y0.8691.00
77_M81_L0.8691.00
46_D287_P0.8681.00
70_S104_T0.8671.00
276_G301_D0.8641.00
21_P204_F0.8601.00
199_E202_T0.8581.00
352_T361_T0.8571.00
344_E347_A0.8551.00
64_I98_M0.8530.99
128_F179_D0.8530.99
77_M98_M0.8530.99
77_M116_A0.8520.99
153_S188_P0.8490.99
215_D219_D0.8470.99
219_D222_E0.8440.99
114_Q155_L0.8410.99
313_M372_L0.8390.99
83_G87_R0.8370.99
37_D75_P0.8360.99
73_S109_R0.8360.99
142_P145_A0.8320.99
47_L83_G0.8320.99
257_F270_K0.8300.99
162_L188_P0.8280.99
353_E358_W0.8220.99
30_L36_H0.8210.99
81_L116_A0.8160.99
341_Q374_L0.8090.99
85_R89_P0.8090.99
276_G287_P0.8080.99
164_L176_A0.8080.99
342_L358_W0.8060.99
8_S61_T0.8040.99
252_L256_R0.7990.99
123_I148_A0.7980.99
296_L299_Q0.7970.99
225_H362_E0.7950.99
17_V104_T0.7950.99
277_R287_P0.7940.99
148_A151_L0.7940.99
305_T337_V0.7910.99
273_F307_K0.7870.99
370_S373_E0.7840.99
257_F311_F0.7770.99
21_P137_G0.7770.99
149_A162_L0.7710.99
11_I43_L0.7710.99
119_N159_S0.7700.99
324_R358_W0.7650.99
290_F294_R0.7620.99
250_H254_Y0.7620.99
216_A220_I0.7580.99
105_V110_F0.7580.99
40_V79_T0.7560.99
164_L183_A0.7550.99
125_V162_L0.7550.99
75_P78_Q0.7540.99
187_N233_Y0.7480.99
128_F142_P0.7440.99
63_F248_C0.7440.99
28_H284_T0.7420.99
288_R292_Q0.7390.99
19_K29_A0.7390.99
42_H291_M0.7380.99
145_A162_L0.7370.99
81_L85_R0.7360.99
311_F327_F0.7330.98
6_P58_E0.7320.98
166_H176_A0.7300.98
100_A123_I0.7300.98
133_L140_H0.7280.98
51_V87_R0.7270.98
166_H193_W0.7260.98
273_F276_G0.7200.98
304_A308_P0.7200.98
259_D271_V0.7200.98
96_I118_V0.7150.98
278_I287_P0.7070.98
315_R326_E0.7060.98
203_L206_S0.7060.98
346_I351_L0.7050.98
103_G144_E0.7040.98
38_D288_R0.7020.98
257_F307_K0.7000.98
326_E329_A0.6970.98
369_N372_L0.6970.98
122_S161_N0.6960.98
131_E135_R0.6940.98
47_L88_L0.6940.98
363_H366_L0.6920.98
77_M112_D0.6900.98
132_K171_Q0.6900.98
327_F337_V0.6870.98
343_D353_E0.6870.98
350_Y367_F0.6870.98
143_Q146_K0.6870.98
59_V94_A0.6850.98
90_L93_D0.6840.98
34_V38_D0.6840.98
161_N248_C0.6830.98
152_A157_L0.6830.98
334_C338_I0.6810.98
43_L80_L0.6800.98
325_V328_I0.6790.98
39_Y43_L0.6790.98
151_L155_L0.6780.97
38_D41_Q0.6780.97
77_M113_Y0.6780.97
345_A351_L0.6760.97
111_V154_G0.6750.97
219_D223_Q0.6740.97
70_S109_R0.6740.97
302_V307_K0.6720.97
262_G269_G0.6710.97
363_H367_F0.6660.97
38_D42_H0.6650.97
367_F370_S0.6640.97
82_D85_R0.6640.97
21_P136_L0.6620.97
58_E92_A0.6620.97
36_H40_V0.6620.97
235_Q365_K0.6560.97
327_F333_L0.6560.97
200_P205_G0.6540.97
168_L179_D0.6540.97
280_R283_K0.6540.97
176_A180_L0.6530.97
350_Y364_G0.6530.97
335_E339_R0.6520.97
338_I375_F0.6490.97
113_Y118_V0.6490.97
279_L282_T0.6490.97
242_A247_Q0.6480.97
50_D53_Y0.6470.97
62_I94_A0.6460.97
59_V88_L0.6460.97
44_L80_L0.6460.97
218_W366_L0.6460.97
17_V139_I0.6440.97
309_F313_M0.6430.97
174_E178_G0.6420.97
33_E76_A0.6410.96
225_H365_K0.6390.96
180_L184_I0.6380.96
11_I263_I0.6370.96
64_I81_L0.6370.96
189_P243_K0.6360.96
342_L351_L0.6360.96
105_V109_R0.6360.96
215_D218_W0.6330.96
44_L87_R0.6310.96
60_K94_A0.6300.96
305_T309_F0.6280.96
50_D261_I0.6270.96
110_F121_I0.6250.96
105_V151_L0.6210.96
204_F209_P0.6210.96
338_I341_Q0.6210.96
84_V263_I0.6190.96
177_L226_Q0.6170.96
180_L223_Q0.6160.96
132_K168_L0.6130.95
312_F375_F0.6130.95
289_G292_Q0.6110.95
370_S374_L0.6090.95
90_L96_I0.6090.95
308_P331_T0.6090.95
221_F235_Q0.6080.95
249_Q252_L0.6060.95
56_G89_P0.6060.95
74_G116_A0.6060.95
328_I334_C0.6030.95
222_E226_Q0.6020.95
49_N53_Y0.6020.95
342_L346_I0.6020.95
84_V87_R0.6010.95
175_E179_D0.5990.95
110_F157_L0.5980.95
52_A87_R0.5960.95
184_I230_A0.5950.95
61_T249_Q0.5930.95
250_H255_W0.5900.94
152_A155_L0.5860.94
75_P112_D0.5860.94
315_R318_L0.5840.94
64_I118_V0.5840.94
47_L80_L0.5830.94
18_Q137_G0.5830.94
327_F331_T0.5830.94
93_D96_I0.5810.94
181_R231_A0.5790.94
79_T83_G0.5750.94
40_V73_S0.5750.94
360_I364_G0.5750.94
341_Q345_A0.5740.94
339_R353_E0.5740.94
181_R184_I0.5740.94
105_V148_A0.5730.94
130_E141_G0.5720.93
7_L59_V0.5710.93
168_L171_Q0.5690.93
18_Q29_A0.5690.93
160_F188_P0.5680.93
310_E314_N0.5670.93
276_G290_F0.5670.93
46_D50_D0.5660.93
49_N294_R0.5660.93
233_Y243_K0.5640.93
150_K153_S0.5620.93
128_F145_A0.5620.93
82_D116_A0.5610.93
11_I47_L0.5610.93
341_Q344_E0.5600.93
93_D119_N0.5580.93
222_E362_E0.5570.93
9_L261_I0.5560.93
188_P191_L0.5550.92
333_L337_V0.5550.92
283_K287_P0.5550.92
235_Q319_L0.5490.92
349_G363_H0.5480.92
248_C252_L0.5460.92
311_F326_E0.5460.92
247_Q252_L0.5460.92
277_R310_E0.5440.92
20_C23_C0.5440.92
312_F327_F0.5440.92
324_R354_C0.5430.92
316_F358_W0.5430.92
184_I187_N0.5430.92
114_Q119_N0.5420.92
8_S60_K0.5390.91
7_L261_I0.5330.91
333_L336_D0.5320.91
238_T250_H0.5320.91
235_Q366_L0.5300.91
229_T234_Q0.5300.91
61_T94_A0.5290.91
146_K185_E0.5270.90
265_C268_H0.5270.90
18_Q139_I0.5270.90
351_L358_W0.5270.90
346_I352_T0.5260.90
276_G280_R0.5260.90
345_A350_Y0.5250.90
335_E353_E0.5250.90
304_A333_L0.5240.90
166_H224_G0.5240.90
317_R372_L0.5240.90
283_K290_F0.5230.90
161_N192_S0.5220.90
262_G278_I0.5220.90
310_E317_R0.5190.90
234_Q319_L0.5190.90
184_I233_Y0.5170.90
33_E37_D0.5160.89
281_T287_P0.5160.89
218_W222_E0.5150.89
8_S258_G0.5150.89
191_L233_Y0.5150.89
158_R189_P0.5140.89
176_A220_I0.5140.89
60_K93_D0.5140.89
224_G228_L0.5130.89
166_H221_F0.5120.89
64_I96_I0.5120.89
127_S179_D0.5110.89
63_F97_T0.5090.89
277_R280_R0.5070.89
171_Q175_E0.5060.89
324_R355_A0.5040.88
110_F151_L0.5040.88
175_E178_G0.5040.88
237_E251_N0.5040.88
105_V123_I0.5030.88
145_A149_A0.5030.88
21_P207_R0.5030.88
324_R328_I0.5020.88
248_C255_W0.5020.88
327_F334_C0.5020.88
25_F251_N0.5010.88
47_L50_D0.5000.88
89_P93_D0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oltA 1 0.9947 100 0.311 Contact Map
1r30A 2 0.7196 100 0.743 Contact Map
4jc0A 1 0.7619 100 0.754 Contact Map
4u0oB 1 0.6032 100 0.754 Contact Map
4r33A 2 0.7804 100 0.759 Contact Map
2qgqA 1 0.6852 99.9 0.76 Contact Map
4wcxA 1 0.8889 99.9 0.762 Contact Map
4rtbA 2 0.8545 99.9 0.771 Contact Map
3t7vA 1 0.754 99.9 0.777 Contact Map
3iixA 1 0.7804 99.9 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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