GREMLIN Database
RDGB - dITP/XTP pyrophosphatase
UniProt: P52061 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12982
Length: 197 (188)
Sequences: 4639 (3242)
Seq/√Len: 236.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_G48_E3.3821.00
140_W169_A3.0581.00
149_A171_E2.9741.00
80_A105_T2.6911.00
99_L159_I2.6511.00
173_T176_E2.4301.00
73_A117_R2.4281.00
101_K105_T2.3811.00
3_K27_D2.3731.00
42_T52_L2.3671.00
117_R139_S2.3231.00
145_T168_T2.3031.00
50_A123_V2.2881.00
117_R141_P2.2491.00
167_K176_E2.2481.00
3_K29_V2.2421.00
75_D115_Q2.2001.00
136_C193_A2.1221.00
111_D146_R2.1171.00
75_D117_R2.0321.00
47_I137_H2.0041.00
73_A119_H1.9751.00
96_Q100_Q1.9171.00
12_G15_R1.9161.00
145_T161_F1.8981.00
74_V102_L1.8781.00
88_Y105_T1.8711.00
104_E107_K1.8321.00
119_H137_H1.8191.00
3_K63_L1.7961.00
100_Q148_P1.7811.00
94_T97_K1.7771.00
96_Q148_P1.7561.00
51_I55_R1.7321.00
14_V30_A1.7311.00
165_E176_E1.6501.00
19_S178_S1.6361.00
75_D113_Q1.6181.00
55_R133_P1.5921.00
184_G188_K1.5561.00
99_L148_P1.5441.00
123_V135_V1.5281.00
9_G32_T1.5201.00
64_P124_Y1.4601.00
51_I133_P1.4501.00
185_Q188_K1.4461.00
44_L48_E1.4101.00
6_L17_L1.4091.00
51_I135_V1.3961.00
39_A52_L1.3861.00
55_R59_K1.3791.00
145_T149_A1.3751.00
80_A88_Y1.3661.00
39_A56_H1.3641.00
54_A123_V1.3521.00
143_V163_P1.3481.00
126_R129_E1.3371.00
5_V57_A1.3171.00
134_L193_A1.3151.00
29_V34_L1.3071.00
46_F73_A1.3031.00
161_F166_G1.3031.00
143_V161_F1.2731.00
47_I135_V1.2731.00
100_Q104_E1.2651.00
8_T14_V1.2391.00
176_E179_A1.2291.00
56_H60_V1.2081.00
93_A97_K1.2051.00
124_Y190_L1.1971.00
58_A125_L1.1841.00
46_F70_S1.1691.00
116_A144_I1.1511.00
162_V172_L1.1491.00
92_D97_K1.1471.00
172_L176_E1.1441.00
126_R130_D1.1351.00
103_L159_I1.1251.00
108_D146_R1.1151.00
47_I123_V1.1131.00
167_K172_L1.1061.00
89_S98_N1.1041.00
161_F164_S1.1011.00
189_L192_D1.1011.00
51_I123_V1.0821.00
119_H139_S1.0791.00
43_G52_L1.0771.00
40_E52_L1.0671.00
61_T65_A1.0641.00
11_V15_R1.0631.00
17_L122_L1.0461.00
5_V63_L1.0431.00
57_A65_A1.0431.00
37_D60_V1.0301.00
72_L144_I1.0281.00
141_P163_P1.0261.00
165_E180_I1.0251.00
36_V61_T1.0191.00
164_S185_Q1.0171.00
66_I122_L1.0031.00
52_L56_H0.9981.00
102_L159_I0.9871.00
162_V165_E0.9851.00
66_I190_L0.9761.00
125_L133_P0.9681.00
136_C190_L0.9541.00
45_T83_I0.9441.00
75_D79_G0.9431.00
23_D191_L0.9431.00
51_I125_L0.9401.00
89_S97_K0.9351.00
95_D98_N0.9301.00
122_L190_L0.9231.00
111_D143_V0.9221.00
54_A125_L0.9211.00
9_G31_Q0.9111.00
5_V65_A0.9101.00
89_S93_A0.9041.00
152_G173_T0.9011.00
115_Q141_P0.9001.00
55_R125_L0.8971.00
103_L114_R0.8920.99
189_L193_A0.8910.99
169_A172_L0.8900.99
64_P126_R0.8840.99
70_S120_C0.8820.99
121_V137_H0.8750.99
97_K100_Q0.8740.99
58_A129_E0.8740.99
98_N101_K0.8690.99
126_R131_P0.8670.99
85_S156_Y0.8630.99
165_E172_L0.8620.99
39_A57_A0.8590.99
14_V18_A0.8510.99
99_L158_P0.8480.99
122_L187_L0.8440.99
162_V180_I0.8340.99
136_C189_L0.8320.99
12_G17_L0.8320.99
188_K191_L0.8310.99
150_G170_A0.8270.99
121_V135_V0.8250.99
140_W185_Q0.8010.99
49_N83_I0.7890.99
19_S174_R0.7850.99
108_D111_D0.7790.99
91_E94_T0.7780.99
106_M144_I0.7730.99
145_T159_I0.7640.98
157_D177_K0.7640.98
29_V33_D0.7620.98
19_S22_S0.7570.98
6_L66_I0.7570.98
188_K192_D0.7550.98
140_W180_I0.7550.98
56_H59_K0.7510.98
162_V166_G0.7450.98
162_V169_A0.7400.98
72_L118_F0.7370.98
98_N102_L0.7360.98
14_V28_I0.7340.98
111_D115_Q0.7320.98
17_L187_L0.7230.98
103_L106_M0.7220.98
126_R132_T0.7200.98
5_V61_T0.7130.98
17_L21_L0.7120.97
151_T171_E0.7080.97
45_T48_E0.7060.97
6_L28_I0.6890.97
107_K146_R0.6880.97
168_T171_E0.6880.97
115_Q143_V0.6870.97
44_L84_Y0.6840.97
177_K181_S0.6830.97
15_R19_S0.6820.97
12_G20_L0.6800.97
89_S101_K0.6770.97
75_D141_P0.6750.97
83_I87_R0.6740.97
185_Q189_L0.6720.96
15_R18_A0.6670.96
121_V136_C0.6670.96
99_L102_L0.6650.96
12_G95_D0.6640.96
31_Q57_A0.6640.96
101_K104_E0.6630.96
108_D114_R0.6590.96
44_L83_I0.6580.96
107_K111_D0.6560.96
11_V32_T0.6540.96
149_A161_F0.6520.96
88_Y101_K0.6500.96
90_G93_A0.6460.96
167_K171_E0.6450.96
103_L145_T0.6440.96
46_F119_H0.6440.96
11_V18_A0.6420.95
66_I124_Y0.6370.95
20_L187_L0.6360.95
138_G185_Q0.6290.95
30_A33_D0.6290.95
20_L174_R0.6240.95
20_L122_L0.6240.95
18_A27_D0.6230.95
102_L105_T0.6230.95
169_A180_I0.6230.95
118_F159_I0.6230.95
161_F167_K0.6220.95
125_L129_E0.6210.95
120_C186_A0.6150.94
16_E177_K0.6070.94
143_V146_R0.6040.94
154_F157_D0.6040.94
179_A184_G0.6030.94
16_E178_S0.6020.94
15_R174_R0.5990.93
62_A65_A0.5980.93
154_F177_K0.5940.93
18_A22_S0.5920.93
36_V57_A0.5900.93
105_T108_D0.5870.93
124_Y134_L0.5820.92
36_V60_V0.5780.92
118_F156_Y0.5770.92
118_F169_A0.5740.92
113_Q143_V0.5740.92
149_A168_T0.5740.92
58_A64_P0.5710.92
161_F165_E0.5700.92
59_K62_A0.5690.92
47_I121_V0.5680.92
4_V124_Y0.5670.91
46_F71_G0.5660.91
129_E132_T0.5630.91
114_R145_T0.5610.91
50_A135_V0.5540.90
112_D143_V0.5520.90
178_S181_S0.5500.90
74_V116_A0.5440.90
137_H189_L0.5430.90
148_P158_P0.5420.90
74_V159_I0.5390.89
78_G81_P0.5370.89
58_A126_R0.5360.89
29_V32_T0.5340.89
103_L144_I0.5330.89
22_S25_G0.5310.89
17_L66_I0.5290.88
34_L37_D0.5290.88
167_K173_T0.5280.88
121_V138_G0.5270.88
126_R134_L0.5250.88
19_S175_E0.5240.88
190_L194_L0.5240.88
90_G94_T0.5230.88
95_D99_L0.5230.88
114_R144_I0.5220.88
150_G154_F0.5210.88
16_E183_R0.5210.88
70_S85_S0.5200.88
70_S99_L0.5190.87
170_A178_S0.5190.87
58_A65_A0.5180.87
38_S41_E0.5170.87
20_L178_S0.5170.87
4_V66_I0.5160.87
115_Q163_P0.5150.87
148_P159_I0.5150.87
95_D102_L0.5140.87
73_A79_G0.5130.87
9_G57_A0.5130.87
144_I159_I0.5100.87
42_T83_I0.5100.87
11_V33_D0.5090.86
74_V77_L0.5060.86
179_A188_K0.5060.86
149_A167_K0.5050.86
93_A102_L0.5050.86
106_M114_R0.5020.86
58_A63_L0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k7kA 1 1 100 0.003 Contact Map
3tquA 2 1 100 0.046 Contact Map
1vp2A 3 0.9492 100 0.056 Contact Map
2carA 2 0.9391 100 0.088 Contact Map
1v7rA 1 0.9289 100 0.09 Contact Map
1b78A 2 0.9188 100 0.09 Contact Map
4bnqA 2 0.9645 100 0.111 Contact Map
4jhcA 2 0.7513 97.6 0.875 Contact Map
1ex2A 2 0.7513 97.1 0.884 Contact Map
2amhA 1 0.7716 96.9 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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