GREMLIN Database
YGGP - Uncharacterized protein YggP
UniProt: P52048 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12976
Length: 425 (324)
Sequences: 17740 (11268)
Seq/√Len: 626.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
348_A351_E3.2241.00
9_Y17_R3.0211.00
34_I73_V2.9071.00
32_S75_V2.7741.00
248_M251_A2.6721.00
9_Y15_R2.5881.00
89_Q133_P2.5591.00
34_I139_F2.4671.00
29_L131_V2.4631.00
26_D79_K2.4191.00
27_N80_N2.3491.00
70_C114_G2.3321.00
354_L358_D2.3281.00
212_D216_A2.3231.00
177_N204_R2.3181.00
345_G348_A2.2881.00
47_L357_P2.2641.00
327_A331_T2.2081.00
30_L75_V2.2051.00
140_A343_I2.1981.00
23_E76_E2.1961.00
184_A207_V2.1771.00
26_D80_N2.1521.00
204_R235_V2.1451.00
344_G355_N2.1401.00
179_A258_F2.1311.00
196_I224_V2.1291.00
278_L284_L2.0941.00
220_K338_F2.0401.00
343_I367_Y2.0361.00
216_A220_K2.0161.00
32_S73_V2.0071.00
216_A219_Q1.9571.00
134_Y142_A1.9531.00
99_L102_G1.9501.00
102_G105_A1.9141.00
7_A17_R1.9131.00
212_D238_N1.8851.00
283_C310_H1.8831.00
83_G123_E1.8791.00
137_S330_A1.8711.00
342_H355_N1.8471.00
179_A208_V1.8431.00
344_G352_T1.8431.00
30_L120_I1.8011.00
217_Q220_K1.7981.00
335_Q338_F1.7951.00
6_A349_V1.7921.00
32_S118_Y1.7861.00
173_K176_G1.7861.00
178_I195_A1.7831.00
4_K347_D1.7761.00
25_T28_E1.7711.00
86_K89_Q1.7671.00
4_K18_V1.7481.00
77_V87_K1.7341.00
259_D279_A1.7211.00
192_I223_P1.7161.00
215_L219_Q1.6991.00
327_A330_A1.6771.00
90_R139_F1.6651.00
351_E354_L1.6591.00
141_A337_S1.6451.00
74_I85_Y1.6441.00
156_H324_E1.6391.00
76_E87_K1.6341.00
224_V235_V1.6231.00
244_D247_Q1.6211.00
235_V252_L1.6161.00
24_I30_L1.6141.00
350_P354_L1.6131.00
351_E355_N1.6121.00
278_L309_T1.6101.00
261_I278_L1.6091.00
283_C312_V1.5801.00
210_I239_T1.5771.00
192_I207_V1.5591.00
21_L118_Y1.5531.00
78_G81_L1.5401.00
156_H198_G1.5331.00
206_V258_F1.5211.00
215_L236_Y1.5201.00
4_K117_T1.5141.00
29_L85_Y1.5131.00
243_S248_M1.5061.00
85_Y133_P1.4981.00
24_I120_I1.4941.00
261_I274_A1.4811.00
90_R136_G1.4801.00
75_V118_Y1.4791.00
73_V139_F1.4761.00
70_C93_L1.4591.00
247_Q251_A1.4431.00
355_N360_P1.4401.00
265_A270_V1.4381.00
276_E303_N1.4331.00
85_Y131_V1.4311.00
28_E120_I1.4301.00
10_G13_D1.4241.00
33_V70_C1.4131.00
21_L30_L1.4111.00
99_L105_A1.3881.00
219_Q236_Y1.3871.00
248_M252_L1.3801.00
209_D215_L1.3771.00
28_E122_P1.3591.00
9_Y13_D1.3571.00
35_S367_Y1.3551.00
5_V19_F1.3531.00
204_R224_V1.3501.00
191_A262_F1.3231.00
71_A139_F1.3151.00
278_L282_G1.3101.00
176_G283_C1.3101.00
90_R134_Y1.3021.00
272_E276_E1.2871.00
73_V90_R1.2791.00
27_N123_E1.2691.00
36_D114_G1.2621.00
184_A209_D1.2561.00
176_G260_D1.2351.00
24_I28_E1.2281.00
169_R310_H1.2171.00
215_L238_N1.2171.00
242_M248_M1.2161.00
35_S140_A1.2111.00
30_L76_E1.2051.00
170_M285_N1.1971.00
179_A277_L1.1831.00
30_L118_Y1.1781.00
85_Y89_Q1.1731.00
274_A284_L1.1701.00
210_I240_K1.1581.00
38_V352_T1.1571.00
212_D242_M1.1501.00
345_G367_Y1.1501.00
6_A16_L1.1491.00
346_L368_N1.1391.00
140_A367_Y1.1241.00
19_F65_I1.1181.00
135_H330_A1.1141.00
33_V119_M1.1141.00
246_V250_R1.1111.00
177_N206_V1.0971.00
181_L270_V1.0931.00
31_V72_G1.0921.00
249_L258_F1.0891.00
148_M190_G1.0861.00
19_F112_F1.0821.00
246_V276_E1.0791.00
268_P272_E1.0781.00
199_G202_P1.0761.00
207_V218_V1.0651.00
145_A329_S1.0571.00
213_K216_A1.0551.00
31_V91_F1.0491.00
210_I215_L1.0481.00
183_C207_V1.0481.00
208_V239_T1.0391.00
181_L208_V1.0361.00
154_A287_F1.0321.00
170_M260_D1.0261.00
192_I205_V1.0181.00
27_N122_P1.0171.00
75_V87_K1.0171.00
32_S117_T1.0161.00
156_H321_D1.0091.00
207_V223_P1.0031.00
193_D335_Q0.9931.00
267_V270_V0.9921.00
304_V311_V0.9901.00
151_I194_Y0.9901.00
103_Y256_A0.9851.00
172_V176_G0.9801.00
181_L274_A0.9801.00
238_N242_M0.9791.00
7_A19_F0.9771.00
34_I71_A0.9711.00
272_E296_K0.9701.00
21_L76_E0.9691.00
151_I191_A0.9691.00
197_N333_Q0.9691.00
206_V252_L0.9671.00
35_S365_L0.9621.00
349_V366_I0.9501.00
7_A65_I0.9491.00
152_I325_A0.9441.00
344_G366_I0.9441.00
175_G203_S0.9431.00
176_G259_D0.9421.00
77_V86_K0.9411.00
258_F261_I0.9391.00
33_V368_N0.9371.00
103_Y279_A0.9371.00
324_E327_A0.9371.00
354_L357_P0.9371.00
197_N328_L0.9321.00
5_V65_I0.9291.00
153_G308_S0.9251.00
246_V277_L0.9231.00
196_I205_V0.9231.00
153_G321_D0.9191.00
344_G348_A0.9161.00
177_N259_D0.9161.00
261_I284_L0.9051.00
3_T21_L0.9051.00
103_Y259_D0.9021.00
180_L195_A0.9021.00
6_A346_L0.9011.00
115_N366_I0.9011.00
39_C69_E0.9011.00
141_A335_Q0.8991.00
35_S139_F0.8981.00
134_Y139_F0.8961.00
304_V313_G0.8941.00
328_L333_Q0.8891.00
244_D248_M0.8851.00
115_N353_V0.8801.00
27_N79_K0.8761.00
3_T117_T0.8741.00
39_C68_H0.8691.00
303_N307_N0.8641.00
253_T257_G0.8621.00
36_D115_N0.8581.00
172_V202_P0.8541.00
70_C119_M0.8521.00
181_L261_I0.8501.00
151_I190_G0.8481.00
249_L277_L0.8431.00
212_D215_L0.8421.00
246_V273_M0.8351.00
34_I90_R0.8341.00
64_V112_F0.8321.00
115_N349_V0.8281.00
323_K327_A0.8281.00
180_L207_V0.8251.00
3_T116_A0.8231.00
16_L347_D0.8231.00
6_A14_V0.8221.00
341_T362_G0.8171.00
6_A350_P0.8161.00
138_Y141_A0.8131.00
329_S336_P0.8081.00
177_N203_S0.8061.00
184_A192_I0.8031.00
82_T123_E0.8011.00
361_G364_K0.8011.00
342_H361_G0.7981.00
94_Q132_L0.7941.00
35_S368_N0.7921.00
77_V81_L0.7921.00
244_D273_M0.7901.00
86_K133_P0.7871.00
25_T120_I0.7861.00
340_V343_I0.7861.00
206_V237_V0.7781.00
206_V249_L0.7761.00
93_L121_I0.7711.00
145_A326_I0.7701.00
261_I277_L0.7681.00
22_P30_L0.7681.00
171_G312_V0.7681.00
124_I130_C0.7651.00
27_N78_G0.7621.00
21_L75_V0.7611.00
268_P298_P0.7601.00
344_G364_K0.7601.00
202_P205_V0.7581.00
272_E298_P0.7541.00
151_I155_Y0.7531.00
91_F131_V0.7501.00
38_V115_N0.7481.00
121_I131_V0.7461.00
83_G86_K0.7451.00
237_V245_P0.7421.00
152_I156_H0.7411.00
186_P363_K0.7411.00
219_Q235_V0.7401.00
211_D214_R0.7381.00
71_A143_S0.7381.00
191_A264_Y0.7361.00
155_Y194_Y0.7331.00
190_G339_M0.7321.00
46_A357_P0.7301.00
138_Y142_A0.7291.00
209_D239_T0.7281.00
281_D308_S0.7261.00
179_A249_L0.7251.00
189_I218_V0.7241.00
24_I76_E0.7201.00
178_I202_P0.7201.00
263_V266_A0.7181.00
193_D338_F0.7171.00
193_D221_L0.7151.00
304_V309_T0.7151.00
177_N258_F0.7101.00
269_A272_E0.7091.00
135_H138_Y0.7071.00
24_I78_G0.7051.00
169_R312_V0.7021.00
215_L239_T0.7021.00
155_Y195_A0.7001.00
90_R137_S0.6981.00
280_E307_N0.6901.00
194_Y325_A0.6891.00
237_V248_M0.6891.00
247_Q250_R0.6871.00
286_F311_V0.6871.00
191_A287_F0.6861.00
171_G283_C0.6861.00
212_D219_Q0.6841.00
108_S112_F0.6831.00
260_D283_C0.6781.00
294_N300_N0.6761.00
235_V248_M0.6741.00
151_I187_M0.6691.00
23_E30_L0.6691.00
189_I362_G0.6641.00
271_V286_F0.6641.00
285_N312_V0.6581.00
300_N303_N0.6581.00
320_D323_K0.6521.00
132_L326_I0.6511.00
46_A353_V0.6511.00
12_R46_A0.6491.00
14_V66_T0.6471.00
172_V203_S0.6471.00
296_K300_N0.6451.00
245_P273_M0.6431.00
273_M277_L0.6421.00
97_M130_C0.6421.00
269_A273_M0.6421.00
152_I328_L0.6411.00
150_C187_M0.6401.00
237_V252_L0.6391.00
3_T118_Y0.6381.00
180_L192_I0.6371.00
148_M325_A0.6371.00
178_I262_F0.6341.00
5_V116_A0.6331.00
132_L323_K0.6321.00
16_L346_L0.6321.00
265_A289_G0.6311.00
204_R252_L0.6311.00
104_S280_E0.6301.00
218_V223_P0.6301.00
146_E150_C0.6291.00
71_A90_R0.6271.00
284_L311_V0.6251.00
31_V93_L0.6211.00
35_S343_I0.6201.00
155_Y198_G0.6161.00
100_P124_I0.6151.00
220_K335_Q0.6141.00
181_L277_L0.6131.00
141_A145_A0.6131.00
263_V270_V0.6121.00
171_G310_H0.6111.00
29_L123_E0.6101.00
89_Q136_G0.6091.00
45_A109_Y0.6091.00
221_L338_F0.6091.00
12_R47_L0.6071.00
208_V245_P0.6051.00
260_D285_N0.6041.00
273_M276_E0.6021.00
153_G314_T0.6001.00
181_L273_M0.6001.00
213_K360_P0.6001.00
31_V131_V0.6001.00
22_P118_Y0.6001.00
285_N314_T0.6001.00
263_V289_G0.5951.00
258_F277_L0.5901.00
319_T323_K0.5881.00
342_H351_E0.5871.00
174_P199_G0.5871.00
196_I333_Q0.5861.00
95_P146_E0.5831.00
290_P305_H0.5821.00
172_V260_D0.5821.00
253_T258_F0.5791.00
93_L131_V0.5791.00
152_I194_Y0.5791.00
114_G119_M0.5791.00
355_N358_D0.5771.00
136_G330_A0.5761.00
320_D324_E0.5761.00
356_L364_K0.5761.00
152_I324_E0.5761.00
148_M334_L0.5761.00
95_P316_G0.5761.00
175_G202_P0.5751.00
364_K367_Y0.5721.00
189_I221_L0.5671.00
210_I267_V0.5661.00
86_K136_G0.5651.00
243_S247_Q0.5641.00
132_L322_M0.5631.00
16_L349_V0.5621.00
85_Y123_E0.5621.00
174_P198_G0.5611.00
44_K49_G0.5601.00
256_A279_A0.5601.00
3_T22_P0.5591.00
14_V353_V0.5581.00
238_N244_D0.5581.00
195_A202_P0.5581.00
149_C317_G0.5581.00
224_V236_Y0.5581.00
193_D334_L0.5571.00
197_N334_L0.5551.00
8_I46_A0.5541.00
36_D368_N0.5541.00
293_K296_K0.5531.00
37_S69_E0.5531.00
37_S365_L0.5521.00
306_Y315_S0.5491.00
303_N309_T0.5481.00
250_R253_T0.5481.00
148_M193_D0.5471.00
147_P190_G0.5451.00
4_K16_L0.5430.99
183_C192_I0.5430.99
35_S71_A0.5430.99
13_D350_P0.5430.99
206_V235_V0.5420.99
237_V243_S0.5420.99
81_L123_E0.5400.99
155_Y191_A0.5400.99
150_C287_F0.5390.99
297_V301_F0.5380.99
82_T85_Y0.5370.99
145_A325_A0.5360.99
39_C146_E0.5340.99
328_L332_G0.5340.99
250_R257_G0.5330.99
177_N253_T0.5330.99
178_I260_D0.5310.99
22_P120_I0.5310.99
154_A314_T0.5300.99
90_R138_Y0.5270.99
8_I14_V0.5260.99
83_G133_P0.5260.99
37_S143_S0.5250.99
61_N64_V0.5250.99
14_V46_A0.5230.99
77_V85_Y0.5230.99
155_Y262_F0.5230.99
155_Y172_V0.5220.99
33_V93_L0.5220.99
271_V311_V0.5210.99
29_L81_L0.5210.99
173_K260_D0.5200.99
148_M194_Y0.5200.99
97_M122_P0.5180.99
245_P277_L0.5180.99
43_W356_L0.5180.99
188_G209_D0.5170.99
77_V89_Q0.5170.99
139_F144_L0.5160.99
83_G87_K0.5160.99
184_A218_V0.5130.99
74_I89_Q0.5130.99
65_I116_A0.5120.99
250_R307_N0.5110.99
249_L253_T0.5110.99
41_S68_H0.5100.99
92_V322_M0.5100.99
152_I321_D0.5080.99
274_A278_L0.5080.99
8_I66_T0.5080.99
251_A254_G0.5060.99
270_V274_A0.5050.99
181_L265_A0.5050.99
92_V134_Y0.5040.99
324_E328_L0.5040.99
355_N364_K0.5040.99
205_V224_V0.5030.99
180_L191_A0.5030.99
29_L74_I0.5020.99
194_Y197_N0.5010.99
328_L331_T0.5010.99
29_L77_V0.5010.99
38_V356_L0.5000.99
50_S59_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ej6A 1 0.7671 100 0.267 Contact Map
3ukoA 4 0.7765 100 0.271 Contact Map
3ip1A 4 0.7835 100 0.272 Contact Map
3m6iA 4 0.7741 100 0.274 Contact Map
1f8fA 4 0.7671 100 0.277 Contact Map
1p0fA 2 0.7694 100 0.28 Contact Map
1cdoA 2 0.7694 100 0.281 Contact Map
4oh1A 4 0.7788 100 0.281 Contact Map
1e3iA 2 0.7647 100 0.282 Contact Map
4ilkA 2 0.7553 100 0.283 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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