GREMLIN Database
SCPB - Methylmalonyl-CoA decarboxylase
UniProt: P52045 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12972
Length: 261 (246)
Sequences: 30240 (19730)
Seq/√Len: 1257.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_T166_P3.1851.00
123_A178_L2.9971.00
180_H190_F2.9551.00
125_S183_E2.8971.00
101_S118_S2.8821.00
16_V192_L2.6941.00
190_F193_Q2.6361.00
41_S91_M2.5061.00
44_N96_P2.3351.00
10_T15_A2.2951.00
126_T184_V2.2881.00
165_S197_H2.1921.00
171_R174_A2.1871.00
16_V54_R2.1551.00
37_M91_M2.0961.00
7_N20_N2.0741.00
25_L60_K2.0521.00
13_K49_R2.0401.00
25_L61_V2.0051.00
135_N201_K1.9921.00
102_M191_T1.9901.00
168_T171_R1.9851.00
156_I175_V1.9821.00
159_E165_S1.9761.00
161_I209_I1.9691.00
248_N252_E1.9671.00
18_E54_R1.9581.00
8_V15_A1.9371.00
102_M188_E1.9311.00
220_H223_N1.9281.00
192_L196_H1.8181.00
154_F158_K1.7991.00
15_A48_I1.7891.00
108_W130_S1.7881.00
186_E189_D1.7751.00
125_S170_Q1.7651.00
31_V35_D1.7331.00
15_A43_L1.7211.00
158_K214_R1.7031.00
182_V190_F1.6921.00
18_E58_G1.6871.00
122_I182_V1.6841.00
171_R175_V1.6221.00
159_E179_N1.6091.00
20_N58_G1.5841.00
245_E254_R1.5671.00
186_E190_F1.5611.00
123_A129_F1.5591.00
51_I95_F1.5511.00
122_I194_M1.5411.00
125_S184_V1.5341.00
34_D84_P1.5321.00
170_Q174_A1.5271.00
37_M41_S1.5171.00
11_I192_L1.5171.00
90_R94_K1.5131.00
103_V115_I1.5111.00
43_L51_I1.5111.00
159_E180_H1.5091.00
44_N91_M1.4941.00
158_K162_F1.4821.00
17_I39_A1.4691.00
124_A184_V1.4161.00
104_E124_A1.3931.00
173_L181_V1.3741.00
121_I155_H1.3731.00
208_V236_A1.3671.00
121_I151_D1.3651.00
61_V106_S1.3641.00
115_I121_I1.3621.00
112_F131_M1.3511.00
12_N196_H1.3501.00
156_I159_E1.3471.00
90_R222_M1.3441.00
8_V43_L1.3411.00
40_L95_F1.3381.00
119_D210_K1.3371.00
160_L167_I1.3311.00
54_R188_E1.3051.00
103_V107_V1.3011.00
11_I16_V1.2931.00
44_N95_F1.2921.00
16_V188_E1.2911.00
37_M87_Q1.2891.00
21_Y24_K1.2891.00
106_S128_T1.2851.00
104_E126_T1.2791.00
93_Q147_N1.2701.00
50_C195_A1.2701.00
219_A223_N1.2541.00
158_K213_L1.2491.00
92_I99_I1.2481.00
165_S171_R1.2471.00
130_S166_P1.2301.00
7_N58_G1.2271.00
155_H179_N1.2251.00
9_V18_E1.2101.00
54_R104_E1.2041.00
156_I171_R1.2011.00
11_I196_H1.2001.00
35_D39_A1.1891.00
215_V227_F1.1851.00
188_E192_L1.1741.00
201_K206_I1.1721.00
55_A58_G1.1691.00
60_K104_E1.1691.00
29_S32_F1.1571.00
7_N18_E1.1491.00
9_V16_V1.1461.00
39_A42_D1.1391.00
19_F32_F1.1381.00
30_K34_D1.1331.00
211_E215_V1.1321.00
243_Y247_M1.1301.00
204_L242_D1.1261.00
30_K70_E1.1221.00
124_A187_L1.1181.00
54_R102_M1.0991.00
113_E144_G1.0961.00
167_I175_V1.0791.00
94_K222_M1.0691.00
188_E191_T1.0681.00
99_I118_S1.0611.00
51_I99_I1.0531.00
169_A181_V1.0531.00
35_D38_Q1.0501.00
170_Q173_L1.0411.00
152_A156_I1.0411.00
219_A227_F1.0371.00
154_F217_G1.0361.00
51_I97_K1.0291.00
10_T47_E1.0291.00
134_V164_A1.0291.00
48_I97_K1.0181.00
19_F63_S1.0171.00
24_K69_H1.0071.00
187_L191_T1.0071.00
183_E186_E0.9961.00
151_D155_H0.9931.00
244_Q248_N0.9891.00
153_G156_I0.9861.00
14_V50_C0.9831.00
52_I191_T0.9811.00
120_L194_M0.9801.00
102_M187_L0.9781.00
85_L142_L0.9731.00
96_P207_A0.9701.00
208_V211_E0.9701.00
211_E233_M0.9671.00
195_A199_S0.9631.00
112_F129_F0.9621.00
189_D193_Q0.9581.00
38_Q42_D0.9371.00
208_V233_M0.9371.00
63_S111_A0.9361.00
128_T168_T0.9281.00
203_P207_A0.9191.00
227_F232_G0.9101.00
108_W166_P0.8831.00
55_A59_S0.8811.00
37_M84_P0.8791.00
173_L180_H0.8781.00
191_T195_A0.8761.00
139_P237_V0.8711.00
79_L83_D0.8701.00
21_Y67_D0.8661.00
25_L64_A0.8661.00
124_A185_E0.8631.00
173_L178_L0.8631.00
10_T48_I0.8601.00
134_V209_I0.8571.00
33_I88_I0.8541.00
103_V129_F0.8541.00
16_V52_I0.8531.00
160_L175_V0.8511.00
190_F194_M0.8491.00
223_N226_E0.8461.00
125_S181_V0.8441.00
40_L92_I0.8441.00
69_H251_L0.8441.00
161_I213_L0.8391.00
193_Q197_H0.8371.00
10_T42_D0.8331.00
104_E187_L0.8211.00
44_N97_K0.8201.00
17_I51_I0.8141.00
197_H201_K0.8141.00
159_E163_T0.8081.00
180_H194_M0.8041.00
233_M236_A0.8011.00
53_L118_S0.8001.00
146_H224_S0.7941.00
30_K84_P0.7861.00
122_I180_H0.7851.00
135_N166_P0.7841.00
154_F214_R0.7811.00
208_V237_V0.7811.00
8_V39_A0.7771.00
34_D38_Q0.7681.00
89_T117_S0.7661.00
152_A160_L0.7651.00
192_L195_A0.7631.00
104_E184_V0.7591.00
194_M197_H0.7591.00
193_Q196_H0.7591.00
41_S45_R0.7571.00
75_G78_P0.7561.00
46_P97_K0.7521.00
215_V219_A0.7521.00
72_P248_N0.7501.00
37_M88_I0.7481.00
221_T225_D0.7481.00
153_G157_V0.7451.00
116_M177_I0.7451.00
172_A177_I0.7451.00
103_V121_I0.7451.00
227_F233_M0.7431.00
241_E244_Q0.7421.00
120_L179_N0.7351.00
200_E255_K0.7351.00
148_L152_A0.7351.00
145_I228_E0.7321.00
6_V39_A0.7301.00
198_I206_I0.7291.00
169_A178_L0.7281.00
189_D192_L0.7281.00
28_L32_F0.7241.00
202_A242_D0.7221.00
25_L106_S0.7151.00
95_F99_I0.7131.00
129_F178_L0.7111.00
21_Y29_S0.7071.00
212_E233_M0.7051.00
41_S87_Q0.7051.00
79_L232_G0.7041.00
146_H149_T0.7011.00
83_D87_Q0.6961.00
96_P211_E0.6941.00
61_V104_E0.6941.00
196_H200_E0.6931.00
29_S70_E0.6911.00
8_V42_D0.6871.00
156_I173_L0.6861.00
43_L48_I0.6851.00
204_L240_S0.6831.00
52_I102_M0.6821.00
212_E227_F0.6811.00
139_P212_E0.6781.00
163_T194_M0.6731.00
49_R203_P0.6691.00
41_S44_N0.6661.00
83_D229_R0.6651.00
247_M251_L0.6651.00
100_I195_A0.6621.00
87_Q90_R0.6591.00
39_A43_L0.6581.00
103_V127_S0.6581.00
49_R199_S0.6521.00
31_V34_D0.6501.00
53_L99_I0.6491.00
123_A127_S0.6471.00
79_L235_R0.6461.00
106_S166_P0.6451.00
32_F35_D0.6451.00
14_V52_I0.6401.00
87_Q91_M0.6391.00
80_S84_P0.6371.00
170_Q181_V0.6321.00
21_Y27_A0.6301.00
182_V187_L0.6261.00
245_E249_A0.6251.00
108_W132_T0.6251.00
122_I187_L0.6211.00
113_E133_P0.6211.00
50_C199_S0.6211.00
241_E245_E0.6211.00
167_I172_A0.6191.00
226_E232_G0.6191.00
14_V192_L0.6171.00
52_I192_L0.6171.00
159_E171_R0.6151.00
248_N251_L0.6141.00
50_C100_I0.6131.00
226_E229_R0.6131.00
154_F213_L0.6121.00
131_M144_G0.6091.00
101_S121_I0.6041.00
145_I224_S0.6031.00
146_H150_R0.6021.00
163_T197_H0.5981.00
178_L181_V0.5951.00
204_L237_V0.5941.00
14_V195_A0.5901.00
229_R235_R0.5891.00
126_T169_A0.5891.00
222_M226_E0.5891.00
152_A157_V0.5871.00
209_I212_E0.5871.00
72_P251_L0.5851.00
162_F206_I0.5831.00
245_E248_N0.5821.00
38_Q41_S0.5811.00
134_V206_I0.5801.00
138_V243_Y0.5801.00
13_K47_E0.5771.00
163_T198_I0.5751.00
24_K67_D0.5691.00
122_I191_T0.5681.00
130_S164_A0.5671.00
33_I37_M0.5671.00
101_S115_I0.5661.00
8_V17_I0.5641.00
40_L99_I0.5641.00
115_I118_S0.5631.00
140_Y209_I0.5611.00
156_I174_A0.5561.00
109_G132_T0.5541.00
232_G236_A0.5531.00
86_R90_R0.5511.00
131_M161_I0.5501.00
112_F177_I0.5491.00
17_I43_L0.5481.00
150_R217_G0.5481.00
120_L198_I0.5441.00
121_I178_L0.5441.00
197_H200_E0.5441.00
133_P141_N0.5431.00
72_P247_M0.5401.00
10_T13_K0.5401.00
17_I53_L0.5371.00
84_P87_Q0.5371.00
112_F116_M0.5341.00
36_L88_I0.5331.00
40_L91_M0.5331.00
155_H158_K0.5321.00
66_H71_L0.5311.00
68_I136_L0.5311.00
104_E188_E0.5291.00
113_E131_M0.5291.00
95_F98_P0.5281.00
74_G78_P0.5281.00
152_A175_V0.5281.00
210_K214_R0.5271.00
28_L110_G0.5261.00
151_D179_N0.5241.00
159_E194_M0.5231.00
219_A224_S0.5201.00
59_S104_E0.5181.00
43_L97_K0.5171.00
186_E193_Q0.5171.00
134_V201_K0.5161.00
150_R220_H0.5161.00
133_P140_Y0.5151.00
50_C191_T0.5131.00
122_I190_F0.5121.00
24_K27_A0.5111.00
31_V70_E0.5091.00
81_Y85_L0.5091.00
52_I100_I0.5091.00
211_E227_F0.5081.00
129_F172_A0.5071.00
165_S180_H0.5061.00
203_P206_I0.5061.00
99_I119_D0.5031.00
93_Q221_T0.5021.00
123_A169_A0.5011.00
131_M148_L0.5011.00
149_T213_L0.5001.00
172_A178_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fbmA 3 0.9387 100 0.059 Contact Map
1ef8A 5 0.9655 100 0.062 Contact Map
3hinA 5 0.9693 100 0.067 Contact Map
2pbpA 5 0.9732 100 0.072 Contact Map
3h81A 5 0.977 100 0.073 Contact Map
4lk5A 3 0.954 100 0.075 Contact Map
3kqfA 3 0.977 100 0.075 Contact Map
2gtrA 3 0.9693 100 0.078 Contact Map
2ej5A 3 0.9579 100 0.079 Contact Map
3swxA 3 0.977 100 0.079 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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