GREMLIN Database
YECM - Protein YecM
UniProt: P52007 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13405
Length: 188 (177)
Sequences: 256 (170)
Seq/√Len: 12.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_K179_E7.7111.00
52_T109_E3.6690.99
27_L169_T3.6020.99
66_L69_E3.5330.99
69_E78_C3.4040.98
180_E183_A2.9340.96
95_I116_I2.8800.95
57_R69_E2.7810.94
40_A116_I2.7020.93
30_R166_D2.4550.90
61_E66_L2.3830.88
27_L94_S2.3410.87
57_R78_C2.3210.87
70_N154_H2.1880.83
72_I152_G2.1730.83
65_E81_K2.0180.78
51_A54_E2.0070.77
10_L59_G1.9570.75
171_I179_E1.9030.73
40_A91_W1.8710.72
110_G181_I1.8030.69
40_A114_I1.7650.67
152_G156_R1.7440.66
57_R66_L1.7330.66
149_S171_I1.7320.66
51_A87_Q1.7140.65
35_I38_L1.6410.61
107_P119_P1.6250.61
47_C80_F1.5880.59
22_H37_P1.5590.57
71_M180_E1.4310.51
120_G131_A1.4190.50
43_I88_V1.3880.48
29_R87_Q1.3680.47
57_R100_W1.3680.47
34_N62_Q1.3570.47
17_L142_G1.3510.47
34_N37_P1.3120.45
66_L88_V1.2890.43
93_F171_I1.2860.43
150_P161_T1.2840.43
59_G62_Q1.2830.43
62_Q167_G1.2790.43
87_Q90_H1.2720.43
127_A143_I1.2710.42
56_W128_R1.2690.42
49_Q182_V1.2640.42
121_D135_D1.2620.42
64_G80_F1.2520.42
82_L96_V1.2400.41
102_G182_V1.2370.41
56_W79_L1.2320.41
29_R89_A1.2260.40
124_T127_A1.2190.40
51_A135_D1.2170.40
95_I107_P1.2170.40
33_L89_A1.2090.39
150_P155_E1.1980.39
87_Q92_Q1.1910.38
44_S107_P1.1870.38
150_P163_A1.1830.38
47_C56_W1.1600.37
156_R184_S1.1580.37
67_L95_I1.1410.36
42_H46_R1.1190.35
38_L63_C1.1170.35
106_Y163_A1.1130.35
82_L94_S1.1080.35
95_I100_W1.1060.34
162_L170_T1.1060.34
69_E136_E1.0940.34
48_H170_T1.0850.33
104_K150_P1.0720.33
46_R112_E1.0640.32
114_I171_I1.0600.32
66_L78_C1.0470.32
42_H112_E1.0450.32
40_A67_L1.0420.31
84_E92_Q1.0340.31
10_L96_V1.0230.31
58_R105_R1.0200.31
105_R141_P1.0190.30
61_E69_E1.0150.30
129_A162_L1.0140.30
38_L137_G1.0130.30
16_D19_R0.9740.29
123_E151_K0.9710.28
50_N54_E0.9630.28
29_R153_E0.9620.28
69_E114_I0.9540.28
29_R121_D0.9450.27
60_F82_L0.9440.27
79_L178_I0.9390.27
102_G128_R0.9350.27
29_R61_E0.9310.27
91_W114_I0.9250.27
132_L181_I0.9120.26
47_C166_D0.9070.26
101_P115_E0.9070.26
36_T83_H0.8970.25
85_P157_L0.8970.25
32_G110_G0.8960.25
93_F114_I0.8960.25
78_C173_F0.8930.25
84_E124_T0.8910.25
83_H183_A0.8870.25
94_S179_E0.8800.25
29_R36_T0.8770.25
12_D59_G0.8730.24
11_Q19_R0.8690.24
136_E139_S0.8680.24
48_H106_Y0.8590.24
148_S163_A0.8540.24
67_L132_L0.8540.24
34_N127_A0.8540.24
38_L181_I0.8530.24
46_R115_E0.8520.24
15_S84_E0.8450.23
65_E87_Q0.8440.23
90_H126_N0.8390.23
118_L162_L0.8390.23
128_R164_V0.8390.23
122_P164_V0.8380.23
42_H115_E0.8360.23
47_C125_L0.8320.23
106_Y150_P0.8300.23
60_F79_L0.8280.23
46_R172_K0.8250.23
57_R178_I0.8220.23
25_D62_Q0.8190.22
30_R136_E0.8140.22
42_H172_K0.8070.22
25_D34_N0.8040.22
69_E80_F0.8040.22
95_I147_T0.7980.22
27_L64_G0.7970.22
43_I93_F0.7930.22
14_A63_C0.7860.21
157_L160_P0.7840.21
73_N148_S0.7820.21
29_R90_H0.7740.21
112_E115_E0.7720.21
49_Q109_E0.7700.21
28_S142_G0.7690.21
100_W176_W0.7650.21
25_D134_S0.7640.21
47_C130_L0.7620.20
26_E37_P0.7560.20
15_S136_E0.7550.20
56_W182_V0.7510.20
50_N105_R0.7510.20
112_E172_K0.7440.20
71_M178_I0.7440.20
71_M140_L0.7420.20
53_A148_S0.7420.20
86_V165_T0.7410.20
165_T183_A0.7400.20
11_Q169_T0.7390.20
53_A106_Y0.7360.20
28_S171_I0.7340.20
55_R59_G0.7330.20
93_F158_P0.7240.19
107_P176_W0.7200.19
146_K150_P0.7200.19
104_K163_A0.7200.19
44_S148_S0.7200.19
70_N183_A0.7160.19
56_W89_A0.7160.19
17_L53_A0.7120.19
18_P171_I0.7090.19
125_L128_R0.7020.19
17_L79_L0.7000.18
142_G178_I0.6980.18
105_R118_L0.6940.18
127_A183_A0.6870.18
44_S53_A0.6750.18
130_L182_V0.6750.18
53_A111_W0.6700.18
96_V105_R0.6690.18
96_V185_E0.6680.17
16_D62_Q0.6660.17
24_L80_F0.6650.17
41_D97_E0.6640.17
97_E113_H0.6640.17
41_D113_H0.6640.17
41_D75_R0.6640.17
75_R97_E0.6640.17
75_R113_H0.6640.17
143_I177_S0.6630.17
127_A180_E0.6610.17
73_N104_K0.6580.17
86_V119_P0.6530.17
120_G128_R0.6480.17
32_G144_S0.6410.17
158_P165_T0.6400.17
106_Y111_W0.6390.17
20_F73_N0.6380.17
32_G36_T0.6370.17
141_P145_V0.6300.16
98_L145_V0.6280.16
126_N147_T0.6270.16
96_V116_I0.6230.16
111_W175_P0.6190.16
77_I144_S0.6170.16
35_I86_V0.6120.16
157_L163_A0.6080.16
111_W161_T0.6080.16
146_K155_E0.6070.16
56_W165_T0.6070.16
17_L158_P0.6030.16
44_S139_S0.6010.16
161_T184_S0.5990.16
106_Y184_S0.5990.16
67_L182_V0.5980.15
16_D28_S0.5980.15
29_R114_I0.5980.15
163_A184_S0.5960.15
36_T92_Q0.5940.15
13_I129_A0.5930.15
153_E156_R0.5930.15
60_F93_F0.5890.15
64_G118_L0.5890.15
29_R50_N0.5860.15
51_A80_F0.5800.15
65_E84_E0.5790.15
14_A88_V0.5780.15
134_S141_P0.5760.15
19_R121_D0.5760.15
20_F146_K0.5750.15
68_S146_K0.5740.15
18_P63_C0.5730.15
135_D158_P0.5730.15
78_C100_W0.5720.15
62_Q151_K0.5690.15
34_N50_N0.5640.15
136_E140_L0.5630.15
22_H32_G0.5610.15
26_E114_I0.5530.14
57_R171_I0.5490.14
95_I176_W0.5480.14
30_R85_P0.5460.14
115_E172_K0.5460.14
62_Q65_E0.5410.14
34_N59_G0.5400.14
133_L136_E0.5390.14
29_R119_P0.5380.14
52_T130_L0.5360.14
31_L161_T0.5340.14
103_E141_P0.5310.14
33_L65_E0.5250.14
106_Y109_E0.5200.13
94_S116_I0.5190.13
148_S159_N0.5180.13
45_L52_T0.5160.13
19_R135_D0.5150.13
53_A170_T0.5120.13
35_I171_I0.5110.13
13_I116_I0.5100.13
50_N76_P0.5090.13
33_L80_F0.5080.13
159_N163_A0.5070.13
69_E84_E0.5060.13
44_S170_T0.5050.13
73_N109_E0.5030.13
95_I131_A0.5020.13
44_S48_H0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k4nA 1 0.9521 100 0.025 Contact Map
1f9zA 2 0.6596 50.4 0.952 Contact Map
4ljxA 1 0.5851 48.6 0.952 Contact Map
4mtsA 2 0.6649 38.5 0.955 Contact Map
2rk0A 4 0.7021 37.4 0.955 Contact Map
2lm1A 1 0.5372 34.5 0.956 Contact Map
1ig6A 1 0.5266 33.4 0.956 Contact Map
1r9cA 2 0.6596 32.7 0.957 Contact Map
4huzA 2 0.7766 31.7 0.957 Contact Map
2li6A 1 0.5745 26.7 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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