GREMLIN Database
TORY - Cytochrome c-type protein TorY
UniProt: P52005 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13277
Length: 366 (356)
Sequences: 188 (115)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_S73_I4.4070.96
223_D230_I4.1620.95
101_D105_K3.9070.93
44_S94_E3.4510.87
47_K103_D3.3370.85
11_F15_A3.0170.79
90_D128_T2.9670.78
36_T67_E2.9090.76
73_I91_I2.8510.75
102_S105_K2.7360.71
48_P113_M2.6520.69
40_L76_S2.6180.68
121_L162_I2.5460.66
159_E324_H2.5260.65
83_A90_D2.5080.64
48_P90_D2.5000.64
103_D107_E2.4890.64
130_R158_S2.4720.63
23_L34_S2.4430.62
99_K109_H2.4400.62
21_G35_D2.4370.62
47_K55_T2.4010.61
98_G123_A2.1820.53
61_Q148_Q2.1470.52
185_L189_A2.1410.52
10_L297_D2.1070.50
347_E351_L2.0800.49
297_D300_P2.0410.48
27_Q77_G2.0390.48
302_W305_A2.0120.47
52_Y58_F1.9890.46
125_D160_T1.9790.46
219_L233_L1.9590.45
274_A277_Y1.8820.42
220_T232_L1.8330.41
338_G360_K1.8220.40
83_A113_M1.8190.40
117_V120_E1.8170.40
48_P106_F1.8050.40
48_P246_Y1.7950.39
347_E355_F1.7900.39
111_Q134_S1.7830.39
30_L81_L1.7820.39
144_S147_A1.7720.39
159_E163_D1.7710.39
89_K116_T1.7500.38
27_Q80_Y1.7270.37
64_I151_H1.7140.37
309_D355_F1.7130.37
196_G351_L1.6940.36
235_G245_L1.6690.35
104_D217_T1.6590.35
80_Y83_A1.6580.35
115_E244_T1.6350.34
82_F85_L1.6230.34
160_T360_K1.6220.34
109_H117_V1.6180.34
86_K90_D1.6140.33
325_Y358_N1.5940.33
28_K77_G1.5910.33
9_L26_A1.5820.32
148_Q187_S1.5780.32
195_N223_D1.5490.31
10_L245_L1.5490.31
235_G255_L1.5450.31
213_V236_Y1.5440.31
228_Q291_T1.5380.31
172_P277_Y1.5370.31
55_T168_I1.5320.31
23_L29_V1.5000.30
25_L29_V1.4990.30
238_M329_A1.4950.30
38_F42_C1.4920.30
38_F43_H1.4920.30
39_C42_C1.4920.30
39_C43_H1.4920.30
143_Q359_A1.4890.30
30_L69_A1.4840.29
220_T287_Q1.4790.29
333_I341_T1.4780.29
122_K130_R1.4710.29
309_D334_A1.4630.29
90_D113_M1.4600.29
213_V331_P1.4450.28
206_H233_L1.4440.28
130_R341_T1.4160.27
171_F352_T1.4150.27
111_Q175_I1.3940.27
253_L277_Y1.3920.27
52_Y101_D1.3780.26
135_F160_T1.3770.26
218_D223_D1.3740.26
239_Q314_A1.3620.26
16_V22_G1.3600.26
130_R146_S1.3560.26
100_I351_L1.3530.26
134_S235_G1.3460.25
326_T329_A1.3460.25
213_V284_A1.3400.25
88_S121_L1.3340.25
44_S295_L1.2950.24
83_A86_K1.2860.24
83_A117_V1.2860.24
46_S50_E1.2850.24
231_V288_G1.2790.24
24_L77_G1.2720.24
340_R352_T1.2710.23
139_D336_G1.2700.23
156_K347_E1.2660.23
23_L26_A1.2660.23
130_R134_S1.2640.23
125_D352_T1.2640.23
106_F110_R1.2630.23
236_Y277_Y1.2470.23
34_S128_T1.2420.23
231_V290_L1.2410.23
338_G348_L1.2410.23
15_A83_A1.2330.23
44_S90_D1.2320.22
326_T360_K1.2270.22
139_D142_S1.2250.22
217_T357_Y1.2250.22
22_G29_V1.2220.22
10_L194_T1.2190.22
211_A278_G1.2160.22
295_L312_Y1.2150.22
23_L80_Y1.2150.22
27_Q31_H1.2140.22
201_P233_L1.2140.22
253_L332_S1.2120.22
15_A78_M1.2080.22
58_F137_A1.2070.22
336_G360_K1.2020.22
89_K99_K1.1990.22
25_L35_D1.1970.22
322_A355_F1.1950.22
136_D344_S1.1890.21
230_I287_Q1.1810.21
73_I92_Y1.1680.21
44_S113_M1.1660.21
90_D131_S1.1660.21
248_A362_I1.1640.21
236_Y274_A1.1640.21
237_Q246_Y1.1490.20
19_G87_A1.1430.20
160_T340_R1.1410.20
109_H112_E1.1400.20
93_H99_K1.1390.20
94_E157_D1.1320.20
329_A334_A1.1310.20
210_L338_G1.1240.20
143_Q252_R1.1240.20
130_R157_D1.1220.20
112_E168_I1.1220.20
11_F211_A1.1200.20
48_P83_A1.1200.20
319_P347_E1.1150.20
207_I288_G1.1090.20
135_F155_Q1.1000.19
10_L31_H1.0990.19
338_G341_T1.0980.19
32_K131_S1.0980.19
64_I289_A1.0960.19
151_H308_L1.0960.19
76_S79_D1.0940.19
322_A326_T1.0880.19
156_K270_G1.0870.19
162_I301_L1.0780.19
237_Q242_E1.0770.19
115_E218_D1.0760.19
36_T127_A1.0710.19
151_H352_T1.0680.19
49_F211_A1.0570.18
271_E349_D1.0560.18
77_G80_Y1.0460.18
326_T340_R1.0430.18
218_D233_L1.0420.18
213_V321_A1.0410.18
119_K197_A1.0330.18
145_E197_A1.0290.18
83_A360_K1.0270.18
123_A232_L1.0270.18
21_G266_L1.0260.18
17_V32_K1.0260.18
301_L358_N1.0200.18
66_A74_P1.0170.18
329_A338_G1.0160.18
331_P349_D1.0150.18
80_Y90_D0.9980.17
121_L336_G0.9940.17
89_K98_G0.9920.17
331_P334_A0.9900.17
14_I22_G0.9860.17
182_A185_L0.9840.17
80_Y128_T0.9810.17
340_R344_S0.9770.17
73_I124_T0.9770.17
59_S200_Y0.9740.17
313_C317_H0.9690.17
313_C316_C0.9690.17
44_S88_S0.9620.16
196_G335_K0.9590.16
50_E111_Q0.9560.16
26_A81_L0.9560.16
116_T120_E0.9540.16
26_A80_Y0.9530.16
47_K99_K0.9460.16
26_A128_T0.9440.16
219_L269_N0.9390.16
109_H208_G0.9370.16
172_P236_Y0.9290.16
139_D361_D0.9280.16
55_T112_E0.9280.16
29_V69_A0.9270.16
285_S299_K0.9260.16
324_H328_N0.9260.16
31_H34_S0.9240.16
273_Q280_Q0.9210.16
61_Q142_S0.9200.16
236_Y253_L0.9190.16
143_Q160_T0.9150.16
150_M258_L0.9010.15
304_Y359_A0.8940.15
82_F88_S0.8920.15
299_K303_Q0.8910.15
92_Y304_Y0.8910.15
34_S48_P0.8900.15
107_E171_F0.8890.15
160_T359_A0.8860.15
100_I183_H0.8850.15
149_K152_N0.8770.15
50_E227_K0.8750.15
44_S108_A0.8740.15
154_A355_F0.8740.15
220_T303_Q0.8710.15
59_S139_D0.8710.15
108_A198_H0.8700.15
330_W356_Q0.8690.15
140_I151_H0.8650.15
137_A143_Q0.8620.15
152_N156_K0.8610.15
76_S136_D0.8570.15
40_L221_V0.8500.14
52_Y137_A0.8490.14
77_G112_E0.8450.14
220_T307_K0.8430.14
109_H113_M0.8420.14
64_I171_F0.8400.14
204_T235_G0.8380.14
130_R160_T0.8370.14
125_D359_A0.8350.14
37_A224_A0.8340.14
80_Y151_H0.8240.14
65_R137_A0.8240.14
16_V44_S0.8160.14
11_F245_L0.8150.14
241_S352_T0.8140.14
24_L34_S0.8130.14
290_L363_T0.8090.14
187_S261_E0.8070.14
148_Q357_Y0.8030.14
195_N220_T0.8030.14
23_L151_H0.8010.14
12_L280_Q0.7990.14
174_E180_N0.7980.13
51_E65_R0.7970.13
73_I128_T0.7940.13
58_F131_S0.7930.13
234_Q290_L0.7930.13
309_D352_T0.7920.13
168_I343_M0.7890.13
214_N259_S0.7860.13
304_Y351_L0.7840.13
92_Y343_M0.7840.13
88_S226_G0.7840.13
76_S158_S0.7820.13
61_Q304_Y0.7820.13
160_T252_R0.7810.13
259_S299_K0.7810.13
73_I288_G0.7800.13
13_L312_Y0.7800.13
24_L28_K0.7790.13
101_D156_K0.7790.13
96_V299_K0.7790.13
57_H71_C0.7770.13
57_H68_C0.7770.13
68_C72_H0.7770.13
68_C71_C0.7770.13
57_H72_H0.7770.13
211_A221_V0.7750.13
106_F128_T0.7750.13
17_V203_K0.7750.13
91_I291_T0.7750.13
309_D340_R0.7730.13
37_A109_H0.7720.13
118_W173_P0.7700.13
39_C45_M0.7650.13
42_C45_M0.7650.13
38_F45_M0.7650.13
119_K227_K0.7640.13
200_Y227_K0.7630.13
107_E110_R0.7610.13
77_G131_S0.7590.13
236_Y332_S0.7590.13
23_L73_I0.7580.13
172_P278_G0.7580.13
109_H333_I0.7570.13
134_S255_L0.7560.13
326_T352_T0.7480.13
326_T334_A0.7480.13
277_Y327_V0.7460.13
301_L339_A0.7440.13
193_V207_I0.7440.13
159_E336_G0.7430.13
88_S91_I0.7420.13
130_R213_V0.7420.13
21_G195_N0.7400.13
48_P109_H0.7390.13
13_L29_V0.7380.13
51_E74_P0.7380.13
217_T255_L0.7360.12
34_S131_S0.7360.12
62_K99_K0.7310.12
116_T185_L0.7270.12
14_I266_L0.7250.12
40_L104_D0.7250.12
314_A323_D0.7240.12
154_A243_N0.7230.12
10_L81_L0.7230.12
69_A200_Y0.7220.12
121_L264_K0.7220.12
109_H307_K0.7220.12
162_I304_Y0.7160.12
224_A292_D0.7100.12
93_H150_M0.7080.12
121_L142_S0.7080.12
277_Y309_D0.7080.12
213_V251_Q0.7080.12
117_V326_T0.7080.12
14_I123_A0.7000.12
90_D106_F0.7000.12
233_L245_L0.6990.12
106_F319_P0.6970.12
92_Y217_T0.6950.12
265_A286_L0.6950.12
214_N349_D0.6920.12
100_I105_K0.6900.12
300_P305_A0.6900.12
218_D268_V0.6890.12
236_Y271_E0.6880.12
230_I321_A0.6860.12
143_Q334_A0.6840.12
75_K314_A0.6830.12
208_G320_I0.6820.12
172_P332_S0.6800.12
301_L307_K0.6790.12
227_K233_L0.6760.12
23_L128_T0.6760.12
37_A108_A0.6740.12
203_K290_L0.6730.12
94_E115_E0.6730.12
174_E322_A0.6720.12
250_G256_A0.6690.11
127_A131_S0.6660.11
115_E149_K0.6660.11
125_D135_F0.6660.11
75_K111_Q0.6640.11
131_S200_Y0.6620.11
111_Q115_E0.6620.11
69_A285_S0.6600.11
36_T58_F0.6590.11
147_A233_L0.6570.11
13_L345_E0.6550.11
9_L140_I0.6540.11
242_E320_I0.6530.11
79_D134_S0.6520.11
73_I90_D0.6510.11
115_E305_A0.6510.11
256_A300_P0.6510.11
12_L233_L0.6510.11
311_T314_A0.6500.11
119_K225_S0.6480.11
199_I315_G0.6470.11
314_A354_Y0.6460.11
48_P343_M0.6460.11
89_K185_L0.6450.11
172_P211_A0.6450.11
318_A360_K0.6440.11
332_S357_Y0.6430.11
359_A362_I0.6420.11
125_D304_Y0.6420.11
309_D326_T0.6410.11
143_Q351_L0.6400.11
14_I17_V0.6390.11
116_T357_Y0.6390.11
139_D221_V0.6360.11
55_T270_G0.6360.11
145_E324_H0.6350.11
229_P343_M0.6350.11
9_L55_T0.6340.11
189_A227_K0.6340.11
298_R301_L0.6320.11
279_N282_R0.6320.11
144_S155_Q0.6320.11
245_L287_Q0.6310.11
22_G35_D0.6310.11
229_P290_L0.6290.11
326_T344_S0.6280.11
331_P357_Y0.6270.11
120_E242_E0.6260.11
309_D322_A0.6240.11
346_N355_F0.6230.11
40_L82_F0.6230.11
91_I135_F0.6230.11
122_K163_D0.6210.11
221_V224_A0.6200.11
127_A158_S0.6200.11
309_D353_R0.6190.11
154_A236_Y0.6190.11
94_E98_G0.6190.11
136_D255_L0.6160.11
17_V21_G0.6160.11
237_Q282_R0.6150.11
190_A300_P0.6140.11
238_M349_D0.6130.11
25_L28_K0.6130.11
171_F187_S0.6130.11
69_A266_L0.6100.11
65_R327_V0.6100.11
121_L362_I0.6100.11
108_A222_V0.6050.11
15_A20_G0.6050.11
160_T237_Q0.6050.11
10_L307_K0.6040.11
292_D303_Q0.6040.11
172_P253_L0.6010.11
58_F252_R0.5990.10
109_H361_D0.5970.10
77_G127_A0.5970.10
14_I18_V0.5960.10
19_G341_T0.5960.10
60_N63_G0.5950.10
27_Q32_K0.5940.10
214_N239_Q0.5940.10
86_K89_K0.5940.10
213_V355_F0.5890.10
177_M180_N0.5860.10
150_M358_N0.5840.10
135_F359_A0.5840.10
160_T352_T0.5820.10
121_L186_E0.5820.10
343_M351_L0.5820.10
55_T362_I0.5800.10
175_I205_S0.5800.10
118_W281_W0.5790.10
79_D124_T0.5790.10
146_S149_K0.5750.10
337_M356_Q0.5750.10
330_W337_M0.5750.10
237_Q286_L0.5720.10
270_G283_Q0.5720.10
91_I120_E0.5720.10
318_A326_T0.5720.10
125_D329_A0.5710.10
184_E187_S0.5710.10
212_T280_Q0.5690.10
100_I144_S0.5680.10
333_I340_R0.5670.10
160_T326_T0.5660.10
224_A363_T0.5650.10
176_K318_A0.5640.10
155_Q243_N0.5630.10
154_A213_V0.5620.10
236_Y327_V0.5610.10
149_K204_T0.5580.10
55_T154_A0.5580.10
94_E113_M0.5570.10
235_G339_A0.5570.10
226_G297_D0.5560.10
114_A173_P0.5540.10
14_I284_A0.5520.10
176_K357_Y0.5520.10
334_A362_I0.5510.10
334_A340_R0.5500.10
115_E306_E0.5490.10
191_T301_L0.5480.10
91_I334_A0.5470.10
258_L278_G0.5460.10
198_H218_D0.5460.10
85_L314_A0.5460.10
78_M90_D0.5460.10
309_D320_I0.5450.10
103_D149_K0.5440.10
173_P281_W0.5440.10
336_G339_A0.5440.10
157_D298_R0.5420.10
33_T228_Q0.5420.10
294_A319_P0.5410.10
151_H340_R0.5410.10
27_Q131_S0.5400.10
146_S213_V0.5390.10
81_L298_R0.5390.10
146_S187_S0.5360.10
22_G75_K0.5340.10
114_A281_W0.5330.10
295_L300_P0.5310.10
135_F360_K0.5310.10
16_V336_G0.5290.10
56_V186_E0.5290.10
340_R353_R0.5280.10
147_A297_D0.5210.09
77_G83_A0.5180.09
156_K247_L0.5180.09
259_S270_G0.5180.09
35_D76_S0.5170.09
238_M332_S0.5160.09
52_Y82_F0.5150.09
30_L341_T0.5120.09
11_F297_D0.5120.09
64_I352_T0.5120.09
11_F191_T0.5100.09
319_P344_S0.5100.09
52_Y335_K0.5090.09
113_M180_N0.5080.09
275_D331_P0.5070.09
9_L22_G0.5070.09
305_A348_L0.5070.09
36_T128_T0.5060.09
111_Q261_E0.5040.09
193_V203_K0.5030.09
40_L255_L0.5010.09
320_I324_H0.5010.09
48_P80_Y0.5010.09
207_I293_P0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j7aC 2 0.3934 100 0.778 Contact Map
1sp3A 1 0.6339 99.9 0.871 Contact Map
4fasA 3 0.8552 99.9 0.873 Contact Map
1oahA 2 0.7486 99.8 0.88 Contact Map
2j7aA 5 0.6202 99.8 0.883 Contact Map
3u99A 1 0.1612 99.8 0.887 Contact Map
2fwtA 1 0.1721 99.7 0.89 Contact Map
2fw5A 1 0.1803 99.7 0.891 Contact Map
4n4jA 3 0.6721 99.5 0.906 Contact Map
3ucpA 1 0.6967 99.5 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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