GREMLIN Database
AEEP - L-Ala-D/L-Glu epimerase
UniProt: P51981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13228
Length: 321 (299)
Sequences: 9087 (5851)
Seq/√Len: 338.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_I242_E3.5651.00
39_I98_L3.2831.00
35_E40_K3.0281.00
33_E40_K2.9491.00
209_D212_A2.9261.00
231_R256_E2.8541.00
138_S167_A2.8061.00
182_R185_G2.7551.00
70_E81_I2.6581.00
92_D255_T2.5381.00
190_C201_L2.5181.00
214_E218_H2.4881.00
251_T260_L2.4431.00
191_Q194_A2.3731.00
194_A219_P2.3681.00
215_N218_H2.3291.00
138_S142_Q2.2931.00
134_A167_A2.2801.00
100_A107_L2.2731.00
130_P134_A2.2661.00
39_I102_R2.1881.00
162_V196_L2.1841.00
120_I146_K2.1621.00
172_T199_A2.1481.00
158_S192_L2.1081.00
74_T77_E2.0911.00
214_E238_K2.0771.00
129_T132_Q2.0311.00
211_A238_K1.9561.00
105_Q109_D1.9121.00
141_W171_A1.8891.00
192_L195_D1.8881.00
163_A166_T1.8801.00
183_A215_N1.8161.00
92_D96_W1.7921.00
189_R193_L1.7861.00
34_L95_L1.7811.00
183_A216_F1.7731.00
205_L216_F1.7531.00
18_V23_S1.7511.00
159_E162_V1.7411.00
162_V166_T1.7321.00
194_A220_L1.7261.00
64_S68_Q1.7211.00
139_T143_A1.7041.00
258_L262_T1.6881.00
256_E259_A1.6841.00
175_V198_V1.6601.00
148_L171_A1.6531.00
45_C90_A1.6371.00
158_S196_L1.6171.00
162_V195_D1.6061.00
174_I199_A1.5941.00
39_I101_R1.5851.00
156_L159_E1.5831.00
33_E42_T1.5831.00
106_S109_D1.5771.00
132_Q135_N1.5541.00
151_K178_N1.5461.00
187_A216_F1.5361.00
56_A60_A1.5341.00
99_A103_Q1.5311.00
100_A110_L1.5291.00
138_S141_W1.4761.00
223_C243_M1.4701.00
234_L260_L1.4601.00
32_V90_A1.4571.00
230_T233_N1.4561.00
135_N138_S1.4541.00
71_K74_T1.4441.00
257_A289_L1.4421.00
262_T265_R1.4341.00
75_R99_A1.4231.00
114_T117_E1.4191.00
259_A265_R1.4001.00
97_D101_R1.3711.00
135_N139_T1.3661.00
237_L241_Y1.3651.00
59_M63_M1.3651.00
76_E259_A1.3591.00
141_W148_L1.3471.00
150_V164_I1.3391.00
168_V173_L1.3301.00
137_A168_V1.3301.00
70_E77_E1.3191.00
37_E102_R1.3101.00
224_A237_L1.2921.00
96_W255_T1.2851.00
223_C245_N1.2821.00
191_Q219_P1.2801.00
158_S162_V1.2791.00
205_L212_A1.2611.00
303_W307_D1.2561.00
128_G132_Q1.2531.00
265_R294_S1.2501.00
235_K263_E1.2441.00
161_M175_V1.2361.00
139_T142_Q1.2321.00
248_L257_A1.2201.00
31_V42_T1.2171.00
165_R173_L1.2161.00
78_L82_L1.2121.00
73_L102_R1.2041.00
161_M196_L1.2031.00
263_E267_Q1.2021.00
140_L143_A1.2011.00
73_L99_A1.2001.00
70_E74_T1.2001.00
134_A166_T1.1991.00
147_L174_I1.1951.00
60_A63_M1.1931.00
153_D157_I1.1921.00
134_A168_V1.1901.00
55_D59_M1.1881.00
137_A148_L1.1881.00
296_A300_G1.1881.00
297_D300_G1.1851.00
244_V264_A1.1801.00
103_Q110_L1.1771.00
234_L244_V1.1681.00
53_E57_S1.1681.00
263_E266_A1.1671.00
131_D135_N1.1641.00
259_A262_T1.1641.00
165_R170_D1.1581.00
247_K274_G1.1571.00
168_V171_A1.1551.00
130_P163_A1.1551.00
188_A191_Q1.1501.00
187_A215_N1.1451.00
251_T257_A1.1341.00
183_A212_A1.1331.00
82_L88_R1.1221.00
246_I257_A1.1211.00
163_A167_A1.1181.00
188_A192_L1.1181.00
31_V281_R1.1141.00
134_A138_S1.1111.00
181_W201_L1.1111.00
233_N236_A1.1091.00
203_Q245_N1.1001.00
177_A201_L1.0961.00
105_Q110_L1.0881.00
79_Q83_P1.0811.00
229_H233_N1.0801.00
304_L307_D1.0721.00
75_R78_L1.0671.00
181_W189_R1.0611.00
77_E81_I1.0601.00
177_A181_W1.0591.00
159_E163_A1.0571.00
235_K267_Q1.0571.00
93_C285_A1.0551.00
228_C234_L1.0541.00
217_I239_G1.0531.00
107_L254_L1.0481.00
211_A236_A1.0461.00
53_E58_V1.0441.00
79_Q82_L1.0431.00
231_R263_E1.0431.00
213_L224_A1.0431.00
224_A241_Y1.0411.00
258_L292_Q1.0361.00
198_V220_L1.0351.00
63_M67_P1.0351.00
161_M193_L1.0291.00
296_A299_D1.0231.00
123_Q145_A1.0231.00
36_E72_G1.0191.00
152_L177_A1.0171.00
16_P23_S1.0121.00
241_Y244_V1.0071.00
123_Q140_L1.0071.00
107_L111_I1.0061.00
70_E78_L1.0041.00
78_L81_I0.9941.00
205_L213_L0.9901.00
130_P159_E0.9831.00
35_E42_T0.9821.00
297_D301_P0.9821.00
212_A215_N0.9751.00
63_M68_Q0.9751.00
261_A293_V0.9721.00
169_P197_G0.9571.00
43_G90_A0.9531.00
150_V161_M0.9501.00
76_E258_L0.9481.00
216_F222_I0.9471.00
164_I168_V0.9441.00
42_T281_R0.9391.00
60_A64_S0.9361.00
289_L292_Q0.9321.00
215_N239_G0.9301.00
231_R259_A0.9271.00
136_S139_T0.9231.00
303_W306_V0.9141.00
137_A164_I0.9111.00
57_S60_A0.9051.00
228_C233_N0.9041.00
35_E38_G0.9011.00
57_S61_Q0.9011.00
73_L103_Q0.8981.00
134_A163_A0.8941.00
183_A187_A0.8861.00
174_I200_M0.8751.00
62_I91_L0.8741.00
135_N167_A0.8711.00
111_I254_L0.8661.00
239_G269_F0.8621.00
185_G188_A0.8621.00
183_A205_L0.8611.00
98_L102_R0.8611.00
79_Q255_T0.8591.00
147_L172_T0.8591.00
228_C237_L0.8571.00
152_L181_W0.8541.00
41_G94_A0.8541.00
204_P222_I0.8531.00
75_R82_L0.8531.00
165_R197_G0.8471.00
214_E240_R0.8451.00
191_Q195_D0.8451.00
246_I271_L0.8451.00
158_S195_D0.8411.00
99_A110_L0.8381.00
210_D240_R0.8281.00
225_D247_K0.8281.00
68_Q71_K0.8261.00
93_C254_L0.8261.00
292_Q295_F0.8251.00
133_M160_R0.8201.00
64_S67_P0.8171.00
187_A191_Q0.8171.00
99_A102_R0.8151.00
72_G75_R0.8151.00
78_L95_L0.8121.00
186_L216_F0.8061.00
65_V68_Q0.8011.00
217_I222_I0.8001.00
83_P256_E0.7921.00
108_A288_P0.7881.00
141_W168_V0.7861.00
310_P313_Q0.7841.00
156_L160_R0.7811.00
122_A174_I0.7781.00
203_Q225_D0.7731.00
210_D238_K0.7691.00
210_D236_A0.7661.00
68_Q72_G0.7661.00
148_L168_V0.7651.00
107_L288_P0.7631.00
61_Q68_Q0.7621.00
157_I181_W0.7571.00
165_R196_L0.7551.00
100_A105_Q0.7541.00
210_D237_L0.7531.00
245_N274_G0.7501.00
103_Q106_S0.7440.99
190_C220_L0.7430.99
184_E188_A0.7410.99
61_Q64_S0.7390.99
44_E279_T0.7390.99
36_E102_R0.7340.99
138_S168_V0.7330.99
257_A273_L0.7290.99
146_K170_D0.7260.99
203_Q227_S0.7250.99
244_V269_F0.7220.99
232_S235_K0.7190.99
199_A221_P0.7180.99
100_A103_Q0.7180.99
96_W107_L0.7160.99
120_I172_T0.7130.99
109_D114_T0.7130.99
213_L216_F0.7110.99
93_C281_R0.7100.99
264_A269_F0.7080.99
95_L99_A0.7070.99
136_S140_L0.7050.99
183_A209_D0.7020.99
59_M64_S0.7010.99
254_L285_A0.7010.99
288_P291_P0.7000.99
74_T109_D0.6990.99
107_L110_L0.6980.99
179_E207_A0.6980.99
288_P292_Q0.6960.99
121_T124_T0.6930.99
187_A190_C0.6920.99
297_D302_T0.6920.99
79_Q92_D0.6910.99
278_C282_A0.6910.99
137_A167_A0.6910.99
217_I240_R0.6900.99
158_S189_R0.6880.99
211_A214_E0.6880.99
275_C283_I0.6870.99
36_E39_I0.6850.99
141_W167_A0.6820.99
41_G97_D0.6800.99
63_M66_V0.6770.99
218_H239_G0.6760.99
118_T316_T0.6760.99
279_T282_A0.6730.99
92_D253_G0.6730.99
254_L289_L0.6710.99
46_T49_P0.6690.99
65_V81_I0.6660.99
261_A271_L0.6660.99
296_A301_P0.6620.99
254_L258_L0.6600.99
179_E227_S0.6600.99
284_S288_P0.6590.99
192_L196_L0.6560.99
264_A271_L0.6550.99
132_Q136_S0.6550.99
152_L175_V0.6530.99
75_R83_P0.6500.99
50_R54_S0.6480.99
32_V91_L0.6420.99
131_D134_A0.6350.98
306_V309_E0.6290.98
72_G98_L0.6280.98
93_C249_D0.6280.98
93_C107_L0.6260.98
299_D302_T0.6250.98
47_P86_A0.6240.98
55_D58_V0.6220.98
106_S110_L0.6220.98
71_K109_D0.6220.98
165_R169_P0.6220.98
111_I258_L0.6200.98
130_P156_L0.6170.98
282_A286_A0.6130.98
243_M270_S0.6100.98
175_V193_L0.6100.98
287_L312_L0.6070.98
125_V137_A0.6070.98
151_K176_D0.6060.98
232_S236_A0.6040.98
162_V192_L0.6030.98
71_K79_Q0.6030.98
209_D268_G0.6030.98
248_L286_A0.6020.98
95_L98_L0.6000.98
252_G256_E0.6000.98
258_L293_V0.5990.98
134_A137_A0.5990.98
109_D113_I0.5970.98
44_E281_R0.5960.98
284_S287_L0.5960.98
256_E260_L0.5940.98
106_S112_G0.5930.98
56_A59_M0.5920.97
124_T151_K0.5900.97
108_A114_T0.5890.97
158_S193_L0.5880.97
214_E239_G0.5870.97
128_G136_S0.5840.97
30_V59_M0.5840.97
303_W308_V0.5820.97
189_R192_L0.5800.97
186_L190_C0.5800.97
262_T266_A0.5800.97
96_W254_L0.5800.97
46_T278_C0.5780.97
186_L205_L0.5740.97
158_S161_M0.5740.97
45_C86_A0.5730.97
134_A164_I0.5720.97
200_M272_M0.5700.97
99_A109_D0.5700.97
213_L222_I0.5680.97
234_L246_I0.5670.97
157_I160_R0.5650.97
20_A180_S0.5650.97
83_P88_R0.5640.97
261_A265_R0.5620.97
275_C278_C0.5600.96
66_V91_L0.5590.96
244_V260_L0.5590.96
47_P250_K0.5580.96
118_T315_T0.5560.96
221_P243_M0.5560.96
40_K101_R0.5560.96
133_M137_A0.5560.96
72_G79_Q0.5550.96
89_N93_C0.5540.96
137_A141_W0.5510.96
105_Q113_I0.5510.96
203_Q226_E0.5510.96
161_M198_V0.5490.96
131_D163_A0.5460.96
198_V201_L0.5420.96
80_K84_A0.5410.96
249_D276_M0.5410.96
165_R171_A0.5400.96
97_D100_A0.5380.96
85_G88_R0.5380.96
75_R79_Q0.5370.96
96_W100_A0.5360.96
179_E203_Q0.5360.96
71_K82_L0.5360.96
61_Q65_V0.5350.95
213_L240_R0.5330.95
97_D106_S0.5330.95
175_V201_L0.5310.95
86_A250_K0.5300.95
166_T196_L0.5300.95
141_W170_D0.5280.95
245_N272_M0.5280.95
108_A112_G0.5280.95
66_V78_L0.5240.95
59_M91_L0.5240.95
208_Q232_S0.5240.95
160_R164_I0.5240.95
71_K81_I0.5220.95
234_L269_F0.5220.95
60_A68_Q0.5220.95
98_L101_R0.5220.95
200_M243_M0.5210.95
147_L199_A0.5200.95
195_D198_V0.5190.95
16_P25_S0.5180.95
261_A295_F0.5180.95
137_A163_A0.5180.95
157_I177_A0.5160.95
42_T101_R0.5160.95
96_W110_L0.5150.94
45_C87_A0.5150.94
63_M91_L0.5130.94
231_R235_K0.5110.94
150_V160_R0.5090.94
30_V58_V0.5080.94
121_T145_A0.5080.94
89_N252_G0.5080.94
201_L220_L0.5070.94
186_L201_L0.5060.94
190_C222_I0.5050.94
44_E282_A0.5050.94
53_E64_S0.5050.94
91_L95_L0.5050.94
211_A215_N0.5040.94
74_T78_L0.5030.94
248_L289_L0.5030.94
246_I261_A0.5010.94
298_L302_T0.5000.94
59_M62_I0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jpdX 1 0.9813 100 0.118 Contact Map
4gfiA 2 0.9782 100 0.154 Contact Map
3ijlA 2 0.9813 100 0.155 Contact Map
3s5sA 2 0.9907 100 0.157 Contact Map
3u9iA 2 0.9595 100 0.163 Contact Map
1sjdA 5 0.9875 100 0.163 Contact Map
1r0mA 2 0.9564 100 0.166 Contact Map
2zc8A 5 0.9875 100 0.168 Contact Map
1wufA 2 0.9875 100 0.17 Contact Map
3qldA 2 0.9875 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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