GREMLIN Database
SFGH1 - S-formylglutathione hydrolase FrmB
UniProt: P51025 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13295
Length: 277 (230)
Sequences: 8381 (6243)
Seq/√Len: 411.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_A165_V4.1061.00
130_M139_K3.5001.00
20_Y27_E3.2651.00
167_A170_P2.8491.00
234_E238_Q2.8011.00
130_M135_A2.6511.00
105_N119_D2.6041.00
128_L132_H2.5731.00
119_D123_N2.4991.00
168_F266_H2.3791.00
219_L250_E2.3241.00
75_I135_A2.3011.00
236_I240_M2.2761.00
247_R265_E2.2681.00
38_A134_P2.2511.00
118_Y158_N2.2471.00
234_E244_T2.2191.00
37_K73_N2.2161.00
46_L74_I2.1551.00
18_R27_E2.1491.00
231_P248_Y2.1081.00
45_V77_V2.0831.00
43_L75_I2.0321.00
46_L142_S1.9731.00
118_Y154_L1.9631.00
47_Y139_K1.9351.00
216_D262_F1.9171.00
166_S266_H1.8831.00
20_Y25_K1.8201.00
48_W142_S1.8051.00
126_P139_K1.7281.00
38_A43_L1.7141.00
140_S164_S1.6881.00
16_M29_N1.6851.00
32_V77_V1.6701.00
19_H120_Y1.6571.00
235_K239_E1.6551.00
77_V129_V1.6521.00
47_Y130_M1.6001.00
18_R29_N1.5851.00
118_Y157_R1.5771.00
99_G102_F1.5591.00
34_L75_I1.5521.00
122_R158_N1.5401.00
120_Y125_L1.5311.00
17_Y30_V1.5261.00
67_R71_E1.5221.00
196_L202_S1.5221.00
47_Y126_P1.5031.00
264_G268_A1.4951.00
193_D196_L1.4801.00
165_V213_I1.4661.00
66_Q70_A1.4621.00
41_E73_N1.4441.00
235_K238_Q1.4401.00
129_V135_A1.4191.00
170_P230_T1.4111.00
234_E246_I1.3931.00
153_V198_Y1.3611.00
232_N235_K1.3581.00
21_S124_E1.3541.00
231_P235_K1.3541.00
234_E248_Y1.3481.00
152_L172_V1.3251.00
141_I151_A1.3201.00
164_S212_E1.3161.00
144_H259_V1.3151.00
214_M247_R1.3101.00
30_V125_L1.3041.00
236_I239_E1.2861.00
153_V157_R1.2641.00
219_L248_Y1.2571.00
72_H267_I1.2551.00
15_N133_F1.2501.00
173_S232_N1.2421.00
64_G67_R1.2371.00
126_P130_M1.2341.00
49_L117_M1.2311.00
123_N158_N1.2211.00
126_P161_E1.2121.00
23_S123_N1.2121.00
49_L150_G1.2041.00
16_M31_G1.2031.00
151_A165_V1.2011.00
23_S124_E1.2011.00
169_S259_V1.1981.00
60_I78_A1.1981.00
230_T246_I1.1801.00
48_W59_F1.1801.00
142_S166_S1.1781.00
100_A103_Y1.1741.00
45_V135_A1.1681.00
123_N127_D1.1671.00
202_S205_S1.1631.00
122_R161_E1.1361.00
23_S119_D1.1141.00
46_L76_V1.1111.00
148_G167_A1.1081.00
42_K134_P1.1071.00
122_R154_L1.0991.00
99_G103_Y1.0981.00
224_Y231_P1.0981.00
238_Q244_T1.0941.00
212_E243_K1.0941.00
152_L167_A1.0901.00
199_D202_S1.0831.00
204_I207_G1.0801.00
68_Y264_G1.0711.00
48_W78_A1.0581.00
72_H268_A1.0571.00
139_K161_E1.0571.00
30_V128_L1.0551.00
237_C244_T1.0501.00
118_Y122_R1.0491.00
57_Q61_T1.0441.00
15_N34_L1.0391.00
215_V234_E1.0271.00
63_S256_Y1.0251.00
16_M56_E1.0161.00
21_S24_L1.0111.00
141_I154_L1.0091.00
28_M120_Y1.0011.00
212_E269_Y1.0001.00
43_L134_P0.9971.00
37_K43_L0.9941.00
68_Y71_E0.9851.00
194_A197_D0.9831.00
153_V200_P0.9821.00
30_V120_Y0.9781.00
126_P162_Y0.9741.00
17_Y128_L0.9721.00
121_I154_L0.9691.00
47_Y77_V0.9641.00
47_Y129_V0.9631.00
172_V233_L0.9611.00
158_N161_E0.9531.00
22_Q124_E0.9511.00
54_C58_N0.9501.00
120_Y124_E0.9451.00
17_Y132_H0.9411.00
168_F259_V0.9391.00
65_M76_V0.9381.00
215_V233_L0.9301.00
99_G105_N0.9221.00
69_A76_V0.9191.00
237_C242_I0.9141.00
102_F105_N0.9131.00
138_K163_V0.9111.00
122_R127_D0.9111.00
149_L153_V0.9071.00
195_W199_D0.9051.00
45_V139_K0.9051.00
44_P74_I0.9031.00
145_S254_H0.9021.00
151_A167_A0.9011.00
55_N58_N0.8961.00
219_L249_H0.8901.00
59_F63_S0.8881.00
77_V125_L0.8801.00
122_R162_Y0.8751.00
203_L206_Q0.8751.00
128_L131_H0.8731.00
249_H262_F0.8631.00
47_Y162_Y0.8581.00
126_P129_V0.8411.00
215_V244_T0.8391.00
75_I133_F0.8351.00
202_S206_Q0.8341.00
31_G56_E0.8341.00
215_V230_T0.8291.00
29_N80_D0.8271.00
49_L141_I0.8181.00
233_L237_C0.8121.00
116_K119_D0.8061.00
205_S239_E0.8011.00
155_A211_A0.8011.00
24_L28_M0.7961.00
29_N56_E0.7961.00
63_S68_Y0.7921.00
127_D162_Y0.7911.00
218_G251_G0.7891.00
39_A42_K0.7881.00
149_L200_P0.7851.00
249_H258_F0.7831.00
45_V75_I0.7811.00
144_H256_Y0.7811.00
34_L38_A0.7811.00
166_S270_H0.7791.00
49_L79_P0.7781.00
98_Q102_F0.7771.00
258_F262_F0.7761.00
219_L251_G0.7671.00
31_G80_D0.7651.00
38_A75_I0.7641.00
245_L269_Y0.7571.00
265_E268_A0.7551.00
50_S58_N0.7551.00
43_L73_N0.7541.00
141_I165_V0.7531.00
102_F106_A0.7471.00
152_L170_P0.7431.00
66_Q69_A0.7401.00
142_S168_F0.7391.00
139_K163_V0.7361.00
148_G170_P0.7351.00
217_Q230_T0.7331.00
262_F265_E0.7331.00
16_M57_Q0.7331.00
127_D161_E0.7291.00
193_D197_D0.7261.00
39_A134_P0.7251.00
157_R197_D0.7241.00
34_L43_L0.7231.00
213_I237_C0.7221.00
33_Y36_P0.7221.00
67_R70_A0.7201.00
167_A215_V0.7191.00
104_L153_V0.7181.00
79_P121_I0.7171.00
216_D249_H0.7151.00
105_N116_K0.7121.00
52_L100_A0.7121.00
33_Y66_Q0.7061.00
147_G150_G0.7051.00
229_R232_N0.7001.00
204_I240_M0.6951.00
152_L213_I0.6931.00
204_I208_Q0.6921.00
142_S263_I0.6901.00
220_S251_G0.6891.00
44_P138_K0.6831.00
45_V130_M0.6791.00
64_G68_Y0.6730.99
130_M161_E0.6700.99
32_V133_F0.6690.99
49_L151_A0.6680.99
122_R126_P0.6670.99
58_N256_Y0.6660.99
22_Q25_K0.6560.99
184_F187_Y0.6540.99
211_A242_I0.6530.99
14_Q60_I0.6530.99
97_G101_G0.6510.99
48_W263_I0.6500.99
68_Y267_I0.6480.99
168_F216_D0.6460.99
201_V205_S0.6450.99
17_Y133_F0.6440.99
98_Q186_A0.6410.99
210_V242_I0.6340.99
19_H30_V0.6270.99
127_D131_H0.6270.99
221_D224_Y0.6230.99
72_H271_A0.6200.99
249_H261_S0.6180.99
59_F144_H0.6170.99
185_A190_E0.6150.99
169_S218_G0.6140.99
44_P73_N0.6140.99
23_S116_K0.6140.99
164_S269_Y0.6120.99
249_H265_E0.6120.99
31_G57_Q0.6080.99
42_K135_A0.6070.99
63_S260_S0.6060.99
144_H170_P0.6030.99
45_V76_V0.6030.99
118_Y153_V0.6000.99
182_Q185_A0.6000.99
203_L207_G0.5990.99
263_I267_I0.5990.99
65_M69_A0.5980.99
164_S270_H0.5970.99
56_E59_F0.5950.99
61_T66_Q0.5890.99
182_Q186_A0.5890.99
68_Y72_H0.5880.99
117_M150_G0.5880.99
204_I237_C0.5860.99
123_N161_E0.5850.99
118_Y198_Y0.5850.99
24_L124_E0.5800.98
196_L206_Q0.5800.98
230_T244_T0.5770.98
59_F78_A0.5760.98
103_Y150_G0.5760.98
205_S236_I0.5750.98
38_A42_K0.5740.98
155_A159_P0.5720.98
33_Y70_A0.5720.98
64_G260_S0.5720.98
183_A186_A0.5720.98
32_V75_I0.5700.98
56_E60_I0.5690.98
217_Q221_D0.5680.98
58_N61_T0.5670.98
136_T139_K0.5640.98
65_M68_Y0.5640.98
114_H150_G0.5610.98
142_S266_H0.5600.98
51_G145_S0.5600.98
220_S250_E0.5590.98
208_Q240_M0.5570.98
59_F65_M0.5560.98
245_L265_E0.5550.98
50_S54_C0.5520.98
34_L133_F0.5520.98
205_S208_Q0.5500.98
14_Q66_Q0.5480.98
216_D258_F0.5470.98
255_S258_F0.5470.98
102_F146_M0.5450.98
97_G100_A0.5350.97
57_Q60_I0.5350.97
68_Y268_A0.5310.97
103_Y106_A0.5280.97
46_L140_S0.5280.97
201_V236_I0.5270.97
28_M125_L0.5260.97
58_N144_H0.5250.97
46_L267_I0.5230.97
261_S264_G0.5220.97
37_K41_E0.5220.97
64_G69_A0.5210.97
100_A106_A0.5200.97
33_Y76_V0.5200.97
225_A229_R0.5200.97
129_V133_F0.5190.97
214_M266_H0.5170.97
75_I134_P0.5170.97
60_I66_Q0.5170.97
186_A189_A0.5150.97
184_F188_L0.5140.97
163_V211_A0.5130.97
20_Y23_S0.5110.97
58_N62_K0.5090.97
79_P125_L0.5070.97
59_F259_V0.5060.96
45_V129_V0.5050.96
135_A139_K0.5050.96
154_L162_Y0.5040.96
60_I63_S0.5030.96
28_M81_T0.5010.96
50_S79_P0.5000.96
173_S176_Q0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ls2A 2 0.9928 100 0.356 Contact Map
3i6yA 1 0.9964 100 0.391 Contact Map
3e4dA 3 0.9928 100 0.394 Contact Map
4folA 2 0.9783 100 0.401 Contact Map
3fcxA 2 0.9928 100 0.426 Contact Map
4b6gA 1 0.9928 100 0.433 Contact Map
4rotA 4 0.8809 100 0.45 Contact Map
2uz0A 4 0.8592 100 0.456 Contact Map
4w9rA 2 0.8195 100 0.456 Contact Map
4h18A 3 0.917 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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