SFGH1 - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

SFGH1 - S-formylglutathione hydrolase FrmB

UniProt:	P51025	Sequences: MELIEKHVSFGGWQNMYRHYSQSLKCEMNVGVYLPPKAANEKLPVLYWLSGLTCNEQNFITKSGMQRYAAEHNIIVVAPDTSPRGSHVADADRYDLGQGAGFYLNATQAPWNEHYKMYDYIRNELPDLVMHHFPATAKKSISGHSMGGLGALVLALRNPDEYVSVSAFSPIVSPSQVPWGQQAFAAYLAENKDAWLDYDPVSLISQGQRVAEIMVDQGLSDDFYAEQLRTPNLEKICQEMNIKTLIRYHEGYDHSYYFVSSFIGEHIAYHANKLNMR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13295
Length:	277 (230)
Sequences:	8381 (6243)
Seq/√Len:	411.6

ECOLI - SFGH1 SFGH2 FES YIEL
BACSU - YJCH BESA YBBA
SULSO - Q97UM5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_A	165_V	4.106	1.00
130_M	139_K	3.500	1.00
20_Y	27_E	3.265	1.00
167_A	170_P	2.849	1.00
234_E	238_Q	2.801	1.00
130_M	135_A	2.651	1.00
105_N	119_D	2.604	1.00
128_L	132_H	2.573	1.00
119_D	123_N	2.499	1.00
168_F	266_H	2.379	1.00
219_L	250_E	2.324	1.00
75_I	135_A	2.301	1.00
236_I	240_M	2.276	1.00
247_R	265_E	2.268	1.00
38_A	134_P	2.251	1.00
118_Y	158_N	2.247	1.00
234_E	244_T	2.219	1.00
37_K	73_N	2.216	1.00
46_L	74_I	2.155	1.00
18_R	27_E	2.149	1.00
231_P	248_Y	2.108	1.00
45_V	77_V	2.083	1.00
43_L	75_I	2.032	1.00
46_L	142_S	1.973	1.00
118_Y	154_L	1.963	1.00
47_Y	139_K	1.935	1.00
216_D	262_F	1.917	1.00
166_S	266_H	1.883	1.00
20_Y	25_K	1.820	1.00
48_W	142_S	1.805	1.00
126_P	139_K	1.728	1.00
38_A	43_L	1.714	1.00
140_S	164_S	1.688	1.00
16_M	29_N	1.685	1.00
32_V	77_V	1.670	1.00
19_H	120_Y	1.657	1.00
235_K	239_E	1.655	1.00
77_V	129_V	1.652	1.00
47_Y	130_M	1.600	1.00
18_R	29_N	1.585	1.00
118_Y	157_R	1.577	1.00
99_G	102_F	1.559	1.00
34_L	75_I	1.552	1.00
122_R	158_N	1.540	1.00
120_Y	125_L	1.531	1.00
17_Y	30_V	1.526	1.00
67_R	71_E	1.522	1.00
196_L	202_S	1.522	1.00
47_Y	126_P	1.503	1.00
264_G	268_A	1.495	1.00
193_D	196_L	1.480	1.00
165_V	213_I	1.466	1.00
66_Q	70_A	1.462	1.00
41_E	73_N	1.444	1.00
235_K	238_Q	1.440	1.00
129_V	135_A	1.419	1.00
170_P	230_T	1.411	1.00
234_E	246_I	1.393	1.00
153_V	198_Y	1.361	1.00
232_N	235_K	1.358	1.00
21_S	124_E	1.354	1.00
231_P	235_K	1.354	1.00
234_E	248_Y	1.348	1.00
152_L	172_V	1.325	1.00
141_I	151_A	1.320	1.00
164_S	212_E	1.316	1.00
144_H	259_V	1.315	1.00
214_M	247_R	1.310	1.00
30_V	125_L	1.304	1.00
236_I	239_E	1.286	1.00
153_V	157_R	1.264	1.00
219_L	248_Y	1.257	1.00
72_H	267_I	1.255	1.00
15_N	133_F	1.250	1.00
173_S	232_N	1.242	1.00
64_G	67_R	1.237	1.00
126_P	130_M	1.234	1.00
49_L	117_M	1.231	1.00
123_N	158_N	1.221	1.00
126_P	161_E	1.212	1.00
23_S	123_N	1.212	1.00
49_L	150_G	1.204	1.00
16_M	31_G	1.203	1.00
151_A	165_V	1.201	1.00
23_S	124_E	1.201	1.00
169_S	259_V	1.198	1.00
60_I	78_A	1.198	1.00
230_T	246_I	1.180	1.00
48_W	59_F	1.180	1.00
142_S	166_S	1.178	1.00
100_A	103_Y	1.174	1.00
45_V	135_A	1.168	1.00
123_N	127_D	1.167	1.00
202_S	205_S	1.163	1.00
122_R	161_E	1.136	1.00
23_S	119_D	1.114	1.00
46_L	76_V	1.111	1.00
148_G	167_A	1.108	1.00
42_K	134_P	1.107	1.00
122_R	154_L	1.099	1.00
99_G	103_Y	1.098	1.00
224_Y	231_P	1.098	1.00
238_Q	244_T	1.094	1.00
212_E	243_K	1.094	1.00
152_L	167_A	1.090	1.00
199_D	202_S	1.083	1.00
204_I	207_G	1.080	1.00
68_Y	264_G	1.071	1.00
48_W	78_A	1.058	1.00
72_H	268_A	1.057	1.00
139_K	161_E	1.057	1.00
30_V	128_L	1.055	1.00
237_C	244_T	1.050	1.00
118_Y	122_R	1.049	1.00
57_Q	61_T	1.044	1.00
15_N	34_L	1.039	1.00
215_V	234_E	1.027	1.00
63_S	256_Y	1.025	1.00
16_M	56_E	1.016	1.00
21_S	24_L	1.011	1.00
141_I	154_L	1.009	1.00
28_M	120_Y	1.001	1.00
212_E	269_Y	1.000	1.00
43_L	134_P	0.997	1.00
37_K	43_L	0.994	1.00
68_Y	71_E	0.985	1.00
194_A	197_D	0.983	1.00
153_V	200_P	0.982	1.00
30_V	120_Y	0.978	1.00
126_P	162_Y	0.974	1.00
17_Y	128_L	0.972	1.00
121_I	154_L	0.969	1.00
47_Y	77_V	0.964	1.00
47_Y	129_V	0.963	1.00
172_V	233_L	0.961	1.00
158_N	161_E	0.953	1.00
22_Q	124_E	0.951	1.00
54_C	58_N	0.950	1.00
120_Y	124_E	0.945	1.00
17_Y	132_H	0.941	1.00
168_F	259_V	0.939	1.00
65_M	76_V	0.938	1.00
215_V	233_L	0.930	1.00
99_G	105_N	0.922	1.00
69_A	76_V	0.919	1.00
237_C	242_I	0.914	1.00
102_F	105_N	0.913	1.00
138_K	163_V	0.911	1.00
122_R	127_D	0.911	1.00
149_L	153_V	0.907	1.00
195_W	199_D	0.905	1.00
45_V	139_K	0.905	1.00
44_P	74_I	0.903	1.00
145_S	254_H	0.902	1.00
151_A	167_A	0.901	1.00
55_N	58_N	0.896	1.00
219_L	249_H	0.890	1.00
59_F	63_S	0.888	1.00
77_V	125_L	0.880	1.00
122_R	162_Y	0.875	1.00
203_L	206_Q	0.875	1.00
128_L	131_H	0.873	1.00
249_H	262_F	0.863	1.00
47_Y	162_Y	0.858	1.00
126_P	129_V	0.841	1.00
215_V	244_T	0.839	1.00
75_I	133_F	0.835	1.00
202_S	206_Q	0.834	1.00
31_G	56_E	0.834	1.00
215_V	230_T	0.829	1.00
29_N	80_D	0.827	1.00
49_L	141_I	0.818	1.00
233_L	237_C	0.812	1.00
116_K	119_D	0.806	1.00
205_S	239_E	0.801	1.00
155_A	211_A	0.801	1.00
24_L	28_M	0.796	1.00
29_N	56_E	0.796	1.00
63_S	68_Y	0.792	1.00
127_D	162_Y	0.791	1.00
218_G	251_G	0.789	1.00
39_A	42_K	0.788	1.00
149_L	200_P	0.785	1.00
249_H	258_F	0.783	1.00
45_V	75_I	0.781	1.00
144_H	256_Y	0.781	1.00
34_L	38_A	0.781	1.00
166_S	270_H	0.779	1.00
49_L	79_P	0.778	1.00
98_Q	102_F	0.777	1.00
258_F	262_F	0.776	1.00
219_L	251_G	0.767	1.00
31_G	80_D	0.765	1.00
38_A	75_I	0.764	1.00
245_L	269_Y	0.757	1.00
265_E	268_A	0.755	1.00
50_S	58_N	0.755	1.00
43_L	73_N	0.754	1.00
141_I	165_V	0.753	1.00
102_F	106_A	0.747	1.00
152_L	170_P	0.743	1.00
66_Q	69_A	0.740	1.00
142_S	168_F	0.739	1.00
139_K	163_V	0.736	1.00
148_G	170_P	0.735	1.00
217_Q	230_T	0.733	1.00
262_F	265_E	0.733	1.00
16_M	57_Q	0.733	1.00
127_D	161_E	0.729	1.00
193_D	197_D	0.726	1.00
39_A	134_P	0.725	1.00
157_R	197_D	0.724	1.00
34_L	43_L	0.723	1.00
213_I	237_C	0.722	1.00
33_Y	36_P	0.722	1.00
67_R	70_A	0.720	1.00
167_A	215_V	0.719	1.00
104_L	153_V	0.718	1.00
79_P	121_I	0.717	1.00
216_D	249_H	0.715	1.00
105_N	116_K	0.712	1.00
52_L	100_A	0.712	1.00
33_Y	66_Q	0.706	1.00
147_G	150_G	0.705	1.00
229_R	232_N	0.700	1.00
204_I	240_M	0.695	1.00
152_L	213_I	0.693	1.00
204_I	208_Q	0.692	1.00
142_S	263_I	0.690	1.00
220_S	251_G	0.689	1.00
44_P	138_K	0.683	1.00
45_V	130_M	0.679	1.00
64_G	68_Y	0.673	0.99
130_M	161_E	0.670	0.99
32_V	133_F	0.669	0.99
49_L	151_A	0.668	0.99
122_R	126_P	0.667	0.99
58_N	256_Y	0.666	0.99
22_Q	25_K	0.656	0.99
184_F	187_Y	0.654	0.99
211_A	242_I	0.653	0.99
14_Q	60_I	0.653	0.99
97_G	101_G	0.651	0.99
48_W	263_I	0.650	0.99
68_Y	267_I	0.648	0.99
168_F	216_D	0.646	0.99
201_V	205_S	0.645	0.99
17_Y	133_F	0.644	0.99
98_Q	186_A	0.641	0.99
210_V	242_I	0.634	0.99
19_H	30_V	0.627	0.99
127_D	131_H	0.627	0.99
221_D	224_Y	0.623	0.99
72_H	271_A	0.620	0.99
249_H	261_S	0.618	0.99
59_F	144_H	0.617	0.99
185_A	190_E	0.615	0.99
169_S	218_G	0.614	0.99
44_P	73_N	0.614	0.99
23_S	116_K	0.614	0.99
164_S	269_Y	0.612	0.99
249_H	265_E	0.612	0.99
31_G	57_Q	0.608	0.99
42_K	135_A	0.607	0.99
63_S	260_S	0.606	0.99
144_H	170_P	0.603	0.99
45_V	76_V	0.603	0.99
118_Y	153_V	0.600	0.99
182_Q	185_A	0.600	0.99
203_L	207_G	0.599	0.99
263_I	267_I	0.599	0.99
65_M	69_A	0.598	0.99
164_S	270_H	0.597	0.99
56_E	59_F	0.595	0.99
61_T	66_Q	0.589	0.99
182_Q	186_A	0.589	0.99
68_Y	72_H	0.588	0.99
117_M	150_G	0.588	0.99
204_I	237_C	0.586	0.99
123_N	161_E	0.585	0.99
118_Y	198_Y	0.585	0.99
24_L	124_E	0.580	0.98
196_L	206_Q	0.580	0.98
230_T	244_T	0.577	0.98
59_F	78_A	0.576	0.98
103_Y	150_G	0.576	0.98
205_S	236_I	0.575	0.98
38_A	42_K	0.574	0.98
155_A	159_P	0.572	0.98
33_Y	70_A	0.572	0.98
64_G	260_S	0.572	0.98
183_A	186_A	0.572	0.98
32_V	75_I	0.570	0.98
56_E	60_I	0.569	0.98
217_Q	221_D	0.568	0.98
58_N	61_T	0.567	0.98
136_T	139_K	0.564	0.98
65_M	68_Y	0.564	0.98
114_H	150_G	0.561	0.98
142_S	266_H	0.560	0.98
51_G	145_S	0.560	0.98
220_S	250_E	0.559	0.98
208_Q	240_M	0.557	0.98
59_F	65_M	0.556	0.98
245_L	265_E	0.555	0.98
50_S	54_C	0.552	0.98
34_L	133_F	0.552	0.98
205_S	208_Q	0.550	0.98
14_Q	66_Q	0.548	0.98
216_D	258_F	0.547	0.98
255_S	258_F	0.547	0.98
102_F	146_M	0.545	0.98
97_G	100_A	0.535	0.97
57_Q	60_I	0.535	0.97
68_Y	268_A	0.531	0.97
103_Y	106_A	0.528	0.97
46_L	140_S	0.528	0.97
201_V	236_I	0.527	0.97
28_M	125_L	0.526	0.97
58_N	144_H	0.525	0.97
46_L	267_I	0.523	0.97
261_S	264_G	0.522	0.97
37_K	41_E	0.522	0.97
64_G	69_A	0.521	0.97
100_A	106_A	0.520	0.97
33_Y	76_V	0.520	0.97
225_A	229_R	0.520	0.97
129_V	133_F	0.519	0.97
214_M	266_H	0.517	0.97
75_I	134_P	0.517	0.97
60_I	66_Q	0.517	0.97
186_A	189_A	0.515	0.97
184_F	188_L	0.514	0.97
163_V	211_A	0.513	0.97
20_Y	23_S	0.511	0.97
58_N	62_K	0.509	0.97
79_P	125_L	0.507	0.97
59_F	259_V	0.506	0.96
45_V	129_V	0.505	0.96
135_A	139_K	0.505	0.96
154_L	162_Y	0.504	0.96
60_I	63_S	0.503	0.96
28_M	81_T	0.501	0.96
50_S	79_P	0.500	0.96
173_S	176_Q	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ls2A	2	0.9928	100	0.356	Contact Map
3i6yA	1	0.9964	100	0.391	Contact Map
3e4dA	3	0.9928	100	0.394	Contact Map
4folA	2	0.9783	100	0.401	Contact Map
3fcxA	2	0.9928	100	0.426	Contact Map
4b6gA	1	0.9928	100	0.433	Contact Map
4rotA	4	0.8809	100	0.45	Contact Map
2uz0A	4	0.8592	100	0.456	Contact Map
4w9rA	2	0.8195	100	0.456	Contact Map
4h18A	3	0.917	100	0.466	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.