GREMLIN Database
YAIL - Uncharacterized protein YaiL
UniProt: P51024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13294
Length: 179 (170)
Sequences: 475 (290)
Seq/√Len: 22.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_Q58_E4.2451.00
95_D132_Y3.9251.00
44_E48_A3.5421.00
95_D121_R3.4881.00
81_R133_A2.9830.99
43_E46_K2.8520.99
58_E62_Q2.7210.99
120_A135_I2.6970.99
73_V147_D2.6740.99
88_D106_K2.5620.98
55_Q59_Q2.4500.98
4_L8_E2.4300.98
73_V149_S2.3810.97
90_G103_F2.3600.97
118_A140_A2.3330.97
105_D108_T2.2270.96
42_V45_N2.1720.95
90_G101_K2.1620.95
120_A151_I2.0970.95
45_N49_Q2.0830.94
49_Q53_D2.0800.94
64_A68_E1.9950.93
17_T20_K1.9430.92
61_K65_L1.9200.91
57_S68_E1.8850.91
91_F153_L1.8490.90
59_Q63_A1.8120.89
47_K50_L1.7950.88
72_Q146_R1.7640.87
82_I117_L1.7470.87
93_F132_Y1.6970.85
169_A172_K1.6750.84
141_D154_H1.6710.84
104_V112_L1.6210.82
135_I151_I1.6130.82
62_Q99_I1.6130.82
52_R173_V1.5040.77
138_S141_D1.4470.74
73_V99_I1.4300.74
48_A52_R1.4210.73
71_A142_K1.4090.72
51_E55_Q1.3960.72
51_E54_K1.3670.70
58_E61_K1.3650.70
72_Q142_K1.3440.69
7_Q11_L1.3410.69
108_T134_I1.3250.68
142_K146_R1.3240.68
120_A133_A1.2910.66
167_P170_D1.2710.64
174_P179_W1.2500.63
57_S60_Q1.2450.63
20_K24_V1.2100.60
4_L12_K1.2010.60
40_A43_E1.1910.59
68_E173_V1.1890.59
63_A84_I1.1800.58
173_V178_M1.1760.58
65_L68_E1.1690.58
54_K58_E1.1650.57
104_V142_K1.1630.57
84_I133_A1.1620.57
175_D179_W1.1280.55
122_L165_D1.1150.54
167_P178_M1.1030.53
38_A42_V1.0940.53
176_D179_W1.0710.51
64_A99_I1.0580.50
6_L10_L1.0570.50
89_I109_Q1.0520.50
174_P177_L1.0510.50
99_I102_I1.0470.49
19_K26_R1.0340.49
37_E41_A1.0310.48
83_T86_N1.0250.48
67_K163_D1.0230.48
33_V36_R1.0210.48
8_E21_A1.0040.46
168_Y175_D0.9910.46
68_E72_Q0.9890.45
60_Q63_A0.9760.45
167_P172_K0.9750.45
22_A57_S0.9670.44
118_A137_A0.9600.43
59_Q102_I0.9560.43
23_K38_A0.9540.43
107_L173_V0.9510.43
87_G164_E0.9460.43
41_A44_E0.9400.42
64_A72_Q0.9390.42
71_A146_R0.9380.42
13_A88_D0.9280.41
163_D167_P0.9080.40
162_Q167_P0.8950.39
164_E167_P0.8940.39
69_Y72_Q0.8900.39
74_K99_I0.8860.39
65_L72_Q0.8810.38
168_Y174_P0.8700.38
168_Y179_W0.8700.38
76_L79_M0.8650.37
6_L9_Q0.8600.37
80_N102_I0.8540.37
72_Q139_V0.8490.36
61_K64_A0.8450.36
25_E33_V0.8400.36
4_L21_A0.8380.36
109_Q173_V0.8310.35
101_K130_G0.8290.35
103_F131_E0.8240.35
106_K110_A0.8230.35
8_E94_T0.8170.34
134_I148_A0.8060.34
7_Q25_E0.7980.33
42_V142_K0.7950.33
60_Q101_K0.7950.33
105_D117_L0.7940.33
112_L119_I0.7940.33
162_Q172_K0.7910.33
82_I112_L0.7900.33
136_P146_R0.7880.32
73_V143_I0.7870.32
57_S61_K0.7850.32
119_I158_S0.7800.32
102_I158_S0.7770.32
106_K134_I0.7700.31
20_K94_T0.7700.31
41_A45_N0.7700.31
109_Q113_I0.7690.31
80_N138_S0.7680.31
135_I143_I0.7660.31
37_E66_A0.7640.31
16_V163_D0.7580.31
21_A24_V0.7550.31
138_S162_Q0.7510.30
107_L110_A0.7500.30
25_E28_A0.7490.30
30_K34_Q0.7480.30
76_L139_V0.7460.30
101_K109_Q0.7460.30
22_A26_R0.7380.30
92_N101_K0.7340.29
152_V155_S0.7290.29
73_V150_S0.7250.29
85_A88_D0.7240.29
23_K29_K0.7230.29
161_E164_E0.7230.29
90_G135_I0.7230.29
49_Q100_K0.7220.29
42_V159_A0.7110.28
98_L166_D0.7110.28
56_L169_A0.7080.28
7_Q20_K0.7040.28
23_K80_N0.7010.27
34_Q102_I0.6970.27
5_T21_A0.6960.27
9_Q14_G0.6950.27
8_E31_S0.6910.27
66_A108_T0.6900.27
106_K156_A0.6900.27
77_I120_A0.6830.27
50_L134_I0.6830.27
21_A49_Q0.6810.26
43_E47_K0.6800.26
166_D169_A0.6760.26
59_Q62_Q0.6740.26
44_E82_I0.6730.26
167_P171_F0.6720.26
87_G105_D0.6660.26
12_K16_V0.6630.25
28_A32_R0.6610.25
67_K173_V0.6600.25
168_Y176_D0.6560.25
115_G166_D0.6520.25
168_Y171_F0.6500.25
77_I81_R0.6430.24
26_R71_A0.6430.24
101_K173_V0.6390.24
50_L163_D0.6380.24
139_V142_K0.6370.24
33_V63_A0.6320.24
148_A156_A0.6320.24
39_R131_E0.6320.24
121_R171_F0.6290.24
168_Y177_L0.6230.23
15_L21_A0.6230.23
70_K99_I0.6150.23
8_E170_D0.6150.23
25_E137_A0.6140.23
52_R56_L0.6100.23
25_E34_Q0.6080.23
139_V146_R0.6080.23
32_R97_N0.6010.22
4_L7_Q0.5980.22
12_K15_L0.5980.22
71_A93_F0.5970.22
20_K23_K0.5970.22
29_K67_K0.5970.22
71_A99_I0.5940.22
105_D158_S0.5930.22
102_I118_A0.5930.22
135_I139_V0.5930.22
79_M171_F0.5910.22
119_I152_V0.5900.22
70_K147_D0.5890.22
8_E33_V0.5850.22
20_K164_E0.5800.21
141_D145_Q0.5760.21
42_V52_R0.5670.21
69_Y143_I0.5640.21
10_L14_G0.5620.21
162_Q166_D0.5610.21
90_G172_K0.5610.21
56_L75_Q0.5600.21
18_S24_V0.5600.21
16_V91_F0.5500.20
49_Q59_Q0.5500.20
7_Q94_T0.5420.20
23_K33_V0.5420.20
37_E51_E0.5400.20
59_Q110_A0.5390.20
43_E50_L0.5380.20
73_V155_S0.5380.20
72_Q136_P0.5380.20
71_A143_I0.5360.19
6_L14_G0.5330.19
47_K51_E0.5330.19
47_K58_E0.5300.19
65_L162_Q0.5290.19
102_I120_A0.5280.19
52_R93_F0.5270.19
58_E171_F0.5270.19
73_V134_I0.5260.19
24_V106_K0.5260.19
69_Y114_N0.5250.19
59_Q87_G0.5250.19
74_K92_N0.5250.19
38_A41_A0.5240.19
41_A83_T0.5220.19
77_I155_S0.5180.19
49_Q109_Q0.5170.19
137_A154_H0.5160.19
50_L160_E0.5150.19
46_K129_E0.5150.19
110_A114_N0.5110.18
98_L114_N0.5090.18
74_K78_E0.5080.18
53_D56_L0.5080.18
84_I108_T0.5080.18
54_K66_A0.5060.18
74_K129_E0.5060.18
22_A27_T0.5020.18
18_S33_V0.5010.18
50_L64_A0.5000.18
46_K114_N0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pkhA 5 0.3631 11.1 0.96 Contact Map
4ogeA 1 0.8715 8.5 0.962 Contact Map
3vhjA 1 0.4581 6.7 0.964 Contact Map
4ujrT 1 0.1844 6.3 0.964 Contact Map
4a18L 1 0.1508 5.6 0.965 Contact Map
2id0A 1 0.5754 5.3 0.965 Contact Map
3lzdA 2 0.1788 4.7 0.966 Contact Map
1n81A 1 0.5866 4.7 0.966 Contact Map
3u5eg 1 0.1844 4.5 0.966 Contact Map
1tj7A 4 0.514 4.5 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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