GREMLIN Database
HOA - 4-hydroxy-2-oxovalerate aldolase
UniProt: P51020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13292
Length: 337 (288)
Sequences: 9718 (4804)
Seq/√Len: 283.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_R161_T3.2481.00
178_R215_E3.2021.00
102_A140_S2.9091.00
196_M212_A2.8921.00
38_D256_A2.8741.00
290_S294_H2.7201.00
178_R214_E2.6561.00
153_K187_E2.6081.00
111_T114_T2.5161.00
120_A124_Q2.4471.00
101_Q112_H2.3301.00
211_A214_E2.2681.00
182_R215_E2.2541.00
47_A66_D2.2151.00
145_P183_A2.2121.00
110_A118_V2.1641.00
25_S28_N2.1621.00
152_A163_I2.0921.00
182_R186_A1.9761.00
256_A259_D1.9681.00
154_L157_G1.9611.00
147_N150_K1.9571.00
175_S214_E1.9471.00
120_A154_L1.9401.00
209_S239_F1.9171.00
185_K218_D1.9151.00
153_K157_G1.9081.00
253_D256_A1.8961.00
213_V220_I1.8881.00
183_A187_E1.8791.00
35_A260_A1.8491.00
185_K194_T1.8361.00
30_R72_A1.8221.00
5_K249_Q1.8201.00
177_I198_A1.8131.00
113_C150_K1.8041.00
210_I242_A1.7781.00
120_A158_Y1.7781.00
106_V295_C1.7711.00
149_A183_A1.7601.00
117_D121_Q1.7521.00
240_I252_T1.7381.00
117_D120_A1.7171.00
178_R182_R1.7121.00
49_G71_E1.6961.00
126_A133_T1.6701.00
211_A215_E1.6601.00
35_A259_D1.6231.00
209_S220_I1.6021.00
244_D249_Q1.5791.00
124_Q128_E1.5751.00
119_S151_Q1.5711.00
198_A209_S1.5381.00
178_R211_A1.5281.00
150_K154_L1.5161.00
213_V243_A1.5111.00
132_D161_T1.4931.00
153_K188_L1.4901.00
265_V269_Q1.4821.00
35_A38_D1.4781.00
37_D67_L1.4741.00
196_M220_I1.4741.00
175_S179_D1.4721.00
104_A115_E1.4671.00
149_A187_E1.4661.00
156_E189_K1.4561.00
177_I196_M1.4511.00
125_Y128_E1.4501.00
146_E150_K1.4441.00
86_L129_L1.4371.00
123_I133_T1.4281.00
37_D66_D1.4101.00
80_A83_A1.4101.00
203_S238_V1.4011.00
181_F196_M1.4001.00
113_C117_D1.3981.00
99_A143_T1.3941.00
225_A261_A1.3651.00
110_A114_T1.3631.00
156_E192_T1.3481.00
101_Q144_T1.3421.00
240_I257_L1.3321.00
39_A260_A1.3291.00
209_S234_A1.3211.00
7_Y43_S1.3201.00
222_A236_L1.3171.00
125_Y129_L1.3141.00
107_V138_M1.3041.00
114_T117_D1.2991.00
82_I129_L1.2981.00
146_E183_A1.2971.00
172_M177_I1.2961.00
31_Q35_A1.2641.00
258_M262_D1.2621.00
53_Q57_F1.2581.00
57_F61_F1.2551.00
60_G64_H1.2461.00
140_S143_T1.2411.00
179_D183_A1.2401.00
83_A125_Y1.2391.00
35_A264_L1.2361.00
193_Q218_D1.2351.00
104_A112_H1.2331.00
165_V180_R1.2251.00
41_V252_T1.2191.00
26_L61_F1.2161.00
165_V184_L1.2141.00
183_A186_A1.2121.00
145_P179_D1.2101.00
69_W72_A1.1961.00
6_L248_W1.1941.00
136_F171_A1.1851.00
15_D233_N1.1811.00
218_D248_W1.1801.00
13_L33_A1.1701.00
196_M217_C1.1701.00
181_F194_T1.1661.00
31_Q267_P1.1651.00
241_A254_L1.1631.00
198_A212_A1.1571.00
61_F64_H1.1491.00
142_M176_D1.1461.00
5_K251_G1.1441.00
72_A75_D1.1431.00
244_D250_H1.1341.00
265_V270_D1.1321.00
152_A184_L1.1301.00
153_K156_E1.1241.00
234_A239_F1.1131.00
177_I212_A1.1121.00
135_G155_M1.1101.00
188_L192_T1.1051.00
32_I265_V1.1001.00
35_A256_A1.0961.00
26_L65_S1.0951.00
152_A188_L1.0911.00
135_G151_Q1.0891.00
97_K104_A1.0851.00
222_A239_F1.0811.00
6_L213_V1.0621.00
119_S155_M1.0561.00
34_K37_D1.0541.00
154_L158_Y1.0531.00
120_A157_G1.0511.00
116_A151_Q1.0451.00
181_F215_E1.0451.00
98_N103_G1.0421.00
82_I86_L1.0421.00
75_D91_G1.0371.00
28_N267_P1.0361.00
205_G234_A1.0341.00
149_A153_K1.0321.00
123_I158_Y1.0291.00
99_A151_Q1.0281.00
102_A106_V1.0271.00
144_T147_N1.0261.00
173_N176_D1.0231.00
36_L44_I1.0131.00
264_L268_L1.0121.00
132_D162_C1.0031.00
68_E72_A0.9991.00
11_V233_N0.9951.00
224_L260_A0.9911.00
110_A115_E0.9871.00
57_F60_G0.9821.00
7_Y219_R0.9771.00
82_I122_H0.9741.00
98_N101_Q0.9681.00
112_H147_N0.9591.00
7_Y193_Q0.9571.00
30_R69_W0.9541.00
9_S219_R0.9511.00
267_P270_D0.9481.00
206_V242_A0.9471.00
149_A184_L0.9431.00
77_V121_Q0.9431.00
28_N31_Q0.9431.00
181_F217_C0.9411.00
238_V273_V0.9391.00
17_M24_Y0.9331.00
135_G160_A0.9311.00
67_L84_T0.9281.00
145_P149_A0.9251.00
100_W131_M0.9251.00
34_K76_V0.9171.00
8_I240_I0.9091.00
213_V248_W0.9041.00
121_Q125_Y0.9041.00
8_I222_A0.9031.00
145_P180_R0.8981.00
43_S132_D0.8981.00
116_A154_L0.8961.00
121_Q124_Q0.8951.00
235_P238_V0.8921.00
264_L269_Q0.8911.00
13_L44_I0.8911.00
200_H203_S0.8901.00
137_L140_S0.8881.00
26_L30_R0.8811.00
105_R109_V0.8811.00
239_F243_A0.8791.00
116_A158_Y0.8711.00
206_V239_F0.8631.00
5_K42_D0.8621.00
82_I125_Y0.8611.00
86_L131_M0.8611.00
101_Q105_R0.8611.00
150_K153_K0.8611.00
162_C219_R0.8551.00
72_A78_K0.8531.00
83_A86_L0.8511.00
175_S211_A0.8461.00
210_I246_L0.8421.00
176_D179_D0.8411.00
112_H144_T0.8391.00
75_D79_H0.8301.00
149_A188_L0.8301.00
134_V162_C0.8301.00
75_D78_K0.8291.00
11_V45_E0.8281.00
64_H87_L0.8271.00
185_K191_E0.8261.00
42_D251_G0.8221.00
124_Q158_Y0.8191.00
181_F212_A0.8181.00
7_Y42_D0.8171.00
47_A70_I0.8160.99
105_R111_T0.8150.99
141_H172_M0.8140.99
34_K74_A0.8140.99
220_I239_F0.8070.99
262_D266_R0.8060.99
92_T132_D0.8050.99
194_T217_C0.8000.99
210_I214_E0.7960.99
271_R278_E0.7940.99
10_D236_L0.7900.99
153_K189_K0.7870.99
137_L152_A0.7830.99
30_R34_K0.7820.99
47_A63_A0.7810.99
24_Y269_Q0.7800.99
94_H97_K0.7740.99
184_L188_L0.7730.99
181_F185_K0.7720.99
33_A58_N0.7710.99
156_E188_L0.7700.99
85_L90_I0.7680.99
164_Y195_G0.7670.99
195_G219_R0.7650.99
180_R183_A0.7640.99
179_D182_R0.7630.99
107_V290_S0.7620.99
176_D180_R0.7620.99
33_A77_V0.7610.99
68_E132_D0.7610.99
74_A77_V0.7580.99
167_D208_N0.7580.99
9_S43_S0.7530.99
242_A246_L0.7520.99
26_L29_V0.7500.99
266_R269_Q0.7500.99
6_L218_D0.7480.99
27_E61_F0.7480.99
6_L243_A0.7470.99
94_H164_Y0.7460.99
7_Y162_C0.7450.99
38_D259_D0.7440.99
137_L141_H0.7430.99
24_Y268_L0.7400.99
32_I224_L0.7390.99
136_F143_T0.7360.99
112_H150_K0.7320.99
156_E163_I0.7300.99
134_V195_G0.7270.99
146_E187_E0.7260.99
180_R184_L0.7260.99
175_S178_R0.7260.99
96_L166_V0.7240.99
24_Y29_V0.7230.99
173_N246_L0.7210.99
155_M160_A0.7170.99
62_G69_W0.7160.99
34_K75_D0.7140.99
240_I254_L0.7110.99
152_A165_V0.7110.99
31_Q34_K0.7100.99
266_R270_D0.7060.99
94_H134_V0.7060.99
109_V294_H0.7040.99
19_A22_H0.7040.99
146_E149_A0.7020.98
39_A257_L0.7010.98
185_K215_E0.6990.98
223_S232_G0.6970.98
203_S235_P0.6950.98
8_I236_L0.6910.98
49_G59_Y0.6910.98
69_W74_A0.6860.98
60_G87_L0.6860.98
156_E193_Q0.6860.98
214_E246_L0.6850.98
70_I78_K0.6840.98
74_A78_K0.6830.98
34_K38_D0.6810.98
32_I36_L0.6760.98
207_A211_A0.6750.98
27_E31_Q0.6750.98
213_V239_F0.6740.98
74_A79_H0.6730.98
101_Q104_A0.6730.98
96_L287_V0.6730.98
83_A87_L0.6720.98
116_A150_K0.6710.98
5_K248_W0.6690.98
214_E248_W0.6680.98
71_E102_A0.6660.98
244_D254_L0.6660.98
177_I208_N0.6650.98
244_D247_G0.6610.98
27_E72_A0.6610.98
97_K119_S0.6590.98
31_Q264_L0.6570.98
118_V121_Q0.6560.98
95_D122_H0.6460.97
90_I131_M0.6460.97
200_H205_G0.6440.97
41_V236_L0.6410.97
51_G59_Y0.6400.97
175_S246_L0.6400.97
59_Y109_V0.6390.97
85_L91_G0.6380.97
206_V209_S0.6350.97
100_W143_T0.6350.97
220_I243_A0.6350.97
136_F166_V0.6320.97
72_A77_V0.6260.97
238_V274_R0.6240.97
97_K135_G0.6230.97
165_V181_F0.6220.97
113_C116_A0.6210.97
265_V268_L0.6200.97
141_H180_R0.6190.97
114_T118_V0.6180.97
264_L270_D0.6170.97
120_A155_M0.6160.97
139_M142_M0.6120.96
65_S68_E0.6120.96
104_A143_T0.6100.96
43_S92_T0.6090.96
16_G223_S0.6070.96
151_Q154_L0.6050.96
136_F142_M0.6040.96
172_M176_D0.6010.96
188_L194_T0.5990.96
134_V164_Y0.5970.96
9_S94_H0.5960.96
136_F164_Y0.5950.96
172_M180_R0.5910.96
8_I250_H0.5900.96
117_D154_L0.5880.96
33_A46_V0.5850.95
132_D135_G0.5840.95
206_V238_V0.5800.95
53_Q80_A0.5790.95
70_I73_A0.5780.95
167_D170_G0.5780.95
108_R115_E0.5770.95
73_A77_V0.5760.95
104_A144_T0.5710.95
184_L194_T0.5700.95
70_I75_D0.5700.95
46_V82_I0.5660.95
9_S195_G0.5650.94
18_H229_A0.5640.94
69_W73_A0.5640.94
209_S233_N0.5630.94
113_C154_L0.5610.94
37_D65_S0.5600.94
33_A44_I0.5600.94
11_V15_D0.5570.94
30_R73_A0.5560.94
161_T193_Q0.5550.94
260_A264_L0.5550.94
30_R61_F0.5510.94
206_V234_A0.5510.94
39_A256_A0.5510.94
138_M143_T0.5490.94
200_H206_V0.5480.94
181_F184_L0.5460.93
8_I41_V0.5440.93
104_A110_A0.5430.93
44_I77_V0.5420.93
43_S219_R0.5420.93
42_D252_T0.5410.93
287_V290_S0.5400.93
19_A227_M0.5400.93
13_L36_L0.5380.93
137_L163_I0.5380.93
94_H221_D0.5380.93
73_A76_V0.5380.93
70_I90_I0.5380.93
200_H274_R0.5370.93
162_C193_Q0.5360.93
96_L135_G0.5350.93
19_A272_P0.5330.93
236_L257_L0.5300.92
240_I250_H0.5270.92
67_L71_E0.5270.92
254_L258_M0.5270.92
283_G288_Y0.5260.92
37_D73_A0.5240.92
124_Q127_R0.5240.92
262_D267_P0.5240.92
271_R279_T0.5220.92
173_N204_L0.5210.92
258_M278_E0.5210.92
128_E131_M0.5200.92
201_N230_G0.5200.92
76_V79_H0.5190.92
112_H115_E0.5170.91
259_D262_D0.5170.91
237_E261_A0.5170.91
147_N151_Q0.5150.91
70_I92_T0.5120.91
59_Y63_A0.5110.91
238_V241_A0.5100.91
65_S89_G0.5080.91
272_P277_R0.5030.90
48_H287_V0.5030.90
292_L296_E0.5010.90
274_R277_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ov4A 2 0.9644 100 0.129 Contact Map
2ztjA 2 0.8902 100 0.153 Contact Map
3ivsA 2 0.9407 100 0.166 Contact Map
3rmjA 2 0.8694 100 0.167 Contact Map
3bleA 2 0.8605 100 0.174 Contact Map
3hq1A 2 0.9822 100 0.177 Contact Map
3eegA 2 0.7685 100 0.248 Contact Map
3bg3A 4 0.9496 100 0.287 Contact Map
4jn6A 2 0.9911 100 0.291 Contact Map
2nx9A 2 0.8991 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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