HOA - ECOLI - GREMLIN Contacts

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HOA - 4-hydroxy-2-oxovalerate aldolase

UniProt:	P51020	Sequences: MNGKKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGAHSDLEWIEAAADVVKHAKIATLLLPGIGTIHDLKNAWQAGARVVRVATHCTEADVSAQHIQYARELGMDTVGFLMMSHMTTPENLAKQAKLMEGYGATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCDRIDASLAGMGAGAGNAPLEVFIAAADKLGWQHGTDLYALMDAADDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHCETAAARYGLSAVDILVELGKRRMVGGQEDMIVDVALDLRNNK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13292
Length:	337 (288)
Sequences:	9718 (4804)
Seq/√Len:	283.1

ECOLI - HOA LEU1
BACSU - LEU1 HMGCL PYC
SULSO - HOSA Q980Z1 LEU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
127_R	161_T	3.248	1.00
178_R	215_E	3.202	1.00
102_A	140_S	2.909	1.00
196_M	212_A	2.892	1.00
38_D	256_A	2.874	1.00
290_S	294_H	2.720	1.00
178_R	214_E	2.656	1.00
153_K	187_E	2.608	1.00
111_T	114_T	2.516	1.00
120_A	124_Q	2.447	1.00
101_Q	112_H	2.330	1.00
211_A	214_E	2.268	1.00
182_R	215_E	2.254	1.00
47_A	66_D	2.215	1.00
145_P	183_A	2.212	1.00
110_A	118_V	2.164	1.00
25_S	28_N	2.162	1.00
152_A	163_I	2.092	1.00
182_R	186_A	1.976	1.00
256_A	259_D	1.968	1.00
154_L	157_G	1.961	1.00
147_N	150_K	1.957	1.00
175_S	214_E	1.947	1.00
120_A	154_L	1.940	1.00
209_S	239_F	1.917	1.00
185_K	218_D	1.915	1.00
153_K	157_G	1.908	1.00
253_D	256_A	1.896	1.00
213_V	220_I	1.888	1.00
183_A	187_E	1.879	1.00
35_A	260_A	1.849	1.00
185_K	194_T	1.836	1.00
30_R	72_A	1.822	1.00
5_K	249_Q	1.820	1.00
177_I	198_A	1.813	1.00
113_C	150_K	1.804	1.00
210_I	242_A	1.778	1.00
120_A	158_Y	1.778	1.00
106_V	295_C	1.771	1.00
149_A	183_A	1.760	1.00
117_D	121_Q	1.752	1.00
240_I	252_T	1.738	1.00
117_D	120_A	1.717	1.00
178_R	182_R	1.712	1.00
49_G	71_E	1.696	1.00
126_A	133_T	1.670	1.00
211_A	215_E	1.660	1.00
35_A	259_D	1.623	1.00
209_S	220_I	1.602	1.00
244_D	249_Q	1.579	1.00
124_Q	128_E	1.575	1.00
119_S	151_Q	1.571	1.00
198_A	209_S	1.538	1.00
178_R	211_A	1.528	1.00
150_K	154_L	1.516	1.00
213_V	243_A	1.511	1.00
132_D	161_T	1.493	1.00
153_K	188_L	1.490	1.00
265_V	269_Q	1.482	1.00
35_A	38_D	1.478	1.00
37_D	67_L	1.474	1.00
196_M	220_I	1.474	1.00
175_S	179_D	1.472	1.00
104_A	115_E	1.467	1.00
149_A	187_E	1.466	1.00
156_E	189_K	1.456	1.00
177_I	196_M	1.451	1.00
125_Y	128_E	1.450	1.00
146_E	150_K	1.444	1.00
86_L	129_L	1.437	1.00
123_I	133_T	1.428	1.00
37_D	66_D	1.410	1.00
80_A	83_A	1.410	1.00
203_S	238_V	1.401	1.00
181_F	196_M	1.400	1.00
113_C	117_D	1.398	1.00
99_A	143_T	1.394	1.00
225_A	261_A	1.365	1.00
110_A	114_T	1.363	1.00
156_E	192_T	1.348	1.00
101_Q	144_T	1.342	1.00
240_I	257_L	1.332	1.00
39_A	260_A	1.329	1.00
209_S	234_A	1.321	1.00
7_Y	43_S	1.320	1.00
222_A	236_L	1.317	1.00
125_Y	129_L	1.314	1.00
107_V	138_M	1.304	1.00
114_T	117_D	1.299	1.00
82_I	129_L	1.298	1.00
146_E	183_A	1.297	1.00
172_M	177_I	1.296	1.00
31_Q	35_A	1.264	1.00
258_M	262_D	1.262	1.00
53_Q	57_F	1.258	1.00
57_F	61_F	1.255	1.00
60_G	64_H	1.246	1.00
140_S	143_T	1.241	1.00
179_D	183_A	1.240	1.00
83_A	125_Y	1.239	1.00
35_A	264_L	1.236	1.00
193_Q	218_D	1.235	1.00
104_A	112_H	1.233	1.00
165_V	180_R	1.225	1.00
41_V	252_T	1.219	1.00
26_L	61_F	1.216	1.00
165_V	184_L	1.214	1.00
183_A	186_A	1.212	1.00
145_P	179_D	1.210	1.00
69_W	72_A	1.196	1.00
6_L	248_W	1.194	1.00
136_F	171_A	1.185	1.00
15_D	233_N	1.181	1.00
218_D	248_W	1.180	1.00
13_L	33_A	1.170	1.00
196_M	217_C	1.170	1.00
181_F	194_T	1.166	1.00
31_Q	267_P	1.165	1.00
241_A	254_L	1.163	1.00
198_A	212_A	1.157	1.00
61_F	64_H	1.149	1.00
142_M	176_D	1.146	1.00
5_K	251_G	1.144	1.00
72_A	75_D	1.143	1.00
244_D	250_H	1.134	1.00
265_V	270_D	1.132	1.00
152_A	184_L	1.130	1.00
153_K	156_E	1.124	1.00
234_A	239_F	1.113	1.00
177_I	212_A	1.112	1.00
135_G	155_M	1.110	1.00
188_L	192_T	1.105	1.00
32_I	265_V	1.100	1.00
35_A	256_A	1.096	1.00
26_L	65_S	1.095	1.00
152_A	188_L	1.091	1.00
135_G	151_Q	1.089	1.00
97_K	104_A	1.085	1.00
222_A	239_F	1.081	1.00
6_L	213_V	1.062	1.00
119_S	155_M	1.056	1.00
34_K	37_D	1.054	1.00
154_L	158_Y	1.053	1.00
120_A	157_G	1.051	1.00
116_A	151_Q	1.045	1.00
181_F	215_E	1.045	1.00
98_N	103_G	1.042	1.00
82_I	86_L	1.042	1.00
75_D	91_G	1.037	1.00
28_N	267_P	1.036	1.00
205_G	234_A	1.034	1.00
149_A	153_K	1.032	1.00
123_I	158_Y	1.029	1.00
99_A	151_Q	1.028	1.00
102_A	106_V	1.027	1.00
144_T	147_N	1.026	1.00
173_N	176_D	1.023	1.00
36_L	44_I	1.013	1.00
264_L	268_L	1.012	1.00
132_D	162_C	1.003	1.00
68_E	72_A	0.999	1.00
11_V	233_N	0.995	1.00
224_L	260_A	0.991	1.00
110_A	115_E	0.987	1.00
57_F	60_G	0.982	1.00
7_Y	219_R	0.977	1.00
82_I	122_H	0.974	1.00
98_N	101_Q	0.968	1.00
112_H	147_N	0.959	1.00
7_Y	193_Q	0.957	1.00
30_R	69_W	0.954	1.00
9_S	219_R	0.951	1.00
267_P	270_D	0.948	1.00
206_V	242_A	0.947	1.00
149_A	184_L	0.943	1.00
77_V	121_Q	0.943	1.00
28_N	31_Q	0.943	1.00
181_F	217_C	0.941	1.00
238_V	273_V	0.939	1.00
17_M	24_Y	0.933	1.00
135_G	160_A	0.931	1.00
67_L	84_T	0.928	1.00
145_P	149_A	0.925	1.00
100_W	131_M	0.925	1.00
34_K	76_V	0.917	1.00
8_I	240_I	0.909	1.00
213_V	248_W	0.904	1.00
121_Q	125_Y	0.904	1.00
8_I	222_A	0.903	1.00
145_P	180_R	0.898	1.00
43_S	132_D	0.898	1.00
116_A	154_L	0.896	1.00
121_Q	124_Q	0.895	1.00
235_P	238_V	0.892	1.00
264_L	269_Q	0.891	1.00
13_L	44_I	0.891	1.00
200_H	203_S	0.890	1.00
137_L	140_S	0.888	1.00
26_L	30_R	0.881	1.00
105_R	109_V	0.881	1.00
239_F	243_A	0.879	1.00
116_A	158_Y	0.871	1.00
206_V	239_F	0.863	1.00
5_K	42_D	0.862	1.00
82_I	125_Y	0.861	1.00
86_L	131_M	0.861	1.00
101_Q	105_R	0.861	1.00
150_K	153_K	0.861	1.00
162_C	219_R	0.855	1.00
72_A	78_K	0.853	1.00
83_A	86_L	0.851	1.00
175_S	211_A	0.846	1.00
210_I	246_L	0.842	1.00
176_D	179_D	0.841	1.00
112_H	144_T	0.839	1.00
75_D	79_H	0.830	1.00
149_A	188_L	0.830	1.00
134_V	162_C	0.830	1.00
75_D	78_K	0.829	1.00
11_V	45_E	0.828	1.00
64_H	87_L	0.827	1.00
185_K	191_E	0.826	1.00
42_D	251_G	0.822	1.00
124_Q	158_Y	0.819	1.00
181_F	212_A	0.818	1.00
7_Y	42_D	0.817	1.00
47_A	70_I	0.816	0.99
105_R	111_T	0.815	0.99
141_H	172_M	0.814	0.99
34_K	74_A	0.814	0.99
220_I	239_F	0.807	0.99
262_D	266_R	0.806	0.99
92_T	132_D	0.805	0.99
194_T	217_C	0.800	0.99
210_I	214_E	0.796	0.99
271_R	278_E	0.794	0.99
10_D	236_L	0.790	0.99
153_K	189_K	0.787	0.99
137_L	152_A	0.783	0.99
30_R	34_K	0.782	0.99
47_A	63_A	0.781	0.99
24_Y	269_Q	0.780	0.99
94_H	97_K	0.774	0.99
184_L	188_L	0.773	0.99
181_F	185_K	0.772	0.99
33_A	58_N	0.771	0.99
156_E	188_L	0.770	0.99
85_L	90_I	0.768	0.99
164_Y	195_G	0.767	0.99
195_G	219_R	0.765	0.99
180_R	183_A	0.764	0.99
179_D	182_R	0.763	0.99
107_V	290_S	0.762	0.99
176_D	180_R	0.762	0.99
33_A	77_V	0.761	0.99
68_E	132_D	0.761	0.99
74_A	77_V	0.758	0.99
167_D	208_N	0.758	0.99
9_S	43_S	0.753	0.99
242_A	246_L	0.752	0.99
26_L	29_V	0.750	0.99
266_R	269_Q	0.750	0.99
6_L	218_D	0.748	0.99
27_E	61_F	0.748	0.99
6_L	243_A	0.747	0.99
94_H	164_Y	0.746	0.99
7_Y	162_C	0.745	0.99
38_D	259_D	0.744	0.99
137_L	141_H	0.743	0.99
24_Y	268_L	0.740	0.99
32_I	224_L	0.739	0.99
136_F	143_T	0.736	0.99
112_H	150_K	0.732	0.99
156_E	163_I	0.730	0.99
134_V	195_G	0.727	0.99
146_E	187_E	0.726	0.99
180_R	184_L	0.726	0.99
175_S	178_R	0.726	0.99
96_L	166_V	0.724	0.99
24_Y	29_V	0.723	0.99
173_N	246_L	0.721	0.99
155_M	160_A	0.717	0.99
62_G	69_W	0.716	0.99
34_K	75_D	0.714	0.99
240_I	254_L	0.711	0.99
152_A	165_V	0.711	0.99
31_Q	34_K	0.710	0.99
266_R	270_D	0.706	0.99
94_H	134_V	0.706	0.99
109_V	294_H	0.704	0.99
19_A	22_H	0.704	0.99
146_E	149_A	0.702	0.98
39_A	257_L	0.701	0.98
185_K	215_E	0.699	0.98
223_S	232_G	0.697	0.98
203_S	235_P	0.695	0.98
8_I	236_L	0.691	0.98
49_G	59_Y	0.691	0.98
69_W	74_A	0.686	0.98
60_G	87_L	0.686	0.98
156_E	193_Q	0.686	0.98
214_E	246_L	0.685	0.98
70_I	78_K	0.684	0.98
74_A	78_K	0.683	0.98
34_K	38_D	0.681	0.98
32_I	36_L	0.676	0.98
207_A	211_A	0.675	0.98
27_E	31_Q	0.675	0.98
213_V	239_F	0.674	0.98
74_A	79_H	0.673	0.98
101_Q	104_A	0.673	0.98
96_L	287_V	0.673	0.98
83_A	87_L	0.672	0.98
116_A	150_K	0.671	0.98
5_K	248_W	0.669	0.98
214_E	248_W	0.668	0.98
71_E	102_A	0.666	0.98
244_D	254_L	0.666	0.98
177_I	208_N	0.665	0.98
244_D	247_G	0.661	0.98
27_E	72_A	0.661	0.98
97_K	119_S	0.659	0.98
31_Q	264_L	0.657	0.98
118_V	121_Q	0.656	0.98
95_D	122_H	0.646	0.97
90_I	131_M	0.646	0.97
200_H	205_G	0.644	0.97
41_V	236_L	0.641	0.97
51_G	59_Y	0.640	0.97
175_S	246_L	0.640	0.97
59_Y	109_V	0.639	0.97
85_L	91_G	0.638	0.97
206_V	209_S	0.635	0.97
100_W	143_T	0.635	0.97
220_I	243_A	0.635	0.97
136_F	166_V	0.632	0.97
72_A	77_V	0.626	0.97
238_V	274_R	0.624	0.97
97_K	135_G	0.623	0.97
165_V	181_F	0.622	0.97
113_C	116_A	0.621	0.97
265_V	268_L	0.620	0.97
141_H	180_R	0.619	0.97
114_T	118_V	0.618	0.97
264_L	270_D	0.617	0.97
120_A	155_M	0.616	0.97
139_M	142_M	0.612	0.96
65_S	68_E	0.612	0.96
104_A	143_T	0.610	0.96
43_S	92_T	0.609	0.96
16_G	223_S	0.607	0.96
151_Q	154_L	0.605	0.96
136_F	142_M	0.604	0.96
172_M	176_D	0.601	0.96
188_L	194_T	0.599	0.96
134_V	164_Y	0.597	0.96
9_S	94_H	0.596	0.96
136_F	164_Y	0.595	0.96
172_M	180_R	0.591	0.96
8_I	250_H	0.590	0.96
117_D	154_L	0.588	0.96
33_A	46_V	0.585	0.95
132_D	135_G	0.584	0.95
206_V	238_V	0.580	0.95
53_Q	80_A	0.579	0.95
70_I	73_A	0.578	0.95
167_D	170_G	0.578	0.95
108_R	115_E	0.577	0.95
73_A	77_V	0.576	0.95
104_A	144_T	0.571	0.95
184_L	194_T	0.570	0.95
70_I	75_D	0.570	0.95
46_V	82_I	0.566	0.95
9_S	195_G	0.565	0.94
18_H	229_A	0.564	0.94
69_W	73_A	0.564	0.94
209_S	233_N	0.563	0.94
113_C	154_L	0.561	0.94
37_D	65_S	0.560	0.94
33_A	44_I	0.560	0.94
11_V	15_D	0.557	0.94
30_R	73_A	0.556	0.94
161_T	193_Q	0.555	0.94
260_A	264_L	0.555	0.94
30_R	61_F	0.551	0.94
206_V	234_A	0.551	0.94
39_A	256_A	0.551	0.94
138_M	143_T	0.549	0.94
200_H	206_V	0.548	0.94
181_F	184_L	0.546	0.93
8_I	41_V	0.544	0.93
104_A	110_A	0.543	0.93
44_I	77_V	0.542	0.93
43_S	219_R	0.542	0.93
42_D	252_T	0.541	0.93
287_V	290_S	0.540	0.93
19_A	227_M	0.540	0.93
13_L	36_L	0.538	0.93
137_L	163_I	0.538	0.93
94_H	221_D	0.538	0.93
73_A	76_V	0.538	0.93
70_I	90_I	0.538	0.93
200_H	274_R	0.537	0.93
162_C	193_Q	0.536	0.93
96_L	135_G	0.535	0.93
19_A	272_P	0.533	0.93
236_L	257_L	0.530	0.92
240_I	250_H	0.527	0.92
67_L	71_E	0.527	0.92
254_L	258_M	0.527	0.92
283_G	288_Y	0.526	0.92
37_D	73_A	0.524	0.92
124_Q	127_R	0.524	0.92
262_D	267_P	0.524	0.92
271_R	279_T	0.522	0.92
173_N	204_L	0.521	0.92
258_M	278_E	0.521	0.92
128_E	131_M	0.520	0.92
201_N	230_G	0.520	0.92
76_V	79_H	0.519	0.92
112_H	115_E	0.517	0.91
259_D	262_D	0.517	0.91
237_E	261_A	0.517	0.91
147_N	151_Q	0.515	0.91
70_I	92_T	0.512	0.91
59_Y	63_A	0.511	0.91
238_V	241_A	0.510	0.91
65_S	89_G	0.508	0.91
272_P	277_R	0.503	0.90
48_H	287_V	0.503	0.90
292_L	296_E	0.501	0.90
274_R	277_R	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ov4A	2	0.9644	100	0.129	Contact Map
2ztjA	2	0.8902	100	0.153	Contact Map
3ivsA	2	0.9407	100	0.166	Contact Map
3rmjA	2	0.8694	100	0.167	Contact Map
3bleA	2	0.8605	100	0.174	Contact Map
3hq1A	2	0.9822	100	0.177	Contact Map
3eegA	2	0.7685	100	0.248	Contact Map
3bg3A	4	0.9496	100	0.287	Contact Map
4jn6A	2	0.9911	100	0.291	Contact Map
2nx9A	2	0.8991	100	0.299	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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