GREMLIN Database
AER - Aerotaxis receptor
UniProt: P50466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12955
Length: 506 (400)
Sequences: 6829 (5914)
Seq/√Len: 295.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_R240_G4.9571.00
327_A330_G4.2541.00
221_K226_E3.4781.00
247_G250_G2.8591.00
343_D417_K2.5431.00
215_V243_L2.5211.00
462_S465_R2.5151.00
220_L241_L2.4961.00
206_W210_R2.4511.00
237_D240_G2.4091.00
230_V254_R2.2931.00
347_S417_K2.2081.00
221_K229_S2.1451.00
205_E209_V2.1421.00
219_A249_L2.1061.00
346_D349_Q2.1011.00
395_H398_S2.0741.00
298_T302_M2.0311.00
308_Q311_A2.0241.00
216_A245_A1.9991.00
332_E336_T1.9821.00
184_A188_V1.9791.00
432_M435_I1.9701.00
340_T421_G1.9611.00
219_A246_V1.9431.00
133_L136_G1.9121.00
350_R353_T1.9001.00
461_S465_R1.8991.00
219_A245_A1.8721.00
352_G415_A1.8651.00
408_R412_D1.8521.00
419_Q423_Q1.8491.00
441_N444_Q1.8361.00
400_S404_A1.8361.00
357_L403_A1.8231.00
181_W185_A1.8161.00
315_A318_K1.8001.00
140_K144_K1.7941.00
341_M421_G1.7891.00
222_V249_L1.7841.00
220_L248_Q1.7541.00
479_E482_E1.7321.00
325_N329_Q1.7111.00
483_E486_Q1.7061.00
347_S413_A1.7051.00
187_V191_I1.6971.00
350_R406_D1.6961.00
188_V192_L1.6911.00
230_V251_L1.6851.00
230_V247_G1.6711.00
348_T418_V1.6651.00
427_A430_R1.6641.00
111_Y115_R1.6581.00
373_A394_R1.6531.00
259_D497_R1.6451.00
215_V242_T1.6361.00
183_V187_V1.6291.00
316_A320_S1.6241.00
220_L224_T1.6181.00
469_E472_L1.6111.00
345_A422_S1.6011.00
426_H430_R1.5991.00
216_A241_L1.5891.00
342_D346_D1.5761.00
402_N406_D1.5581.00
356_S360_D1.5521.00
230_V250_G1.5451.00
290_D293_Q1.5431.00
241_L244_R1.5391.00
354_I410_L1.5301.00
435_I446_I1.5251.00
391_G394_R1.5181.00
430_R434_D1.5121.00
353_T356_S1.5101.00
493_H497_R1.5051.00
398_S402_N1.5031.00
313_A316_A1.4931.00
490_M493_H1.4891.00
412_D416_D1.4871.00
331_G338_I1.4831.00
201_S205_E1.4831.00
479_E483_E1.4801.00
294_Q297_A1.4781.00
222_V250_G1.4701.00
316_A327_A1.4691.00
220_L245_A1.4471.00
451_H454_L1.4181.00
121_E125_A1.4161.00
121_E129_L1.4161.00
279_D283_E1.4071.00
373_A391_G1.4041.00
163_W166_R1.4041.00
316_A330_G1.4011.00
290_D294_Q1.3971.00
259_D501_A1.3791.00
132_A137_R1.3771.00
440_K444_Q1.3701.00
185_A188_V1.3661.00
217_H220_L1.3601.00
219_A242_T1.3561.00
316_A446_I1.3551.00
482_E486_Q1.3531.00
215_V246_V1.3511.00
322_T325_N1.3421.00
442_V446_I1.3421.00
269_N273_T1.3371.00
110_G116_T1.3341.00
301_Q304_A1.3311.00
454_L458_D1.3301.00
433_E437_A1.3301.00
133_L137_R1.3291.00
132_A135_A1.3191.00
211_P238_E1.3181.00
402_N405_N1.3051.00
120_D123_I1.3051.00
299_M302_M1.3041.00
458_D462_S1.3041.00
343_D346_D1.3031.00
428_A432_M1.3021.00
273_T276_K1.3021.00
340_T420_S1.3011.00
497_R500_D1.3001.00
215_V219_A1.3001.00
233_L244_R1.2991.00
254_R258_N1.2981.00
320_S330_G1.2921.00
409_K413_A1.2911.00
276_K280_E1.2901.00
246_V250_G1.2861.00
126_V130_Y1.2841.00
260_V502_V1.2831.00
346_D350_R1.2831.00
359_N408_R1.2771.00
300_N304_A1.2731.00
123_I126_V1.2721.00
259_D262_S1.2671.00
468_D472_L1.2611.00
430_R433_E1.2591.00
127_E130_Y1.2581.00
317_D320_S1.2461.00
233_L243_L1.2451.00
321_I325_N1.2431.00
332_E335_T1.2401.00
280_E283_E1.2391.00
314_S318_K1.2361.00
344_I414_S1.2361.00
132_A136_G1.2321.00
226_E229_S1.2311.00
146_L150_K1.2301.00
339_K343_D1.2221.00
162_R166_R1.2221.00
337_V425_V1.2181.00
233_L247_G1.2091.00
347_S350_R1.2071.00
318_K321_I1.2061.00
349_Q419_Q1.2061.00
309_N453_T1.2031.00
405_N409_K1.1971.00
125_A129_L1.1951.00
184_A187_V1.1941.00
213_E216_A1.1931.00
323_A330_G1.1921.00
339_K342_D1.1891.00
151_G155_K1.1851.00
318_K322_T1.1781.00
115_R118_A1.1771.00
342_D345_A1.1751.00
246_V249_L1.1691.00
197_V201_S1.1641.00
437_A441_N1.1611.00
269_N272_E1.1561.00
360_D363_F1.1541.00
340_T424_Q1.1521.00
333_A336_T1.1481.00
161_L164_R1.1481.00
247_G251_L1.1401.00
251_L255_W1.1401.00
122_E126_V1.1391.00
172_M176_L1.1381.00
134_N138_T1.1371.00
382_Q393_V1.1321.00
462_S466_A1.1291.00
199_L203_C1.1281.00
179_M183_V1.1281.00
333_A338_I1.1271.00
283_E287_Q1.1221.00
180_L184_A1.1201.00
344_I421_G1.1171.00
168_V171_L1.1161.00
119_T123_I1.1151.00
209_V213_E1.1141.00
324_S328_V1.1141.00
191_I195_L1.1121.00
221_K249_L1.1111.00
463_L467_V1.1091.00
348_T414_S1.1041.00
341_M422_S1.0971.00
252_M504_V1.0951.00
262_S266_S1.0881.00
208_I211_P1.0871.00
211_P240_G1.0841.00
278_T481_V1.0841.00
243_L247_G1.0791.00
216_A220_L1.0761.00
250_G254_R1.0761.00
405_N408_R1.0751.00
218_Q246_V1.0701.00
307_K311_A1.0641.00
284_H473_I1.0601.00
255_W259_D1.0601.00
231_E247_G1.0591.00
413_A417_K1.0561.00
434_D437_A1.0531.00
501_A504_V1.0521.00
118_A130_Y1.0501.00
211_P235_R1.0481.00
133_L138_T1.0471.00
180_L183_V1.0461.00
283_E286_Q1.0461.00
214_N217_H1.0401.00
166_R170_T1.0381.00
218_Q231_E1.0361.00
227_R253_C1.0311.00
326_A434_D1.0311.00
343_D347_S1.0221.00
444_Q447_A1.0211.00
341_M425_V1.0211.00
144_K148_V1.0211.00
336_T339_K1.0201.00
271_S488_S1.0191.00
476_K479_E1.0091.00
326_A330_G1.0061.00
496_S500_D1.0021.00
345_A419_Q1.0011.00
334_M338_I0.9971.00
418_V421_G0.9931.00
265_S269_N0.9921.00
163_W171_L0.9871.00
475_Q479_E0.9861.00
335_T339_K0.9861.00
169_M173_F0.9851.00
161_L165_A0.9851.00
239_L243_L0.9831.00
222_V246_V0.9791.00
202_A206_W0.9771.00
216_A242_T0.9771.00
304_A308_Q0.9771.00
144_K147_V0.9741.00
214_N218_Q0.9721.00
316_A324_S0.9691.00
272_E492_K0.9651.00
479_E486_Q0.9611.00
148_V151_G0.9601.00
146_L155_K0.9591.00
150_K155_K0.9581.00
132_A138_T0.9541.00
302_M306_V0.9521.00
473_I477_N0.9511.00
287_Q290_D0.9491.00
135_A138_T0.9471.00
299_M305_S0.9451.00
248_Q251_L0.9441.00
498_L505_L0.9421.00
437_A440_K0.9401.00
455_E458_D0.9371.00
214_N232_H0.9351.00
146_L151_G0.9351.00
298_T301_Q0.9331.00
456_Q463_L0.9301.00
252_M255_W0.9241.00
486_Q490_M0.9231.00
345_A349_Q0.9231.00
118_A123_I0.9221.00
314_S454_L0.9211.00
369_A394_R0.9191.00
406_D409_K0.9171.00
363_F374_V0.9161.00
115_R121_E0.9161.00
291_N469_E0.9121.00
453_T456_Q0.9121.00
324_S327_A0.9111.00
472_L476_K0.9101.00
272_E276_K0.9081.00
292_V295_T0.9071.00
444_Q448_Q0.9071.00
233_L237_D0.9061.00
112_M115_R0.9051.00
260_V498_L0.9021.00
447_A451_H0.9001.00
162_R165_A0.8991.00
320_S327_A0.8981.00
134_N137_R0.8971.00
288_T302_M0.8961.00
499_E503_T0.8931.00
432_M446_I0.8931.00
297_A301_Q0.8911.00
327_A436_V0.8911.00
122_E125_A0.8911.00
118_A126_V0.8901.00
173_F177_A0.8851.00
248_Q252_M0.8811.00
458_D461_S0.8801.00
193_C197_V0.8761.00
329_Q427_A0.8741.00
135_A140_K0.8711.00
461_S464_T0.8701.00
493_H496_S0.8651.00
106_G110_G0.8611.00
401_A405_N0.8611.00
219_A222_V0.8571.00
143_H147_V0.8571.00
421_G425_V0.8541.00
310_S313_A0.8541.00
400_S410_L0.8541.00
150_K154_G0.8531.00
297_A300_N0.8511.00
421_G424_Q0.8491.00
170_T174_I0.8471.00
300_N464_T0.8421.00
262_S265_S0.8391.00
356_S359_N0.8391.00
198_L202_A0.8371.00
435_I442_V0.8361.00
302_M309_N0.8351.00
226_E506_H0.8311.00
391_G395_H0.8261.00
311_A315_A0.8251.00
146_L149_R0.8221.00
171_L175_L0.8181.00
350_R413_A0.8171.00
489_A493_H0.8171.00
212_I242_T0.8161.00
455_E459_G0.8151.00
118_A121_E0.8141.00
123_I127_E0.8121.00
276_K279_D0.8121.00
175_L179_M0.8111.00
213_E217_H0.8111.00
235_R238_E0.8091.00
432_M456_Q0.8061.00
399_R402_N0.8051.00
353_T357_L0.8041.00
111_Y116_T0.8031.00
451_H455_E0.8021.00
145_G149_R0.8021.00
426_H429_G0.8011.00
225_G249_L0.8001.00
359_N404_A0.7950.99
354_I403_A0.7950.99
119_T122_E0.7930.99
268_R492_K0.7930.99
177_A181_W0.7910.99
108_I115_R0.7880.99
354_I411_I0.7850.99
261_S265_S0.7850.99
431_T435_I0.7830.99
216_A239_L0.7830.99
211_P239_L0.7830.99
217_H221_K0.7770.99
397_A400_S0.7770.99
274_L488_S0.7740.99
163_W182_F0.7720.99
343_D420_S0.7720.99
242_T249_L0.7710.99
329_Q434_D0.7690.99
159_L164_R0.7640.99
231_E243_L0.7640.99
225_G256_L0.7630.99
354_I357_L0.7610.99
224_T248_Q0.7600.99
441_N445_L0.7600.99
165_A171_L0.7590.99
273_T483_E0.7580.99
299_M306_V0.7570.99
311_A314_S0.7570.99
338_I429_G0.7570.99
163_W170_T0.7560.99
400_S411_I0.7520.99
366_N394_R0.7520.99
218_Q229_S0.7490.99
249_L253_C0.7480.99
359_N363_F0.7480.99
330_G435_I0.7480.99
195_L199_L0.7450.99
280_E284_H0.7440.99
414_S418_V0.7430.99
331_G335_T0.7420.99
284_H288_T0.7420.99
209_V239_L0.7380.99
312_T316_A0.7360.99
399_R406_D0.7350.99
500_D504_V0.7340.99
225_G242_T0.7310.99
348_T354_I0.7300.99
333_A424_Q0.7290.99
307_K461_S0.7270.99
354_I404_A0.7270.99
113_S116_T0.7250.99
203_C206_W0.7220.99
126_V129_L0.7210.99
320_S323_A0.7210.99
373_A399_R0.7200.99
448_Q451_H0.7190.99
288_T291_N0.7150.99
152_W155_K0.7150.99
143_H146_L0.7150.99
265_S499_E0.7130.99
359_N401_A0.7110.99
124_A128_P0.7100.99
264_V268_R0.7080.99
221_K224_T0.7060.99
416_D420_S0.7060.99
432_M445_L0.7050.99
268_R499_E0.7040.99
286_Q290_D0.7040.99
363_F367_I0.7030.99
145_G151_G0.7000.99
287_Q291_N0.6990.99
350_R410_L0.6980.99
238_E241_L0.6910.99
456_Q459_G0.6910.99
486_Q489_A0.6880.99
369_A373_A0.6870.98
125_A130_Y0.6870.98
292_V470_L0.6870.98
121_E128_P0.6860.98
117_R120_D0.6820.98
222_V227_R0.6810.98
145_G150_K0.6800.98
124_A127_E0.6800.98
309_N316_A0.6770.98
481_V484_S0.6750.98
110_G115_R0.6750.98
149_R153_L0.6720.98
411_I415_A0.6720.98
165_A168_V0.6710.98
291_N294_Q0.6690.98
319_L323_A0.6680.98
293_Q471_N0.6670.98
316_A323_A0.6660.98
115_R130_Y0.6640.98
209_V216_A0.6620.98
367_I374_V0.6610.98
166_R169_M0.6600.98
394_R398_S0.6600.98
484_S487_V0.6600.98
222_V253_C0.6590.98
325_N328_V0.6590.98
229_S250_G0.6590.98
120_D124_A0.6580.98
329_Q332_E0.6550.98
121_E124_A0.6550.98
210_R214_N0.6540.98
331_G337_V0.6480.98
323_A327_A0.6460.98
146_L153_L0.6460.98
277_G480_L0.6450.98
304_A307_K0.6450.98
147_V151_G0.6430.98
477_N481_V0.6410.98
118_A125_A0.6390.98
261_S499_E0.6390.98
264_V499_E0.6390.98
359_N405_N0.6360.98
333_A337_V0.6360.98
472_L475_Q0.6350.97
496_S499_E0.6350.97
263_Q266_S0.6340.97
181_W184_A0.6330.97
443_T446_I0.6320.97
442_V456_Q0.6320.97
106_G116_T0.6310.97
176_L179_M0.6300.97
302_M313_A0.6290.97
298_T309_N0.6290.97
199_L202_A0.6240.97
344_I418_V0.6180.97
500_D503_T0.6170.97
459_G463_L0.6160.97
218_Q221_K0.6160.97
357_L397_A0.6120.97
118_A128_P0.6120.97
420_S423_Q0.6110.97
294_Q462_S0.6100.97
258_N262_S0.6080.97
460_L464_T0.6080.97
355_T408_R0.6050.97
464_T468_D0.6020.97
132_A140_K0.6000.96
173_F176_L0.5970.96
412_D415_A0.5950.96
171_L174_I0.5950.96
369_A393_V0.5940.96
268_R272_E0.5940.96
134_N140_K0.5940.96
459_G462_S0.5940.96
326_A329_Q0.5910.96
291_N298_T0.5900.96
302_M460_L0.5900.96
351_I414_S0.5890.96
113_S130_Y0.5870.96
298_T459_G0.5850.96
313_A327_A0.5840.96
140_K143_H0.5830.96
266_S490_M0.5820.96
467_V471_N0.5820.96
113_S118_A0.5820.96
203_C207_Q0.5800.96
409_K412_D0.5800.96
148_V152_W0.5790.96
327_A429_G0.5790.96
151_G154_G0.5790.96
428_A431_T0.5780.96
303_A460_L0.5770.96
281_L285_T0.5750.96
282_N478_A0.5750.96
141_R144_K0.5750.96
331_G436_V0.5740.95
185_A189_T0.5740.95
267_V491_V0.5720.95
211_P242_T0.5700.95
310_S450_S0.5690.95
189_T193_C0.5690.95
111_Y114_I0.5690.95
140_K145_G0.5680.95
192_L196_V0.5670.95
341_M345_A0.5670.95
344_I354_I0.5660.95
157_P164_R0.5650.95
446_I450_S0.5650.95
457_A460_L0.5650.95
271_S495_A0.5620.95
131_K135_A0.5620.95
288_T456_Q0.5610.95
281_L481_V0.5610.95
192_L199_L0.5610.95
141_R145_G0.5610.95
474_T478_A0.5600.95
469_E473_I0.5600.95
355_T359_N0.5590.95
138_T142_I0.5590.95
244_R247_G0.5590.95
435_I439_V0.5560.95
159_L163_W0.5540.95
164_R168_V0.5530.95
415_A419_Q0.5530.95
218_Q243_L0.5510.94
159_L162_R0.5500.94
491_V495_A0.5500.94
237_D243_L0.5490.94
260_V264_V0.5460.94
291_N466_A0.5440.94
357_L411_I0.5440.94
186_P190_Y0.5410.94
320_S326_A0.5390.94
152_W156_L0.5380.94
305_S308_Q0.5370.94
136_G139_S0.5370.94
141_R147_V0.5370.94
148_V155_K0.5370.94
110_G165_A0.5360.94
439_V446_I0.5350.93
176_L180_L0.5340.93
466_A469_E0.5320.93
260_V263_Q0.5290.93
428_A435_I0.5260.93
316_A445_L0.5260.93
108_I111_Y0.5250.93
235_R243_L0.5250.93
353_T406_D0.5240.93
111_Y118_A0.5230.93
121_E130_Y0.5220.93
303_A464_T0.5190.92
159_L166_R0.5190.92
118_A122_E0.5190.92
418_V422_S0.5180.92
113_S117_R0.5170.92
449_I456_Q0.5170.92
236_S240_G0.5150.92
459_G467_V0.5130.92
227_R249_L0.5130.92
269_N276_K0.5120.92
444_Q451_H0.5120.92
232_H247_G0.5120.92
316_A319_L0.5120.92
148_V153_L0.5090.92
298_T463_L0.5090.92
303_A306_V0.5080.92
429_G432_M0.5070.92
243_L246_V0.5060.92
243_L249_L0.5050.91
436_V440_K0.5040.91
373_A384_K0.5030.91
293_Q297_A0.5030.91
223_A245_A0.5020.91
136_G140_K0.5020.91
322_T326_A0.5010.91
145_G152_W0.5000.91
358_I400_S0.5000.91
298_T316_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.5949 100 0.389 Contact Map
1qu7A 2 0.4407 100 0.516 Contact Map
2ch7A 2 0.5494 100 0.556 Contact Map
3g67A 2 0.4209 100 0.611 Contact Map
4i3mA 2 0.2905 99.9 0.754 Contact Map
3volA 2 0.247 99.7 0.835 Contact Map
4cq4A 4 0.17 99.5 0.849 Contact Map
2gj3A 7 0.2352 99.5 0.855 Contact Map
3lyxA 2 0.2352 99.5 0.857 Contact Map
2f95B 2 0.1047 99.5 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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