GREMLIN Database
END8 - Endonuclease 8
UniProt: P50465 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13237
Length: 263 (256)
Sequences: 5449 (3711)
Seq/√Len: 231.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_E58_H3.7801.00
185_H194_Q3.6751.00
245_I256_Y3.0421.00
191_N194_Q2.9121.00
157_L187_A2.8751.00
167_L172_R2.8621.00
178_Q208_F2.7781.00
154_F181_L2.7211.00
151_N188_K2.6681.00
56_L64_T2.5821.00
15_E19_K2.5381.00
229_K239_E2.3141.00
137_P199_A2.3111.00
21_K96_T2.2651.00
144_L157_L2.2381.00
179_V201_A2.1741.00
25_D41_I2.1421.00
11_A55_L2.1411.00
147_P152_R2.1241.00
67_S75_W2.0891.00
46_T60_S2.0711.00
233_R239_E2.0551.00
27_W93_K2.0131.00
67_S109_I1.9841.00
141_K195_L1.9651.00
177_W240_R1.9521.00
246_E259_P1.9081.00
243_S259_P1.9081.00
125_R162_A1.9061.00
11_A15_E1.9021.00
185_H189_D1.8811.00
194_Q197_A1.8711.00
137_P196_D1.8511.00
15_E47_H1.8461.00
178_Q201_A1.8381.00
184_N248_T1.8371.00
248_T257_W1.8361.00
233_R236_E1.8331.00
21_K95_Q1.8021.00
141_K192_A1.7831.00
43_Q60_S1.7801.00
21_K98_D1.7441.00
152_R160_D1.7351.00
198_L202_L1.7161.00
139_V143_R1.7111.00
47_H58_H1.7001.00
157_L163_F1.6841.00
201_A204_E1.6401.00
48_V57_T1.6181.00
23_L59_F1.6141.00
247_K254_P1.6101.00
90_L109_I1.6021.00
113_T116_Q1.6001.00
137_P200_H1.5971.00
39_Q63_L1.5911.00
30_F105_S1.5571.00
190_L194_Q1.5511.00
167_L202_L1.5391.00
175_I202_L1.5351.00
215_Q228_F1.5341.00
25_D93_K1.5271.00
230_V245_I1.5171.00
243_S260_G1.5101.00
153_Q156_G1.5011.00
178_Q229_K1.4841.00
178_Q205_I1.4831.00
24_T95_Q1.4781.00
8_R50_T1.4561.00
140_V199_A1.4561.00
203_L207_R1.4531.00
192_A196_D1.4451.00
152_R157_L1.4201.00
141_K145_L1.4161.00
186_K189_D1.4121.00
144_L195_L1.4091.00
22_P44_H1.4011.00
156_G251_S1.4001.00
178_Q204_E1.3981.00
139_V142_E1.3871.00
58_H64_T1.3711.00
51_R129_D1.3691.00
167_L175_I1.3681.00
137_P140_V1.3561.00
208_F227_R1.3521.00
173_V256_Y1.3421.00
8_R12_D1.3401.00
64_T114_P1.3281.00
144_L154_F1.3121.00
136_T139_V1.2881.00
138_E192_A1.2861.00
180_G240_R1.2641.00
63_L111_M1.2631.00
234_D247_K1.2561.00
128_P132_D1.2271.00
207_R211_A1.2251.00
182_T257_W1.2131.00
45_V59_F1.2081.00
88_R101_I1.2041.00
19_K47_H1.1911.00
234_D256_Y1.1651.00
175_I198_L1.1451.00
52_G161_Q1.1421.00
44_H60_S1.1411.00
37_Q41_I1.1401.00
208_F211_A1.1381.00
29_A91_R1.1231.00
155_A172_R1.1201.00
246_E257_W1.1201.00
8_R11_A1.1171.00
138_E142_E1.1131.00
147_P157_L1.1111.00
35_P39_Q1.1071.00
212_T227_R1.1021.00
45_V57_T1.1011.00
197_A201_A1.1011.00
43_Q62_D1.0921.00
164_L167_L1.0891.00
258_C261_C1.0891.00
152_R156_G1.0781.00
200_H204_E1.0721.00
158_L202_L1.0591.00
238_C258_C1.0461.00
217_D221_H1.0461.00
179_V197_A1.0421.00
137_P141_K1.0411.00
199_A203_L1.0401.00
100_T109_I1.0341.00
130_V135_L1.0341.00
79_D82_E1.0301.00
66_Y112_L1.0251.00
135_L164_L1.0241.00
220_K223_G1.0051.00
250_L255_F1.0041.00
26_V40_L0.9991.00
177_W229_K0.9961.00
36_Y109_I0.9941.00
63_L113_T0.9901.00
43_Q63_L0.9841.00
146_S188_K0.9841.00
238_C241_C0.9721.00
54_A66_Y0.9641.00
238_C261_C0.9621.00
22_P95_Q0.9601.00
46_T58_H0.9601.00
126_V165_A0.9581.00
181_L198_L0.9501.00
84_P91_R0.9451.00
190_L195_L0.9441.00
241_C258_C0.9401.00
89_V105_S0.9371.00
27_W91_R0.9331.00
59_F65_L0.9171.00
143_R163_F0.9010.99
196_D200_H0.8980.99
172_R255_F0.8880.99
153_Q184_N0.8880.99
141_K144_L0.8870.99
40_L59_F0.8860.99
75_W100_T0.8860.99
15_E48_V0.8790.99
34_K37_Q0.8760.99
18_I45_V0.8620.99
138_E196_D0.8590.99
67_S100_T0.8560.99
65_L92_V0.8550.99
221_H224_A0.8520.99
237_P243_S0.8460.99
91_R99_K0.8440.99
191_N195_L0.8380.99
96_T99_K0.8370.99
193_A197_A0.8350.99
145_L195_L0.8340.99
184_N250_L0.8320.99
11_A48_V0.8320.99
88_R91_R0.8310.99
95_Q98_D0.8220.99
57_T65_L0.8190.99
141_K196_D0.8160.99
237_P244_I0.8140.99
177_W239_E0.8120.99
167_L206_P0.8100.99
72_Y107_S0.8040.99
23_L92_V0.8030.99
74_V103_L0.8020.99
13_N213_R0.8010.99
121_P124_Q0.7980.99
72_Y103_L0.7950.99
66_Y123_L0.7900.99
159_L173_V0.7840.99
12_D15_E0.7830.99
230_V233_R0.7720.98
154_F187_A0.7680.98
204_E208_F0.7650.98
57_T67_S0.7640.98
51_R56_L0.7630.98
159_L253_R0.7630.98
92_V109_I0.7600.98
153_Q186_K0.7590.98
45_V94_L0.7550.98
18_I57_T0.7550.98
216_V220_K0.7510.98
6_E214_G0.7500.98
218_E221_H0.7490.98
170_Y231_F0.7480.98
23_L94_L0.7460.98
62_D114_P0.7460.98
38_S41_I0.7410.98
247_K256_Y0.7410.98
18_I94_L0.7390.98
19_K22_P0.7390.98
23_L45_V0.7370.98
35_P38_S0.7350.98
131_L203_L0.7330.98
100_T107_S0.7290.98
103_L106_A0.7290.98
133_P203_L0.7270.98
147_P187_A0.7260.98
241_C261_C0.7250.98
147_P163_F0.7250.98
243_S246_E0.7240.98
58_H114_P0.7220.98
110_E122_F0.7210.98
218_E222_H0.7200.98
208_F229_K0.7180.97
102_L106_A0.7150.97
175_I179_V0.7150.97
26_V36_Y0.7140.97
220_K224_A0.7140.97
30_F33_L0.7130.97
28_F90_L0.7130.97
29_A89_V0.7100.97
156_G250_L0.7090.97
154_F176_L0.7080.97
25_D37_Q0.7060.97
189_D194_Q0.7060.97
9_R210_Y0.7050.97
116_Q119_T0.7010.97
137_P195_L0.6990.97
154_F195_L0.6960.97
132_D203_L0.6960.97
170_Y175_I0.6940.97
249_T252_S0.6900.97
140_V144_L0.6900.97
222_H225_L0.6890.97
208_F212_T0.6890.97
192_A195_L0.6840.97
4_G8_R0.6840.97
21_K94_L0.6820.97
43_Q46_T0.6800.97
12_D211_A0.6780.96
65_L109_I0.6770.96
132_D135_L0.6740.96
33_L105_S0.6730.96
151_N186_K0.6730.96
131_L207_R0.6720.96
173_V250_L0.6700.96
249_T254_P0.6660.96
6_E170_Y0.6660.96
102_L107_S0.6650.96
170_Y215_Q0.6630.96
153_Q251_S0.6630.96
17_A77_V0.6590.96
195_L199_A0.6560.96
8_R210_Y0.6550.96
112_L122_F0.6550.96
143_R146_S0.6540.96
220_K225_L0.6520.96
197_A200_H0.6490.95
120_H123_L0.6480.95
36_Y65_L0.6470.95
108_D122_F0.6470.95
94_L98_D0.6450.95
158_L167_L0.6410.95
100_T104_Y0.6380.95
171_L206_P0.6360.95
32_Q105_S0.6360.95
228_F232_H0.6350.95
57_T75_W0.6320.95
177_W180_G0.6320.95
4_G206_P0.6300.95
212_T226_F0.6280.95
13_N218_E0.6270.95
189_D246_E0.6270.95
235_G244_I0.6250.94
39_Q113_T0.6180.94
160_D163_F0.6180.94
153_Q183_G0.6170.94
127_G165_A0.6110.94
40_L65_L0.6090.94
184_N246_E0.6090.94
232_H256_Y0.6040.93
219_N224_A0.6040.93
248_T254_P0.6030.93
49_E64_T0.6030.93
135_L199_A0.6030.93
14_L48_V0.6010.93
70_Q108_D0.5990.93
53_K73_G0.5980.93
86_T89_V0.5960.93
36_Y111_M0.5950.93
26_V92_V0.5950.93
182_T185_H0.5940.93
136_T199_A0.5930.93
4_G9_R0.5910.93
214_G223_G0.5880.92
155_A173_V0.5870.92
181_L194_Q0.5850.92
100_T106_A0.5850.92
217_D222_H0.5840.92
104_Y107_S0.5820.92
59_F63_L0.5780.92
6_E107_S0.5760.92
77_V98_D0.5740.92
176_L187_A0.5720.91
72_Y100_T0.5710.91
85_Q88_R0.5710.91
14_L75_W0.5680.91
234_D246_E0.5650.91
128_P165_A0.5650.91
67_S92_V0.5640.91
171_L209_S0.5640.91
228_F231_F0.5630.91
13_N77_V0.5620.91
70_Q106_A0.5620.91
214_G220_K0.5600.91
48_V58_H0.5590.90
4_G50_T0.5590.90
128_P164_L0.5570.90
78_V85_Q0.5570.90
234_D244_I0.5570.90
244_I259_P0.5550.90
45_V48_V0.5530.90
51_R123_L0.5490.90
74_V101_I0.5490.90
144_L187_A0.5490.90
78_V84_P0.5460.89
185_H191_N0.5460.89
70_Q104_Y0.5440.89
142_E146_S0.5420.89
128_P143_R0.5420.89
7_I104_Y0.5410.89
18_I77_V0.5410.89
54_A110_E0.5400.89
193_A196_D0.5390.89
7_I71_L0.5380.89
52_G101_I0.5380.89
199_A202_L0.5370.89
43_Q114_P0.5370.89
180_G197_A0.5360.89
52_G165_A0.5350.88
131_L206_P0.5330.88
145_L192_A0.5330.88
229_K240_R0.5320.88
78_V82_E0.5310.88
71_L106_A0.5300.88
172_R250_L0.5280.88
177_W241_C0.5270.88
30_F70_Q0.5270.88
205_I209_S0.5220.87
250_L254_P0.5200.87
222_H226_F0.5200.87
223_G228_F0.5190.87
14_L57_T0.5180.87
75_W92_V0.5180.87
143_R147_P0.5170.87
240_R244_I0.5150.87
218_E224_A0.5150.87
53_K68_H0.5140.86
140_V195_L0.5110.86
68_H73_G0.5100.86
138_E141_K0.5100.86
147_P151_N0.5090.86
52_G129_D0.5090.86
87_T96_T0.5050.85
143_R164_L0.5050.85
50_T129_D0.5040.85
71_L87_T0.5040.85
143_R157_L0.5030.85
236_E244_I0.5020.85
112_L119_T0.5020.85
156_G252_S0.5020.85
14_L77_V0.5010.85
9_R12_D0.5000.85
36_Y67_S0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u6pA 1 0.924 100 0.073 Contact Map
4pd2A 1 0.9848 100 0.073 Contact Map
1k82A 1 0.9544 100 0.074 Contact Map
3twlA 1 0.9202 100 0.089 Contact Map
1k3xA 1 0.9544 100 0.1 Contact Map
1ee8A 2 0.9658 100 0.129 Contact Map
3vk8A 1 0.9316 100 0.13 Contact Map
4mb7A 2 0.9202 100 0.167 Contact Map
3w0fA 1 0.9278 100 0.22 Contact Map
1tdhA 1 0.8517 100 0.235 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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