GREMLIN Database
PUUE - 4-aminobutyrate aminotransferase PuuE
UniProt: P50457 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13187
Length: 421 (377)
Sequences: 20840 (12279)
Seq/√Len: 632.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_E70_Q4.4381.00
381_Q417_D4.0521.00
225_R229_D4.0071.00
33_T41_E3.5811.00
329_R409_D3.3151.00
183_L223_A3.3051.00
91_K312_N3.1331.00
28_S35_K3.1261.00
249_K255_H2.8701.00
318_S321_E2.8541.00
329_R405_D2.8501.00
60_D316_K2.6801.00
322_R326_L2.6791.00
404_P407_Q2.6351.00
63_A67_Q2.6281.00
340_S416_Q2.5901.00
91_K315_D2.4021.00
45_F411_A2.3991.00
309_A312_N2.3671.00
223_A226_R2.3421.00
60_D313_I2.2911.00
333_T412_M2.2621.00
33_T407_Q2.2591.00
226_R230_E2.2391.00
27_Q37_V2.2391.00
58_H313_I2.2071.00
325_Q405_D2.1661.00
377_R380_A2.1641.00
60_D309_A2.1421.00
35_K41_E2.1091.00
187_E230_E2.0621.00
333_T409_D2.0391.00
91_K308_H2.0171.00
341_V416_Q1.9631.00
88_L307_A1.9521.00
103_K282_A1.9051.00
331_K335_I1.8981.00
129_G198_Q1.8981.00
169_P185_A1.8931.00
383_L414_I1.8931.00
410_A414_I1.8921.00
62_V66_E1.8901.00
377_R381_Q1.8881.00
328_Q332_N1.8831.00
282_A286_D1.8301.00
203_I236_I1.8171.00
40_N382_G1.8091.00
36_D40_N1.8091.00
313_I317_E1.7821.00
83_E87_T1.7801.00
102_A282_A1.7681.00
27_Q71_Q1.7591.00
33_T410_A1.7341.00
186_I224_I1.7291.00
331_K349_G1.6961.00
187_E191_K1.6961.00
90_E94_A1.6941.00
333_T336_D1.6771.00
65_V306_A1.6461.00
95_L315_D1.6401.00
202_I228_C1.6351.00
114_V264_T1.6271.00
107_F276_S1.6151.00
129_G166_Y1.6081.00
65_V69_L1.6081.00
30_E59_P1.6021.00
204_F224_I1.5901.00
273_M303_A1.5831.00
249_K324_N1.5751.00
190_F233_I1.5691.00
326_L329_R1.5351.00
91_K94_A1.5351.00
265_M277_G1.5181.00
87_T308_H1.5161.00
331_K354_I1.5121.00
184_D188_R1.5111.00
270_A275_L1.5051.00
32_A407_Q1.5041.00
67_Q71_Q1.4911.00
237_A253_M1.4701.00
124_H284_I1.4691.00
219_E222_A1.4651.00
326_L408_F1.4641.00
41_E410_A1.4621.00
377_R418_A1.4531.00
187_E223_A1.4451.00
134_S169_P1.4391.00
378_A385_L1.4311.00
32_A402_T1.4301.00
322_R325_Q1.4221.00
116_N278_V1.4211.00
265_M279_V1.4161.00
96_A279_V1.4101.00
181_D217_P1.4101.00
381_Q418_A1.4091.00
133_F220_L1.4061.00
225_R228_C1.4061.00
131_I199_V1.4041.00
130_V201_A1.3991.00
225_R235_M1.3851.00
333_T413_K1.3701.00
308_H312_N1.3641.00
104_T279_V1.3631.00
59_P63_A1.3571.00
118_V130_V1.3451.00
93_N104_T1.3341.00
309_A313_I1.3331.00
124_H287_A1.3331.00
36_D42_Y1.3261.00
250_L254_D1.3261.00
191_K231_H1.3261.00
89_A106_F1.3201.00
337_A416_Q1.3161.00
249_K254_D1.3131.00
329_R333_T1.3081.00
275_L304_V1.3051.00
321_E325_Q1.3051.00
326_L405_D1.2981.00
94_A315_D1.2971.00
117_A264_T1.2961.00
337_A412_M1.2961.00
333_T416_Q1.2921.00
30_E57_R1.2861.00
63_A66_E1.2851.00
403_I408_F1.2831.00
184_D187_E1.2791.00
132_A167_H1.2761.00
204_F221_V1.2721.00
26_A34_L1.2681.00
58_H317_E1.2621.00
255_H350_L1.2601.00
87_T312_N1.2601.00
114_V203_I1.2541.00
187_E227_L1.2451.00
262_L280_G1.2441.00
28_S71_Q1.2421.00
202_I224_I1.2411.00
253_M263_M1.2411.00
269_L275_L1.2401.00
259_K281_N1.2391.00
121_A236_I1.2281.00
54_T313_I1.2231.00
335_I338_K1.2221.00
256_Y350_L1.2111.00
103_K286_D1.2091.00
64_A309_A1.2001.00
219_E256_Y1.1941.00
407_Q410_A1.1911.00
183_L227_L1.1881.00
178_S182_S1.1861.00
222_A226_R1.1861.00
345_A359_N1.1851.00
57_R62_V1.1781.00
107_F278_V1.1721.00
62_V69_L1.1671.00
275_L307_A1.1621.00
269_L277_G1.1611.00
65_V302_L1.1601.00
312_N316_K1.1601.00
62_V70_Q1.1501.00
324_N328_Q1.1481.00
106_F304_V1.1361.00
378_A414_I1.1331.00
66_E69_L1.1301.00
222_A257_A1.1151.00
381_Q414_I1.1121.00
378_A418_A1.1091.00
413_K417_D1.1071.00
335_I339_E1.1061.00
245_A320_C1.1021.00
262_L278_V1.0941.00
147_L165_V1.0901.00
147_L203_I1.0881.00
251_F265_M1.0841.00
332_N336_D1.0731.00
32_A43_I1.0711.00
33_T43_I1.0691.00
410_A413_K1.0681.00
188_R192_S1.0651.00
27_Q83_E1.0641.00
237_A258_D1.0641.00
383_L411_A1.0601.00
405_D409_D1.0511.00
313_I316_K1.0481.00
27_Q39_G1.0461.00
182_S185_A1.0271.00
187_E226_R1.0241.00
409_D413_K1.0241.00
30_E41_E1.0211.00
187_E231_H1.0191.00
111_A144_T1.0121.00
25_F37_V1.0051.00
120_I278_V1.0041.00
228_C233_I1.0031.00
88_L308_H1.0021.00
378_A383_L1.0001.00
113_A264_T0.9941.00
127_R232_G0.9921.00
248_G254_D0.9921.00
271_G310_V0.9851.00
168_V189_L0.9811.00
27_Q35_K0.9781.00
30_E35_K0.9761.00
234_V284_I0.9751.00
185_A188_R0.9751.00
320_C323_A0.9701.00
95_L250_L0.9661.00
132_A203_I0.9631.00
373_K377_R0.9601.00
345_A357_E0.9551.00
60_D312_N0.9541.00
118_V147_L0.9521.00
226_R229_D0.9461.00
321_E324_N0.9461.00
63_A70_Q0.9381.00
91_K95_L0.9371.00
406_A409_D0.9361.00
218_K222_A0.9331.00
338_K344_I0.9321.00
201_A236_I0.9251.00
60_D63_A0.9241.00
53_N268_S0.9221.00
54_T310_V0.9181.00
355_A394_V0.9171.00
357_E393_N0.9161.00
206_P237_A0.9121.00
305_A309_A0.9091.00
61_L306_A0.9091.00
224_I235_M0.9071.00
244_F314_I0.9071.00
128_P198_Q0.9041.00
25_F86_V0.9031.00
43_I407_Q0.9021.00
98_V263_M0.9011.00
314_I319_L0.9001.00
322_R405_D0.8971.00
376_Q380_A0.8911.00
196_A231_H0.8881.00
101_Q279_V0.8861.00
207_V350_L0.8841.00
43_I410_A0.8821.00
133_F216_A0.8821.00
120_I280_G0.8811.00
67_Q305_A0.8791.00
215_V350_L0.8791.00
221_V256_Y0.8791.00
54_T61_L0.8741.00
314_I320_C0.8721.00
52_L271_G0.8721.00
179_T185_A0.8721.00
97_P253_M0.8721.00
146_A162_P0.8691.00
117_A236_I0.8671.00
327_G331_K0.8651.00
129_G191_K0.8651.00
219_E223_A0.8651.00
67_Q70_Q0.8631.00
190_F199_V0.8631.00
180_Q223_A0.8611.00
180_Q184_D0.8591.00
124_H234_V0.8571.00
45_F403_I0.8541.00
32_A404_P0.8511.00
255_H324_N0.8481.00
111_A141_T0.8481.00
95_L311_L0.8441.00
227_L231_H0.8411.00
37_V83_E0.8401.00
336_D340_S0.8371.00
133_F170_Y0.8301.00
332_N335_I0.8281.00
403_I411_A0.8251.00
346_A357_E0.8241.00
319_L323_A0.8111.00
121_A201_A0.8111.00
129_G199_V0.8101.00
87_T91_K0.8091.00
352_S403_I0.8081.00
121_A234_V0.8071.00
250_L320_C0.8071.00
207_V353_M0.8071.00
179_T182_S0.8031.00
84_S305_A0.8031.00
93_N101_Q0.7991.00
189_L192_S0.7961.00
242_S353_M0.7961.00
333_T408_F0.7941.00
273_M302_L0.7911.00
60_D64_A0.7891.00
97_P101_Q0.7841.00
372_Q376_Q0.7841.00
244_F311_L0.7801.00
232_G283_N0.7801.00
320_C324_N0.7801.00
43_I411_A0.7761.00
92_I279_V0.7741.00
170_Y216_A0.7711.00
229_D259_K0.7701.00
128_P164_S0.7701.00
348_R357_E0.7681.00
169_P182_S0.7651.00
166_Y189_L0.7641.00
88_L304_V0.7621.00
195_E198_Q0.7591.00
185_A189_L0.7591.00
353_M398_L0.7591.00
397_F415_L0.7581.00
31_N402_T0.7541.00
253_M258_D0.7531.00
228_C235_M0.7521.00
336_D416_Q0.7521.00
225_R258_D0.7511.00
244_F265_M0.7481.00
329_R332_N0.7461.00
337_A341_V0.7461.00
45_F383_L0.7441.00
84_S308_H0.7431.00
325_Q329_R0.7421.00
123_A292_G0.7421.00
209_G241_Q0.7391.00
190_F227_L0.7391.00
50_A398_L0.7381.00
202_I233_I0.7371.00
283_N286_D0.7371.00
206_P221_V0.7351.00
336_D339_E0.7261.00
251_F263_M0.7261.00
325_Q328_Q0.7251.00
244_F269_L0.7241.00
84_S87_T0.7231.00
165_V168_V0.7221.00
250_L315_D0.7201.00
207_V247_T0.7191.00
244_F250_L0.7171.00
223_A227_L0.7171.00
107_F113_A0.7151.00
347_V354_I0.7141.00
186_I202_I0.7131.00
64_A306_A0.7121.00
121_A262_L0.7121.00
126_G198_Q0.7121.00
375_Q387_T0.7121.00
32_A400_P0.7121.00
82_Y85_Y0.7111.00
118_V203_I0.7091.00
295_G298_A0.7061.00
104_T277_G0.7041.00
289_A292_G0.7041.00
108_T112_E0.7031.00
247_T255_H0.7021.00
349_G354_I0.7011.00
204_F235_M0.7011.00
374_I415_L0.6991.00
222_A256_Y0.6991.00
61_L271_G0.6991.00
326_L352_S0.6981.00
43_I383_L0.6981.00
374_I418_A0.6971.00
215_V349_G0.6971.00
216_A219_E0.6901.00
199_V233_I0.6901.00
84_S304_V0.6881.00
81_P86_V0.6861.00
323_A327_G0.6841.00
179_T183_L0.6821.00
26_A29_A0.6811.00
358_F374_I0.6801.00
131_I186_I0.6791.00
178_S181_D0.6781.00
120_I288_P0.6771.00
46_A386_L0.6761.00
265_M269_L0.6741.00
229_D235_M0.6701.00
68_Q71_Q0.6681.00
114_V144_T0.6671.00
329_R408_F0.6661.00
406_A410_A0.6641.00
109_T112_E0.6621.00
280_G285_M0.6621.00
374_I378_A0.6621.00
168_V186_I0.6611.00
117_A262_L0.6611.00
86_V90_E0.6591.00
378_A415_L0.6591.00
73_T273_M0.6591.00
71_Q83_E0.6591.00
98_V102_A0.6571.00
84_S88_L0.6551.00
327_G349_G0.6551.00
245_A314_I0.6541.00
411_A414_I0.6531.00
69_L302_L0.6511.00
85_Y89_A0.6511.00
34_L384_L0.6501.00
343_A359_N0.6461.00
91_K311_L0.6461.00
347_V356_V0.6441.00
143_M162_P0.6441.00
357_E394_V0.6431.00
47_A398_L0.6421.00
98_V253_M0.6401.00
95_L251_F0.6401.00
40_N380_A0.6401.00
155_K159_G0.6381.00
395_I415_L0.6371.00
96_A263_M0.6341.00
235_M258_D0.6331.00
253_M260_P0.6291.00
190_F231_H0.6291.00
221_V237_A0.6291.00
97_P254_D0.6281.00
32_A403_I0.6271.00
68_Q84_S0.6271.00
124_H283_N0.6271.00
25_F81_P0.6251.00
97_P259_K0.6241.00
341_V419_L0.6221.00
209_G353_M0.6221.00
373_K376_Q0.6211.00
322_R404_P0.6211.00
236_I262_L0.6201.00
266_A276_S0.6191.00
119_K293_L0.6191.00
188_R191_K0.6181.00
110_G240_V0.6181.00
383_L410_A0.6181.00
57_R69_L0.6161.00
284_I287_A0.6151.00
218_K256_Y0.6131.00
208_Q214_N0.6121.00
98_V259_K0.6121.00
358_F370_I0.6111.00
186_I227_L0.6111.00
240_V264_T0.6101.00
64_A67_Q0.6101.00
218_K350_L0.6081.00
356_V415_L0.6061.00
328_Q331_K0.6061.00
330_L412_M0.6051.00
412_M416_Q0.6051.00
183_L187_E0.6051.00
72_F75_T0.6051.00
326_L403_I0.6051.00
88_L275_L0.6051.00
227_L230_E0.6051.00
131_I189_L0.6041.00
29_A72_F0.6041.00
120_I262_L0.6031.00
281_N284_I0.6031.00
96_A251_F0.6021.00
208_Q211_G0.6011.00
41_E414_I0.6001.00
54_T319_L0.6001.00
397_F411_A0.5991.00
71_Q84_S0.5981.00
93_N102_A0.5961.00
47_A400_P0.5951.00
101_Q263_M0.5931.00
403_I407_Q0.5911.00
122_R142_Y0.5911.00
95_L249_K0.5901.00
137_F140_R0.5901.00
244_F251_F0.5881.00
323_A401_L0.5871.00
116_N293_L0.5871.00
358_F419_L0.5851.00
134_S167_H0.5831.00
178_S189_L0.5811.00
192_S195_E0.5801.00
338_K347_V0.5801.00
127_R233_I0.5791.00
326_L404_P0.5791.00
330_L354_I0.5771.00
306_A309_A0.5761.00
162_P165_V0.5761.00
53_N401_L0.5741.00
374_I395_I0.5731.00
414_I418_A0.5731.00
330_L408_F0.5721.00
125_T200_A0.5711.00
333_T337_A0.5701.00
69_L306_A0.5681.00
53_N314_I0.5671.00
186_I223_A0.5671.00
229_D283_N0.5671.00
156_I159_G0.5661.00
46_A384_L0.5651.00
127_R198_Q0.5641.00
191_K198_Q0.5641.00
24_F379_L0.5641.00
133_F168_V0.5631.00
118_V143_M0.5621.00
315_D318_S0.5621.00
206_P242_S0.5611.00
29_A34_L0.5601.00
24_F27_Q0.5591.00
96_A265_M0.5581.00
69_L73_T0.5551.00
61_L310_V0.5551.00
323_A352_S0.5541.00
370_I373_K0.5491.00
59_P70_Q0.5491.00
88_L106_F0.5491.00
184_D223_A0.5481.00
27_Q30_E0.5481.00
166_Y169_P0.5471.00
64_A312_N0.5471.00
183_L224_I0.5461.00
414_I417_D0.5461.00
133_F204_F0.5461.00
348_R355_A0.5441.00
322_R408_F0.5431.00
30_E33_T0.5400.99
329_R412_M0.5400.99
107_F112_E0.5390.99
68_Q72_F0.5390.99
222_A225_R0.5310.99
348_R394_V0.5310.99
165_V169_P0.5290.99
415_L419_L0.5280.99
376_Q379_L0.5280.99
25_F83_E0.5280.99
26_A80_V0.5280.99
375_Q379_L0.5270.99
93_N279_V0.5260.99
343_A419_L0.5260.99
132_A165_V0.5250.99
133_F224_I0.5240.99
241_Q353_M0.5240.99
65_V73_T0.5230.99
28_S41_E0.5220.99
87_T90_E0.5210.99
43_I403_I0.5200.99
67_Q309_A0.5180.99
324_N327_G0.5180.99
250_L311_L0.5170.99
191_K230_E0.5170.99
93_N96_A0.5160.99
65_V273_M0.5160.99
186_I220_L0.5160.99
160_P164_S0.5160.99
29_A52_L0.5140.99
286_D290_P0.5130.99
96_A104_T0.5120.99
250_L314_I0.5110.99
122_R160_P0.5110.99
317_E322_R0.5100.99
337_A413_K0.5100.99
129_G195_E0.5100.99
382_G414_I0.5090.99
218_K257_A0.5090.99
411_A415_L0.5090.99
344_I356_V0.5080.99
410_A417_D0.5080.99
26_A72_F0.5060.99
300_N303_A0.5060.99
204_F237_A0.5060.99
266_A297_Y0.5050.99
408_F412_M0.5030.99
263_M279_V0.5020.99
262_L284_I0.5020.99
356_V397_F0.5010.99
61_L309_A0.5010.99
62_V271_G0.5010.99
135_G211_G0.5000.99
80_V384_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oksA 2 1 100 0.35 Contact Map
4atqA 7 1 100 0.353 Contact Map
4uoxA 3 0.9525 100 0.369 Contact Map
4ffcA 4 0.9905 100 0.37 Contact Map
1sffA 3 0.9976 100 0.377 Contact Map
1z7dA 2 0.8765 100 0.378 Contact Map
4e3qA 3 0.9786 100 0.381 Contact Map
2epjA 2 0.9311 100 0.391 Contact Map
4a0gA 2 0.962 100 0.391 Contact Map
3hmuA 2 0.9762 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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