GREMLIN Database
MLC - Protein mlc
UniProt: P50456 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13156
Length: 406 (368)
Sequences: 7220 (5299)
Seq/√Len: 276.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_D107_K3.7441.00
111_E381_Q3.3931.00
193_Q236_H3.2721.00
177_P180_E3.2701.00
148_S391_K2.9681.00
61_Q81_E2.8981.00
217_Q341_G2.8751.00
158_D161_N2.8091.00
102_R388_A2.7771.00
216_I329_M2.6441.00
257_C264_C2.5631.00
88_L132_I2.5501.00
149_I186_T2.5481.00
259_C264_C2.5401.00
239_S334_N2.4411.00
277_L317_G2.4341.00
248_T328_I2.4041.00
100_A384_M2.3941.00
179_G183_E2.3651.00
25_I31_V2.3401.00
61_Q79_V2.3301.00
126_D185_H2.3151.00
129_I185_H2.3141.00
265_L325_I2.2541.00
99_L131_H2.2061.00
337_K374_E2.1461.00
212_A337_K2.1331.00
319_G323_G2.1151.00
209_S215_V2.0601.00
112_E134_Q2.0591.00
320_A358_S2.0571.00
326_L338_I2.0181.00
89_S384_M2.0081.00
316_T354_V1.9951.00
99_L135_F1.9941.00
25_I60_V1.9911.00
112_E138_R1.9611.00
180_E184_Q1.9541.00
256_R262_H1.9371.00
151_I182_L1.9221.00
230_T235_L1.9141.00
68_A71_R1.9021.00
21_V36_L1.8501.00
218_V326_L1.8251.00
133_D185_H1.8111.00
356_S360_R1.8071.00
193_Q198_A1.7931.00
323_G358_S1.7851.00
206_F389_L1.7721.00
213_R336_Q1.7501.00
18_A57_A1.7491.00
55_L62_E1.7471.00
319_G355_I1.7421.00
200_T229_I1.7391.00
181_A184_Q1.7301.00
152_T198_A1.7181.00
214_D336_Q1.7031.00
63_L79_V1.6931.00
18_A53_E1.6871.00
193_Q197_S1.6821.00
51_V60_V1.6691.00
247_H257_C1.6691.00
149_I188_V1.6681.00
257_C260_G1.6561.00
238_G336_Q1.6531.00
324_R328_I1.6411.00
88_L146_L1.6241.00
200_T227_G1.6241.00
352_F356_S1.6081.00
86_H109_V1.6031.00
110_V138_R1.5981.00
199_W217_Q1.5971.00
247_H259_C1.5961.00
359_I373_V1.5761.00
249_Q328_I1.5691.00
296_T299_S1.5521.00
194_H244_E1.5451.00
146_L188_V1.5361.00
213_R231_D1.5301.00
357_D361_Q1.5211.00
215_V229_I1.5211.00
110_V135_F1.5141.00
62_E76_V1.5021.00
28_L39_L1.4921.00
302_Q306_R1.4851.00
304_A315_I1.4851.00
90_L128_I1.4741.00
349_D353_P1.4701.00
337_K372_S1.4691.00
224_V269_A1.4681.00
87_Y392_D1.4581.00
247_H264_C1.4491.00
129_I186_T1.4341.00
176_M181_A1.4211.00
305_L350_I1.4121.00
36_L47_I1.4071.00
319_G354_V1.4011.00
278_A314_I1.3981.00
277_L280_L1.3931.00
101_L135_F1.3881.00
51_V78_L1.3761.00
90_L132_I1.3761.00
142_K145_R1.3731.00
35_D38_R1.3711.00
85_W147_T1.3531.00
303_A308_D1.3511.00
212_A336_Q1.3481.00
200_T215_V1.3451.00
358_S362_Q1.3391.00
96_E113_S1.3361.00
354_V357_D1.3161.00
90_L99_L1.3141.00
274_I318_V1.2981.00
83_E103_D1.2911.00
55_L78_L1.2861.00
205_L393_A1.2751.00
133_D186_T1.2741.00
100_A108_L1.2691.00
260_G264_C1.2671.00
24_L31_V1.2601.00
299_S302_Q1.2441.00
255_K276_E1.2441.00
358_S361_Q1.2421.00
122_L181_A1.2421.00
329_M332_L1.2411.00
348_A352_F1.2401.00
298_D302_Q1.2391.00
198_A387_A1.2331.00
24_L39_L1.2331.00
152_T383_T1.2231.00
98_F113_S1.2131.00
255_K267_T1.2111.00
202_A378_F1.1931.00
182_L190_V1.1921.00
156_I167_M1.1881.00
112_E131_H1.1801.00
134_Q138_R1.1781.00
330_V359_I1.1761.00
203_E207_G1.1761.00
354_V358_S1.1751.00
352_F375_S1.1701.00
215_V339_L1.1691.00
133_D143_L1.1691.00
33_R78_L1.1651.00
255_K268_I1.1531.00
89_S387_A1.1371.00
131_H134_Q1.1301.00
18_A50_I1.1271.00
114_Q131_H1.1241.00
125_L181_A1.1191.00
281_R313_D1.1131.00
177_P181_A1.1091.00
237_A243_V1.1061.00
194_H223_N1.1051.00
330_V338_I1.1011.00
126_D130_S1.0811.00
35_D39_L1.0801.00
277_L281_R1.0801.00
114_Q134_Q1.0791.00
62_E78_L1.0761.00
277_L314_I1.0731.00
204_A215_V1.0621.00
255_K277_L1.0621.00
66_K75_A1.0621.00
216_I226_A1.0591.00
278_A311_A1.0591.00
23_R27_Q1.0531.00
30_P79_V1.0531.00
231_D235_L1.0501.00
197_S234_L1.0461.00
214_D231_D1.0451.00
20_A40_A1.0441.00
237_A242_L1.0441.00
21_V47_I1.0411.00
31_V39_L1.0381.00
247_H260_G1.0381.00
216_I228_V1.0371.00
102_R108_L1.0281.00
120_D123_P1.0251.00
133_D137_I1.0191.00
89_S150_A1.0181.00
22_Y80_V1.0161.00
163_I175_E1.0161.00
183_E187_G1.0131.00
281_R314_I1.0121.00
87_Y391_K1.0091.00
316_T357_D1.0091.00
252_P324_R1.0081.00
141_K145_R1.0081.00
124_L173_V1.0081.00
64_E77_G0.9971.00
278_A282_L0.9951.00
223_N244_E0.9911.00
181_A185_H0.9841.00
33_R62_E0.9811.00
299_S303_A0.9791.00
196_I219_V0.9781.00
228_V235_L0.9751.00
204_A229_I0.9721.00
220_I322_V0.9701.00
353_P356_S0.9681.00
44_P48_T0.9661.00
183_E190_V0.9661.00
121_D173_V0.9651.00
163_I177_P0.9641.00
235_L333_F0.9631.00
304_A312_K0.9631.00
82_T105_S0.9611.00
86_H141_K0.9571.00
304_A350_I0.9521.00
302_Q305_L0.9481.00
340_I345_S0.9461.00
228_V333_F0.9421.00
330_V371_I0.9421.00
187_G190_V0.9411.00
24_L40_A0.9361.00
353_P357_D0.9361.00
88_L136_F0.9331.00
251_D268_I0.9301.00
101_L139_H0.9301.00
264_C267_T0.9281.00
348_A375_S0.9171.00
86_H145_R0.9161.00
191_Y394_M0.9151.00
323_G327_A0.9151.00
108_L111_E0.9141.00
191_Y391_K0.9141.00
150_A198_A0.9101.00
58_H81_E0.9081.00
324_R362_Q0.9061.00
274_I300_L0.9011.00
129_I133_D0.8991.00
312_K316_T0.8981.00
114_Q127_R0.8961.00
257_C263_G0.8951.00
121_D176_M0.8931.00
173_V176_M0.8891.00
212_A215_V0.8871.00
88_L149_I0.8871.00
277_L318_V0.8841.00
90_L149_I0.8821.00
25_I36_L0.8821.00
198_A390_V0.8811.00
199_W341_G0.8791.00
87_Y102_R0.8771.00
203_E378_F0.8711.00
379_S382_G0.8711.00
199_W383_T0.8711.00
251_D255_K0.8711.00
339_L376_T0.8701.00
150_A391_K0.8681.00
55_L60_V0.8681.00
204_A232_G0.8591.00
278_A300_L0.8581.00
66_K71_R0.8581.00
349_D375_S0.8541.00
114_Q130_S0.8541.00
30_P77_G0.8541.00
34_I75_A0.8541.00
193_Q390_V0.8501.00
88_L101_L0.8501.00
136_F146_L0.8491.00
323_G359_I0.8491.00
320_A354_V0.8481.00
52_R56_E0.8441.00
98_F111_E0.8441.00
130_S134_Q0.8441.00
255_K280_L0.8411.00
261_N362_Q0.8411.00
218_V245_I0.8411.00
129_I182_L0.8401.00
135_F139_H0.8341.00
274_I314_I0.8321.00
195_D225_G0.8311.00
210_R377_Q0.8311.00
282_L295_L0.8311.00
378_F382_G0.8281.00
249_Q252_P0.8271.00
123_P126_D0.8260.99
117_A127_R0.8260.99
214_D238_G0.8240.99
214_D230_T0.8230.99
339_L374_E0.8210.99
196_I227_G0.8200.99
249_Q261_N0.8200.99
127_R131_H0.8190.99
279_Q293_Q0.8160.99
205_L389_L0.8160.99
59_L84_A0.8150.99
225_G244_E0.8140.99
257_C267_T0.8110.99
179_G192_I0.8010.99
42_L47_I0.8000.99
276_E280_L0.7960.99
223_N266_E0.7950.99
305_L349_D0.7940.99
132_I149_I0.7920.99
61_Q82_T0.7910.99
316_T358_S0.7900.99
92_I97_I0.7870.99
207_G210_R0.7850.99
26_D80_V0.7840.99
213_R232_G0.7790.99
197_S227_G0.7740.99
304_A307_G0.7730.99
162_G177_P0.7700.99
251_D254_G0.7700.99
326_L359_I0.7690.99
310_L313_D0.7690.99
259_C263_G0.7670.99
110_V139_H0.7650.99
214_D235_L0.7650.99
320_A324_R0.7610.99
79_V105_S0.7600.99
194_H225_G0.7590.99
331_N364_L0.7580.99
317_G321_H0.7570.99
275_L297_V0.7570.99
237_A334_N0.7540.99
44_P49_K0.7530.99
301_C305_L0.7530.99
153_L164_V0.7520.99
87_Y147_T0.7510.99
304_A311_A0.7480.99
376_T382_G0.7480.99
153_L157_I0.7450.99
97_I116_L0.7450.99
261_N264_C0.7450.99
254_G268_I0.7440.99
301_C315_I0.7440.99
122_L126_D0.7440.99
28_L31_V0.7420.99
322_V355_I0.7420.99
334_N371_I0.7410.99
25_I78_L0.7400.99
309_L313_D0.7380.99
281_R310_L0.7380.99
207_G211_G0.7370.99
265_L318_V0.7330.99
313_D316_T0.7320.99
125_L178_L0.7320.99
323_G362_Q0.7310.99
103_D109_V0.7310.99
346_K380_N0.7300.99
200_T217_Q0.7270.99
228_V243_V0.7260.99
34_I38_R0.7250.99
260_G263_G0.7230.99
100_A111_E0.7220.99
352_F355_I0.7180.99
275_L300_L0.7140.99
203_E376_T0.7140.99
351_L354_V0.7130.99
167_M170_Y0.7130.99
127_R130_S0.7120.99
242_L334_N0.7080.98
158_D165_H0.7070.98
136_F143_L0.7050.98
182_L186_T0.7040.98
21_V50_I0.7040.98
248_T325_I0.7030.98
97_I114_Q0.7010.98
348_A353_P0.7010.98
24_L36_L0.6990.98
102_R385_A0.6970.98
20_A24_L0.6950.98
303_A306_R0.6920.98
247_H263_G0.6900.98
156_I241_S0.6890.98
301_C304_A0.6820.98
91_R383_T0.6810.98
212_A372_S0.6810.98
371_I375_S0.6770.98
308_D311_A0.6740.98
221_D343_P0.6730.98
199_W382_G0.6720.98
268_I321_H0.6710.98
223_N246_G0.6710.98
125_L176_M0.6690.98
220_I344_L0.6680.98
81_E84_A0.6670.98
279_Q282_L0.6660.98
101_L146_L0.6660.98
238_G334_N0.6640.98
162_G179_G0.6630.98
316_T319_G0.6610.98
319_G358_S0.6600.98
319_G351_L0.6600.98
101_L110_V0.6590.98
321_H325_I0.6590.98
108_L385_A0.6590.98
216_I338_I0.6590.98
282_L310_L0.6550.97
155_G266_E0.6550.97
320_A357_D0.6490.97
250_V265_L0.6480.97
86_H101_L0.6470.97
24_L28_L0.6460.97
349_D356_S0.6440.97
208_A377_Q0.6420.97
98_F384_M0.6410.97
197_S244_E0.6410.97
93_S343_P0.6400.97
180_E183_E0.6390.97
136_F139_H0.6380.97
82_T107_K0.6370.97
245_I332_L0.6370.97
99_L114_Q0.6350.97
249_Q362_Q0.6350.97
203_E377_Q0.6320.97
250_V325_I0.6310.97
206_F385_A0.6310.97
112_E135_F0.6300.97
32_S75_A0.6300.97
259_C267_T0.6290.97
195_D219_V0.6280.97
303_A311_A0.6240.97
208_A339_L0.6210.96
83_E109_V0.6210.96
194_H197_S0.6180.96
43_A46_S0.6170.96
313_D317_G0.6170.96
208_A211_G0.6160.96
363_A368_S0.6140.96
257_C261_N0.6140.96
300_L304_A0.6110.96
271_V275_L0.6080.96
254_G264_C0.6080.96
102_R106_S0.6060.96
360_R370_H0.6040.96
217_Q339_L0.6030.96
63_L77_G0.6020.96
131_H135_F0.6020.96
251_D324_R0.6010.96
295_L299_S0.6000.96
341_G376_T0.5990.96
254_G257_C0.5990.96
250_V321_H0.5980.96
91_R194_H0.5980.96
249_Q324_R0.5970.96
238_G335_P0.5970.96
23_R26_D0.5960.96
268_I277_L0.5960.96
245_I265_L0.5960.96
35_D66_K0.5960.96
133_D136_F0.5960.96
94_R222_H0.5940.95
327_A331_N0.5930.95
93_S222_H0.5880.95
116_L124_L0.5880.95
51_V55_L0.5860.95
253_Y320_A0.5850.95
96_E271_V0.5820.95
121_D181_A0.5810.95
215_V337_K0.5810.95
53_E56_E0.5800.95
89_S388_A0.5790.95
297_V300_L0.5790.95
224_V318_V0.5790.95
199_W219_V0.5780.95
143_L188_V0.5770.95
184_Q187_G0.5770.95
252_P320_A0.5770.95
191_Y390_V0.5770.95
33_R44_P0.5750.95
297_V301_C0.5740.95
272_D276_E0.5730.95
130_S133_D0.5730.95
59_L104_L0.5720.94
248_T329_M0.5710.94
357_D360_R0.5710.94
97_I124_L0.5690.94
301_C347_A0.5680.94
250_V268_I0.5650.94
327_A358_S0.5650.94
40_A47_I0.5630.94
53_E57_A0.5630.94
154_P169_F0.5630.94
261_N267_T0.5610.94
91_R152_T0.5590.94
374_E377_Q0.5590.94
315_I319_G0.5560.94
92_I151_I0.5540.93
148_S191_Y0.5540.93
309_L312_K0.5530.93
314_I318_V0.5520.93
47_I51_V0.5520.93
326_L355_I0.5500.93
275_L279_Q0.5480.93
251_D321_H0.5480.93
218_V226_A0.5480.93
248_T265_L0.5470.93
378_F385_A0.5460.93
254_G262_H0.5460.93
140_Q143_L0.5460.93
349_D352_F0.5450.93
82_T103_D0.5440.93
129_I181_A0.5440.93
91_R98_F0.5440.93
269_A321_H0.5430.93
159_T236_H0.5430.93
292_G295_L0.5410.93
216_I335_P0.5400.93
92_I128_I0.5390.93
166_R174_K0.5380.92
360_R368_S0.5370.92
348_A354_V0.5370.92
263_G267_T0.5360.92
340_I375_S0.5340.92
267_T276_E0.5340.92
97_I128_I0.5330.92
201_M390_V0.5330.92
326_L340_I0.5330.92
249_Q254_G0.5330.92
201_M204_A0.5310.92
169_F258_Y0.5300.92
331_N363_A0.5280.92
81_E85_W0.5280.92
141_K144_E0.5270.92
279_Q283_N0.5250.92
226_A245_I0.5240.91
24_L27_Q0.5240.91
22_Y59_L0.5230.91
204_A214_D0.5220.91
336_Q372_S0.5220.91
312_K350_I0.5190.91
93_S96_E0.5180.91
84_A145_R0.5170.91
320_A361_Q0.5140.91
153_L178_L0.5140.91
162_G183_E0.5140.91
327_A362_Q0.5140.91
111_E384_M0.5140.91
381_Q384_M0.5120.91
85_W145_R0.5110.90
179_G190_V0.5110.90
334_N363_A0.5110.90
278_A283_N0.5090.90
147_T391_K0.5080.90
150_A191_Y0.5080.90
237_A240_S0.5060.90
298_D346_K0.5050.90
49_K53_E0.5050.90
82_T85_W0.5030.90
61_Q83_E0.5030.90
273_S276_E0.5030.90
341_G345_S0.5030.90
326_L329_M0.5020.90
49_K52_R0.5020.90
91_R343_P0.5020.90
271_V343_P0.5010.90
204_A213_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z05A 2 0.968 100 0.177 Contact Map
1z6rA 3 0.9384 100 0.178 Contact Map
2hoeA 2 0.8695 100 0.25 Contact Map
4ijaA 2 0.9064 100 0.283 Contact Map
3o8mA 1 0.9138 100 0.382 Contact Map
2ap1A 2 0.7266 100 0.4 Contact Map
1bdgA 1 0.8695 100 0.404 Contact Map
4db3A 2 0.7414 100 0.405 Contact Map
2yhwA 2 0.7438 100 0.408 Contact Map
3f9mA 1 0.8744 100 0.416 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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