GREMLIN Database
TORZ - Trimethylamine-N-oxide reductase 2
UniProt: P46923 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13276
Length: 809 (678)
Sequences: 9311 (5664)
Seq/√Len: 217.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_N112_Q5.8071.00
714_I733_A4.8181.00
120_K551_L4.5981.00
721_R790_E4.4031.00
718_D791_K3.9741.00
539_R547_D3.7241.00
280_G324_A3.5211.00
708_D742_G3.5131.00
288_Q340_E3.4781.00
670_L712_F3.4211.00
322_V332_E3.2161.00
721_R728_Q3.1821.00
125_Q128_R3.1211.00
543_D547_D3.0931.00
121_L501_I3.0631.00
284_T288_Q3.0321.00
119_L551_L2.9991.00
530_Q533_A2.9411.00
487_V499_A2.9361.00
707_E741_K2.8521.00
723_W790_E2.8511.00
122_I501_I2.8461.00
293_K297_E2.8001.00
301_T631_S2.7731.00
282_A306_F2.7621.00
213_W278_M2.7531.00
113_V501_I2.7331.00
114_S117_Q2.7161.00
724_N787_V2.7011.00
129_I137_A2.6941.00
565_D568_A2.6791.00
720_V733_A2.6781.00
704_I789_I2.6571.00
704_I733_A2.6381.00
283_H287_T2.6261.00
723_W788_Y2.6201.00
282_A374_M2.6111.00
100_Q501_I2.6031.00
128_R132_A2.6021.00
277_L328_T2.5901.00
325_A332_E2.5671.00
265_T337_K2.5321.00
631_S635_E2.5301.00
97_N537_E2.4641.00
100_Q113_V2.4381.00
100_Q121_L2.4241.00
291_H296_L2.4041.00
331_P334_Q2.3921.00
699_R732_G2.3851.00
332_E336_V2.3771.00
245_P341_L2.3201.00
320_S323_W2.3131.00
119_L547_D2.3021.00
709_A735_V2.2961.00
711_R741_K2.2831.00
126_H457_M2.2731.00
334_Q337_K2.2631.00
723_W728_Q2.2591.00
207_S210_V2.2131.00
712_F788_Y2.1991.00
248_A260_F2.1911.00
289_G293_K2.1691.00
112_Q537_E2.1441.00
294_V298_K2.1231.00
471_D770_D2.1191.00
714_I720_V2.0861.00
547_D551_L2.0841.00
122_I486_V2.0691.00
702_I744_V2.0601.00
206_N381_P2.0531.00
702_I720_V2.0451.00
267_I330_V2.0271.00
267_I338_L2.0201.00
716_N735_V2.0081.00
113_V121_L2.0051.00
277_L335_I2.0041.00
456_K483_E1.9981.00
702_I746_V1.9621.00
129_I457_M1.9321.00
209_V341_L1.9251.00
535_Q538_A1.9091.00
702_I722_V1.9071.00
121_L125_Q1.8991.00
337_K341_L1.8981.00
273_T327_I1.8951.00
283_H321_A1.8901.00
704_I744_V1.8871.00
731_T746_V1.8741.00
48_N63_L1.8671.00
286_M303_Y1.8471.00
100_Q111_V1.8191.00
209_V247_I1.8181.00
459_W488_S1.8091.00
670_L744_V1.8061.00
96_D536_F1.7921.00
104_G107_E1.7901.00
265_T334_Q1.7881.00
286_M307_E1.7871.00
296_L303_Y1.7841.00
492_W496_A1.7781.00
721_R730_L1.7771.00
208_Q345_N1.7361.00
744_V787_V1.7301.00
719_L730_L1.7271.00
284_T321_A1.7241.00
239_L244_K1.7241.00
284_T340_E1.7151.00
288_Q336_V1.7131.00
286_M310_L1.7041.00
324_A335_I1.7031.00
308_E311_T1.6991.00
249_I277_L1.6971.00
342_M375_L1.6971.00
99_L502_V1.6891.00
482_P485_I1.6861.00
477_K480_Q1.6861.00
476_I480_Q1.6811.00
120_K124_E1.6621.00
322_V336_V1.6581.00
290_K343_A1.6531.00
46_A65_K1.6341.00
593_A597_Q1.6311.00
162_M167_G1.6301.00
707_E710_A1.6271.00
547_D550_E1.6221.00
716_N734_V1.6211.00
284_T336_V1.6161.00
512_N530_Q1.6141.00
590_M593_A1.6111.00
325_A335_I1.6111.00
484_M501_I1.6111.00
287_T311_T1.6081.00
715_A718_D1.6021.00
300_T636_I1.6011.00
380_T383_G1.6001.00
265_T341_L1.5941.00
325_A331_P1.5891.00
211_V338_L1.5821.00
113_V117_Q1.5801.00
342_M347_T1.5701.00
209_V338_L1.5681.00
277_L338_L1.5661.00
670_L708_D1.5621.00
240_K261_D1.5591.00
290_K340_E1.5591.00
675_A745_C1.5581.00
506_T540_N1.5431.00
117_Q121_L1.5151.00
564_K568_A1.5141.00
122_I503_L1.5141.00
287_T336_V1.5111.00
284_T290_K1.5101.00
703_T736_T1.4941.00
291_H303_Y1.4941.00
98_P115_W1.4911.00
126_H486_V1.4871.00
211_V249_I1.4791.00
285_L291_H1.4751.00
729_I746_V1.4731.00
374_M636_I1.4721.00
99_L112_Q1.4641.00
56_I89_M1.4631.00
665_A725_K1.4501.00
719_L732_G1.4441.00
425_T429_V1.4441.00
137_A456_K1.4421.00
285_L343_A1.4381.00
49_V56_I1.4371.00
265_T338_L1.4341.00
428_P434_D1.4291.00
340_E344_A1.4271.00
50_E60_T1.4181.00
127_D131_K1.4171.00
140_A162_M1.4071.00
460_W485_I1.4031.00
670_L788_Y1.3981.00
161_Y552_L1.3961.00
133_N456_K1.3951.00
117_Q501_I1.3941.00
281_I342_M1.3941.00
575_D578_Q1.3821.00
712_F789_I1.3751.00
124_E128_R1.3611.00
247_I338_L1.3601.00
276_A327_I1.3581.00
119_L539_R1.3521.00
301_T635_E1.3491.00
451_T474_R1.3441.00
251_P266_W1.3431.00
487_V496_A1.3391.00
307_E311_T1.3381.00
420_D423_G1.3381.00
281_I338_L1.3371.00
319_K324_A1.3371.00
139_F455_I1.3321.00
273_T328_T1.3241.00
539_R543_D1.3231.00
294_V297_E1.3211.00
550_E555_G1.3171.00
253_R258_E1.3171.00
121_L484_M1.3061.00
36_G49_V1.3001.00
283_H311_T1.2901.00
702_I731_T1.2831.00
49_V59_S1.2821.00
319_K327_I1.2751.00
183_I365_H1.2741.00
529_K595_W1.2701.00
34_K51_V1.2701.00
355_I368_L1.2651.00
267_I334_Q1.2631.00
490_C507_T1.2581.00
203_I206_N1.2521.00
269_P330_V1.2451.00
296_L636_I1.2441.00
329_G740_K1.2431.00
248_A257_I1.2431.00
492_W502_V1.2421.00
612_Y615_Y1.2391.00
705_H741_K1.2341.00
474_R477_K1.2331.00
319_K323_W1.2321.00
746_V764_A1.2271.00
615_Y618_F1.2231.00
284_T287_T1.2221.00
286_M291_H1.2161.00
323_W326_E1.2131.00
305_Q308_E1.2121.00
211_V281_I1.2101.00
281_I285_L1.2101.00
722_V746_V1.2051.00
488_S544_V1.1981.00
104_G111_V1.1961.00
303_Y374_M1.1941.00
130_R138_I1.1921.00
138_I457_M1.1901.00
284_T335_I1.1821.00
543_D550_E1.1741.00
35_G48_N1.1721.00
377_Q383_G1.1721.00
706_T737_D1.1721.00
567_M571_K1.1711.00
568_A571_K1.1691.00
428_P435_A1.1651.00
311_T318_P1.1581.00
139_F446_N1.1571.00
540_N543_D1.1551.00
238_Q241_K1.1541.00
293_K307_E1.1531.00
269_P273_T1.1471.00
471_D474_R1.1431.00
123_H551_L1.1401.00
96_D112_Q1.1381.00
423_G426_A1.1361.00
210_V244_K1.1351.00
127_D130_R1.1321.00
48_N60_T1.1281.00
488_S505_I1.1251.00
130_R165_A1.1221.00
736_T739_I1.1221.00
48_N62_A1.1211.00
281_I339_A1.1211.00
240_K259_F1.1181.00
306_F374_M1.1131.00
701_P734_V1.1061.00
101_P110_Y1.1031.00
55_K90_V1.1011.00
667_E788_Y1.1011.00
629_T635_E1.0991.00
506_T538_A1.0961.00
282_A310_L1.0951.00
744_V789_I1.0941.00
342_M349_L1.0931.00
285_L375_L1.0921.00
129_I484_M1.0911.00
182_V776_L1.0901.00
303_Y307_E1.0901.00
210_V239_L1.0871.00
325_A333_A1.0861.00
35_G62_A1.0851.00
325_A328_T1.0841.00
278_M368_L1.0811.00
281_I371_L1.0791.00
110_Y502_V1.0791.00
333_A336_V1.0771.00
280_G335_I1.0751.00
302_G305_Q1.0741.00
451_T477_K1.0741.00
129_I483_E1.0721.00
702_I789_I1.0681.00
204_L348_M1.0661.00
503_L544_V1.0661.00
208_Q242_S1.0631.00
130_R135_P1.0631.00
457_M484_M1.0611.00
667_E725_K1.0591.00
249_I338_L1.0581.00
703_T734_V1.0581.00
571_K574_Y1.0561.00
115_W503_L1.0521.00
126_H552_L1.0501.00
290_K344_A1.0471.00
209_V345_N1.0451.00
212_L215_M1.0441.00
122_I484_M1.0421.00
106_G111_V1.0391.00
89_M532_V1.0381.00
457_M486_V1.0371.00
324_A328_T1.0351.00
213_W249_I1.0351.00
614_R618_F1.0291.00
249_I267_I1.0291.00
477_K481_K1.0281.00
283_H310_L1.0271.00
125_Q483_E1.0271.00
208_Q346_R1.0261.00
210_V236_F1.0251.00
567_M595_W1.0251.00
59_S86_Q1.0251.00
721_R792_Y1.0241.00
461_A545_F1.0201.00
258_E738_G1.0191.00
460_W495_A1.0131.00
280_G284_T1.0121.00
571_K575_D1.0121.00
592_N596_Q1.0091.00
119_L543_D1.0091.00
187_V366_W1.0091.00
428_P433_V1.0081.00
41_A45_G1.0061.00
318_P323_W1.0041.00
111_V117_Q0.9991.00
125_Q129_I0.9981.00
284_T339_A0.9971.00
672_L787_V0.9901.00
275_V364_K0.9901.00
668_K788_Y0.9891.00
247_I341_L0.9871.00
459_W548_L0.9871.00
209_V347_T0.9861.00
373_A634_I0.9851.00
466_F476_I0.9781.00
370_T636_I0.9771.00
271_M743_V0.9731.00
330_V335_I0.9731.00
703_T738_G0.9701.00
46_A62_A0.9681.00
49_V509_F0.9671.00
466_F472_T0.9661.00
668_K724_N0.9621.00
570_L574_Y0.9621.00
253_R738_G0.9611.00
279_L319_K0.9601.00
347_T377_Q0.9561.00
665_A786_L0.9521.00
705_H739_I0.9521.00
527_P595_W0.9511.00
608_K612_Y0.9511.00
115_W544_V0.9491.00
95_L502_V0.9481.00
283_H320_S0.9481.00
509_F531_A0.9461.00
257_I260_F0.9431.00
278_M367_M0.9411.00
705_H735_V0.9401.00
251_P268_A0.9391.00
61_G70_S0.9371.00
446_N455_I0.9310.99
300_T373_A0.9310.99
336_V340_E0.9290.99
122_I548_L0.9280.99
704_I709_A0.9270.99
704_I714_I0.9270.99
134_G137_A0.9260.99
306_F310_L0.9260.99
349_L372_A0.9240.99
337_K340_E0.9240.99
306_F636_I0.9230.99
669_Q788_Y0.9200.99
119_L548_L0.9190.99
403_V406_E0.9190.99
332_E335_I0.9150.99
673_L743_V0.9150.99
321_A324_A0.9150.99
301_T633_K0.9090.99
138_I165_A0.9080.99
512_N527_P0.9070.99
93_S689_E0.9070.99
564_K572_F0.9060.99
320_S324_A0.9060.99
722_V787_V0.9060.99
726_R768_T0.9030.99
96_D535_Q0.8990.99
670_L789_I0.8970.99
52_K57_V0.8950.99
292_D380_T0.8950.99
726_R785_A0.8940.99
270_N740_K0.8920.99
614_R617_D0.8920.99
269_P277_L0.8910.99
512_N567_M0.8910.99
291_H374_M0.8910.99
707_E737_D0.8910.99
279_L309_Y0.8890.99
424_M428_P0.8880.99
285_L371_L0.8870.99
353_W357_R0.8860.99
245_P261_D0.8850.99
433_V436_L0.8840.99
325_A330_V0.8840.99
54_G533_A0.8840.99
304_P307_E0.8800.99
464_G683_S0.8790.99
729_I767_L0.8780.99
287_T321_A0.8770.99
321_A336_V0.8770.99
555_G558_E0.8770.99
341_L345_N0.8770.99
449_E454_N0.8750.99
209_V245_P0.8740.99
123_H552_L0.8730.99
122_I125_Q0.8730.99
87_H690_L0.8720.99
708_D741_K0.8720.99
50_E58_S0.8700.99
269_P328_T0.8690.99
532_V535_Q0.8670.99
458_I482_P0.8640.99
505_I544_V0.8630.99
321_A325_A0.8630.99
330_V334_Q0.8600.99
425_T433_V0.8600.99
161_Y545_F0.8590.99
212_L246_V0.8590.99
284_T332_E0.8580.99
709_A714_I0.8570.99
280_G323_W0.8570.99
561_T565_D0.8540.99
411_I426_A0.8530.99
116_E551_L0.8500.99
700_E750_A0.8480.99
512_N566_E0.8470.99
307_E310_L0.8470.99
136_S168_Y0.8460.99
245_P265_T0.8460.99
205_E235_Y0.8450.99
340_E343_A0.8410.99
249_I269_P0.8400.99
250_D254_S0.8390.99
161_Y548_L0.8390.99
494_A751_W0.8390.99
100_Q117_Q0.8380.99
253_R737_D0.8380.99
684_Q688_A0.8360.99
106_G109_T0.8350.99
277_L281_I0.8330.99
183_I369_V0.8320.99
506_T534_P0.8320.99
323_W327_I0.8310.99
217_P236_F0.8310.99
237_H240_K0.8280.99
525_I589_P0.8280.99
126_H459_W0.8270.99
126_H165_A0.8270.99
429_V433_V0.8250.99
571_K592_N0.8250.99
43_R223_I0.8250.99
38_I41_A0.8250.99
136_S438_N0.8240.99
610_E613_V0.8240.99
240_K246_V0.8230.99
442_K778_N0.8220.99
418_A424_M0.8180.99
725_K786_L0.8160.99
334_Q341_L0.8150.99
276_A280_G0.8130.99
448_K452_Y0.8120.99
428_P431_R0.8110.99
123_H127_D0.8110.99
704_I720_V0.8110.99
493_T496_A0.8100.99
37_K526_V0.8090.99
98_P114_S0.8060.99
496_A502_V0.8030.98
247_I265_T0.8020.98
212_L256_T0.8020.98
430_A576_A0.8020.98
432_I435_A0.8010.98
539_R544_V0.7980.98
199_S203_I0.7980.98
150_V461_A0.7970.98
442_K445_H0.7960.98
421_D425_T0.7960.98
466_F479_W0.7940.98
38_I45_G0.7930.98
428_P432_I0.7930.98
457_M501_I0.7930.98
550_E564_K0.7920.98
267_I277_L0.7900.98
296_L300_T0.7900.98
635_E638_S0.7890.98
567_M591_F0.7870.98
731_T764_A0.7870.98
321_A332_E0.7870.98
280_G326_E0.7870.98
665_A669_Q0.7850.98
115_W539_R0.7840.98
456_K482_P0.7840.98
127_D552_L0.7830.98
205_E238_Q0.7820.98
423_G428_P0.7820.98
473_N477_K0.7820.98
280_G321_A0.7780.98
706_T710_A0.7770.98
97_N114_S0.7770.98
101_P108_D0.7750.98
355_I364_K0.7750.98
126_H130_R0.7730.98
285_L289_G0.7720.98
428_P436_L0.7720.98
211_V349_L0.7690.98
480_Q498_H0.7670.98
282_A371_L0.7660.98
441_G449_E0.7660.98
89_M507_T0.7650.98
105_R108_D0.7650.98
507_T535_Q0.7650.98
422_G425_T0.7640.98
91_R491_Y0.7640.98
714_I735_V0.7630.98
268_A740_K0.7600.98
218_L256_T0.7590.98
47_M72_Q0.7580.98
613_V616_G0.7580.98
52_K55_K0.7580.98
119_L123_H0.7560.98
209_V342_M0.7560.98
489_E502_V0.7510.98
591_F595_W0.7490.98
450_Q482_P0.7480.98
591_F594_F0.7480.98
122_I459_W0.7480.98
278_M371_L0.7470.98
296_L374_M0.7470.98
280_G320_S0.7470.98
593_A596_Q0.7460.98
722_V731_T0.7430.97
704_I735_V0.7420.97
740_K743_V0.7410.97
626_A632_G0.7410.97
49_V531_A0.7390.97
182_V362_E0.7370.97
253_R268_A0.7360.97
445_H448_K0.7340.97
726_R786_L0.7340.97
309_Y318_P0.7330.97
466_F498_H0.7330.97
690_L693_K0.7320.97
164_L559_I0.7320.97
99_L492_W0.7290.97
472_T763_S0.7290.97
349_L368_L0.7250.97
113_V118_A0.7250.97
665_A668_K0.7250.97
448_K474_R0.7240.97
104_G109_T0.7230.97
208_Q347_T0.7230.97
35_G64_A0.7220.97
627_L634_I0.7220.97
781_A784_S0.7220.97
687_Y693_K0.7210.97
161_Y549_A0.7200.97
570_L573_F0.7200.97
512_N529_K0.7180.97
425_T428_P0.7160.97
333_A337_K0.7160.97
186_H366_W0.7160.97
101_P500_D0.7160.97
555_G559_I0.7160.97
119_L122_I0.7150.97
96_D99_L0.7130.97
662_K786_L0.7130.97
429_V432_I0.7130.97
729_I764_A0.7130.97
69_N238_Q0.7120.97
270_N329_G0.7110.97
299_Y625_N0.7100.97
464_G495_A0.7080.97
252_I703_T0.7070.97
288_Q343_A0.7070.97
451_T481_K0.7060.97
709_A736_T0.7060.97
104_G480_Q0.7060.97
188_V369_V0.7050.97
179_A779_A0.7040.97
65_K68_P0.7030.97
129_I456_K0.7020.96
90_V535_Q0.7010.96
460_W487_V0.7010.96
275_V367_M0.6990.96
714_I718_D0.6980.96
309_Y319_K0.6940.96
458_I485_I0.6930.96
235_Y238_Q0.6930.96
107_E111_V0.6930.96
662_K725_K0.6920.96
154_A511_R0.6910.96
450_Q453_P0.6900.96
119_L544_V0.6900.96
670_L742_G0.6890.96
284_T343_A0.6880.96
164_L554_P0.6880.96
90_V532_V0.6880.96
453_P456_K0.6870.96
300_T303_Y0.6850.96
213_W368_L0.6840.96
498_H502_V0.6840.96
125_Q484_M0.6840.96
124_E127_D0.6820.96
186_H776_L0.6820.96
120_K123_H0.6810.96
200_W203_I0.6810.96
203_I382_G0.6810.96
339_A343_A0.6800.96
51_V532_V0.6790.96
630_P635_E0.6790.96
405_P408_S0.6790.96
121_L124_E0.6780.96
506_T511_R0.6780.96
125_Q457_M0.6780.96
333_A340_E0.6770.96
418_A428_P0.6760.96
45_G82_T0.6760.96
338_L341_L0.6750.96
425_T431_R0.6720.95
572_F576_A0.6710.95
245_P344_A0.6710.95
184_M369_V0.6700.95
158_L545_F0.6690.95
363_Q366_W0.6690.95
707_E711_R0.6690.95
304_P308_E0.6690.95
543_D546_A0.6680.95
126_H484_M0.6680.95
729_I766_V0.6670.95
473_N766_V0.6670.95
419_A423_G0.6670.95
610_E614_R0.6660.95
451_T454_N0.6650.95
219_N255_E0.6650.95
722_V789_I0.6650.95
286_M374_M0.6640.95
133_N137_A0.6640.95
710_A715_A0.6630.95
279_L310_L0.6620.95
359_Q781_A0.6620.95
61_G72_Q0.6610.95
280_G332_E0.6590.95
489_E493_T0.6590.95
238_Q242_S0.6590.95
474_R770_D0.6570.95
219_N252_I0.6560.95
546_A550_E0.6560.95
47_M61_G0.6560.95
257_I266_W0.6540.95
425_T435_A0.6540.95
110_Y113_V0.6530.95
285_L374_M0.6530.95
425_T432_I0.6530.95
116_E120_K0.6520.95
187_V369_V0.6500.95
507_T532_V0.6500.95
420_D425_T0.6490.95
132_A483_E0.6480.95
339_A371_L0.6480.95
157_L562_E0.6470.94
422_G426_A0.6470.94
233_L236_F0.6470.94
149_G152_H0.6460.94
199_S348_M0.6440.94
530_Q534_P0.6440.94
421_D428_P0.6420.94
412_A419_A0.6420.94
688_A691_R0.6410.94
295_F300_T0.6400.94
404_L407_M0.6400.94
136_S167_G0.6380.94
276_A323_W0.6380.94
592_N595_W0.6380.94
432_I436_L0.6380.94
443_Y446_N0.6370.94
449_E452_Y0.6360.94
211_V347_T0.6360.94
139_F458_I0.6360.94
427_I435_A0.6350.94
372_A385_F0.6350.94
346_R380_T0.6350.94
280_G283_H0.6340.94
342_M371_L0.6340.94
100_Q104_G0.6340.94
204_L350_M0.6310.94
34_K531_A0.6300.94
677_P701_P0.6300.94
279_L367_M0.6290.94
134_G456_K0.6280.94
180_A365_H0.6270.94
275_V360_Y0.6260.93
187_V637_Y0.6260.93
299_Y624_K0.6260.93
735_V738_G0.6250.93
473_N476_I0.6250.93
154_A157_L0.6250.93
486_V503_L0.6250.93
116_E547_D0.6240.93
672_L746_V0.6240.93
65_K526_V0.6240.93
188_V385_F0.6240.93
101_P106_G0.6230.93
460_W465_N0.6230.93
216_N250_D0.6220.93
252_I745_C0.6210.93
187_V370_T0.6210.93
373_A636_I0.6200.93
268_A271_M0.6200.93
250_D257_I0.6200.93
253_R257_I0.6190.93
431_R435_A0.6180.93
604_R608_K0.6180.93
133_N483_E0.6170.93
306_F309_Y0.6170.93
567_M574_Y0.6160.93
422_G427_I0.6160.93
611_Q614_R0.6160.93
587_T590_M0.6150.93
588_M593_A0.6130.93
427_I433_V0.6130.93
601_I604_R0.6120.93
769_A785_A0.6120.93
54_G57_V0.6120.93
297_E304_P0.6120.93
253_R266_W0.6110.93
80_H678_A0.6110.93
351_A385_F0.6110.93
728_Q790_E0.6100.93
424_M433_V0.6100.93
561_T564_K0.6090.93
282_A370_T0.6090.93
51_V54_G0.6090.93
98_P544_V0.6080.92
99_L110_Y0.6080.92
287_T307_E0.6080.92
34_K49_V0.6070.92
448_K451_T0.6060.92
56_I86_Q0.6050.92
730_L792_Y0.6050.92
165_A552_L0.6050.92
505_I541_D0.6040.92
121_L457_M0.6040.92
479_W498_H0.6030.92
285_L344_A0.6030.92
334_Q338_L0.6020.92
444_Q447_G0.5990.92
431_R434_D0.5990.92
773_S777_A0.5990.92
669_Q712_F0.5980.92
609_N612_Y0.5980.92
211_V342_M0.5980.92
539_R551_L0.5970.92
768_T785_A0.5960.92
205_E242_S0.5960.92
113_V484_M0.5950.92
322_V325_A0.5950.92
292_D295_F0.5950.92
276_A324_A0.5940.92
126_H138_I0.5940.92
116_E539_R0.5930.92
277_L330_V0.5930.92
128_R483_E0.5930.92
624_K627_L0.5920.91
283_H324_A0.5920.91
615_Y619_R0.5910.91
239_L242_S0.5910.91
612_Y616_G0.5910.91
200_W602_E0.5900.91
106_G110_Y0.5900.91
468_H683_S0.5900.91
567_M570_L0.5900.91
132_A456_K0.5890.91
85_I508_S0.5890.91
708_D735_V0.5860.91
280_G325_A0.5860.91
701_P747_H0.5860.91
51_V56_I0.5850.91
285_L342_M0.5850.91
241_K244_K0.5850.91
118_A503_L0.5850.91
662_K726_R0.5840.91
362_E777_A0.5830.91
570_L578_Q0.5830.91
283_H323_W0.5810.91
614_R619_R0.5810.91
177_T181_Q0.5810.91
285_L290_K0.5800.91
342_M372_A0.5800.91
216_N219_N0.5790.91
443_Y447_G0.5790.91
288_Q321_A0.5780.90
420_D424_M0.5780.90
207_S348_M0.5780.90
603_M612_Y0.5770.90
676_H748_E0.5770.90
364_K368_L0.5770.90
510_E535_Q0.5760.90
724_N727_G0.5750.90
671_Q784_S0.5740.90
135_P166_G0.5740.90
218_L233_L0.5740.90
213_W277_L0.5740.90
140_A158_L0.5730.90
366_W637_Y0.5730.90
59_S85_I0.5730.90
282_A367_M0.5720.90
540_N566_E0.5720.90
450_Q481_K0.5720.90
423_G427_I0.5720.90
129_I138_I0.5720.90
705_H740_K0.5720.90
486_V501_I0.5710.90
712_F744_V0.5710.90
219_N678_A0.5700.90
212_L217_P0.5690.90
458_I465_N0.5690.90
362_E776_L0.5690.90
35_G38_I0.5680.90
358_Q784_S0.5680.90
430_A575_D0.5680.90
668_K725_K0.5670.90
165_A554_P0.5660.90
423_G429_V0.5660.90
426_A429_V0.5660.90
245_P337_K0.5650.89
445_H778_N0.5650.89
555_G561_T0.5650.89
444_Q449_E0.5650.89
423_G431_R0.5640.89
670_L705_H0.5640.89
51_V55_K0.5640.89
594_F598_N0.5630.89
213_W371_L0.5630.89
277_L325_A0.5620.89
612_Y617_D0.5620.89
719_L733_A0.5610.89
89_M509_F0.5610.89
177_T180_A0.5610.89
97_N113_V0.5600.89
427_I434_D0.5590.89
283_H318_P0.5590.89
487_V495_A0.5580.89
726_R769_A0.5580.89
250_D256_T0.5570.89
129_I133_N0.5570.89
215_M352_G0.5560.89
215_M350_M0.5560.89
177_T389_Y0.5560.89
213_W355_I0.5550.89
51_V531_A0.5550.89
204_L236_F0.5550.89
62_A65_K0.5540.89
38_I73_S0.5540.89
670_L704_I0.5540.89
475_L479_W0.5520.88
542_F569_W0.5520.88
706_T736_T0.5510.88
430_A434_D0.5500.88
160_R163_N0.5500.88
715_A791_K0.5500.88
562_E569_W0.5480.88
252_I675_A0.5470.88
546_A561_T0.5470.88
448_K453_P0.5470.88
718_D733_A0.5470.88
60_T63_L0.5460.88
490_C505_I0.5450.88
36_G528_M0.5450.88
286_M296_L0.5450.88
183_I187_V0.5440.88
281_I347_T0.5430.88
295_F299_Y0.5430.88
246_V259_F0.5430.88
123_H548_L0.5430.88
268_A334_Q0.5420.87
629_T632_G0.5420.87
108_D111_V0.5420.87
105_R500_D0.5410.87
558_E561_T0.5410.87
543_D551_L0.5400.87
422_G432_I0.5400.87
345_N380_T0.5400.87
331_P336_V0.5400.87
705_H708_D0.5400.87
208_Q377_Q0.5400.87
603_M608_K0.5390.87
551_L554_P0.5380.87
281_I290_K0.5380.87
220_T352_G0.5370.87
207_S347_T0.5370.87
126_H548_L0.5370.87
608_K613_V0.5360.87
418_A423_G0.5360.87
574_Y590_M0.5360.87
342_M377_Q0.5360.87
423_G432_I0.5350.87
586_V589_P0.5350.87
271_M673_L0.5350.87
170_G174_D0.5340.87
270_N671_Q0.5340.87
705_H712_F0.5340.87
377_Q380_T0.5340.87
335_I339_A0.5340.87
570_L577_A0.5330.87
355_I365_H0.5330.87
537_E540_N0.5320.86
662_K665_A0.5320.86
427_I430_A0.5320.86
541_D544_V0.5320.86
280_G339_A0.5310.86
209_V337_K0.5310.86
111_V121_L0.5310.86
169_S441_G0.5310.86
457_M482_P0.5310.86
485_I495_A0.5300.86
211_V371_L0.5290.86
249_I328_T0.5290.86
424_M437_E0.5290.86
772_P778_N0.5290.86
706_T735_V0.5290.86
589_P593_A0.5280.86
86_Q90_V0.5280.86
460_W479_W0.5280.86
616_G619_R0.5270.86
215_M388_S0.5270.86
542_F546_A0.5270.86
182_V777_A0.5260.86
570_L575_D0.5260.86
398_T401_G0.5250.86
54_G90_V0.5250.86
769_A781_A0.5250.86
330_V338_L0.5240.86
122_I126_H0.5240.86
180_A351_A0.5220.85
282_A286_M0.5220.85
343_A347_T0.5220.85
286_M289_G0.5220.85
429_V435_A0.5210.85
609_N615_Y0.5210.85
700_E747_H0.5210.85
788_Y791_K0.5210.85
631_S634_I0.5210.85
571_K599_K0.5200.85
570_L591_F0.5200.85
739_I745_C0.5200.85
97_N536_F0.5190.85
573_F577_A0.5180.85
100_Q122_I0.5170.85
494_A497_K0.5170.85
459_W486_V0.5170.85
357_R783_N0.5170.85
449_E453_P0.5160.85
628_G632_G0.5160.85
718_D792_Y0.5160.85
360_Y364_K0.5160.85
297_E303_Y0.5150.85
441_G454_N0.5150.85
446_N458_I0.5150.85
421_D435_A0.5130.84
51_V57_V0.5130.84
510_E538_A0.5120.84
329_G742_G0.5110.84
95_L492_W0.5110.84
71_L234_E0.5110.84
421_D424_M0.5110.84
689_E693_K0.5100.84
701_P732_G0.5100.84
724_N788_Y0.5090.84
748_E764_A0.5090.84
444_Q448_K0.5090.84
628_G631_S0.5090.84
202_L206_N0.5090.84
459_W545_F0.5080.84
324_A327_I0.5080.84
566_E570_L0.5080.84
389_Y394_G0.5080.84
687_Y691_R0.5070.84
353_W356_Q0.5070.84
628_G633_K0.5070.84
472_T476_I0.5060.84
178_G779_A0.5050.84
251_P673_L0.5050.84
356_Q387_F0.5050.84
447_G450_Q0.5050.84
379_G384_G0.5040.83
219_N703_T0.5030.83
212_L248_A0.5030.83
711_R742_G0.5030.83
546_A549_A0.5030.83
708_D740_K0.5020.83
714_I789_I0.5020.83
248_A256_T0.5020.83
162_M165_A0.5020.83
141_G463_G0.5010.83
184_M385_F0.5010.83
283_H307_E0.5010.83
36_G47_M0.5010.83
310_L320_S0.5000.83
608_K614_R0.5000.83
703_T735_V0.5000.83
524_H602_E0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfA 3 0.8826 100 0.25 Contact Map
2vpzA 1 0.8826 100 0.252 Contact Map
2ivfA 1 0.885 100 0.262 Contact Map
1tmoA 1 0.9295 100 0.276 Contact Map
1h0hA 1 0.8888 100 0.283 Contact Map
2e7zA 1 0.848 100 0.288 Contact Map
2iv2X 1 0.8331 100 0.293 Contact Map
1q16A 2 0.9543 100 0.293 Contact Map
1eu1A 1 0.9197 100 0.295 Contact Map
2napA 1 0.8541 100 0.302 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0179 seconds.