GREMLIN Database
COF - HMP-PP phosphatase
UniProt: P46891 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13216
Length: 272 (253)
Sequences: 10938 (8991)
Seq/√Len: 565.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_G256_H4.6181.00
16_P250_R3.4691.00
209_A223_V3.1841.00
248_H251_N2.9291.00
220_L226_G2.8551.00
21_G252_Q2.7551.00
3_R206_D2.7151.00
23_K252_Q2.6151.00
197_T207_C2.5681.00
7_F38_L2.4451.00
234_P238_A2.4421.00
23_K259_T2.4331.00
15_M19_H2.4071.00
221_V239_E2.3721.00
42_T49_M2.3591.00
194_T222_S2.3441.00
204_L222_S2.1301.00
188_N218_E2.0401.00
247_G251_N2.0021.00
79_H195_V1.9261.00
214_M235_Q1.9011.00
22_E26_S1.8881.00
217_R236_L1.8861.00
30_R33_E1.8831.00
217_R239_E1.8471.00
214_M233_M1.8451.00
228_I240_L1.8401.00
226_G241_P1.8361.00
28_L38_L1.8181.00
30_R259_T1.8061.00
4_L39_T1.7711.00
25_L55_A1.7641.00
203_S206_D1.7581.00
6_A193_L1.7331.00
31_L36_I1.7321.00
234_P237_R1.7271.00
84_P87_V1.7211.00
194_T198_Q1.7071.00
225_S241_P1.6871.00
30_R34_R1.6851.00
195_V199_H1.6831.00
195_V198_Q1.6351.00
227_F257_Y1.6011.00
9_M14_L1.5811.00
190_G222_S1.5741.00
236_L239_E1.5731.00
96_W113_G1.5641.00
191_A194_T1.5571.00
81_D195_V1.5311.00
95_Q148_F1.5281.00
37_T200_L1.5281.00
21_G24_T1.5191.00
193_L219_M1.5181.00
7_F210_F1.5111.00
205_R224_G1.4621.00
26_S30_R1.4501.00
90_L169_R1.4481.00
210_F254_V1.4421.00
209_A219_M1.4351.00
24_T252_Q1.4251.00
25_L29_A1.4071.00
23_K256_H1.4031.00
32_R59_D1.3981.00
159_Q163_Y1.3821.00
210_F257_Y1.3791.00
27_T255_S1.3431.00
228_I232_A1.3401.00
6_A41_A1.2991.00
171_H218_E1.2981.00
87_V90_L1.2981.00
217_R221_V1.2921.00
197_T204_L1.2861.00
77_L80_R1.2801.00
257_Y261_W1.2791.00
220_L236_L1.2791.00
204_L207_C1.2761.00
154_D157_R1.2751.00
81_D184_P1.2671.00
87_V169_R1.2661.00
235_Q238_A1.2631.00
246_I257_Y1.2601.00
85_A89_E1.2561.00
27_T259_T1.2451.00
80_R142_S1.2321.00
230_G248_H1.2261.00
254_V258_L1.2141.00
87_V170_A1.2011.00
90_L165_A1.1981.00
29_A33_E1.1841.00
15_M250_R1.1791.00
4_L202_L1.1791.00
208_M261_W1.1751.00
5_A31_L1.1751.00
69_R77_L1.1681.00
39_T196_L1.1601.00
207_C223_V1.1551.00
156_T160_I1.1491.00
63_I192_A1.1491.00
23_K27_T1.1481.00
173_C183_L1.1341.00
80_R144_T1.1161.00
5_A258_L1.1141.00
5_A36_I1.1111.00
61_Y200_L1.1091.00
22_E25_L1.1061.00
171_H186_G1.1061.00
231_N249_C1.1041.00
208_M225_S1.1041.00
229_M253_A1.1031.00
255_S259_T1.1021.00
209_A220_L1.1021.00
237_R245_V1.0891.00
4_L197_T1.0871.00
156_T174_F1.0861.00
204_L224_G1.0841.00
32_R60_A1.0731.00
16_P249_C1.0701.00
223_V226_G1.0691.00
70_V195_V1.0611.00
6_A207_C1.0561.00
145_K181_E1.0451.00
184_P187_C1.0411.00
227_F246_I1.0381.00
188_N191_A1.0381.00
169_R185_V1.0381.00
9_M52_I1.0321.00
257_Y260_H1.0271.00
233_M236_L1.0231.00
29_A32_R1.0221.00
197_T222_S1.0211.00
94_Q97_D1.0161.00
232_A237_R1.0141.00
256_H260_H1.0101.00
13_L24_T1.0091.00
193_L223_V1.0041.00
93_Y97_D1.0011.00
246_I253_A1.0001.00
70_V79_H0.9991.00
247_G253_A0.9971.00
213_A233_M0.9961.00
160_I163_Y0.9941.00
208_M227_F0.9941.00
29_A57_S0.9921.00
4_L207_C0.9891.00
190_G218_E0.9881.00
194_T204_L0.9691.00
46_A64_T0.9681.00
13_L28_L0.9671.00
208_M257_Y0.9611.00
50_Q75_G0.9541.00
230_G237_R0.9531.00
89_E93_Y0.9531.00
196_L200_L0.9531.00
68_T187_C0.9521.00
157_R161_Q0.9501.00
214_M217_R0.9491.00
81_D186_G0.9461.00
94_Q98_T0.9441.00
82_D142_S0.9441.00
7_F254_V0.9431.00
36_I208_M0.9421.00
228_I236_L0.9341.00
71_H77_L0.9291.00
50_Q54_G0.9261.00
161_Q165_A0.9231.00
157_R160_I0.9211.00
70_V192_A0.9201.00
229_M246_I0.9191.00
6_A39_T0.9191.00
197_T202_L0.9181.00
256_H259_T0.9181.00
31_L38_L0.9181.00
230_G246_I0.9171.00
98_T161_Q0.9131.00
90_L93_Y0.9061.00
246_I256_H0.9061.00
64_T69_R0.9051.00
230_G245_V0.8931.00
26_S29_A0.8911.00
63_I196_L0.8731.00
183_L188_N0.8731.00
197_T224_G0.8651.00
5_A208_M0.8651.00
24_T255_S0.8631.00
235_Q239_E0.8611.00
86_D90_L0.8571.00
230_G251_N0.8561.00
220_L239_E0.8481.00
83_L184_P0.8461.00
71_H75_G0.8431.00
117_P121_Q0.8431.00
46_A71_H0.8421.00
42_T64_T0.8421.00
224_G241_P0.8351.00
7_F13_L0.8331.00
230_G247_G0.8331.00
78_L199_H0.8331.00
117_P120_L0.8291.00
172_L182_V0.8291.00
171_H188_N0.8271.00
27_T30_R0.8261.00
207_C224_G0.8261.00
80_R107_D0.8251.00
150_G154_D0.8241.00
41_A63_I0.8231.00
135_V138_M0.8211.00
151_D154_D0.8181.00
168_E185_V0.8121.00
15_M21_G0.8091.00
31_L258_L0.8061.00
82_D144_T0.8051.00
209_A226_G0.8031.00
23_K255_S0.7931.00
94_Q161_Q0.7901.00
134_D137_K0.7891.00
159_Q174_F0.7891.00
24_T27_T0.7881.00
207_C222_S0.7821.00
150_G155_L0.7771.00
97_D161_Q0.7751.00
45_H65_G0.7741.00
13_L20_L0.7691.00
9_M40_F0.7681.00
212_D232_A0.7611.00
193_L209_A0.7611.00
220_L240_L0.7581.00
92_L96_W0.7561.00
232_A236_L0.7511.00
36_I206_D0.7461.00
191_A195_V0.7441.00
90_L94_Q0.7421.00
156_T159_Q0.7421.00
225_S257_Y0.7421.00
98_T157_R0.7411.00
61_Y196_L0.7391.00
171_H185_V0.7371.00
49_M64_T0.7331.00
85_A142_S0.7241.00
229_M232_A0.7171.00
15_M249_C0.7171.00
39_T61_Y0.7171.00
94_Q165_A0.7161.00
194_T197_T0.7131.00
241_P245_V0.7121.00
13_L249_C0.7101.00
11_G229_M0.7041.00
40_F49_M0.7021.00
147_C181_E0.6991.00
161_Q164_E0.6981.00
69_R144_T0.6981.00
23_K26_S0.6981.00
17_D250_R0.6961.00
120_L124_V0.6941.00
152_H156_T0.6931.00
131_Q134_D0.6921.00
106_N143_V0.6901.00
64_T71_H0.6891.00
218_E221_V0.6861.00
145_K175_S0.6841.00
109_G131_Q0.6791.00
66_N181_E0.6731.00
41_A219_M0.6711.00
86_D89_E0.6711.00
96_W102_M0.6651.00
187_C191_A0.6621.00
160_I164_E0.6611.00
206_D224_G0.6611.00
106_N141_G0.6541.00
46_A50_Q0.6511.00
9_M49_M0.6501.00
68_T184_P0.6491.00
103_H147_C0.6491.00
139_P142_S0.6481.00
49_M62_L0.6441.00
9_M13_L0.6441.00
247_G257_Y0.6391.00
228_I239_E0.6361.00
76_E199_H0.6351.00
236_L240_L0.6331.00
4_L196_L0.6321.00
231_N248_H0.6301.00
231_N237_R0.6271.00
214_M236_L0.6261.00
40_F53_L0.6251.00
212_D229_M0.6231.00
70_V196_L0.6231.00
13_L40_F0.6201.00
210_F246_I0.6201.00
247_G260_H0.6191.00
226_G240_L0.6191.00
152_H174_F0.6151.00
21_G255_S0.6141.00
217_R220_L0.6121.00
92_L104_I0.6121.00
37_T60_A0.6111.00
107_D142_S0.6111.00
89_E139_P0.6111.00
210_F227_F0.6051.00
226_G236_L0.6041.00
70_V199_H0.6041.00
252_Q255_S0.6021.00
14_L249_C0.6001.00
88_A92_L0.6001.00
53_L62_L0.6001.00
88_A143_V0.5971.00
51_H54_G0.5941.00
107_D144_T0.5931.00
5_A210_F0.5911.00
115_E120_L0.5911.00
255_S258_L0.5911.00
190_G194_T0.5911.00
39_T60_A0.5901.00
121_Q125_Y0.5851.00
20_L25_L0.5841.00
229_M249_C0.5831.00
186_G191_A0.5821.00
171_H183_L0.5811.00
172_L180_L0.5811.00
155_L159_Q0.5811.00
27_T31_L0.5801.00
227_F241_P0.5781.00
176_A213_A0.5781.00
99_R154_D0.5761.00
24_T28_L0.5761.00
202_L224_G0.5660.99
26_S259_T0.5660.99
32_R57_S0.5620.99
152_H177_T0.5620.99
155_L174_F0.5620.99
77_L107_D0.5610.99
119_L123_F0.5610.99
15_M252_Q0.5600.99
31_L255_S0.5590.99
104_I143_V0.5560.99
37_T61_Y0.5550.99
65_G68_T0.5530.99
210_F258_L0.5510.99
4_L37_T0.5480.99
107_D141_G0.5480.99
3_R36_I0.5440.99
45_H48_E0.5440.99
225_S261_W0.5420.99
92_L102_M0.5390.99
155_L180_L0.5390.99
233_M237_R0.5380.99
204_L223_V0.5360.99
19_H55_A0.5350.99
41_A66_N0.5340.99
49_M52_I0.5340.99
147_C179_C0.5320.99
53_L58_L0.5310.99
100_A148_F0.5300.99
65_G144_T0.5280.99
7_F31_L0.5280.99
202_L207_C0.5240.99
122_A126_S0.5240.99
252_Q256_H0.5240.99
85_A140_L0.5230.99
50_Q53_L0.5220.99
88_A146_I0.5210.99
65_G179_C0.5200.99
69_R107_D0.5200.99
202_L206_D0.5200.99
81_D187_C0.5200.99
6_A197_T0.5190.99
13_L254_V0.5190.99
20_L44_R0.5170.99
37_T202_L0.5160.99
28_L258_L0.5110.99
40_F56_L0.5100.99
148_F182_V0.5100.99
91_V182_V0.5090.99
148_F158_L0.5060.99
94_Q162_L0.5050.99
85_A141_G0.5050.99
43_G215_N0.5050.99
121_Q124_V0.5040.99
190_G207_C0.5030.99
193_L197_T0.5010.99
223_V241_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9522 100 0.207 Contact Map
1nrwA 1 0.9449 100 0.233 Contact Map
2b30A 2 0.9632 100 0.243 Contact Map
4qjbA 1 0.9632 100 0.244 Contact Map
1nf2A 4 0.9706 100 0.246 Contact Map
3l7yA 1 0.9559 100 0.253 Contact Map
1rkqA 1 0.9632 100 0.262 Contact Map
3daoA 1 0.9522 100 0.263 Contact Map
3dnpA 2 0.9706 100 0.272 Contact Map
2rbkA 1 0.9375 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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