COF - ECOLI - GREMLIN Contacts

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COF - HMP-PP phosphatase

UniProt:	P46891	Sequences: MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLVSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13216
Length:	272 (253)
Sequences:	10938 (8991)
Seq/√Len:	565.3

ECOLI - COF YIGL YIDA SUPH YBJI YBHA MPGP
BACSU - YXEH YWPJ YITU YHAX YWTE YKRA YCSE NTDB
HALSA - PGP
SULSO - PGP1 PGP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
247_G	256_H	4.618	1.00
16_P	250_R	3.469	1.00
209_A	223_V	3.184	1.00
248_H	251_N	2.929	1.00
220_L	226_G	2.855	1.00
21_G	252_Q	2.755	1.00
3_R	206_D	2.715	1.00
23_K	252_Q	2.615	1.00
197_T	207_C	2.568	1.00
7_F	38_L	2.445	1.00
234_P	238_A	2.442	1.00
23_K	259_T	2.433	1.00
15_M	19_H	2.407	1.00
221_V	239_E	2.372	1.00
42_T	49_M	2.359	1.00
194_T	222_S	2.344	1.00
204_L	222_S	2.130	1.00
188_N	218_E	2.040	1.00
247_G	251_N	2.002	1.00
79_H	195_V	1.926	1.00
214_M	235_Q	1.901	1.00
22_E	26_S	1.888	1.00
217_R	236_L	1.886	1.00
30_R	33_E	1.883	1.00
217_R	239_E	1.847	1.00
214_M	233_M	1.845	1.00
228_I	240_L	1.840	1.00
226_G	241_P	1.836	1.00
28_L	38_L	1.818	1.00
30_R	259_T	1.806	1.00
4_L	39_T	1.771	1.00
25_L	55_A	1.764	1.00
203_S	206_D	1.758	1.00
6_A	193_L	1.733	1.00
31_L	36_I	1.732	1.00
234_P	237_R	1.727	1.00
84_P	87_V	1.721	1.00
194_T	198_Q	1.707	1.00
225_S	241_P	1.687	1.00
30_R	34_R	1.685	1.00
195_V	199_H	1.683	1.00
195_V	198_Q	1.635	1.00
227_F	257_Y	1.601	1.00
9_M	14_L	1.581	1.00
190_G	222_S	1.574	1.00
236_L	239_E	1.573	1.00
96_W	113_G	1.564	1.00
191_A	194_T	1.557	1.00
81_D	195_V	1.531	1.00
95_Q	148_F	1.528	1.00
37_T	200_L	1.528	1.00
21_G	24_T	1.519	1.00
193_L	219_M	1.518	1.00
7_F	210_F	1.511	1.00
205_R	224_G	1.462	1.00
26_S	30_R	1.450	1.00
90_L	169_R	1.448	1.00
210_F	254_V	1.442	1.00
209_A	219_M	1.435	1.00
24_T	252_Q	1.425	1.00
25_L	29_A	1.407	1.00
23_K	256_H	1.403	1.00
32_R	59_D	1.398	1.00
159_Q	163_Y	1.382	1.00
210_F	257_Y	1.379	1.00
27_T	255_S	1.343	1.00
228_I	232_A	1.340	1.00
6_A	41_A	1.299	1.00
171_H	218_E	1.298	1.00
87_V	90_L	1.298	1.00
217_R	221_V	1.292	1.00
197_T	204_L	1.286	1.00
77_L	80_R	1.280	1.00
257_Y	261_W	1.279	1.00
220_L	236_L	1.279	1.00
204_L	207_C	1.276	1.00
154_D	157_R	1.275	1.00
81_D	184_P	1.267	1.00
87_V	169_R	1.266	1.00
235_Q	238_A	1.263	1.00
246_I	257_Y	1.260	1.00
85_A	89_E	1.256	1.00
27_T	259_T	1.245	1.00
80_R	142_S	1.232	1.00
230_G	248_H	1.226	1.00
254_V	258_L	1.214	1.00
87_V	170_A	1.201	1.00
90_L	165_A	1.198	1.00
29_A	33_E	1.184	1.00
15_M	250_R	1.179	1.00
4_L	202_L	1.179	1.00
208_M	261_W	1.175	1.00
5_A	31_L	1.175	1.00
69_R	77_L	1.168	1.00
39_T	196_L	1.160	1.00
207_C	223_V	1.155	1.00
156_T	160_I	1.149	1.00
63_I	192_A	1.149	1.00
23_K	27_T	1.148	1.00
173_C	183_L	1.134	1.00
80_R	144_T	1.116	1.00
5_A	258_L	1.114	1.00
5_A	36_I	1.111	1.00
61_Y	200_L	1.109	1.00
22_E	25_L	1.106	1.00
171_H	186_G	1.106	1.00
231_N	249_C	1.104	1.00
208_M	225_S	1.104	1.00
229_M	253_A	1.103	1.00
255_S	259_T	1.102	1.00
209_A	220_L	1.102	1.00
237_R	245_V	1.089	1.00
4_L	197_T	1.087	1.00
156_T	174_F	1.086	1.00
204_L	224_G	1.084	1.00
32_R	60_A	1.073	1.00
16_P	249_C	1.070	1.00
223_V	226_G	1.069	1.00
70_V	195_V	1.061	1.00
6_A	207_C	1.056	1.00
145_K	181_E	1.045	1.00
184_P	187_C	1.041	1.00
227_F	246_I	1.038	1.00
188_N	191_A	1.038	1.00
169_R	185_V	1.038	1.00
9_M	52_I	1.032	1.00
257_Y	260_H	1.027	1.00
233_M	236_L	1.023	1.00
29_A	32_R	1.022	1.00
197_T	222_S	1.021	1.00
94_Q	97_D	1.016	1.00
232_A	237_R	1.014	1.00
256_H	260_H	1.010	1.00
13_L	24_T	1.009	1.00
193_L	223_V	1.004	1.00
93_Y	97_D	1.001	1.00
246_I	253_A	1.000	1.00
70_V	79_H	0.999	1.00
247_G	253_A	0.997	1.00
213_A	233_M	0.996	1.00
160_I	163_Y	0.994	1.00
208_M	227_F	0.994	1.00
29_A	57_S	0.992	1.00
4_L	207_C	0.989	1.00
190_G	218_E	0.988	1.00
194_T	204_L	0.969	1.00
46_A	64_T	0.968	1.00
13_L	28_L	0.967	1.00
208_M	257_Y	0.961	1.00
50_Q	75_G	0.954	1.00
230_G	237_R	0.953	1.00
89_E	93_Y	0.953	1.00
196_L	200_L	0.953	1.00
68_T	187_C	0.952	1.00
157_R	161_Q	0.950	1.00
214_M	217_R	0.949	1.00
81_D	186_G	0.946	1.00
94_Q	98_T	0.944	1.00
82_D	142_S	0.944	1.00
7_F	254_V	0.943	1.00
36_I	208_M	0.942	1.00
228_I	236_L	0.934	1.00
71_H	77_L	0.929	1.00
50_Q	54_G	0.926	1.00
161_Q	165_A	0.923	1.00
157_R	160_I	0.921	1.00
70_V	192_A	0.920	1.00
229_M	246_I	0.919	1.00
6_A	39_T	0.919	1.00
197_T	202_L	0.918	1.00
256_H	259_T	0.918	1.00
31_L	38_L	0.918	1.00
230_G	246_I	0.917	1.00
98_T	161_Q	0.913	1.00
90_L	93_Y	0.906	1.00
246_I	256_H	0.906	1.00
64_T	69_R	0.905	1.00
230_G	245_V	0.893	1.00
26_S	29_A	0.891	1.00
63_I	196_L	0.873	1.00
183_L	188_N	0.873	1.00
197_T	224_G	0.865	1.00
5_A	208_M	0.865	1.00
24_T	255_S	0.863	1.00
235_Q	239_E	0.861	1.00
86_D	90_L	0.857	1.00
230_G	251_N	0.856	1.00
220_L	239_E	0.848	1.00
83_L	184_P	0.846	1.00
71_H	75_G	0.843	1.00
117_P	121_Q	0.843	1.00
46_A	71_H	0.842	1.00
42_T	64_T	0.842	1.00
224_G	241_P	0.835	1.00
7_F	13_L	0.833	1.00
230_G	247_G	0.833	1.00
78_L	199_H	0.833	1.00
117_P	120_L	0.829	1.00
172_L	182_V	0.829	1.00
171_H	188_N	0.827	1.00
27_T	30_R	0.826	1.00
207_C	224_G	0.826	1.00
80_R	107_D	0.825	1.00
150_G	154_D	0.824	1.00
41_A	63_I	0.823	1.00
135_V	138_M	0.821	1.00
151_D	154_D	0.818	1.00
168_E	185_V	0.812	1.00
15_M	21_G	0.809	1.00
31_L	258_L	0.806	1.00
82_D	144_T	0.805	1.00
209_A	226_G	0.803	1.00
23_K	255_S	0.793	1.00
94_Q	161_Q	0.790	1.00
134_D	137_K	0.789	1.00
159_Q	174_F	0.789	1.00
24_T	27_T	0.788	1.00
207_C	222_S	0.782	1.00
150_G	155_L	0.777	1.00
97_D	161_Q	0.775	1.00
45_H	65_G	0.774	1.00
13_L	20_L	0.769	1.00
9_M	40_F	0.768	1.00
212_D	232_A	0.761	1.00
193_L	209_A	0.761	1.00
220_L	240_L	0.758	1.00
92_L	96_W	0.756	1.00
232_A	236_L	0.751	1.00
36_I	206_D	0.746	1.00
191_A	195_V	0.744	1.00
90_L	94_Q	0.742	1.00
156_T	159_Q	0.742	1.00
225_S	257_Y	0.742	1.00
98_T	157_R	0.741	1.00
61_Y	196_L	0.739	1.00
171_H	185_V	0.737	1.00
49_M	64_T	0.733	1.00
85_A	142_S	0.724	1.00
229_M	232_A	0.717	1.00
15_M	249_C	0.717	1.00
39_T	61_Y	0.717	1.00
94_Q	165_A	0.716	1.00
194_T	197_T	0.713	1.00
241_P	245_V	0.712	1.00
13_L	249_C	0.710	1.00
11_G	229_M	0.704	1.00
40_F	49_M	0.702	1.00
147_C	181_E	0.699	1.00
161_Q	164_E	0.698	1.00
69_R	144_T	0.698	1.00
23_K	26_S	0.698	1.00
17_D	250_R	0.696	1.00
120_L	124_V	0.694	1.00
152_H	156_T	0.693	1.00
131_Q	134_D	0.692	1.00
106_N	143_V	0.690	1.00
64_T	71_H	0.689	1.00
218_E	221_V	0.686	1.00
145_K	175_S	0.684	1.00
109_G	131_Q	0.679	1.00
66_N	181_E	0.673	1.00
41_A	219_M	0.671	1.00
86_D	89_E	0.671	1.00
96_W	102_M	0.665	1.00
187_C	191_A	0.662	1.00
160_I	164_E	0.661	1.00
206_D	224_G	0.661	1.00
106_N	141_G	0.654	1.00
46_A	50_Q	0.651	1.00
9_M	49_M	0.650	1.00
68_T	184_P	0.649	1.00
103_H	147_C	0.649	1.00
139_P	142_S	0.648	1.00
49_M	62_L	0.644	1.00
9_M	13_L	0.644	1.00
247_G	257_Y	0.639	1.00
228_I	239_E	0.636	1.00
76_E	199_H	0.635	1.00
236_L	240_L	0.633	1.00
4_L	196_L	0.632	1.00
231_N	248_H	0.630	1.00
231_N	237_R	0.627	1.00
214_M	236_L	0.626	1.00
40_F	53_L	0.625	1.00
212_D	229_M	0.623	1.00
70_V	196_L	0.623	1.00
13_L	40_F	0.620	1.00
210_F	246_I	0.620	1.00
247_G	260_H	0.619	1.00
226_G	240_L	0.619	1.00
152_H	174_F	0.615	1.00
21_G	255_S	0.614	1.00
217_R	220_L	0.612	1.00
92_L	104_I	0.612	1.00
37_T	60_A	0.611	1.00
107_D	142_S	0.611	1.00
89_E	139_P	0.611	1.00
210_F	227_F	0.605	1.00
226_G	236_L	0.604	1.00
70_V	199_H	0.604	1.00
252_Q	255_S	0.602	1.00
14_L	249_C	0.600	1.00
88_A	92_L	0.600	1.00
53_L	62_L	0.600	1.00
88_A	143_V	0.597	1.00
51_H	54_G	0.594	1.00
107_D	144_T	0.593	1.00
5_A	210_F	0.591	1.00
115_E	120_L	0.591	1.00
255_S	258_L	0.591	1.00
190_G	194_T	0.591	1.00
39_T	60_A	0.590	1.00
121_Q	125_Y	0.585	1.00
20_L	25_L	0.584	1.00
229_M	249_C	0.583	1.00
186_G	191_A	0.582	1.00
171_H	183_L	0.581	1.00
172_L	180_L	0.581	1.00
155_L	159_Q	0.581	1.00
27_T	31_L	0.580	1.00
227_F	241_P	0.578	1.00
176_A	213_A	0.578	1.00
99_R	154_D	0.576	1.00
24_T	28_L	0.576	1.00
202_L	224_G	0.566	0.99
26_S	259_T	0.566	0.99
32_R	57_S	0.562	0.99
152_H	177_T	0.562	0.99
155_L	174_F	0.562	0.99
77_L	107_D	0.561	0.99
119_L	123_F	0.561	0.99
15_M	252_Q	0.560	0.99
31_L	255_S	0.559	0.99
104_I	143_V	0.556	0.99
37_T	61_Y	0.555	0.99
65_G	68_T	0.553	0.99
210_F	258_L	0.551	0.99
4_L	37_T	0.548	0.99
107_D	141_G	0.548	0.99
3_R	36_I	0.544	0.99
45_H	48_E	0.544	0.99
225_S	261_W	0.542	0.99
92_L	102_M	0.539	0.99
155_L	180_L	0.539	0.99
233_M	237_R	0.538	0.99
204_L	223_V	0.536	0.99
19_H	55_A	0.535	0.99
41_A	66_N	0.534	0.99
49_M	52_I	0.534	0.99
147_C	179_C	0.532	0.99
53_L	58_L	0.531	0.99
100_A	148_F	0.530	0.99
65_G	144_T	0.528	0.99
7_F	31_L	0.528	0.99
202_L	207_C	0.524	0.99
122_A	126_S	0.524	0.99
252_Q	256_H	0.524	0.99
85_A	140_L	0.523	0.99
50_Q	53_L	0.522	0.99
88_A	146_I	0.521	0.99
65_G	179_C	0.520	0.99
69_R	107_D	0.520	0.99
202_L	206_D	0.520	0.99
81_D	187_C	0.520	0.99
6_A	197_T	0.519	0.99
13_L	254_V	0.519	0.99
20_L	44_R	0.517	0.99
37_T	202_L	0.516	0.99
28_L	258_L	0.511	0.99
40_F	56_L	0.510	0.99
148_F	182_V	0.510	0.99
91_V	182_V	0.509	0.99
148_F	158_L	0.506	0.99
94_Q	162_L	0.505	0.99
85_A	141_G	0.505	0.99
43_G	215_N	0.505	0.99
121_Q	124_V	0.504	0.99
190_G	207_C	0.503	0.99
193_L	197_T	0.501	0.99
223_V	241_P	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pgvA	3	0.9522	100	0.207	Contact Map
1nrwA	1	0.9449	100	0.233	Contact Map
2b30A	2	0.9632	100	0.243	Contact Map
4qjbA	1	0.9632	100	0.244	Contact Map
1nf2A	4	0.9706	100	0.246	Contact Map
3l7yA	1	0.9559	100	0.253	Contact Map
1rkqA	1	0.9632	100	0.262	Contact Map
3daoA	1	0.9522	100	0.263	Contact Map
3dnpA	2	0.9706	100	0.272	Contact Map
2rbkA	1	0.9375	100	0.274	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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