GREMLIN Database
YBAE - Uncharacterized protein YbaE
UniProt: P46890 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13217
Length: 566 (444)
Sequences: 19665 (14585)
Seq/√Len: 692.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_T282_E4.0361.00
356_W407_T3.2801.00
229_T235_T3.1601.00
227_E235_T3.1541.00
400_D403_K3.0671.00
188_S232_Q3.0281.00
368_S372_Q2.8871.00
496_S500_A2.8551.00
230_H233_C2.8411.00
204_H208_L2.8391.00
270_R282_E2.7191.00
504_M509_N2.6491.00
350_S353_L2.5791.00
204_H228_V2.5461.00
363_S400_D2.4411.00
122_T296_A2.4181.00
366_H369_G2.4121.00
172_H185_Y2.3861.00
403_K407_T2.3521.00
361_V429_L2.3171.00
198_V266_T2.3101.00
174_E185_Y2.2811.00
159_D164_R2.2501.00
430_A435_E2.2431.00
493_H496_S2.2331.00
227_E237_F2.1911.00
156_T173_W2.1851.00
181_R235_T2.1701.00
356_W359_R2.1631.00
355_L359_R2.1611.00
409_T437_T2.1501.00
193_H284_H2.1241.00
201_S228_V2.1181.00
159_D166_I2.1151.00
356_W404_L2.0681.00
509_N512_N2.0561.00
183_D235_T2.0541.00
409_T439_I2.0521.00
489_P524_D2.0241.00
500_A513_A2.0221.00
191_H197_A2.0161.00
191_H286_Y2.0061.00
181_R237_F2.0041.00
491_Y520_Q2.0031.00
280_R296_A2.0011.00
175_T182_W1.9741.00
190_L198_V1.9741.00
153_S168_D1.9531.00
176_S180_L1.9341.00
506_D509_N1.9301.00
122_T298_E1.9181.00
207_L236_F1.9031.00
135_Q209_M1.8991.00
512_N516_A1.8761.00
185_Y233_C1.8711.00
126_P318_V1.8601.00
491_Y524_D1.8551.00
199_K202_H1.8461.00
224_K239_H1.8341.00
349_K456_D1.8331.00
312_T317_P1.8261.00
203_L234_L1.8071.00
171_H188_S1.7991.00
270_R285_D1.7701.00
494_L517_V1.7701.00
478_C490_A1.7541.00
273_Q280_R1.7481.00
501_V514_L1.7391.00
124_R298_E1.7301.00
493_H516_A1.7261.00
426_Q430_A1.7101.00
253_C256_L1.7081.00
273_Q278_L1.6841.00
364_I432_E1.6791.00
519_S523_T1.6711.00
355_L524_D1.6701.00
201_S231_P1.6681.00
497_T516_A1.6681.00
493_H520_Q1.6661.00
161_N164_R1.6541.00
384_S532_N1.6471.00
171_H185_Y1.6191.00
449_T454_H1.6161.00
501_V513_A1.6101.00
282_E296_A1.6041.00
225_R237_F1.5961.00
257_A260_Q1.5921.00
478_C495_Q1.5911.00
176_S181_R1.5821.00
252_Y255_H1.5761.00
359_R400_D1.5681.00
189_T197_A1.5661.00
121_P295_K1.5661.00
516_A519_S1.5651.00
272_T296_A1.5481.00
201_S204_H1.5471.00
278_L298_E1.5271.00
442_N445_N1.5251.00
171_H187_R1.5231.00
329_Q332_S1.5191.00
224_K237_F1.5171.00
490_A495_Q1.5091.00
269_F294_L1.5061.00
397_Q400_D1.5051.00
302_T312_T1.5011.00
275_T278_L1.4991.00
359_R525_A1.4991.00
200_A228_V1.4941.00
156_T184_F1.4881.00
492_A496_S1.4821.00
199_K231_P1.4781.00
283_S295_K1.4601.00
355_L523_T1.4571.00
365_I425_L1.4531.00
314_C330_R1.4521.00
448_D452_Q1.4511.00
362_I525_A1.4471.00
368_S383_A1.4391.00
419_H423_E1.4371.00
402_V406_K1.4281.00
357_Q405_P1.4191.00
497_T513_A1.4151.00
513_A516_A1.4131.00
511_F515_K1.4121.00
183_D233_C1.4101.00
343_C346_T1.4061.00
176_S183_D1.3881.00
173_W184_F1.3791.00
399_P402_V1.3701.00
512_N515_K1.3661.00
141_G144_E1.3651.00
347_L528_T1.3561.00
500_A509_N1.3561.00
153_S266_T1.3561.00
398_V432_E1.3511.00
280_R298_E1.3511.00
504_M513_A1.3491.00
153_S288_H1.3381.00
371_L383_A1.3281.00
349_K353_L1.3251.00
479_D490_A1.3231.00
193_H270_R1.3101.00
197_A232_Q1.3101.00
361_V434_C1.3031.00
124_R319_Q1.3021.00
439_I449_T1.3001.00
428_T431_A1.2891.00
272_T280_R1.2881.00
412_Y438_I1.2871.00
124_R300_W1.2841.00
196_D255_H1.2711.00
120_T295_K1.2681.00
204_H226_I1.2661.00
229_T233_C1.2611.00
191_H284_H1.2501.00
520_Q524_D1.2481.00
185_Y232_Q1.2471.00
496_S499_D1.2441.00
509_N513_A1.2341.00
190_L266_T1.2331.00
497_T520_Q1.2201.00
236_F245_L1.2151.00
187_R288_H1.2141.00
240_R503_I1.2111.00
479_D495_Q1.2041.00
412_Y440_F1.2021.00
453_A488_A1.2011.00
500_A504_M1.1951.00
390_G532_N1.1861.00
371_L381_I1.1861.00
352_R361_V1.1851.00
427_A431_A1.1831.00
443_A447_D1.1781.00
123_L320_I1.1761.00
278_L300_W1.1741.00
169_L266_T1.1741.00
312_T318_V1.1721.00
347_L457_L1.1711.00
352_R408_L1.1681.00
313_S538_S1.1641.00
187_R190_L1.1481.00
126_P308_K1.1471.00
508_E511_F1.1471.00
424_R428_T1.1431.00
319_Q542_G1.1401.00
281_L299_Y1.1401.00
208_L212_Q1.1381.00
493_H497_T1.1361.00
228_V231_P1.1361.00
314_C334_V1.1351.00
404_L407_T1.1341.00
403_K406_K1.1281.00
167_G173_W1.1261.00
157_R168_D1.1241.00
346_T458_M1.1231.00
477_R499_D1.1101.00
147_L281_L1.1041.00
364_I429_L1.1001.00
489_P494_L1.0971.00
182_W245_L1.0951.00
319_Q540_P1.0941.00
270_R284_H1.0911.00
359_R404_L1.0881.00
157_R166_I1.0871.00
429_L436_L1.0861.00
201_S254_S1.0841.00
193_H286_Y1.0841.00
355_L525_A1.0771.00
369_G428_T1.0761.00
426_Q438_I1.0741.00
226_I234_L1.0731.00
174_E183_D1.0561.00
194_N255_H1.0561.00
375_E531_F1.0551.00
123_L294_L1.0541.00
497_T517_V1.0511.00
329_Q333_Q1.0471.00
494_L521_L1.0471.00
283_S292_P1.0431.00
555_E558_E1.0401.00
508_E512_N1.0361.00
171_H232_Q1.0361.00
169_L203_L1.0331.00
410_L436_L1.0291.00
202_H205_Q1.0241.00
468_P510_R1.0231.00
184_F236_F1.0231.00
282_E285_D1.0161.00
500_A516_A1.0121.00
311_G314_C1.0121.00
252_Y256_L1.0091.00
556_F559_A1.0081.00
501_V517_V1.0031.00
400_D404_L0.9981.00
398_V402_V0.9981.00
425_L429_L0.9971.00
408_L457_L0.9951.00
222_S242_D0.9941.00
193_H264_I0.9931.00
489_P526_T0.9881.00
497_T500_A0.9881.00
520_Q523_T0.9871.00
208_L211_L0.9831.00
327_E330_R0.9761.00
473_E477_R0.9741.00
197_A231_P0.9711.00
188_S197_A0.9691.00
382_T534_H0.9691.00
169_L190_L0.9671.00
426_Q436_L0.9671.00
362_I528_T0.9631.00
200_A229_T0.9631.00
123_L543_V0.9631.00
445_N449_T0.9571.00
422_A438_I0.9551.00
370_L421_M0.9531.00
427_A430_A0.9521.00
182_W246_A0.9491.00
399_P403_K0.9441.00
202_H206_R0.9441.00
119_D293_L0.9431.00
130_P274_F0.9391.00
185_Y188_S0.9391.00
359_R363_S0.9371.00
192_W202_H0.9351.00
499_D503_I0.9341.00
420_T423_E0.9321.00
441_H449_T0.9321.00
362_I367_Q0.9301.00
201_S205_Q0.9291.00
182_W238_L0.9291.00
408_L436_L0.9261.00
369_G373_T0.9251.00
342_F346_T0.9241.00
156_T170_A0.9231.00
336_S534_H0.9221.00
398_V431_A0.9171.00
193_H265_G0.9171.00
359_R523_T0.9161.00
154_G168_D0.9121.00
450_T458_M0.9091.00
289_L557_T0.9041.00
375_E381_I0.9041.00
318_V321_T0.9031.00
189_T232_Q0.9001.00
371_L531_F0.8991.00
180_L237_F0.8991.00
183_D229_T0.8981.00
343_C347_L0.8931.00
200_A234_L0.8911.00
204_H234_L0.8871.00
169_L198_V0.8841.00
382_T390_G0.8811.00
283_S291_H0.8811.00
372_Q379_N0.8781.00
430_A434_C0.8751.00
494_L498_L0.8751.00
185_Y230_H0.8751.00
307_E312_T0.8751.00
245_L249_L0.8691.00
367_Q383_A0.8661.00
194_N264_I0.8631.00
192_W255_H0.8601.00
156_T165_P0.8581.00
310_L314_C0.8581.00
507_E511_F0.8571.00
184_F246_A0.8561.00
151_I281_L0.8541.00
193_H271_L0.8521.00
517_V520_Q0.8521.00
176_S179_G0.8461.00
152_F265_G0.8451.00
212_Q215_A0.8431.00
498_L517_V0.8421.00
366_H428_T0.8421.00
178_D181_R0.8411.00
150_Q281_L0.8341.00
302_T318_V0.8341.00
360_K405_P0.8331.00
387_L529_P0.8331.00
151_I271_L0.8291.00
396_W431_A0.8281.00
310_L331_V0.8231.00
363_S396_W0.8201.00
269_F292_P0.8201.00
494_L520_Q0.8191.00
411_V439_I0.8191.00
281_L297_V0.8181.00
156_T246_A0.8171.00
500_A503_I0.8161.00
228_V234_L0.8131.00
137_G209_M0.8131.00
313_S321_T0.8111.00
208_L226_I0.8041.00
121_P294_L0.8021.00
130_P301_I0.8001.00
153_S287_Y0.7981.00
515_K519_S0.7961.00
238_L245_L0.7951.00
180_L224_K0.7951.00
366_H396_W0.7951.00
328_L332_S0.7911.00
331_V538_S0.7881.00
174_E177_T0.7871.00
364_I398_V0.7871.00
274_F279_V0.7871.00
516_A520_Q0.7871.00
118_N121_P0.7851.00
347_L361_V0.7851.00
349_K352_R0.7831.00
117_Q293_L0.7811.00
365_I370_L0.7801.00
170_A184_F0.7791.00
324_K327_E0.7781.00
242_D248_R0.7741.00
409_T456_D0.7731.00
130_P276_A0.7711.00
184_F249_L0.7681.00
401_E432_E0.7601.00
338_I346_T0.7581.00
137_G210_L0.7581.00
485_V488_A0.7561.00
160_N547_R0.7561.00
478_C499_D0.7561.00
180_L240_R0.7541.00
419_H440_F0.7541.00
125_I320_I0.7521.00
492_A495_Q0.7511.00
196_D202_H0.7481.00
283_S294_L0.7481.00
477_R480_P0.7471.00
363_S395_H0.7471.00
405_P434_C0.7451.00
489_P520_Q0.7441.00
207_L249_L0.7431.00
222_S240_R0.7421.00
363_S404_L0.7411.00
423_E438_I0.7411.00
151_I265_G0.7401.00
282_E295_K0.7401.00
365_I429_L0.7391.00
546_V559_A0.7381.00
526_T529_P0.7381.00
216_L219_L0.7371.00
186_L198_V0.7351.00
370_L424_R0.7341.00
150_Q297_V0.7341.00
228_V235_T0.7321.00
139_L148_A0.7311.00
343_C348_R0.7311.00
329_Q378_E0.7301.00
190_L232_Q0.7301.00
175_T179_G0.7291.00
271_L279_V0.7281.00
320_I543_V0.7271.00
412_Y422_A0.7241.00
147_L279_V0.7241.00
346_T487_D0.7211.00
361_V457_L0.7211.00
429_L457_L0.7201.00
192_W265_G0.7191.00
386_A518_F0.7191.00
411_V414_L0.7171.00
341_G346_T0.7171.00
223_V226_I0.7151.00
423_E426_Q0.7151.00
416_I420_T0.7141.00
159_D162_T0.7121.00
168_D288_H0.7111.00
445_N448_D0.7091.00
311_G315_R0.7091.00
198_V206_R0.7091.00
200_A204_H0.7071.00
217_D220_F0.7011.00
123_L297_V0.6991.00
173_W246_A0.6991.00
470_Y474_Q0.6981.00
198_V232_Q0.6971.00
415_P419_H0.6941.00
190_L288_H0.6931.00
332_S336_S0.6911.00
354_S357_Q0.6911.00
313_S540_P0.6901.00
361_V528_T0.6891.00
411_V441_H0.6891.00
446_W458_M0.6881.00
211_L239_H0.6861.00
285_D295_K0.6861.00
152_F263_L0.6851.00
192_W266_T0.6841.00
132_E141_G0.6841.00
186_L232_Q0.6841.00
477_R498_L0.6831.00
121_P293_L0.6811.00
155_L170_A0.6801.00
192_W198_V0.6801.00
469_E473_E0.6791.00
430_A436_L0.6781.00
216_L220_F0.6771.00
421_M425_L0.6771.00
443_A460_G0.6761.00
513_A517_V0.6751.00
470_Y502_Q0.6741.00
186_L190_L0.6711.00
302_T308_K0.6691.00
411_V449_T0.6651.00
441_H445_N0.6651.00
540_P543_V0.6641.00
202_H255_H0.6641.00
243_Y510_R0.6641.00
180_L241_P0.6641.00
126_P302_T0.6631.00
413_H418_L0.6631.00
510_R514_L0.6601.00
196_D253_C0.6591.00
199_K232_Q0.6591.00
499_D502_Q0.6581.00
226_I236_F0.6561.00
300_W312_T0.6561.00
352_R357_Q0.6551.00
341_G463_L0.6551.00
208_L225_R0.6541.00
271_L274_F0.6541.00
412_Y419_H0.6541.00
364_I396_W0.6541.00
173_W185_Y0.6531.00
465_G471_T0.6521.00
289_L292_P0.6501.00
345_L425_L0.6501.00
539_A546_V0.6491.00
270_R286_Y0.6481.00
269_F296_A0.6471.00
334_V541_P0.6471.00
222_S239_H0.6471.00
120_T293_L0.6461.00
154_G266_T0.6451.00
204_H227_E0.6451.00
244_W468_P0.6431.00
428_T432_E0.6421.00
308_K321_T0.6411.00
429_L434_C0.6401.00
405_P432_E0.6391.00
425_L436_L0.6391.00
411_V455_A0.6391.00
240_R499_D0.6381.00
370_L425_L0.6381.00
158_F165_P0.6371.00
361_V408_L0.6371.00
205_Q209_M0.6341.00
152_F266_T0.6341.00
304_P307_E0.6321.00
335_S541_P0.6311.00
394_P511_F0.6311.00
313_S318_V0.6311.00
279_V301_I0.6281.00
494_L497_T0.6261.00
283_S290_R0.6251.00
202_H252_Y0.6221.00
441_H446_W0.6211.00
200_A232_Q0.6171.00
139_L144_E0.6171.00
380_L536_R0.6161.00
294_L543_V0.6161.00
297_V556_F0.6161.00
223_V236_F0.6161.00
158_F250_A0.6141.00
473_E476_L0.6141.00
393_I507_E0.6131.00
155_L203_L0.6091.00
507_E510_R0.6081.00
365_I528_T0.6071.00
371_L375_E0.6061.00
423_E427_A0.6051.00
271_L281_L0.6051.00
343_C418_L0.6041.00
336_S380_L0.6041.00
200_A230_H0.6031.00
368_S371_L0.6021.00
127_Y299_Y0.6001.00
263_L271_L0.5981.00
421_M531_F0.5971.00
398_V405_P0.5961.00
495_Q499_D0.5961.00
117_Q121_P0.5951.00
474_Q478_C0.5951.00
181_R227_E0.5951.00
167_G172_H0.5941.00
525_A528_T0.5931.00
462_R465_G0.5921.00
305_L308_K0.5911.00
555_E559_A0.5911.00
175_T246_A0.5891.00
365_I530_L0.5871.00
151_I263_L0.5871.00
338_I534_H0.5871.00
345_L457_L0.5861.00
274_F301_I0.5841.00
316_H540_P0.5821.00
349_K454_H0.5811.00
277_E300_W0.5801.00
134_L279_V0.5801.00
205_Q255_H0.5791.00
153_S289_L0.5781.00
408_L412_Y0.5781.00
186_L203_L0.5771.00
410_L422_A0.5741.00
351_P456_D0.5721.00
320_I539_A0.5711.00
429_L432_E0.5711.00
150_Q299_Y0.5701.00
125_I556_F0.5691.00
269_F283_S0.5681.00
416_I419_H0.5681.00
192_W206_R0.5671.00
436_L457_L0.5671.00
202_H253_C0.5661.00
156_T250_A0.5651.00
501_V510_R0.5641.00
134_L274_F0.5641.00
330_R333_Q0.5631.00
193_H266_T0.5631.00
261_F276_A0.5631.00
402_V432_E0.5611.00
122_T280_R0.5591.00
410_L459_M0.5591.00
462_R475_W0.5581.00
198_V203_L0.5571.00
393_I511_F0.5571.00
137_G206_R0.5571.00
133_P138_F0.5571.00
300_W317_P0.5551.00
310_L327_E0.5551.00
157_R289_L0.5541.00
294_L297_V0.5541.00
418_L459_M0.5531.00
448_D451_L0.5531.00
332_S380_L0.5521.00
472_L477_R0.5521.00
338_I343_C0.5521.00
179_G183_D0.5521.00
491_Y494_L0.5511.00
208_L228_V0.5491.00
422_A459_M0.5491.00
228_V233_C0.5481.00
474_Q502_Q0.5471.00
124_R318_V0.5471.00
363_S401_E0.5471.00
328_L536_R0.5451.00
397_Q403_K0.5441.00
165_P246_A0.5441.00
447_D450_T0.5441.00
120_T296_A0.5431.00
368_S395_H0.5431.00
156_T249_L0.5411.00
269_F559_A0.5401.00
342_F347_L0.5391.00
148_A151_I0.5391.00
192_W199_K0.5381.00
357_Q361_V0.5381.00
539_A543_V0.5351.00
497_T501_V0.5341.00
117_Q120_T0.5331.00
220_F223_V0.5321.00
132_E144_E0.5321.00
200_A233_C0.5321.00
352_R457_L0.5311.00
347_L352_R0.5311.00
517_V521_L0.5301.00
336_S536_R0.5291.00
192_W196_D0.5281.00
466_E470_Y0.5281.00
554_F559_A0.5281.00
487_D527_L0.5281.00
177_T181_R0.5271.00
380_L383_A0.5271.00
396_W428_T0.5261.00
147_L299_Y0.5261.00
179_G505_P0.5251.00
410_L414_L0.5251.00
503_I513_A0.5241.00
413_H446_W0.5241.00
470_Y514_L0.5241.00
504_M510_R0.5231.00
290_R293_L0.5231.00
450_T486_F0.5221.00
197_A202_H0.5221.00
418_L461_D0.5221.00
198_V265_G0.5201.00
336_S346_T0.5191.00
153_S190_L0.5191.00
522_M525_A0.5191.00
127_Y131_L0.5170.99
370_L530_L0.5170.99
414_L419_H0.5170.99
465_G472_L0.5170.99
447_D451_L0.5170.99
171_H190_L0.5170.99
363_S397_Q0.5160.99
148_A152_F0.5160.99
356_W403_K0.5160.99
119_D295_K0.5140.99
537_I546_V0.5140.99
477_R521_L0.5130.99
380_L534_H0.5130.99
369_G424_R0.5130.99
515_K518_F0.5130.99
186_L200_A0.5120.99
340_L346_T0.5110.99
523_T526_T0.5080.99
504_M507_E0.5080.99
306_F327_E0.5080.99
198_V202_H0.5070.99
141_G443_A0.5070.99
332_S335_S0.5060.99
226_I229_T0.5060.99
116_W119_D0.5060.99
256_L264_I0.5040.99
345_L528_T0.5030.99
352_R456_D0.5030.99
184_F234_L0.5030.99
466_E471_T0.5020.99
192_W203_L0.5010.99
207_L226_I0.5010.99
153_S198_V0.5010.99
342_F348_R0.5000.99
505_P509_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xocA 2 0.7774 100 0.371 Contact Map
4tozA 1 0.7968 100 0.371 Contact Map
3zs6A 1 0.7739 100 0.372 Contact Map
3m8uA 1 0.7792 100 0.374 Contact Map
4gl8A 1 0.7721 100 0.376 Contact Map
1jetA 1 0.7933 100 0.378 Contact Map
3tpaA 1 0.7774 100 0.378 Contact Map
1dpeA 1 0.7756 100 0.378 Contact Map
4qflA 1 0.7756 100 0.379 Contact Map
1uqwA 1 0.7739 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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