GREMLIN Database
USPC - Universal stress protein C
UniProt: P46888 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12862
Length: 142 (131)
Sequences: 20422 (16676)
Seq/√Len: 1456.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_S84_F2.9341.00
5_N35_S2.8621.00
7_L103_F2.8381.00
91_S125_R2.7511.00
22_K135_L2.5971.00
5_N33_H2.4621.00
105_L135_L2.3521.00
33_H82_K2.3431.00
84_F97_V2.1621.00
106_V132_V2.1211.00
62_H66_Q2.0841.00
97_V101_H1.9801.00
108_C126_V1.9601.00
124_K128_A1.9581.00
35_S103_F1.8521.00
110_N138_P1.8331.00
88_G93_H1.8281.00
8_V23_A1.8051.00
86_A93_H1.7921.00
35_S101_H1.7771.00
37_I97_V1.7521.00
9_A108_C1.7121.00
35_S97_V1.7011.00
39_L93_H1.6941.00
9_A94_I1.6531.00
35_S82_K1.6061.00
5_N104_D1.5531.00
70_D74_Q1.5311.00
98_C106_V1.5271.00
26_I30_V1.5131.00
93_H96_E1.5051.00
21_A72_L1.4621.00
106_V130_S1.4351.00
125_R129_S1.4211.00
65_T69_L1.4141.00
32_G104_D1.3841.00
95_L129_S1.3741.00
8_V20_L1.3591.00
33_H79_P1.2901.00
66_Q70_D1.2871.00
23_A27_A1.2851.00
68_F71_K1.2751.00
70_D83_T1.2541.00
90_L122_S1.2091.00
106_V126_V1.1921.00
86_A97_V1.1911.00
65_T68_F1.1851.00
97_V100_K1.1381.00
17_Q72_L1.1221.00
116_F120_S1.1181.00
58_R62_H1.1101.00
50_A53_M1.0951.00
61_M65_T1.0901.00
72_L75_D1.0891.00
73_I76_A1.0861.00
110_N136_L1.0851.00
39_L90_L1.0721.00
22_K137_V1.0711.00
37_I86_A1.0611.00
63_E67_S1.0571.00
130_S134_V1.0471.00
17_Q68_F1.0121.00
72_L76_A1.0111.00
5_N103_F1.0041.00
108_C123_A0.9921.00
62_H65_T0.9901.00
25_S29_P0.9881.00
37_I94_I0.9811.00
27_A34_I0.9661.00
118_R124_K0.9641.00
68_F72_L0.9641.00
12_V38_T0.9641.00
5_N101_H0.9421.00
40_A87_Y0.9361.00
16_S19_L0.9361.00
127_I136_L0.9311.00
97_V103_F0.9251.00
22_K26_I0.9211.00
51_A54_L0.9191.00
6_I105_L0.9181.00
61_M64_E0.9141.00
23_A107_I0.9011.00
67_S70_D0.8871.00
53_M56_D0.8831.00
58_R61_M0.8761.00
22_K133_D0.8731.00
113_H117_S0.8691.00
30_V104_D0.8641.00
20_L36_L0.8621.00
59_S63_E0.8571.00
22_K25_S0.8551.00
64_E68_F0.8521.00
66_Q83_T0.8461.00
66_Q69_L0.8441.00
10_V19_L0.8411.00
55_E59_S0.8371.00
10_V36_L0.8361.00
13_T16_S0.8341.00
98_C132_V0.8281.00
110_N123_A0.8261.00
115_F118_R0.8091.00
7_L37_I0.8071.00
67_S71_K0.8031.00
96_E100_K0.8021.00
7_L97_V0.7981.00
38_T65_T0.7981.00
17_Q21_A0.7941.00
98_C103_F0.7931.00
59_S62_H0.7921.00
123_A136_L0.7911.00
23_A34_I0.7811.00
28_R77_G0.7791.00
71_K75_D0.7741.00
64_E67_S0.7641.00
95_L130_S0.7641.00
80_V83_T0.7611.00
89_E92_E0.7591.00
115_F119_A0.7571.00
10_V20_L0.7551.00
95_L126_V0.7521.00
36_L80_V0.7491.00
55_E58_R0.7471.00
9_A109_G0.7451.00
66_Q72_L0.7431.00
28_R76_A0.7411.00
71_K74_Q0.7361.00
20_L24_V0.7241.00
107_I135_L0.7131.00
7_L106_V0.7131.00
24_V78_Y0.7111.00
10_V17_Q0.7091.00
56_D60_V0.7091.00
86_A100_K0.7021.00
70_D73_I0.6991.00
36_L69_L0.6981.00
18_Q21_A0.6961.00
69_L73_I0.6951.00
40_A85_I0.6851.00
37_I93_H0.6851.00
8_V34_I0.6821.00
60_V64_E0.6701.00
27_A30_V0.6691.00
108_C136_L0.6691.00
24_V28_R0.6631.00
77_G80_V0.6611.00
26_I29_P0.6561.00
13_T112_N0.6491.00
25_S28_R0.6481.00
24_V76_A0.6411.00
52_P55_E0.6401.00
84_F101_H0.6381.00
27_A32_G0.6311.00
8_V19_L0.6221.00
93_H97_V0.6221.00
54_L57_L0.6161.00
38_T62_H0.6141.00
111_H123_A0.6101.00
91_S122_S0.6081.00
102_H132_V0.6021.00
51_A55_E0.5941.00
95_L98_C0.5911.00
23_A32_G0.5871.00
6_I107_I0.5861.00
66_Q73_I0.5861.00
91_S95_L0.5831.00
60_V63_E0.5821.00
127_I134_V0.5801.00
5_N32_G0.5741.00
6_I27_A0.5731.00
91_S129_S0.5701.00
65_T76_A0.5691.00
10_V16_S0.5681.00
73_I83_T0.5681.00
73_I80_V0.5521.00
107_I137_V0.5471.00
91_S126_V0.5471.00
112_N115_F0.5471.00
50_A54_L0.5451.00
68_F73_I0.5441.00
15_E18_Q0.5371.00
25_S76_A0.5321.00
63_E66_Q0.5311.00
94_I126_V0.5311.00
21_A75_D0.5301.00
54_L58_R0.5281.00
95_L125_R0.5271.00
26_I107_I0.5231.00
116_F119_A0.5201.00
52_P56_D0.5171.00
62_H85_I0.5151.00
92_E96_E0.5131.00
46_Y49_L0.5091.00
69_L72_L0.5031.00
21_A76_A0.5021.00
14_P17_Q0.5021.00
87_Y93_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jmvA 4 0.9789 99.9 0.18 Contact Map
3tnjA 2 0.8944 99.9 0.186 Contact Map
4wnyA 2 0.8803 99.9 0.213 Contact Map
5ahwA 4 0.9789 99.9 0.215 Contact Map
2dumA 2 0.9577 99.9 0.217 Contact Map
3s3tA 4 0.9648 99.9 0.219 Contact Map
1mjhA 2 0.9507 99.9 0.226 Contact Map
2z08A 4 0.8521 99.9 0.244 Contact Map
1tq8A 4 0.8592 99.9 0.249 Contact Map
2gm3A 2 0.8873 99.8 0.25 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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