GREMLIN Database
GNTK - Thermoresistant gluconokinase
UniProt: P46859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12629
Length: 175 (161)
Sequences: 1920 (1367)
Seq/√Len: 107.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_R49_E4.1551.00
114_F135_V3.9791.00
117_I138_F3.5291.00
154_V163_V3.2121.00
112_G156_I3.2011.00
67_Q97_L3.0821.00
130_K133_M3.0801.00
135_V139_E2.9061.00
111_K143_E2.7951.00
42_L69_L2.6721.00
38_D86_V2.6511.00
50_K61_D2.5621.00
44_P47_N2.4531.00
34_A82_V2.2661.00
144_P150_D2.2641.00
12_V107_F2.2531.00
121_L134_L2.2381.00
37_L42_L2.1171.00
69_L85_I2.1031.00
31_Q165_A2.0681.00
108_I167_T1.9411.00
109_Y143_E1.8671.00
109_Y144_P1.8631.00
27_E160_L1.7651.00
96_D99_R1.7041.00
159_P162_G1.6741.00
112_G117_I1.6441.00
24_V163_V1.6441.00
23_A160_L1.6421.00
37_L72_A1.6311.00
113_D116_V1.5971.00
111_K153_V1.5841.00
60_D63_K1.5751.00
22_S26_S1.5311.00
63_K67_Q1.5231.00
63_K97_L1.5091.00
72_A83_S1.5071.00
119_S123_A1.4771.00
25_A36_F1.4391.00
17_S134_L1.4381.00
18_G121_L1.4251.00
114_F138_F1.3721.00
36_F86_V1.3651.00
49_E53_S1.3631.00
116_V119_S1.3611.00
113_D157_D1.3601.00
158_Q166_S1.3240.99
158_Q162_G1.3170.99
42_L72_A1.2720.99
11_Y171_I1.2690.99
92_K147_D1.2680.99
49_E52_A1.2670.99
26_S30_H1.2620.99
73_A85_I1.2570.99
31_Q168_I1.2370.99
48_I52_A1.2250.99
10_I73_A1.2040.99
112_G116_V1.1850.99
66_L94_Y1.1850.99
27_E164_V1.1690.99
13_L84_L1.1590.99
72_A75_A1.1550.99
47_N68_A1.1530.99
114_F118_E1.1510.98
11_Y108_I1.1480.98
99_R107_F1.1230.98
166_S170_V1.1150.98
99_R150_D1.0810.98
158_Q163_V1.0750.98
93_H140_T1.0580.97
118_E122_K1.0540.97
63_K93_H1.0500.97
67_Q100_E1.0490.97
35_A81_K1.0240.97
70_N74_F0.9950.96
44_P68_A0.9640.95
70_N101_G0.9480.95
26_S41_F0.9480.95
152_L170_V0.9440.95
92_K148_E0.9370.95
114_F139_E0.9340.95
92_K96_D0.9280.94
165_A169_E0.9250.94
73_A102_N0.9140.94
24_V160_L0.9110.94
154_V170_V0.9080.94
91_K140_T0.9070.94
22_S39_G0.9060.94
35_A82_V0.9030.94
27_E161_E0.8910.93
117_I156_I0.8840.93
122_K131_T0.8650.92
69_L72_A0.8650.92
16_V109_Y0.8630.92
38_D41_F0.8600.92
12_V73_A0.8580.92
46_R49_E0.8540.92
48_I127_H0.8540.92
152_L167_T0.8540.92
74_F102_N0.8470.91
118_E134_L0.8420.91
25_A86_V0.8400.91
24_V164_V0.8390.91
10_I83_S0.8390.91
155_D163_V0.8350.91
121_L131_T0.8290.90
16_V134_L0.8200.90
39_G85_I0.8180.90
93_H97_L0.8140.90
47_N50_K0.8000.89
70_N102_N0.7940.88
116_V157_D0.7820.88
91_K94_Y0.7740.87
160_L164_V0.7690.87
25_A29_A0.7680.87
29_A84_L0.7680.87
111_K155_D0.7520.86
71_D74_F0.7500.85
31_Q164_V0.7400.85
29_A36_F0.7290.84
27_E30_H0.7290.84
112_G134_L0.7260.83
166_S169_E0.7250.83
117_I134_L0.7230.83
91_K142_Q0.7220.83
108_I152_L0.7170.83
23_A27_E0.7160.83
14_M141_L0.7140.82
110_L163_V0.7130.82
59_D91_K0.7050.82
59_D94_Y0.7030.81
17_S133_M0.7030.81
92_K142_Q0.7010.81
15_G21_K0.6950.81
19_S141_L0.6910.80
35_A72_A0.6840.80
35_A83_S0.6810.79
116_V156_I0.6800.79
32_L168_I0.6710.78
156_I163_V0.6680.78
11_Y34_A0.6670.78
70_N100_E0.6660.78
154_V167_T0.6590.77
24_V167_T0.6580.77
44_P48_I0.6580.77
58_N63_K0.6500.76
99_R148_E0.6470.76
67_Q139_E0.6440.75
15_G20_G0.6420.75
19_S117_I0.6420.75
28_V160_L0.6420.75
52_A128_F0.6390.75
110_L156_I0.6380.75
106_S150_D0.6370.75
98_L105_L0.6360.75
160_L163_V0.6350.74
14_M109_Y0.6350.74
12_V85_I0.6340.74
108_I154_V0.6320.74
28_V164_V0.6310.74
19_S111_K0.6280.74
66_L87_C0.6270.74
13_L167_T0.6270.74
162_G165_A0.6250.73
56_P136_T0.6240.73
106_S149_T0.6210.73
70_N73_A0.6210.73
13_L28_V0.6210.73
104_N149_T0.6200.73
155_D158_Q0.6180.72
134_L138_F0.6170.72
37_L69_L0.6170.72
129_F136_T0.6160.72
76_M83_S0.6160.72
115_D118_E0.6160.72
39_G42_L0.6150.72
92_K146_A0.6140.72
89_A98_L0.6130.72
59_D66_L0.6110.72
117_I121_L0.6100.72
70_N105_L0.6100.72
22_S128_F0.6050.71
121_L138_F0.5960.70
24_V110_L0.5930.69
71_D75_A0.5920.69
61_D94_Y0.5910.69
119_S157_D0.5870.69
37_L83_S0.5850.68
108_I170_V0.5820.68
25_A76_M0.5800.68
25_A38_D0.5800.68
115_D119_S0.5790.68
121_L129_F0.5780.67
27_E31_Q0.5770.67
51_M62_R0.5760.67
44_P128_F0.5760.67
41_F48_I0.5760.67
38_D69_L0.5750.67
16_V141_L0.5750.67
87_C94_Y0.5740.67
17_S22_S0.5740.67
99_R105_L0.5710.66
10_I144_P0.5700.66
58_N91_K0.5690.66
43_H62_R0.5630.65
109_Y153_V0.5590.65
28_V36_F0.5530.64
76_M81_K0.5520.64
66_L91_K0.5490.63
11_Y106_S0.5480.63
19_S156_I0.5480.63
55_E58_N0.5460.63
70_N97_L0.5440.63
41_F125_K0.5440.63
58_N93_H0.5430.63
52_A133_M0.5430.63
67_Q81_K0.5420.62
52_A55_E0.5400.62
159_P163_V0.5390.62
75_A80_N0.5380.62
17_S64_P0.5310.61
71_D101_G0.5300.61
121_L156_I0.5300.61
18_G21_K0.5290.61
75_A79_T0.5280.60
28_V167_T0.5270.60
43_H51_M0.5250.60
72_A76_M0.5250.60
28_V32_L0.5240.60
47_N94_Y0.5210.59
132_Q135_V0.5140.58
51_M129_F0.5130.58
117_I130_K0.5110.58
36_F84_L0.5100.58
42_L83_S0.5100.58
17_S52_A0.5090.58
75_A78_R0.5070.57
66_L89_A0.5060.57
11_Y25_A0.5020.57
40_D43_H0.5010.57
66_L98_L0.5000.56
23_A64_P0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1knqA 2 0.9771 100 0.61 Contact Map
4eunA 2 0.96 100 0.614 Contact Map
3t61A 2 0.9486 99.9 0.631 Contact Map
4rfvA 2 0.7657 99.9 0.683 Contact Map
2rhmA 2 0.9429 99.9 0.686 Contact Map
4bzpA 2 0.9029 99.9 0.694 Contact Map
2gksA 2 0.9429 99.9 0.697 Contact Map
1e6cA 1 0.8914 99.8 0.7 Contact Map
1m7gA 4 0.9429 99.8 0.701 Contact Map
1m8pA 5 0.9429 99.8 0.701 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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