GREMLIN Database
YHHY - Uncharacterized N-acetyltransferase YhhY
UniProt: P46854 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12945
Length: 162 (154)
Sequences: 20957 (16291)
Seq/√Len: 1312.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_S133_K2.9011.00
118_L131_Y2.7861.00
138_I141_T2.5051.00
7_R13_D2.3821.00
139_E159_A2.3031.00
138_I156_Y2.2951.00
120_V128_I2.2521.00
68_I107_C2.2241.00
80_A113_V2.2131.00
104_I136_F2.1251.00
128_I132_K2.0091.00
25_E88_S2.0051.00
129_K132_K1.9561.00
120_V131_Y1.9361.00
114_D144_K1.8901.00
82_F100_M1.8731.00
141_T156_Y1.8641.00
105_E109_N1.8401.00
16_A62_V1.7951.00
38_D42_Q1.7871.00
104_I116_I1.7551.00
23_Q88_S1.7251.00
87_D90_W1.7221.00
147_L152_Y1.7141.00
66_L99_L1.6481.00
100_M134_Y1.6481.00
122_V154_D1.6021.00
102_E105_E1.5901.00
128_I156_Y1.5871.00
128_I138_I1.5591.00
7_R55_V1.5471.00
11_T46_A1.5241.00
86_V96_A1.5201.00
15_E38_D1.5181.00
132_K138_I1.4931.00
37_S40_M1.4901.00
14_Y42_Q1.4891.00
145_Y155_A1.4811.00
114_D152_Y1.4361.00
125_A128_I1.4051.00
66_L103_M1.3921.00
122_V141_T1.3741.00
63_V90_W1.3471.00
16_A61_D1.3461.00
56_A59_D1.3291.00
123_D153_V1.3221.00
128_I158_M1.3201.00
142_G157_Y1.3181.00
106_M111_L1.3171.00
106_M110_W1.2921.00
97_S130_V1.2801.00
5_V57_C1.2781.00
97_S101_R1.2641.00
97_S134_Y1.2561.00
138_I158_M1.2291.00
61_D90_W1.2171.00
84_I131_Y1.2071.00
107_C116_I1.1761.00
65_H85_C1.1741.00
61_D89_R1.1731.00
16_A19_Q1.1681.00
79_V117_E1.1541.00
24_P27_Y1.1481.00
11_T42_Q1.1381.00
115_R159_A1.1331.00
141_T154_D1.1311.00
122_V156_Y1.1151.00
42_Q46_A1.1131.00
14_Y45_L1.1021.00
143_K159_A1.0941.00
20_I85_C1.0861.00
50_G54_L1.0811.00
19_Q87_D1.0771.00
43_E47_D1.0631.00
84_I127_A1.0541.00
18_R38_D1.0501.00
96_A130_V1.0411.00
53_Q57_C1.0321.00
54_L57_C1.0301.00
144_K154_D1.0291.00
81_D119_T1.0191.00
130_V134_Y1.0171.00
98_A102_E1.0121.00
88_S91_K1.0081.00
78_H147_L1.0071.00
115_R139_E1.0031.00
120_V158_M1.0011.00
20_I87_D0.9801.00
68_I103_M0.9751.00
18_R22_A0.9741.00
7_R57_C0.9721.00
118_L136_F0.9711.00
91_K126_P0.9701.00
107_C111_L0.9601.00
55_V62_V0.9521.00
121_F153_V0.9361.00
101_R105_E0.9341.00
14_Y38_D0.9331.00
101_R134_Y0.9331.00
61_D87_D0.9281.00
125_A129_K0.9281.00
15_E19_Q0.9201.00
104_I134_Y0.9141.00
23_Q87_D0.9081.00
39_H42_Q0.9071.00
95_V98_A0.9071.00
41_W44_R0.9051.00
79_V145_Y0.8971.00
131_Y136_F0.8821.00
142_G145_Y0.8821.00
86_V95_V0.8781.00
53_Q56_A0.8751.00
9_A65_H0.8671.00
14_Y18_R0.8631.00
16_A87_D0.8621.00
58_I63_V0.8591.00
55_V60_G0.8511.00
25_E28_C0.8411.00
90_W93_R0.8401.00
147_L151_E0.8361.00
23_Q89_R0.8261.00
119_T155_A0.8251.00
78_H152_Y0.8221.00
127_A131_Y0.8201.00
107_C113_V0.8141.00
92_N126_P0.8111.00
9_A53_Q0.8111.00
84_I96_A0.8081.00
19_Q61_D0.8081.00
79_V115_R0.8041.00
139_E143_K0.7921.00
38_D41_W0.7911.00
4_I99_L0.7861.00
21_H85_C0.7861.00
43_E46_A0.7811.00
18_R41_W0.7731.00
72_Q77_S0.7691.00
102_E106_M0.7671.00
5_V60_G0.7631.00
11_T14_Y0.7621.00
41_W45_L0.7611.00
68_I80_A0.7541.00
144_K152_Y0.7541.00
33_V36_P0.7531.00
52_K56_A0.7521.00
125_A132_K0.7421.00
20_I62_V0.7331.00
120_V127_A0.7241.00
137_E143_K0.7161.00
100_M130_V0.7161.00
119_T142_G0.7151.00
48_R51_I0.7121.00
4_I102_E0.7111.00
25_E91_K0.7091.00
132_K158_M0.7061.00
81_D117_E0.7051.00
29_N121_F0.7001.00
4_I95_V0.7001.00
19_Q89_R0.6971.00
80_A116_I0.6931.00
26_V91_K0.6921.00
39_H43_E0.6911.00
92_N97_S0.6851.00
115_R145_Y0.6831.00
4_I98_A0.6801.00
123_D151_E0.6721.00
52_K55_V0.6691.00
119_T157_Y0.6671.00
118_L158_M0.6591.00
29_N123_D0.6591.00
143_K154_D0.6581.00
7_R10_E0.6531.00
92_N129_K0.6521.00
49_P52_K0.6521.00
129_K133_K0.6511.00
40_M43_E0.6491.00
84_I100_M0.6441.00
19_Q23_Q0.6431.00
58_I95_V0.6401.00
5_V55_V0.6381.00
82_F116_I0.6261.00
126_P129_K0.6251.00
40_M44_R0.6201.00
53_Q62_V0.6171.00
27_Y30_T0.6101.00
117_E145_Y0.6011.00
117_E142_G0.6011.00
57_C60_G0.6011.00
50_G56_A0.5991.00
118_L127_A0.5971.00
97_S126_P0.5971.00
10_E13_D0.5961.00
54_L58_I0.5891.00
9_A17_I0.5881.00
70_V80_A0.5811.00
148_R151_E0.5791.00
23_Q91_K0.5761.00
32_Q35_H0.5741.00
37_S41_W0.5721.00
78_H114_D0.5721.00
80_A107_C0.5711.00
6_I102_E0.5671.00
148_R153_V0.5661.00
50_G53_Q0.5651.00
86_V90_W0.5651.00
56_A99_L0.5541.00
67_T83_G0.5521.00
9_A55_V0.5471.00
146_A155_A0.5471.00
104_I108_D0.5431.00
63_V95_V0.5431.00
9_A62_V0.5431.00
62_V65_H0.5421.00
30_T33_V0.5361.00
66_L100_M0.5351.00
86_V91_K0.5341.00
6_I99_L0.5281.00
116_I136_F0.5211.00
23_Q26_V0.5201.00
55_V58_I0.5191.00
147_L150_G0.5181.00
17_I65_H0.5171.00
100_M116_I0.5151.00
84_I130_V0.5141.00
15_E18_R0.5141.00
53_Q58_I0.5121.00
58_I93_R0.5111.00
54_L106_M0.5101.00
122_V128_I0.5041.00
120_V156_Y0.5031.00
56_A95_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r9fA 1 0.9877 100 0.26 Contact Map
2vzyA 3 0.8889 100 0.267 Contact Map
2fckA 2 0.9691 100 0.274 Contact Map
3pzjA 2 0.9815 100 0.28 Contact Map
1yreA 2 0.963 100 0.294 Contact Map
1nslA 3 0.9877 99.9 0.297 Contact Map
1s7kA 2 0.8889 99.9 0.298 Contact Map
3fbuA 2 0.9753 99.9 0.302 Contact Map
2z10A 2 0.9815 99.9 0.302 Contact Map
3tthA 5 0.9815 99.9 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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