YHHX - ECOLI - GREMLIN Contacts

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YHHX - Uncharacterized oxidoreductase YhhX

UniProt:	P46853	Sequences: MVINCAFIGFGKSTTRYHLPYVLNRKDSWHVAHIFRRHAKPEEQAPIYSHIHFTSDLDEVLNDPDVKLVVVCTHADSHFEYAKRALEAGKNVLVEKPFTPTLAQAKELFALAKSKGLTVTPYQNRRFDSCFLTAKKAIESGKLGEIVEVESHFDYYRPVAETKPGLPQDGAFYGLGVHTMDQIISLFGRPDHVAYDIRSLRNKANPDDTFEAQLFYGDLKAIVKTSHLVKIDYPKFIVHGKKGSFIKYGIDQQETSLKANIMPGEPGFAADDSVGVLEYVNDEGVTVREEMKPEMGDYGRVYDALYQTITHGAPNYVKESEVLTNLEILERGFEQASPSTVTLAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12944
Length:	345 (311)
Sequences:	25112 (18453)
Seq/√Len:	1046.4

ECOLI - YHHX YGJR YDGJ YCJS YJHC YCEM
BACSU - IOLW IOLG YRBE NTDC IOLX YFII YULF YTET
SULSO - Q97UJ6 Q97UK3 Q97UH0 Q97UK0 Q97UJ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_D	84_R	3.092	1.00
126_R	181_D	2.842	1.00
83_K	111_L	2.820	1.00
192_H	215_F	2.781	1.00
4_N	30_H	2.772	1.00
79_F	107_E	2.760	1.00
133_T	136_K	2.748	1.00
39_A	43_E	2.708	1.00
145_E	241_K	2.690	1.00
106_K	323_L	2.661	1.00
87_E	111_L	2.607	1.00
135_K	139_E	2.402	1.00
73_T	81_Y	2.389	1.00
83_K	87_E	2.368	1.00
6_A	60_V	2.361	1.00
79_F	104_Q	2.360	1.00
83_K	107_E	2.332	1.00
91_N	118_T	2.309	1.00
86_L	117_L	2.300	1.00
212_A	332_G	2.270	1.00
136_K	140_S	2.190	1.00
56_D	59_E	2.173	1.00
33_H	54_T	2.158	1.00
110_A	114_S	2.084	1.00
77_S	81_Y	2.083	1.00
113_K	320_S	2.058	1.00
307_Q	311_H	2.020	1.00
28_S	310_T	1.994	1.00
52_H	63_D	1.991	1.00
79_F	83_K	1.984	1.00
133_T	137_A	1.965	1.00
86_L	112_A	1.959	1.00
68_L	305_L	1.950	1.00
106_K	327_E	1.931	1.00
82_A	94_V	1.925	1.00
106_K	110_A	1.892	1.00
111_L	115_K	1.839	1.00
38_H	41_P	1.816	1.00
80_E	84_R	1.811	1.00
43_E	46_P	1.810	1.00
73_T	77_S	1.804	1.00
25_R	28_S	1.797	1.00
143_L	240_G	1.790	1.00
6_A	66_V	1.773	1.00
87_E	115_K	1.752	1.00
91_N	117_L	1.745	1.00
216_Y	221_A	1.702	1.00
69_V	85_A	1.699	1.00
22_V	70_V	1.689	1.00
102_L	330_E	1.685	1.00
5_C	68_L	1.661	1.00
191_D	215_F	1.653	1.00
55_S	59_E	1.652	1.00
101_T	104_Q	1.637	1.00
66_V	90_K	1.628	1.00
82_A	108_L	1.623	1.00
25_R	303_D	1.622	1.00
29_W	306_Y	1.611	1.00
134_A	245_F	1.598	1.00
62_N	88_A	1.597	1.00
61_L	85_A	1.597	1.00
119_V	319_E	1.592	1.00
87_E	114_S	1.549	1.00
197_I	336_A	1.541	1.00
137_A	142_K	1.538	1.00
122_Y	301_V	1.531	1.00
189_R	324_T	1.518	1.00
135_K	185_S	1.514	1.00
118_T	312_G	1.511	1.00
109_F	323_L	1.497	1.00
57_L	84_R	1.478	1.00
324_T	327_E	1.470	1.00
59_E	62_N	1.456	1.00
109_F	319_E	1.443	1.00
79_F	108_L	1.443	1.00
147_V	241_K	1.436	1.00
54_T	63_D	1.429	1.00
100_P	104_Q	1.429	1.00
58_D	62_N	1.415	1.00
99_T	108_L	1.403	1.00
187_F	219_L	1.402	1.00
111_L	114_S	1.398	1.00
150_E	237_I	1.395	1.00
184_I	189_R	1.385	1.00
42_E	53_F	1.377	1.00
307_Q	313_A	1.364	1.00
54_T	60_V	1.363	1.00
39_A	55_S	1.347	1.00
86_L	115_K	1.346	1.00
99_T	105_A	1.345	1.00
4_N	32_A	1.323	1.00
59_E	63_D	1.320	1.00
84_R	87_E	1.312	1.00
237_I	246_I	1.309	1.00
146_I	238_V	1.304	1.00
143_L	243_G	1.303	1.00
190_P	216_Y	1.299	1.00
105_A	323_L	1.293	1.00
184_I	324_T	1.291	1.00
304_A	308_T	1.290	1.00
84_R	88_A	1.278	1.00
4_N	67_K	1.276	1.00
35_F	57_L	1.276	1.00
44_Q	47_I	1.271	1.00
196_D	215_F	1.266	1.00
102_L	106_K	1.257	1.00
304_A	316_Y	1.251	1.00
10_F	34_I	1.249	1.00
102_L	327_E	1.248	1.00
71_V	81_Y	1.236	1.00
180_M	328_I	1.236	1.00
85_A	92_V	1.212	1.00
35_F	60_V	1.206	1.00
64_P	90_K	1.201	1.00
107_E	110_A	1.182	1.00
57_L	81_Y	1.179	1.00
71_V	82_A	1.178	1.00
184_I	216_Y	1.178	1.00
89_G	115_K	1.176	1.00
235_K	246_I	1.173	1.00
40_K	43_E	1.162	1.00
86_L	111_L	1.158	1.00
33_H	60_V	1.157	1.00
28_S	303_D	1.155	1.00
303_D	307_Q	1.150	1.00
60_V	66_V	1.149	1.00
98_F	105_A	1.134	1.00
65_D	90_K	1.131	1.00
150_E	224_K	1.130	1.00
109_F	320_S	1.127	1.00
45_A	48_Y	1.117	1.00
318_K	321_E	1.113	1.00
91_N	312_G	1.112	1.00
184_I	321_E	1.110	1.00
149_V	187_F	1.109	1.00
5_C	29_W	1.107	1.00
74_H	77_S	1.107	1.00
194_A	213_Q	1.091	1.00
110_A	113_K	1.089	1.00
57_L	61_L	1.089	1.00
107_E	111_L	1.088	1.00
137_A	140_S	1.088	1.00
330_E	334_E	1.087	1.00
83_K	108_L	1.084	1.00
15_T	47_I	1.081	1.00
24_N	299_G	1.077	1.00
61_L	84_R	1.073	1.00
306_Y	310_T	1.071	1.00
143_L	245_F	1.066	1.00
183_I	221_A	1.065	1.00
164_P	167_P	1.061	1.00
331_R	334_E	1.060	1.00
131_F	185_S	1.059	1.00
93_L	122_Y	1.055	1.00
105_A	326_L	1.052	1.00
104_Q	107_E	1.051	1.00
61_L	88_A	1.046	1.00
93_L	301_V	1.045	1.00
28_S	307_Q	1.045	1.00
3_I	310_T	1.040	1.00
3_I	68_L	1.039	1.00
33_H	66_V	1.028	1.00
304_A	313_A	1.026	1.00
94_V	119_V	1.017	1.00
109_F	113_K	1.012	1.00
143_L	146_I	1.009	1.00
8_I	81_Y	1.004	1.00
99_T	104_Q	1.003	1.00
91_N	309_I	1.002	1.00
149_V	221_A	1.001	1.00
127_F	304_A	1.001	1.00
48_Y	51_I	0.999	1.00
18_H	70_V	0.998	1.00
3_I	309_I	0.997	1.00
63_D	66_V	0.988	1.00
108_L	119_V	0.979	1.00
334_E	337_S	0.978	1.00
136_K	139_E	0.977	1.00
42_E	55_S	0.976	1.00
39_A	42_E	0.970	1.00
103_A	106_K	0.970	1.00
41_P	44_Q	0.966	1.00
126_R	321_E	0.960	1.00
331_R	335_Q	0.959	1.00
20_P	24_N	0.953	1.00
304_A	307_Q	0.943	1.00
52_H	65_D	0.938	1.00
146_I	187_F	0.935	1.00
134_A	247_K	0.925	1.00
98_F	319_E	0.921	1.00
102_L	323_L	0.921	1.00
81_Y	84_R	0.921	1.00
112_A	115_K	0.920	1.00
54_T	59_E	0.918	1.00
190_P	214_L	0.917	1.00
146_I	240_G	0.915	1.00
103_A	107_E	0.914	1.00
82_A	92_V	0.912	1.00
299_G	303_D	0.906	1.00
86_L	92_V	0.901	1.00
300_R	303_D	0.897	1.00
149_V	238_V	0.894	1.00
63_D	90_K	0.894	1.00
320_S	324_T	0.891	1.00
120_T	305_L	0.891	1.00
307_Q	312_G	0.887	1.00
71_V	85_A	0.878	1.00
124_N	297_D	0.874	1.00
98_F	119_V	0.871	1.00
10_F	36_R	0.871	1.00
39_A	53_F	0.865	1.00
32_A	52_H	0.864	1.00
94_V	98_F	0.863	1.00
40_K	44_Q	0.863	1.00
79_F	99_T	0.862	1.00
118_T	309_I	0.858	1.00
308_T	311_H	0.855	1.00
76_D	167_P	0.853	1.00
43_E	53_F	0.850	1.00
6_A	33_H	0.848	1.00
22_V	29_W	0.846	1.00
70_V	302_Y	0.844	1.00
211_E	222_I	0.843	1.00
194_A	335_Q	0.841	1.00
180_M	329_L	0.841	1.00
82_A	86_L	0.840	1.00
106_K	109_F	0.836	1.00
196_D	220_K	0.830	1.00
112_A	119_V	0.830	1.00
36_R	41_P	0.828	1.00
190_P	328_I	0.828	1.00
333_F	337_S	0.826	1.00
5_C	22_V	0.824	1.00
77_S	80_E	0.823	1.00
144_G	243_G	0.822	1.00
18_H	302_Y	0.819	1.00
237_I	244_S	0.819	1.00
6_A	35_F	0.818	1.00
151_S	236_F	0.817	1.00
94_V	108_L	0.812	1.00
4_N	66_V	0.812	1.00
45_A	49_S	0.809	1.00
327_E	331_R	0.808	1.00
195_Y	332_G	0.808	1.00
112_A	117_L	0.803	1.00
149_V	183_I	0.802	1.00
100_P	168_Q	0.801	1.00
14_T	72_C	0.800	1.00
152_H	235_K	0.798	1.00
32_A	65_D	0.797	1.00
86_L	119_V	0.797	1.00
150_E	222_I	0.797	1.00
36_R	42_E	0.795	1.00
112_A	319_E	0.792	1.00
75_A	174_G	0.788	1.00
118_T	308_T	0.786	1.00
132_L	136_K	0.785	1.00
214_L	221_A	0.785	1.00
28_S	306_Y	0.784	1.00
7_F	19_L	0.781	1.00
308_T	313_A	0.781	1.00
138_I	240_G	0.777	1.00
184_I	325_N	0.771	1.00
45_A	50_H	0.770	1.00
308_T	315_N	0.768	1.00
144_G	240_G	0.768	1.00
22_V	302_Y	0.764	1.00
14_T	20_P	0.761	1.00
13_S	298_Y	0.759	1.00
19_L	31_V	0.758	1.00
120_T	308_T	0.756	1.00
171_A	225_T	0.750	1.00
25_R	29_W	0.744	1.00
196_D	213_Q	0.742	1.00
183_I	216_Y	0.742	1.00
60_V	63_D	0.742	1.00
79_F	111_L	0.741	1.00
13_S	72_C	0.740	1.00
105_A	109_F	0.740	1.00
164_P	205_N	0.739	1.00
8_I	57_L	0.739	1.00
32_A	63_D	0.738	1.00
10_F	42_E	0.737	1.00
235_K	248_Y	0.736	1.00
174_G	227_H	0.732	1.00
6_A	69_V	0.731	1.00
177_V	325_N	0.731	1.00
170_G	207_D	0.730	1.00
98_F	121_P	0.728	1.00
314_P	318_K	0.727	1.00
139_E	188_G	0.727	1.00
305_L	309_I	0.725	1.00
187_F	216_Y	0.723	1.00
123_Q	177_V	0.720	1.00
32_A	66_V	0.717	1.00
151_S	179_T	0.716	1.00
8_I	73_T	0.715	1.00
172_F	329_L	0.714	1.00
68_L	91_N	0.712	1.00
259_A	262_M	0.709	1.00
121_P	322_V	0.708	1.00
198_R	215_F	0.707	1.00
176_G	225_T	0.705	1.00
46_P	53_F	0.704	1.00
323_L	327_E	0.702	1.00
152_H	224_K	0.702	1.00
15_T	44_Q	0.697	1.00
13_S	18_H	0.694	1.00
319_E	322_V	0.692	1.00
298_Y	301_V	0.689	1.00
94_V	121_P	0.689	1.00
326_L	330_E	0.685	1.00
78_H	94_V	0.684	1.00
8_I	35_F	0.680	1.00
215_F	220_K	0.678	1.00
83_K	86_L	0.675	1.00
145_E	242_K	0.674	1.00
89_G	117_L	0.671	1.00
125_R	128_D	0.670	1.00
132_L	300_R	0.666	1.00
86_L	108_L	0.665	1.00
239_H	244_S	0.663	1.00
4_N	65_D	0.662	1.00
169_D	173_Y	0.661	1.00
172_F	210_F	0.661	1.00
191_D	217_G	0.661	1.00
126_R	185_S	0.660	1.00
213_Q	220_K	0.659	1.00
5_C	306_Y	0.659	1.00
68_L	309_I	0.658	1.00
195_Y	212_A	0.658	1.00
131_F	182_Q	0.658	1.00
80_E	107_E	0.657	1.00
118_T	314_P	0.655	1.00
186_L	238_V	0.655	1.00
192_H	196_D	0.651	1.00
15_T	41_P	0.651	1.00
43_E	47_I	0.651	1.00
207_D	333_F	0.650	1.00
138_I	238_V	0.647	1.00
93_L	120_T	0.646	1.00
118_T	315_N	0.645	1.00
195_Y	210_F	0.644	1.00
200_L	208_D	0.643	1.00
212_A	223_V	0.643	1.00
123_Q	181_D	0.642	1.00
148_E	220_K	0.641	1.00
30_H	51_I	0.638	1.00
135_K	186_L	0.636	1.00
54_T	64_P	0.636	1.00
184_I	328_I	0.635	1.00
304_A	315_N	0.633	1.00
46_P	49_S	0.632	1.00
321_E	324_T	0.630	1.00
45_A	53_F	0.627	1.00
82_A	119_V	0.627	1.00
38_H	43_E	0.626	1.00
90_K	117_L	0.625	1.00
181_D	185_S	0.623	1.00
151_S	183_I	0.623	1.00
216_Y	219_L	0.622	1.00
176_G	179_T	0.621	1.00
124_N	298_Y	0.619	1.00
142_K	259_A	0.618	1.00
178_H	181_D	0.611	1.00
181_D	325_N	0.611	1.00
34_I	45_A	0.608	1.00
226_S	229_V	0.607	1.00
57_L	85_A	0.607	1.00
5_C	70_V	0.607	1.00
214_L	223_V	0.605	1.00
15_T	48_Y	0.604	1.00
138_I	186_L	0.602	1.00
58_D	80_E	0.602	1.00
120_T	304_A	0.600	1.00
70_V	93_L	0.600	1.00
259_A	263_P	0.597	1.00
208_D	228_L	0.595	1.00
180_M	332_G	0.595	1.00
132_L	316_Y	0.595	1.00
307_Q	310_T	0.580	1.00
34_I	42_E	0.580	1.00
34_I	53_F	0.580	1.00
46_P	50_H	0.575	1.00
146_I	219_L	0.574	1.00
325_N	329_L	0.573	1.00
71_V	78_H	0.573	1.00
123_Q	325_N	0.572	1.00
109_F	112_A	0.572	1.00
69_V	90_K	0.571	1.00
134_A	186_L	0.570	1.00
13_S	95_E	0.569	1.00
209_T	226_S	0.569	1.00
25_R	306_Y	0.569	1.00
31_V	50_H	0.568	1.00
154_D	224_K	0.568	1.00
125_R	181_D	0.566	1.00
67_K	310_T	0.566	1.00
87_E	107_E	0.565	1.00
49_S	52_H	0.560	1.00
37_R	73_T	0.559	1.00
194_A	215_F	0.558	1.00
96_K	178_H	0.557	1.00
141_G	240_G	0.557	1.00
11_G	72_C	0.556	1.00
80_E	83_K	0.556	1.00
201_R	208_D	0.554	1.00
329_L	333_F	0.554	1.00
35_F	54_T	0.550	1.00
33_H	52_H	0.550	1.00
18_H	22_V	0.548	1.00
142_K	145_E	0.546	1.00
29_W	68_L	0.545	1.00
12_K	16_R	0.545	1.00
261_I	264_G	0.543	1.00
96_K	174_G	0.543	1.00
183_I	223_V	0.542	1.00
132_L	185_S	0.542	1.00
82_A	112_A	0.542	1.00
213_Q	222_I	0.540	1.00
172_F	212_A	0.539	1.00
173_Y	330_E	0.539	1.00
197_I	210_F	0.539	1.00
148_E	222_I	0.537	1.00
148_E	239_H	0.536	1.00
256_S	259_A	0.535	1.00
101_T	330_E	0.535	1.00
25_R	299_G	0.532	1.00
18_H	72_C	0.531	1.00
20_P	23_L	0.529	1.00
76_D	100_P	0.529	1.00
15_T	20_P	0.527	1.00
296_G	299_G	0.526	1.00
98_F	108_L	0.524	1.00
163_K	174_G	0.522	1.00
187_F	217_G	0.522	1.00
193_V	328_I	0.521	1.00
95_E	122_Y	0.521	1.00
8_I	71_V	0.520	1.00
127_F	317_V	0.520	1.00
120_T	301_V	0.520	1.00
190_P	221_A	0.519	1.00
11_G	14_T	0.519	1.00
129_S	300_R	0.517	1.00
153_F	175_L	0.517	1.00
35_F	55_S	0.516	1.00
124_N	178_H	0.515	1.00
149_V	236_F	0.514	1.00
103_A	330_E	0.513	1.00
72_C	95_E	0.513	1.00
148_E	209_T	0.513	1.00
7_F	70_V	0.513	1.00
73_T	78_H	0.512	1.00
168_Q	206_P	0.510	1.00
118_T	305_L	0.510	1.00
8_I	69_V	0.509	1.00
189_R	327_E	0.509	1.00
289_E	292_K	0.508	1.00
165_G	205_N	0.507	1.00
198_R	220_K	0.506	1.00
257_L	260_N	0.505	1.00
123_Q	178_H	0.505	1.00
121_P	178_H	0.504	1.00
83_K	115_K	0.503	1.00
214_L	328_I	0.501	1.00
7_F	31_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3f4lA	2	0.9942	100	0.205	Contact Map
1h6dA	8	0.9449	100	0.212	Contact Map
3dtyA	4	0.9536	100	0.223	Contact Map
3i23A	2	0.9884	100	0.224	Contact Map
3ezyA	4	0.9362	100	0.225	Contact Map
1zh8A	2	0.8986	100	0.227	Contact Map
3kuxA	2	0.9826	100	0.228	Contact Map
3e82A	2	0.971	100	0.229	Contact Map
2nvwA	3	0.9188	100	0.23	Contact Map
3v5nA	4	0.942	100	0.231	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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