GREMLIN Database
YHHX - Uncharacterized oxidoreductase YhhX
UniProt: P46853 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12944
Length: 345 (311)
Sequences: 25112 (18453)
Seq/√Len: 1046.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_D84_R3.0921.00
126_R181_D2.8421.00
83_K111_L2.8201.00
192_H215_F2.7811.00
4_N30_H2.7721.00
79_F107_E2.7601.00
133_T136_K2.7481.00
39_A43_E2.7081.00
145_E241_K2.6901.00
106_K323_L2.6611.00
87_E111_L2.6071.00
135_K139_E2.4021.00
73_T81_Y2.3891.00
83_K87_E2.3681.00
6_A60_V2.3611.00
79_F104_Q2.3601.00
83_K107_E2.3321.00
91_N118_T2.3091.00
86_L117_L2.3001.00
212_A332_G2.2701.00
136_K140_S2.1901.00
56_D59_E2.1731.00
33_H54_T2.1581.00
110_A114_S2.0841.00
77_S81_Y2.0831.00
113_K320_S2.0581.00
307_Q311_H2.0201.00
28_S310_T1.9941.00
52_H63_D1.9911.00
79_F83_K1.9841.00
133_T137_A1.9651.00
86_L112_A1.9591.00
68_L305_L1.9501.00
106_K327_E1.9311.00
82_A94_V1.9251.00
106_K110_A1.8921.00
111_L115_K1.8391.00
38_H41_P1.8161.00
80_E84_R1.8111.00
43_E46_P1.8101.00
73_T77_S1.8041.00
25_R28_S1.7971.00
143_L240_G1.7901.00
6_A66_V1.7731.00
87_E115_K1.7521.00
91_N117_L1.7451.00
216_Y221_A1.7021.00
69_V85_A1.6991.00
22_V70_V1.6891.00
102_L330_E1.6851.00
5_C68_L1.6611.00
191_D215_F1.6531.00
55_S59_E1.6521.00
101_T104_Q1.6371.00
66_V90_K1.6281.00
82_A108_L1.6231.00
25_R303_D1.6221.00
29_W306_Y1.6111.00
134_A245_F1.5981.00
62_N88_A1.5971.00
61_L85_A1.5971.00
119_V319_E1.5921.00
87_E114_S1.5491.00
197_I336_A1.5411.00
137_A142_K1.5381.00
122_Y301_V1.5311.00
189_R324_T1.5181.00
135_K185_S1.5141.00
118_T312_G1.5111.00
109_F323_L1.4971.00
57_L84_R1.4781.00
324_T327_E1.4701.00
59_E62_N1.4561.00
109_F319_E1.4431.00
79_F108_L1.4431.00
147_V241_K1.4361.00
54_T63_D1.4291.00
100_P104_Q1.4291.00
58_D62_N1.4151.00
99_T108_L1.4031.00
187_F219_L1.4021.00
111_L114_S1.3981.00
150_E237_I1.3951.00
184_I189_R1.3851.00
42_E53_F1.3771.00
307_Q313_A1.3641.00
54_T60_V1.3631.00
39_A55_S1.3471.00
86_L115_K1.3461.00
99_T105_A1.3451.00
4_N32_A1.3231.00
59_E63_D1.3201.00
84_R87_E1.3121.00
237_I246_I1.3091.00
146_I238_V1.3041.00
143_L243_G1.3031.00
190_P216_Y1.2991.00
105_A323_L1.2931.00
184_I324_T1.2911.00
304_A308_T1.2901.00
84_R88_A1.2781.00
4_N67_K1.2761.00
35_F57_L1.2761.00
44_Q47_I1.2711.00
196_D215_F1.2661.00
102_L106_K1.2571.00
304_A316_Y1.2511.00
10_F34_I1.2491.00
102_L327_E1.2481.00
71_V81_Y1.2361.00
180_M328_I1.2361.00
85_A92_V1.2121.00
35_F60_V1.2061.00
64_P90_K1.2011.00
107_E110_A1.1821.00
57_L81_Y1.1791.00
71_V82_A1.1781.00
184_I216_Y1.1781.00
89_G115_K1.1761.00
235_K246_I1.1731.00
40_K43_E1.1621.00
86_L111_L1.1581.00
33_H60_V1.1571.00
28_S303_D1.1551.00
303_D307_Q1.1501.00
60_V66_V1.1491.00
98_F105_A1.1341.00
65_D90_K1.1311.00
150_E224_K1.1301.00
109_F320_S1.1271.00
45_A48_Y1.1171.00
318_K321_E1.1131.00
91_N312_G1.1121.00
184_I321_E1.1101.00
149_V187_F1.1091.00
5_C29_W1.1071.00
74_H77_S1.1071.00
194_A213_Q1.0911.00
110_A113_K1.0891.00
57_L61_L1.0891.00
107_E111_L1.0881.00
137_A140_S1.0881.00
330_E334_E1.0871.00
83_K108_L1.0841.00
15_T47_I1.0811.00
24_N299_G1.0771.00
61_L84_R1.0731.00
306_Y310_T1.0711.00
143_L245_F1.0661.00
183_I221_A1.0651.00
164_P167_P1.0611.00
331_R334_E1.0601.00
131_F185_S1.0591.00
93_L122_Y1.0551.00
105_A326_L1.0521.00
104_Q107_E1.0511.00
61_L88_A1.0461.00
93_L301_V1.0451.00
28_S307_Q1.0451.00
3_I310_T1.0401.00
3_I68_L1.0391.00
33_H66_V1.0281.00
304_A313_A1.0261.00
94_V119_V1.0171.00
109_F113_K1.0121.00
143_L146_I1.0091.00
8_I81_Y1.0041.00
99_T104_Q1.0031.00
91_N309_I1.0021.00
149_V221_A1.0011.00
127_F304_A1.0011.00
48_Y51_I0.9991.00
18_H70_V0.9981.00
3_I309_I0.9971.00
63_D66_V0.9881.00
108_L119_V0.9791.00
334_E337_S0.9781.00
136_K139_E0.9771.00
42_E55_S0.9761.00
39_A42_E0.9701.00
103_A106_K0.9701.00
41_P44_Q0.9661.00
126_R321_E0.9601.00
331_R335_Q0.9591.00
20_P24_N0.9531.00
304_A307_Q0.9431.00
52_H65_D0.9381.00
146_I187_F0.9351.00
134_A247_K0.9251.00
98_F319_E0.9211.00
102_L323_L0.9211.00
81_Y84_R0.9211.00
112_A115_K0.9201.00
54_T59_E0.9181.00
190_P214_L0.9171.00
146_I240_G0.9151.00
103_A107_E0.9141.00
82_A92_V0.9121.00
299_G303_D0.9061.00
86_L92_V0.9011.00
300_R303_D0.8971.00
149_V238_V0.8941.00
63_D90_K0.8941.00
320_S324_T0.8911.00
120_T305_L0.8911.00
307_Q312_G0.8871.00
71_V85_A0.8781.00
124_N297_D0.8741.00
98_F119_V0.8711.00
10_F36_R0.8711.00
39_A53_F0.8651.00
32_A52_H0.8641.00
94_V98_F0.8631.00
40_K44_Q0.8631.00
79_F99_T0.8621.00
118_T309_I0.8581.00
308_T311_H0.8551.00
76_D167_P0.8531.00
43_E53_F0.8501.00
6_A33_H0.8481.00
22_V29_W0.8461.00
70_V302_Y0.8441.00
211_E222_I0.8431.00
194_A335_Q0.8411.00
180_M329_L0.8411.00
82_A86_L0.8401.00
106_K109_F0.8361.00
196_D220_K0.8301.00
112_A119_V0.8301.00
36_R41_P0.8281.00
190_P328_I0.8281.00
333_F337_S0.8261.00
5_C22_V0.8241.00
77_S80_E0.8231.00
144_G243_G0.8221.00
18_H302_Y0.8191.00
237_I244_S0.8191.00
6_A35_F0.8181.00
151_S236_F0.8171.00
94_V108_L0.8121.00
4_N66_V0.8121.00
45_A49_S0.8091.00
327_E331_R0.8081.00
195_Y332_G0.8081.00
112_A117_L0.8031.00
149_V183_I0.8021.00
100_P168_Q0.8011.00
14_T72_C0.8001.00
152_H235_K0.7981.00
32_A65_D0.7971.00
86_L119_V0.7971.00
150_E222_I0.7971.00
36_R42_E0.7951.00
112_A319_E0.7921.00
75_A174_G0.7881.00
118_T308_T0.7861.00
132_L136_K0.7851.00
214_L221_A0.7851.00
28_S306_Y0.7841.00
7_F19_L0.7811.00
308_T313_A0.7811.00
138_I240_G0.7771.00
184_I325_N0.7711.00
45_A50_H0.7701.00
308_T315_N0.7681.00
144_G240_G0.7681.00
22_V302_Y0.7641.00
14_T20_P0.7611.00
13_S298_Y0.7591.00
19_L31_V0.7581.00
120_T308_T0.7561.00
171_A225_T0.7501.00
25_R29_W0.7441.00
196_D213_Q0.7421.00
183_I216_Y0.7421.00
60_V63_D0.7421.00
79_F111_L0.7411.00
13_S72_C0.7401.00
105_A109_F0.7401.00
164_P205_N0.7391.00
8_I57_L0.7391.00
32_A63_D0.7381.00
10_F42_E0.7371.00
235_K248_Y0.7361.00
174_G227_H0.7321.00
6_A69_V0.7311.00
177_V325_N0.7311.00
170_G207_D0.7301.00
98_F121_P0.7281.00
314_P318_K0.7271.00
139_E188_G0.7271.00
305_L309_I0.7251.00
187_F216_Y0.7231.00
123_Q177_V0.7201.00
32_A66_V0.7171.00
151_S179_T0.7161.00
8_I73_T0.7151.00
172_F329_L0.7141.00
68_L91_N0.7121.00
259_A262_M0.7091.00
121_P322_V0.7081.00
198_R215_F0.7071.00
176_G225_T0.7051.00
46_P53_F0.7041.00
323_L327_E0.7021.00
152_H224_K0.7021.00
15_T44_Q0.6971.00
13_S18_H0.6941.00
319_E322_V0.6921.00
298_Y301_V0.6891.00
94_V121_P0.6891.00
326_L330_E0.6851.00
78_H94_V0.6841.00
8_I35_F0.6801.00
215_F220_K0.6781.00
83_K86_L0.6751.00
145_E242_K0.6741.00
89_G117_L0.6711.00
125_R128_D0.6701.00
132_L300_R0.6661.00
86_L108_L0.6651.00
239_H244_S0.6631.00
4_N65_D0.6621.00
169_D173_Y0.6611.00
172_F210_F0.6611.00
191_D217_G0.6611.00
126_R185_S0.6601.00
213_Q220_K0.6591.00
5_C306_Y0.6591.00
68_L309_I0.6581.00
195_Y212_A0.6581.00
131_F182_Q0.6581.00
80_E107_E0.6571.00
118_T314_P0.6551.00
186_L238_V0.6551.00
192_H196_D0.6511.00
15_T41_P0.6511.00
43_E47_I0.6511.00
207_D333_F0.6501.00
138_I238_V0.6471.00
93_L120_T0.6461.00
118_T315_N0.6451.00
195_Y210_F0.6441.00
200_L208_D0.6431.00
212_A223_V0.6431.00
123_Q181_D0.6421.00
148_E220_K0.6411.00
30_H51_I0.6381.00
135_K186_L0.6361.00
54_T64_P0.6361.00
184_I328_I0.6351.00
304_A315_N0.6331.00
46_P49_S0.6321.00
321_E324_T0.6301.00
45_A53_F0.6271.00
82_A119_V0.6271.00
38_H43_E0.6261.00
90_K117_L0.6251.00
181_D185_S0.6231.00
151_S183_I0.6231.00
216_Y219_L0.6221.00
176_G179_T0.6211.00
124_N298_Y0.6191.00
142_K259_A0.6181.00
178_H181_D0.6111.00
181_D325_N0.6111.00
34_I45_A0.6081.00
226_S229_V0.6071.00
57_L85_A0.6071.00
5_C70_V0.6071.00
214_L223_V0.6051.00
15_T48_Y0.6041.00
138_I186_L0.6021.00
58_D80_E0.6021.00
120_T304_A0.6001.00
70_V93_L0.6001.00
259_A263_P0.5971.00
208_D228_L0.5951.00
180_M332_G0.5951.00
132_L316_Y0.5951.00
307_Q310_T0.5801.00
34_I42_E0.5801.00
34_I53_F0.5801.00
46_P50_H0.5751.00
146_I219_L0.5741.00
325_N329_L0.5731.00
71_V78_H0.5731.00
123_Q325_N0.5721.00
109_F112_A0.5721.00
69_V90_K0.5711.00
134_A186_L0.5701.00
13_S95_E0.5691.00
209_T226_S0.5691.00
25_R306_Y0.5691.00
31_V50_H0.5681.00
154_D224_K0.5681.00
125_R181_D0.5661.00
67_K310_T0.5661.00
87_E107_E0.5651.00
49_S52_H0.5601.00
37_R73_T0.5591.00
194_A215_F0.5581.00
96_K178_H0.5571.00
141_G240_G0.5571.00
11_G72_C0.5561.00
80_E83_K0.5561.00
201_R208_D0.5541.00
329_L333_F0.5541.00
35_F54_T0.5501.00
33_H52_H0.5501.00
18_H22_V0.5481.00
142_K145_E0.5461.00
29_W68_L0.5451.00
12_K16_R0.5451.00
261_I264_G0.5431.00
96_K174_G0.5431.00
183_I223_V0.5421.00
132_L185_S0.5421.00
82_A112_A0.5421.00
213_Q222_I0.5401.00
172_F212_A0.5391.00
173_Y330_E0.5391.00
197_I210_F0.5391.00
148_E222_I0.5371.00
148_E239_H0.5361.00
256_S259_A0.5351.00
101_T330_E0.5351.00
25_R299_G0.5321.00
18_H72_C0.5311.00
20_P23_L0.5291.00
76_D100_P0.5291.00
15_T20_P0.5271.00
296_G299_G0.5261.00
98_F108_L0.5241.00
163_K174_G0.5221.00
187_F217_G0.5221.00
193_V328_I0.5211.00
95_E122_Y0.5211.00
8_I71_V0.5201.00
127_F317_V0.5201.00
120_T301_V0.5201.00
190_P221_A0.5191.00
11_G14_T0.5191.00
129_S300_R0.5171.00
153_F175_L0.5171.00
35_F55_S0.5161.00
124_N178_H0.5151.00
149_V236_F0.5141.00
103_A330_E0.5131.00
72_C95_E0.5131.00
148_E209_T0.5131.00
7_F70_V0.5131.00
73_T78_H0.5121.00
168_Q206_P0.5101.00
118_T305_L0.5101.00
8_I69_V0.5091.00
189_R327_E0.5091.00
289_E292_K0.5081.00
165_G205_N0.5071.00
198_R220_K0.5061.00
257_L260_N0.5051.00
123_Q178_H0.5051.00
121_P178_H0.5041.00
83_K115_K0.5031.00
214_L328_I0.5011.00
7_F31_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f4lA 2 0.9942 100 0.205 Contact Map
1h6dA 8 0.9449 100 0.212 Contact Map
3dtyA 4 0.9536 100 0.223 Contact Map
3i23A 2 0.9884 100 0.224 Contact Map
3ezyA 4 0.9362 100 0.225 Contact Map
1zh8A 2 0.8986 100 0.227 Contact Map
3kuxA 2 0.9826 100 0.228 Contact Map
3e82A 2 0.971 100 0.229 Contact Map
2nvwA 3 0.9188 100 0.23 Contact Map
3v5nA 4 0.942 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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