GREMLIN Database
YHHW - Quercetin 2,3-dioxygenase
UniProt: P46852 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12943
Length: 231 (196)
Sequences: 5865 (4006)
Seq/√Len: 286.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_Q216_H2.9791.00
76_Q82_K2.9791.00
147_P151_D2.8321.00
172_Q214_S2.7741.00
174_V214_S2.7661.00
72_T86_P2.6871.00
199_A205_L2.6151.00
193_T216_H2.5891.00
74_E82_K2.5341.00
89_E134_R2.5181.00
174_V212_A2.4781.00
45_D113_H2.4451.00
66_T114_L2.4151.00
70_E111_R2.2201.00
192_V221_S2.2121.00
191_N219_S2.1471.00
74_E84_Q2.1161.00
191_N198_K2.1121.00
70_E113_H2.1001.00
191_N200_S2.0301.00
189_K222_E1.9471.00
126_I157_H1.9461.00
165_W223_V1.9351.00
97_T127_T1.9301.00
56_T100_R1.9081.00
46_D49_E1.8761.00
193_T198_K1.8161.00
169_K219_S1.8021.00
193_T218_D1.7491.00
164_R222_E1.7431.00
191_N218_D1.7411.00
168_L220_D1.7351.00
166_A222_E1.7171.00
96_G126_I1.7031.00
61_D125_G1.6871.00
177_I183_V1.6791.00
193_T196_G1.6351.00
74_E106_P1.6331.00
176_Q212_A1.6311.00
78_S100_R1.6231.00
48_I114_L1.6141.00
37_F184_W1.6001.00
72_T84_Q1.5911.00
200_S203_D1.5731.00
94_S126_I1.5241.00
115_Y188_V1.5201.00
56_T102_S1.5101.00
43_I117_I1.5041.00
63_E94_S1.4991.00
165_W173_S1.4961.00
115_Y224_L1.4951.00
187_V192_V1.4841.00
69_L188_V1.4821.00
131_E155_K1.4621.00
76_Q102_S1.4341.00
146_S153_S1.4261.00
52_Q55_G1.4241.00
58_P100_R1.4191.00
138_V141_K1.4181.00
60_K125_G1.4071.00
169_K220_D1.4041.00
79_M99_I1.3931.00
217_A220_D1.3631.00
207_I213_I1.3611.00
37_F206_A1.3361.00
92_I131_E1.3101.00
91_Q130_Y1.2991.00
129_R155_K1.2891.00
72_T106_P1.2871.00
168_L171_E1.2511.00
189_K201_T1.2441.00
38_S182_R1.2411.00
68_V114_L1.2341.00
159_D181_R1.2301.00
35_M41_R1.2261.00
45_D186_Q1.2261.00
192_V223_V1.2191.00
215_I223_V1.2181.00
47_V50_A1.2091.00
179_A211_Q1.2001.00
167_L217_A1.1721.00
70_E110_E1.1481.00
143_L146_S1.1411.00
46_D50_A1.1401.00
92_I129_R1.1361.00
187_V199_A1.1341.00
143_L150_R1.1031.00
134_R137_A1.0861.00
185_I225_L1.0841.00
119_I160_M1.0731.00
47_V113_H1.0671.00
84_Q106_P1.0411.00
68_V73_V1.0391.00
86_P89_E1.0331.00
67_Y164_R1.0321.00
113_H189_K1.0311.00
194_I205_L1.0261.00
143_L163_Y1.0241.00
57_H101_H1.0191.00
89_E135_F1.0171.00
43_I115_Y1.0051.00
65_L119_I1.0041.00
117_I226_F1.0001.00
49_E111_R0.9831.00
189_K220_D0.9771.00
129_R157_H0.9751.00
167_L171_E0.9671.00
73_V112_L0.9581.00
56_T76_Q0.9561.00
184_W206_A0.9471.00
185_I207_I0.9461.00
89_E132_Q0.9441.00
123_E126_I0.9391.00
45_D202_S0.9381.00
194_I215_I0.9371.00
185_I192_V0.9351.00
64_I93_M0.9341.00
175_H225_L0.9311.00
43_I226_F0.9291.00
70_E189_K0.9271.00
178_A181_R0.9171.00
36_G120_M0.9141.00
184_W204_G0.9081.00
167_L170_D0.8961.00
161_E181_R0.8931.00
115_Y186_Q0.8871.00
188_V222_E0.8691.00
46_D114_L0.8541.00
139_Q168_L0.8511.00
142_Q146_S0.8501.00
92_I145_L0.8471.00
183_V225_L0.8411.00
199_A203_D0.8321.00
150_R161_E0.8311.00
92_I119_I0.8301.00
72_T107_S0.8281.00
61_D124_N0.8281.00
59_H101_H0.8261.00
166_A220_D0.8161.00
75_H130_Y0.8141.00
97_T128_P0.8131.00
169_K217_A0.8110.99
185_I215_I0.8070.99
85_V132_Q0.8060.99
73_V114_L0.7960.99
195_N210_E0.7960.99
34_F206_A0.7950.99
60_K124_N0.7890.99
165_W225_L0.7860.99
167_L173_S0.7840.99
65_L145_L0.7790.99
184_W226_F0.7780.99
70_E87_A0.7780.99
196_G214_S0.7680.99
44_N114_L0.7650.99
163_Y175_H0.7600.99
156_V160_M0.7590.99
38_S184_W0.7580.99
75_H103_E0.7550.99
144_V164_R0.7510.99
141_K171_E0.7480.99
72_T110_E0.7450.99
85_V89_E0.7430.99
68_V112_L0.7410.99
47_V111_R0.7400.99
93_M99_I0.7280.99
137_A140_G0.7270.99
142_Q164_R0.7260.99
75_H93_M0.7250.99
67_Y162_L0.7250.99
217_A221_S0.7250.99
194_I199_A0.7210.99
122_E126_I0.7180.99
192_V215_I0.7150.99
36_G41_R0.7120.99
187_V205_L0.7100.99
75_H101_H0.7050.99
119_I156_V0.7050.99
53_G104_Y0.7020.99
39_A120_M0.7010.99
65_L92_I0.6980.98
185_I194_I0.6880.98
86_P134_R0.6850.98
57_H116_Q0.6820.98
97_T125_G0.6790.98
60_K100_R0.6770.98
186_Q202_S0.6700.98
142_Q166_A0.6680.98
170_D218_D0.6660.98
141_K168_L0.6660.98
187_V190_G0.6650.98
194_I207_I0.6620.98
218_D221_S0.6620.98
179_A209_D0.6610.98
44_N64_I0.6600.98
103_E130_Y0.6570.98
133_R153_S0.6530.98
162_L226_F0.6500.98
147_P161_E0.6430.97
90_F144_V0.6410.97
69_L115_Y0.6390.97
177_I225_L0.6390.97
173_S176_Q0.6380.97
186_Q204_G0.6360.97
120_M124_N0.6340.97
145_L156_V0.6330.97
186_Q226_F0.6300.97
39_A182_R0.6260.97
171_E217_A0.6220.97
75_H91_Q0.6220.97
92_I154_L0.6210.97
83_E132_Q0.6190.97
139_Q171_E0.6190.97
94_S129_R0.6160.97
117_I162_L0.6150.97
34_F37_F0.6130.97
55_G104_Y0.6110.97
48_I112_L0.6110.97
97_T126_I0.6080.96
65_L162_L0.6060.96
185_I223_V0.6060.96
62_M158_Q0.6050.96
69_L113_H0.6010.96
144_V147_P0.6000.96
133_R152_G0.5970.96
170_D216_H0.5960.96
107_S110_E0.5920.96
69_L164_R0.5830.95
57_H75_H0.5810.95
133_R137_A0.5740.95
86_P135_F0.5730.95
189_K219_S0.5690.95
83_E93_M0.5690.95
45_D188_V0.5660.95
33_N172_Q0.5640.95
43_I186_Q0.5610.94
185_I205_L0.5600.94
74_E107_S0.5600.94
55_G114_L0.5590.94
157_H160_M0.5550.94
82_K104_Y0.5550.94
170_D217_A0.5530.94
122_E157_H0.5520.94
195_N214_S0.5480.94
76_Q104_Y0.5480.94
162_L224_L0.5470.94
37_F96_G0.5470.94
37_F183_V0.5450.94
113_H201_T0.5440.93
53_G105_N0.5430.93
142_Q145_L0.5420.93
118_W130_Y0.5390.93
81_N132_Q0.5380.93
52_Q73_V0.5350.93
193_T214_S0.5340.93
187_V201_T0.5340.93
169_K218_D0.5330.93
188_V201_T0.5320.93
42_V46_D0.5320.93
65_L156_V0.5300.93
51_G107_S0.5290.93
89_E133_R0.5290.93
56_T78_S0.5280.92
34_F204_G0.5260.92
55_G100_R0.5250.92
91_Q132_Q0.5250.92
59_H75_H0.5250.92
183_V213_I0.5220.92
74_E104_Y0.5220.92
77_D80_G0.5200.92
133_R154_L0.5200.92
176_Q211_Q0.5190.92
171_E216_H0.5150.92
161_E178_A0.5140.91
69_L222_E0.5140.91
90_F154_L0.5140.91
182_R209_D0.5130.91
180_E209_D0.5130.91
43_I224_L0.5130.91
195_N211_Q0.5110.91
148_D213_I0.5100.91
131_E137_A0.5100.91
48_I52_Q0.5090.91
42_V64_I0.5080.91
66_T83_E0.5080.91
67_Y90_F0.5070.91
138_V195_N0.5070.91
45_D201_T0.5060.91
195_N198_K0.5060.91
194_I221_S0.5060.91
198_K218_D0.5050.91
65_L89_E0.5050.91
196_G216_H0.5030.91
165_W175_H0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tq5A 1 1 100 0.029 Contact Map
2vecA 1 0.961 100 0.073 Contact Map
2p17A 1 0.9654 100 0.22 Contact Map
4eweA 1 0.9654 100 0.245 Contact Map
3o14A 2 0.9004 99.8 0.699 Contact Map
1sq4A 5 0.9307 99.4 0.778 Contact Map
3h7jA 1 0.9048 99.2 0.801 Contact Map
1sefA 5 0.9177 99.2 0.803 Contact Map
2d40A 3 0.9481 99.2 0.803 Contact Map
1rc6A 4 0.9091 99.1 0.816 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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