GREMLIN Database
RTCA - RNA 3'-terminal phosphate cyclase
UniProt: P46849 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12938
Length: 338 (315)
Sequences: 983 (724)
Seq/√Len: 40.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_M78_F4.9451.00
263_A267_V4.8231.00
257_V265_Q3.7091.00
55_V76_L3.5981.00
140_E150_Q3.4081.00
207_R260_E3.2091.00
280_V288_L3.1461.00
289_V316_V3.1151.00
34_T75_R2.9321.00
133_D157_H2.8811.00
102_L169_T2.8481.00
23_L58_A2.7701.00
188_I242_S2.7661.00
109_L116_S2.6341.00
305_P309_L2.6091.00
317_E323_R2.5861.00
34_T77_L2.5661.00
195_V208_E2.3721.00
87_D117_R2.3281.00
208_E234_N2.2911.00
190_Q241_E2.2801.00
105_V118_V2.2601.00
126_N129_A2.2411.00
211_T263_A2.2341.00
213_A217_S2.2301.00
181_Q299_E2.1750.99
313_I324_F2.1250.99
52_L69_A2.0920.99
193_G238_L2.0700.99
212_L267_V2.0680.99
279_A301_T2.0620.99
26_S32_P2.0180.99
117_R168_A1.9860.99
92_I101_V1.9520.99
134_F248_R1.9020.99
131_P237_S1.9010.99
295_A298_G1.8820.98
314_A317_E1.8800.98
151_Q170_E1.8740.98
91_A121_S1.8700.98
27_M62_C1.8400.98
138_V248_R1.8160.98
121_S166_V1.8030.98
29_T320_L1.7920.98
27_M58_A1.7910.98
282_E306_S1.7720.98
200_V204_V1.7610.98
158_G161_P1.7300.97
192_R241_E1.7260.97
146_I180_L1.7250.97
23_L55_V1.7210.97
153_T168_A1.7040.97
196_L235_T1.7040.97
144_A149_H1.6570.96
312_N316_V1.6540.96
184_E244_N1.6510.96
142_L284_L1.6020.96
285_A309_L1.5940.96
16_G50_Q1.5870.95
240_V270_V1.5640.95
98_C132_A1.5580.95
28_I108_A1.5130.94
110_W148_I1.5040.94
125_D157_H1.5030.94
21_S312_N1.5010.94
307_C310_L1.4730.93
188_I240_V1.4730.93
67_E77_L1.4720.93
195_V205_A1.4640.93
264_A268_K1.4610.93
159_F198_A1.4510.93
288_L300_F1.4450.93
139_L284_L1.4420.92
24_S28_I1.4400.92
56_K69_A1.4380.92
63_G84_R1.4210.92
89_R121_S1.4200.92
242_S274_L1.4090.92
215_S268_K1.3770.91
189_V243_E1.3670.90
314_A318_R1.3630.90
102_L167_V1.3450.90
106_L306_S1.3440.90
303_A306_S1.3370.89
212_L263_A1.3360.89
212_L216_F1.3350.89
316_V319_F1.3220.89
159_F196_L1.3200.89
197_L205_A1.3200.89
286_D308_H1.3200.89
117_R170_E1.3160.89
212_L236_V1.3130.88
68_G73_S1.2940.88
158_G163_G1.2860.87
61_I109_L1.2710.87
212_L266_L1.2670.87
59_T66_V1.2580.86
211_T264_A1.2470.86
202_R206_E1.2390.85
58_A64_A1.2350.85
23_L52_L1.2330.85
39_R46_G1.2100.84
238_L270_V1.2080.84
132_A152_T1.2050.84
36_T75_R1.1910.83
142_L182_L1.1840.83
215_S264_A1.1750.82
110_W150_Q1.1700.82
293_A320_L1.1680.82
251_V266_L1.1600.81
100_L103_Q1.1600.81
53_T56_K1.1580.81
92_I120_V1.1550.81
272_R282_E1.1530.81
85_G114_G1.1470.80
44_K48_L1.1420.80
76_L319_F1.1400.80
125_D131_P1.1260.79
278_A303_A1.1250.79
155_L166_V1.1250.79
161_P164_G1.1160.79
155_L168_A1.1100.78
123_G286_D1.1100.78
208_E262_V1.1080.78
179_T298_G1.1050.78
146_I292_M1.0980.77
273_Y282_E1.0910.77
16_G42_R1.0750.76
134_F138_V1.0730.76
302_V309_L1.0700.76
309_L313_I1.0670.75
137_R239_E1.0650.75
99_T135_I1.0620.75
119_E166_V1.0610.75
57_A90_F1.0590.75
58_A104_T1.0530.74
154_L194_E1.0500.74
58_A78_F1.0470.74
98_C167_V1.0450.74
134_F284_L1.0250.72
199_G225_N1.0230.72
26_S33_F1.0160.72
95_A130_P1.0150.72
61_I105_V1.0100.71
211_T267_V1.0090.71
20_R103_Q1.0080.71
33_F76_L1.0070.71
156_R185_R1.0050.71
302_V305_P1.0040.71
61_I88_Y1.0000.70
220_E223_I0.9960.70
112_A116_S0.9920.70
236_V263_A0.9910.70
124_T165_G0.9910.70
42_R51_H0.9900.70
118_V169_T0.9880.70
215_S267_V0.9860.69
312_N315_V0.9860.69
253_G256_R0.9760.69
317_E324_F0.9670.68
285_A306_S0.9590.67
17_Q308_H0.9570.67
51_H96_G0.9540.67
95_A100_L0.9540.67
308_H311_T0.9520.67
266_L270_V0.9500.66
95_A123_G0.9500.66
195_V234_N0.9460.66
42_R97_S0.9410.66
61_I116_S0.9400.66
193_G235_T0.9370.65
130_P286_D0.9370.65
308_H315_V0.9340.65
132_A154_L0.9310.65
199_G232_P0.9270.65
289_V302_V0.9260.64
135_I152_T0.9220.64
45_P164_G0.9200.64
236_V267_V0.9190.64
131_P159_F0.9130.63
57_A120_V0.9090.63
43_A48_L0.9080.63
115_P172_S0.9050.63
85_G113_D0.9010.62
242_S279_A0.9000.62
61_I83_V0.8990.62
23_L33_F0.8990.62
95_A163_G0.8980.62
163_G233_G0.8980.62
212_L238_L0.8980.62
285_A303_A0.8970.62
42_R50_Q0.8940.62
33_F319_F0.8930.62
42_R68_G0.8910.61
305_P313_I0.8880.61
65_T81_G0.8870.61
66_V69_A0.8850.61
83_V112_A0.8800.60
191_M270_V0.8790.60
256_R262_V0.8730.60
139_L143_L0.8720.60
17_Q95_A0.8710.60
50_Q95_A0.8710.60
16_G123_G0.8710.60
53_T90_F0.8680.59
154_L167_V0.8610.59
22_A136_R0.8610.59
123_G130_P0.8610.59
195_V212_L0.8610.59
177_F298_G0.8590.59
310_L314_A0.8580.59
89_R119_E0.8540.58
280_V284_L0.8500.58
208_E236_V0.8490.58
251_V262_V0.8470.58
29_T319_F0.8470.58
119_E155_L0.8440.57
57_A101_V0.8420.57
316_V320_L0.8400.57
83_V111_F0.8340.56
34_T254_E0.8280.56
123_G308_H0.8270.56
74_Q292_M0.8240.55
42_R48_L0.8230.55
313_I326_L0.8230.55
267_V271_K0.8220.55
191_M240_V0.8200.55
179_T295_A0.8160.55
65_T79_R0.8130.54
278_A301_T0.8120.54
88_Y118_V0.8110.54
22_A327_I0.8080.54
134_F281_G0.8060.54
292_M313_I0.8040.54
286_D311_T0.8030.54
103_Q287_Q0.8010.53
140_E152_T0.7960.53
42_R95_A0.7940.53
58_A90_F0.7930.53
279_A292_M0.7880.52
161_P231_G0.7860.52
289_V313_I0.7860.52
106_L148_I0.7850.52
62_C65_T0.7840.52
283_Y287_Q0.7790.51
259_A262_V0.7710.51
15_G124_T0.7710.51
50_Q100_L0.7680.50
56_K172_S0.7670.50
54_A104_T0.7640.50
94_S177_F0.7610.50
94_S130_P0.7610.50
102_L106_L0.7610.50
45_P163_G0.7600.50
17_Q100_L0.7580.49
39_R47_L0.7570.49
132_A235_T0.7530.49
62_C79_R0.7520.49
51_H100_L0.7520.49
149_H172_S0.7440.48
193_G209_I0.7420.48
130_P308_H0.7420.48
97_S126_N0.7400.48
313_I316_V0.7390.48
62_C81_G0.7370.47
96_G100_L0.7360.47
109_L141_P0.7330.47
95_A161_P0.7320.47
101_V118_V0.7300.47
323_R326_L0.7290.47
164_G233_G0.7280.47
104_T107_P0.7270.46
215_S271_K0.7250.46
307_C311_T0.7240.46
50_Q308_H0.7200.46
119_E168_A0.7190.46
19_L205_A0.7180.46
96_G129_A0.7180.46
211_T214_G0.7160.45
16_G286_D0.7160.45
48_L71_L0.7140.45
152_T169_T0.7140.45
282_E304_H0.7110.45
166_V316_V0.7080.45
220_E224_H0.7080.45
146_I179_T0.7070.45
42_R123_G0.7050.44
149_H180_L0.7050.44
235_T263_A0.7040.44
162_A249_F0.7020.44
92_I98_C0.7010.44
42_R287_Q0.7000.44
177_F180_L0.6990.44
142_L288_L0.6970.44
74_Q98_C0.6960.44
262_V266_L0.6940.43
217_S222_N0.6920.43
131_P250_F0.6920.43
301_T329_T0.6890.43
118_V176_S0.6870.43
177_F295_A0.6870.43
17_Q50_Q0.6870.43
292_M300_F0.6860.43
42_R286_D0.6830.42
75_R169_T0.6830.42
310_L315_V0.6820.42
23_L78_F0.6810.42
253_G306_S0.6760.42
191_M271_K0.6750.42
281_G306_S0.6730.42
42_R130_P0.6730.42
15_G39_R0.6690.41
60_E210_A0.6660.41
161_P233_G0.6650.41
311_T315_V0.6650.41
22_A73_S0.6630.41
258_S261_V0.6620.41
82_T210_A0.6620.41
38_I46_G0.6610.40
53_T101_V0.6600.40
139_L306_S0.6590.40
292_M298_G0.6590.40
56_K206_E0.6590.40
242_S245_I0.6580.40
35_I167_V0.6570.40
94_S308_H0.6570.40
134_F286_D0.6540.40
17_Q42_R0.6540.40
34_T199_G0.6530.40
50_Q103_Q0.6510.40
50_Q286_D0.6490.39
93_G101_V0.6490.39
197_L204_V0.6480.39
111_F132_A0.6460.39
242_S246_T0.6460.39
25_L320_L0.6460.39
285_A302_V0.6450.39
208_E263_A0.6430.39
255_K269_E0.6390.39
254_E257_V0.6390.39
100_L286_D0.6380.38
16_G20_R0.6380.38
247_E281_G0.6380.38
97_S308_H0.6370.38
69_A73_S0.6360.38
250_F287_Q0.6350.38
57_A105_V0.6350.38
50_Q284_L0.6340.38
54_A171_V0.6310.38
246_T263_A0.6310.38
97_S107_P0.6300.38
100_L308_H0.6300.38
17_Q286_D0.6290.38
76_L188_I0.6270.37
135_I169_T0.6270.37
19_L38_I0.6260.37
137_R237_S0.6250.37
15_G20_R0.6240.37
152_T166_V0.6230.37
261_V264_A0.6230.37
97_S173_P0.6230.37
37_S41_G0.6220.37
225_N232_P0.6200.37
207_R233_G0.6190.37
209_I213_A0.6160.37
97_S198_A0.6150.36
125_D196_L0.6140.36
125_D235_T0.6080.36
42_R308_H0.6070.36
90_F273_Y0.6060.36
175_A275_A0.6050.36
102_L132_A0.6030.35
83_V209_I0.6000.35
199_G229_D0.6000.35
190_Q220_E0.5990.35
272_R275_A0.5960.35
42_R100_L0.5950.35
31_Q63_G0.5950.35
23_L66_V0.5940.35
125_D133_D0.5930.35
203_H209_I0.5920.35
203_H238_L0.5920.35
204_V234_N0.5910.34
125_D237_S0.5910.34
120_V169_T0.5900.34
126_N248_R0.5890.34
234_N259_A0.5880.34
88_Y116_S0.5870.34
287_Q308_H0.5860.34
157_H165_G0.5850.34
163_G231_G0.5840.34
127_P145_K0.5830.34
193_G223_I0.5830.34
107_P286_D0.5810.34
28_I117_R0.5800.34
123_G311_T0.5750.33
34_T171_V0.5740.33
51_H54_A0.5730.33
156_R210_A0.5730.33
35_I150_Q0.5720.33
28_I166_V0.5710.33
28_I192_R0.5710.33
21_S290_L0.5690.33
204_V262_V0.5690.33
22_A315_V0.5670.32
249_F270_V0.5650.32
65_T154_L0.5630.32
193_G240_V0.5620.32
17_Q20_R0.5610.32
76_L267_V0.5610.32
136_R197_L0.5600.32
102_L120_V0.5570.32
133_D194_E0.5530.31
123_G147_G0.5530.31
250_F293_A0.5530.31
62_C302_V0.5520.31
111_F146_I0.5520.31
139_L309_L0.5490.31
131_P235_T0.5470.31
95_A286_D0.5470.31
272_R304_H0.5460.31
249_F273_Y0.5450.31
253_G262_V0.5430.31
269_E287_Q0.5430.31
101_V104_T0.5420.30
320_L324_F0.5420.30
16_G95_A0.5410.30
95_A308_H0.5400.30
51_H123_G0.5390.30
18_I103_Q0.5380.30
100_L123_G0.5350.30
124_T157_H0.5330.30
160_Y256_R0.5330.30
233_G263_A0.5320.30
110_W291_P0.5310.30
26_S307_C0.5300.30
96_G130_P0.5300.30
290_L312_N0.5290.29
134_F237_S0.5290.29
62_C206_E0.5290.29
115_P173_P0.5290.29
164_G231_G0.5290.29
264_A267_V0.5290.29
26_S252_V0.5280.29
33_F58_A0.5250.29
233_G260_E0.5240.29
234_N248_R0.5240.29
50_Q123_G0.5220.29
98_C193_G0.5220.29
90_F105_V0.5200.29
16_G100_L0.5190.29
196_L239_E0.5190.29
57_A92_I0.5180.29
307_C314_A0.5170.29
135_I185_R0.5170.29
188_I274_L0.5160.28
64_A79_R0.5150.28
235_T267_V0.5150.28
97_S115_P0.5150.28
23_L69_A0.5130.28
162_A291_P0.5120.28
133_D136_R0.5120.28
132_A157_H0.5110.28
219_H222_N0.5110.28
16_G308_H0.5080.28
193_G270_V0.5060.28
191_M315_V0.5040.28
208_E212_L0.5020.27
38_I45_P0.5020.27
195_V236_V0.5010.27
55_V135_I0.5010.27
94_S123_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tutA 1 0.9941 100 0.052 Contact Map
4o89A 1 0.9852 100 0.054 Contact Map
4clqA 1 0.9763 100 0.119 Contact Map
2o0bA 1 0.7959 96 0.939 Contact Map
2yvwA 1 0.7485 95.5 0.942 Contact Map
3zh4A 1 0.7692 93.8 0.947 Contact Map
2pqcA 1 0.8639 93.3 0.948 Contact Map
3rmtA 4 0.6923 93.1 0.948 Contact Map
3r38A 2 0.6568 92.8 0.949 Contact Map
4fqdA 2 0.7751 92.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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