GNTX - ECOLI - GREMLIN Contacts

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GNTX - Protein GntX

UniProt:	P46846	Sequences: MLTVPGLCWLCRMPLALGHWGICSVCSRATRTDKTLCPQCGLPATHSHLPCGRCLQKPPPWQRLVTVADYAPPLSPLIHQLKFSRRSEIASALSRLLLLEVLHARRTTGLQLPDRIVSVPLWQRRHWRRGFNQSDLLCQPLSRWLHCQWDSEAVTRTRATATQHFLSARLRKRNLKNAFRLELPVQGRHMVIVDDVVTTGSTVAEIAQLLLRNGAAAVQVWCLCRTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12934
Length:	227 (207)
Sequences:	4065 (3412)
Seq/√Len:	237.2

ECOLI - GNTX
BACSU - COMFC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
203_V	220_V	3.990	1.00
119_V	206_I	3.505	1.00
154_V	206_I	3.470	1.00
163_Q	174_N	3.134	1.00
62_Q	211_L	3.031	1.00
142_S	149_W	2.804	1.00
167_S	170_L	2.755	1.00
197_V	222_C	2.695	1.00
68_A	74_L	2.636	1.00
37_C	40_C	2.588	1.00
181_L	209_L	2.523	1.00
66_T	222_C	2.523	1.00
189_H	217_A	2.520	1.00
51_C	54_C	2.240	1.00
121_L	133_Q	2.065	1.00
23_C	26_C	2.042	1.00
83_F	164_H	2.032	1.00
113_P	191_V	2.004	1.00
116_I	191_V	1.947	1.00
205_E	208_Q	1.946	1.00
168_A	172_K	1.930	1.00
117_V	153_A	1.896	1.00
81_L	90_A	1.886	1.00
60_P	204_A	1.834	1.00
157_T	180_R	1.825	1.00
94_S	98_L	1.786	1.00
166_L	174_N	1.780	1.00
191_V	221_W	1.762	1.00
135_D	139_Q	1.758	1.00
124_R	159_A	1.749	1.00
192_I	206_I	1.713	1.00
155_T	180_R	1.658	1.00
211_L	218_V	1.623	1.00
23_C	29_A	1.613	1.00
115_R	190_M	1.606	1.00
189_H	219_Q	1.594	1.00
116_I	142_S	1.566	1.00
80_Q	86_R	1.566	1.00
123_Q	127_W	1.559	1.00
62_Q	217_A	1.542	1.00
97_L	223_L	1.519	1.00
72_P	75_S	1.517	1.00
210_L	215_A	1.504	1.00
116_I	141_L	1.503	1.00
121_L	125_R	1.493	1.00
125_R	156_R	1.481	1.00
93_L	223_L	1.477	1.00
138_C	149_W	1.463	1.00
121_L	132_N	1.448	1.00
201_S	205_E	1.427	1.00
77_L	93_L	1.411	1.00
203_V	222_C	1.405	1.00
125_R	128_R	1.366	1.00
136_L	139_Q	1.352	1.00
87_S	136_L	1.344	1.00
142_S	147_C	1.337	1.00
209_L	212_R	1.324	1.00
155_T	182_E	1.314	1.00
114_D	189_H	1.312	1.00
97_L	221_W	1.302	1.00
63_R	219_Q	1.301	1.00
70_Y	79_H	1.295	1.00
64_L	222_C	1.288	1.00
122_W	159_A	1.277	1.00
119_V	202_T	1.272	1.00
135_D	149_W	1.266	1.00
156_R	160_T	1.256	1.00
94_S	140_P	1.254	1.00
197_V	203_V	1.249	1.00
79_H	83_F	1.244	1.00
95_R	144_W	1.239	1.00
121_L	126_H	1.227	1.00
134_S	138_C	1.209	1.00
75_S	79_H	1.204	1.00
114_D	191_V	1.197	1.00
91_S	140_P	1.194	1.00
90_A	136_L	1.192	1.00
160_T	178_A	1.189	1.00
74_L	224_C	1.175	1.00
189_H	216_A	1.174	1.00
94_S	141_L	1.161	1.00
23_C	30_T	1.158	1.00
118_S	135_D	1.155	1.00
81_L	137_L	1.155	1.00
64_L	220_V	1.149	1.00
185_V	188_R	1.147	1.00
40_C	51_C	1.145	1.00
190_M	215_A	1.135	1.00
205_E	209_L	1.132	1.00
98_L	144_W	1.131	1.00
11_C	23_C	1.119	1.00
101_V	221_W	1.097	1.00
134_S	137_L	1.094	1.00
115_R	187_G	1.086	1.00
118_S	149_W	1.083	1.00
134_S	193_V	1.080	1.00
81_L	89_I	1.060	1.00
125_R	162_T	1.060	1.00
126_H	135_D	1.059	1.00
142_S	145_L	1.052	1.00
206_I	209_L	1.048	1.00
138_C	141_L	1.046	1.00
187_G	215_A	1.045	1.00
207_A	211_L	1.041	1.00
121_L	156_R	1.035	1.00
181_L	213_N	1.030	1.00
161_A	166_L	1.029	1.00
40_C	54_C	1.029	1.00
8_C	11_C	1.021	1.00
140_P	144_W	1.020	1.00
64_L	197_V	1.014	1.00
97_L	137_L	1.012	1.00
215_A	218_V	1.001	1.00
135_D	151_S	0.995	1.00
177_N	205_E	0.980	1.00
116_I	138_C	0.976	1.00
39_Q	50_P	0.968	1.00
80_Q	84_S	0.967	1.00
122_W	125_R	0.960	1.00
61_W	207_A	0.954	1.00
81_L	136_L	0.949	1.00
114_D	188_R	0.934	1.00
125_R	133_Q	0.929	1.00
142_S	148_Q	0.926	1.00
160_T	175_L	0.912	1.00
79_H	84_S	0.911	1.00
52_G	55_L	0.892	0.99
185_V	215_A	0.890	0.99
89_I	92_A	0.889	0.99
78_I	223_L	0.884	0.99
61_W	220_V	0.883	0.99
173_R	176_K	0.877	0.99
156_R	179_F	0.874	0.99
123_Q	126_H	0.873	0.99
164_H	196_V	0.869	0.99
81_L	93_L	0.869	0.99
68_A	223_L	0.861	0.99
113_P	219_Q	0.857	0.99
141_L	193_V	0.849	0.99
153_A	185_V	0.847	0.99
176_K	205_E	0.844	0.99
118_S	132_N	0.840	0.99
11_C	26_C	0.839	0.99
124_R	127_W	0.830	0.99
207_A	218_V	0.830	0.99
124_R	128_R	0.826	0.99
137_L	223_L	0.824	0.99
204_A	207_A	0.822	0.99
156_R	178_A	0.820	0.99
9_W	13_M	0.820	0.99
81_L	131_F	0.819	0.99
66_T	70_Y	0.818	0.99
121_L	134_S	0.812	0.99
161_A	165_F	0.808	0.99
98_L	145_L	0.799	0.99
135_D	152_E	0.797	0.99
193_V	221_W	0.795	0.99
61_W	203_V	0.794	0.99
68_A	96_L	0.791	0.99
116_I	149_W	0.786	0.99
78_I	224_C	0.786	0.99
86_R	89_I	0.785	0.99
83_F	162_T	0.783	0.99
115_R	188_R	0.783	0.99
207_A	220_V	0.778	0.99
77_L	89_I	0.776	0.99
116_I	193_V	0.775	0.99
32_T	36_L	0.774	0.99
175_L	205_E	0.766	0.98
154_V	192_I	0.764	0.98
175_L	179_F	0.763	0.98
154_V	210_L	0.760	0.98
138_C	193_V	0.757	0.98
76_P	80_Q	0.755	0.98
163_Q	196_V	0.751	0.98
90_A	94_S	0.750	0.98
66_T	225_R	0.750	0.98
179_F	206_I	0.749	0.98
140_P	143_R	0.747	0.98
78_I	196_V	0.744	0.98
177_N	209_L	0.733	0.98
191_V	219_Q	0.731	0.98
152_E	182_E	0.723	0.98
83_F	125_R	0.721	0.98
65_V	219_Q	0.718	0.98
172_K	204_A	0.718	0.98
70_Y	75_S	0.718	0.98
30_T	68_A	0.717	0.98
113_P	189_H	0.713	0.98
83_F	133_Q	0.707	0.97
10_L	22_I	0.701	0.97
65_V	100_E	0.701	0.97
158_R	178_A	0.699	0.97
122_W	160_T	0.698	0.97
174_N	178_A	0.697	0.97
41_G	51_C	0.697	0.97
76_P	84_S	0.693	0.97
94_S	144_W	0.689	0.97
181_L	184_P	0.684	0.97
85_R	88_E	0.682	0.97
92_A	96_L	0.681	0.97
36_L	41_G	0.678	0.97
32_T	43_P	0.673	0.97
77_L	196_V	0.671	0.96
188_R	215_A	0.670	0.96
61_W	64_L	0.666	0.96
169_R	173_R	0.666	0.96
209_L	213_N	0.665	0.96
185_V	190_M	0.664	0.96
175_L	178_A	0.662	0.96
97_L	141_L	0.661	0.96
178_A	205_E	0.661	0.96
89_I	93_L	0.658	0.96
163_Q	179_F	0.658	0.96
115_R	153_A	0.657	0.96
95_R	140_P	0.655	0.96
85_R	130_G	0.653	0.96
41_G	54_C	0.653	0.96
172_K	201_S	0.649	0.96
54_C	225_R	0.646	0.96
211_L	215_A	0.646	0.96
70_Y	224_C	0.644	0.96
115_R	149_W	0.643	0.96
23_C	27_S	0.642	0.95
8_C	23_C	0.641	0.95
192_I	207_A	0.640	0.95
59_P	204_A	0.634	0.95
81_L	223_L	0.632	0.95
38_P	44_A	0.629	0.95
192_I	203_V	0.629	0.95
96_L	99_L	0.627	0.95
186_Q	214_G	0.623	0.95
181_L	185_V	0.619	0.94
62_Q	204_A	0.619	0.94
37_C	51_C	0.617	0.94
68_A	224_C	0.614	0.94
119_V	154_V	0.614	0.94
188_R	216_A	0.613	0.94
23_C	28_R	0.612	0.94
165_F	196_V	0.607	0.94
60_P	208_Q	0.606	0.94
67_V	100_E	0.606	0.94
81_L	133_Q	0.604	0.94
138_C	142_S	0.602	0.94
37_C	54_C	0.602	0.94
43_P	69_D	0.600	0.94
36_L	65_V	0.599	0.93
24_S	28_R	0.596	0.93
98_L	141_L	0.592	0.93
153_A	157_T	0.590	0.93
115_R	148_Q	0.589	0.93
206_I	210_L	0.587	0.93
57_K	61_W	0.586	0.93
65_V	69_D	0.584	0.93
20_W	29_A	0.583	0.93
87_S	131_F	0.582	0.92
101_V	145_L	0.579	0.92
126_H	132_N	0.579	0.92
185_V	213_N	0.574	0.92
9_W	14_P	0.574	0.92
132_N	135_D	0.571	0.92
79_H	164_H	0.571	0.92
40_C	225_R	0.570	0.92
83_F	131_F	0.570	0.92
210_L	214_G	0.568	0.92
55_L	58_P	0.568	0.92
98_L	221_W	0.566	0.91
65_V	101_V	0.562	0.91
132_N	193_V	0.560	0.91
214_G	218_V	0.559	0.91
95_R	99_L	0.557	0.91
148_Q	188_R	0.552	0.90
69_D	225_R	0.545	0.90
139_Q	149_W	0.544	0.90
9_W	89_I	0.543	0.90
67_V	81_L	0.539	0.89
162_T	165_F	0.539	0.89
129_R	132_N	0.538	0.89
20_W	24_S	0.537	0.89
27_S	96_L	0.537	0.89
186_Q	215_A	0.534	0.89
160_T	179_F	0.534	0.89
151_S	155_T	0.534	0.89
10_L	77_L	0.534	0.89
81_L	94_S	0.533	0.89
122_W	133_Q	0.531	0.89
62_Q	219_Q	0.531	0.89
158_R	177_N	0.530	0.89
101_V	191_V	0.530	0.89
118_S	154_V	0.530	0.89
140_P	149_W	0.529	0.88
53_R	56_Q	0.529	0.88
211_L	217_A	0.528	0.88
166_L	199_T	0.525	0.88
211_L	219_Q	0.524	0.88
114_D	147_C	0.524	0.88
74_L	78_I	0.522	0.88
42_L	53_R	0.520	0.88
70_Y	83_F	0.519	0.88
88_E	91_S	0.518	0.87
166_L	170_L	0.517	0.87
192_I	220_V	0.515	0.87
169_R	172_K	0.513	0.87
32_T	35_T	0.511	0.87
113_P	147_C	0.511	0.87
127_W	130_G	0.510	0.87
51_C	55_L	0.505	0.86
67_V	97_L	0.503	0.86
170_L	173_R	0.502	0.86
85_R	131_F	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ecfA	4	0.8855	99.9	0.628	Contact Map
1zn8A	2	0.6916	99.9	0.631	Contact Map
2dy0A	2	0.6828	99.8	0.653	Contact Map
1wd5A	1	0.5507	99.8	0.658	Contact Map
1y0bA	2	0.6872	99.8	0.66	Contact Map
1u9yA	3	0.8238	99.8	0.661	Contact Map
3dahA	5	0.8414	99.8	0.662	Contact Map
4lzaA	2	0.652	99.8	0.667	Contact Map
3lrtA	2	0.9163	99.8	0.668	Contact Map
1yfzA	3	0.5683	99.8	0.668	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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