GREMLIN Database
GNTX - Protein GntX
UniProt: P46846 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12934
Length: 227 (207)
Sequences: 4065 (3412)
Seq/√Len: 237.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_V220_V3.9901.00
119_V206_I3.5051.00
154_V206_I3.4701.00
163_Q174_N3.1341.00
62_Q211_L3.0311.00
142_S149_W2.8041.00
167_S170_L2.7551.00
197_V222_C2.6951.00
68_A74_L2.6361.00
37_C40_C2.5881.00
181_L209_L2.5231.00
66_T222_C2.5231.00
189_H217_A2.5201.00
51_C54_C2.2401.00
121_L133_Q2.0651.00
23_C26_C2.0421.00
83_F164_H2.0321.00
113_P191_V2.0041.00
116_I191_V1.9471.00
205_E208_Q1.9461.00
168_A172_K1.9301.00
117_V153_A1.8961.00
81_L90_A1.8861.00
60_P204_A1.8341.00
157_T180_R1.8251.00
94_S98_L1.7861.00
166_L174_N1.7801.00
191_V221_W1.7621.00
135_D139_Q1.7581.00
124_R159_A1.7491.00
192_I206_I1.7131.00
155_T180_R1.6581.00
211_L218_V1.6231.00
23_C29_A1.6131.00
115_R190_M1.6061.00
189_H219_Q1.5941.00
116_I142_S1.5661.00
80_Q86_R1.5661.00
123_Q127_W1.5591.00
62_Q217_A1.5421.00
97_L223_L1.5191.00
72_P75_S1.5171.00
210_L215_A1.5041.00
116_I141_L1.5031.00
121_L125_R1.4931.00
125_R156_R1.4811.00
93_L223_L1.4771.00
138_C149_W1.4631.00
121_L132_N1.4481.00
201_S205_E1.4271.00
77_L93_L1.4111.00
203_V222_C1.4051.00
125_R128_R1.3661.00
136_L139_Q1.3521.00
87_S136_L1.3441.00
142_S147_C1.3371.00
209_L212_R1.3241.00
155_T182_E1.3141.00
114_D189_H1.3121.00
97_L221_W1.3021.00
63_R219_Q1.3011.00
70_Y79_H1.2951.00
64_L222_C1.2881.00
122_W159_A1.2771.00
119_V202_T1.2721.00
135_D149_W1.2661.00
156_R160_T1.2561.00
94_S140_P1.2541.00
197_V203_V1.2491.00
79_H83_F1.2441.00
95_R144_W1.2391.00
121_L126_H1.2271.00
134_S138_C1.2091.00
75_S79_H1.2041.00
114_D191_V1.1971.00
91_S140_P1.1941.00
90_A136_L1.1921.00
160_T178_A1.1891.00
74_L224_C1.1751.00
189_H216_A1.1741.00
94_S141_L1.1611.00
23_C30_T1.1581.00
118_S135_D1.1551.00
81_L137_L1.1551.00
64_L220_V1.1491.00
185_V188_R1.1471.00
40_C51_C1.1451.00
190_M215_A1.1351.00
205_E209_L1.1321.00
98_L144_W1.1311.00
11_C23_C1.1191.00
101_V221_W1.0971.00
134_S137_L1.0941.00
115_R187_G1.0861.00
118_S149_W1.0831.00
134_S193_V1.0801.00
81_L89_I1.0601.00
125_R162_T1.0601.00
126_H135_D1.0591.00
142_S145_L1.0521.00
206_I209_L1.0481.00
138_C141_L1.0461.00
187_G215_A1.0451.00
207_A211_L1.0411.00
121_L156_R1.0351.00
181_L213_N1.0301.00
161_A166_L1.0291.00
40_C54_C1.0291.00
8_C11_C1.0211.00
140_P144_W1.0201.00
64_L197_V1.0141.00
97_L137_L1.0121.00
215_A218_V1.0011.00
135_D151_S0.9951.00
177_N205_E0.9801.00
116_I138_C0.9761.00
39_Q50_P0.9681.00
80_Q84_S0.9671.00
122_W125_R0.9601.00
61_W207_A0.9541.00
81_L136_L0.9491.00
114_D188_R0.9341.00
125_R133_Q0.9291.00
142_S148_Q0.9261.00
160_T175_L0.9121.00
79_H84_S0.9111.00
52_G55_L0.8920.99
185_V215_A0.8900.99
89_I92_A0.8890.99
78_I223_L0.8840.99
61_W220_V0.8830.99
173_R176_K0.8770.99
156_R179_F0.8740.99
123_Q126_H0.8730.99
164_H196_V0.8690.99
81_L93_L0.8690.99
68_A223_L0.8610.99
113_P219_Q0.8570.99
141_L193_V0.8490.99
153_A185_V0.8470.99
176_K205_E0.8440.99
118_S132_N0.8400.99
11_C26_C0.8390.99
124_R127_W0.8300.99
207_A218_V0.8300.99
124_R128_R0.8260.99
137_L223_L0.8240.99
204_A207_A0.8220.99
156_R178_A0.8200.99
9_W13_M0.8200.99
81_L131_F0.8190.99
66_T70_Y0.8180.99
121_L134_S0.8120.99
161_A165_F0.8080.99
98_L145_L0.7990.99
135_D152_E0.7970.99
193_V221_W0.7950.99
61_W203_V0.7940.99
68_A96_L0.7910.99
116_I149_W0.7860.99
78_I224_C0.7860.99
86_R89_I0.7850.99
83_F162_T0.7830.99
115_R188_R0.7830.99
207_A220_V0.7780.99
77_L89_I0.7760.99
116_I193_V0.7750.99
32_T36_L0.7740.99
175_L205_E0.7660.98
154_V192_I0.7640.98
175_L179_F0.7630.98
154_V210_L0.7600.98
138_C193_V0.7570.98
76_P80_Q0.7550.98
163_Q196_V0.7510.98
90_A94_S0.7500.98
66_T225_R0.7500.98
179_F206_I0.7490.98
140_P143_R0.7470.98
78_I196_V0.7440.98
177_N209_L0.7330.98
191_V219_Q0.7310.98
152_E182_E0.7230.98
83_F125_R0.7210.98
65_V219_Q0.7180.98
172_K204_A0.7180.98
70_Y75_S0.7180.98
30_T68_A0.7170.98
113_P189_H0.7130.98
83_F133_Q0.7070.97
10_L22_I0.7010.97
65_V100_E0.7010.97
158_R178_A0.6990.97
122_W160_T0.6980.97
174_N178_A0.6970.97
41_G51_C0.6970.97
76_P84_S0.6930.97
94_S144_W0.6890.97
181_L184_P0.6840.97
85_R88_E0.6820.97
92_A96_L0.6810.97
36_L41_G0.6780.97
32_T43_P0.6730.97
77_L196_V0.6710.96
188_R215_A0.6700.96
61_W64_L0.6660.96
169_R173_R0.6660.96
209_L213_N0.6650.96
185_V190_M0.6640.96
175_L178_A0.6620.96
97_L141_L0.6610.96
178_A205_E0.6610.96
89_I93_L0.6580.96
163_Q179_F0.6580.96
115_R153_A0.6570.96
95_R140_P0.6550.96
85_R130_G0.6530.96
41_G54_C0.6530.96
172_K201_S0.6490.96
54_C225_R0.6460.96
211_L215_A0.6460.96
70_Y224_C0.6440.96
115_R149_W0.6430.96
23_C27_S0.6420.95
8_C23_C0.6410.95
192_I207_A0.6400.95
59_P204_A0.6340.95
81_L223_L0.6320.95
38_P44_A0.6290.95
192_I203_V0.6290.95
96_L99_L0.6270.95
186_Q214_G0.6230.95
181_L185_V0.6190.94
62_Q204_A0.6190.94
37_C51_C0.6170.94
68_A224_C0.6140.94
119_V154_V0.6140.94
188_R216_A0.6130.94
23_C28_R0.6120.94
165_F196_V0.6070.94
60_P208_Q0.6060.94
67_V100_E0.6060.94
81_L133_Q0.6040.94
138_C142_S0.6020.94
37_C54_C0.6020.94
43_P69_D0.6000.94
36_L65_V0.5990.93
24_S28_R0.5960.93
98_L141_L0.5920.93
153_A157_T0.5900.93
115_R148_Q0.5890.93
206_I210_L0.5870.93
57_K61_W0.5860.93
65_V69_D0.5840.93
20_W29_A0.5830.93
87_S131_F0.5820.92
101_V145_L0.5790.92
126_H132_N0.5790.92
185_V213_N0.5740.92
9_W14_P0.5740.92
132_N135_D0.5710.92
79_H164_H0.5710.92
40_C225_R0.5700.92
83_F131_F0.5700.92
210_L214_G0.5680.92
55_L58_P0.5680.92
98_L221_W0.5660.91
65_V101_V0.5620.91
132_N193_V0.5600.91
214_G218_V0.5590.91
95_R99_L0.5570.91
148_Q188_R0.5520.90
69_D225_R0.5450.90
139_Q149_W0.5440.90
9_W89_I0.5430.90
67_V81_L0.5390.89
162_T165_F0.5390.89
129_R132_N0.5380.89
20_W24_S0.5370.89
27_S96_L0.5370.89
186_Q215_A0.5340.89
160_T179_F0.5340.89
151_S155_T0.5340.89
10_L77_L0.5340.89
81_L94_S0.5330.89
122_W133_Q0.5310.89
62_Q219_Q0.5310.89
158_R177_N0.5300.89
101_V191_V0.5300.89
118_S154_V0.5300.89
140_P149_W0.5290.88
53_R56_Q0.5290.88
211_L217_A0.5280.88
166_L199_T0.5250.88
211_L219_Q0.5240.88
114_D147_C0.5240.88
74_L78_I0.5220.88
42_L53_R0.5200.88
70_Y83_F0.5190.88
88_E91_S0.5180.87
166_L170_L0.5170.87
192_I220_V0.5150.87
169_R172_K0.5130.87
32_T35_T0.5110.87
113_P147_C0.5110.87
127_W130_G0.5100.87
51_C55_L0.5050.86
67_V97_L0.5030.86
170_L173_R0.5020.86
85_R131_F0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ecfA 4 0.8855 99.9 0.628 Contact Map
1zn8A 2 0.6916 99.9 0.631 Contact Map
2dy0A 2 0.6828 99.8 0.653 Contact Map
1wd5A 1 0.5507 99.8 0.658 Contact Map
1y0bA 2 0.6872 99.8 0.66 Contact Map
1u9yA 3 0.8238 99.8 0.661 Contact Map
3dahA 5 0.8414 99.8 0.662 Contact Map
4lzaA 2 0.652 99.8 0.667 Contact Map
3lrtA 2 0.9163 99.8 0.668 Contact Map
1yfzA 3 0.5683 99.8 0.668 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.