GREMLIN Database
AAEA - p-hydroxybenzoic acid efflux pump subunit AaeA
UniProt: P46482 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12823
Length: 310 (263)
Sequences: 29628 (24196)
Seq/√Len: 1492.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_Q77_T3.2871.00
74_I156_V3.2041.00
70_K162_D2.8511.00
77_T156_V2.5031.00
44_S194_L2.4351.00
62_N77_T2.4321.00
105_R109_G2.3491.00
111_R119_M2.3441.00
210_R223_K2.3091.00
227_D266_R2.3021.00
80_Q84_Q2.2681.00
111_R127_A2.2381.00
70_K73_Q2.2141.00
53_D154_R2.2131.00
74_I158_R2.2081.00
68_L164_W2.1451.00
62_N74_I2.0241.00
212_E223_K1.9941.00
131_L135_L1.9871.00
112_N115_G1.9541.00
166_T186_V1.9401.00
91_Q149_K1.9031.00
112_N128_N1.8251.00
71_K162_D1.8161.00
139_A142_Q1.8041.00
212_E221_V1.7661.00
132_Q135_L1.7651.00
195_A283_V1.7641.00
121_R125_D1.7581.00
128_N132_Q1.7401.00
123_E126_Q1.7341.00
108_A112_N1.7051.00
108_A124_I1.6841.00
43_F193_V1.6671.00
88_E91_Q1.6481.00
64_H67_Q1.6321.00
194_L262_P1.6191.00
26_F30_V1.6131.00
26_F29_W1.5811.00
210_R225_T1.5711.00
138_L142_Q1.5601.00
87_L149_K1.5591.00
95_A98_Q1.5381.00
150_L154_R1.4881.00
46_D187_K1.4671.00
220_K274_I1.4661.00
192_Y264_R1.4621.00
58_I170_V1.4611.00
87_L91_Q1.4501.00
84_Q88_E1.4491.00
83_Y155_T1.4481.00
124_I128_N1.4481.00
59_T79_D1.4471.00
56_G78_I1.4441.00
58_I76_F1.4381.00
177_T180_S1.4331.00
224_G265_I1.4301.00
49_A181_T1.4211.00
187_K190_S1.4131.00
225_T268_D1.4121.00
195_A265_I1.4051.00
147_L151_D1.4041.00
96_Y137_Q1.4021.00
84_Q152_L1.4011.00
74_I77_T1.4011.00
94_V98_Q1.3771.00
98_Q142_Q1.3561.00
198_E201_K1.3561.00
89_E144_T1.3521.00
107_E126_Q1.3481.00
193_V281_A1.3471.00
86_A89_E1.3441.00
146_D149_K1.3401.00
108_A128_N1.3311.00
91_Q95_A1.3301.00
122_E126_Q1.3301.00
98_Q102_Q1.3291.00
55_S178_R1.3251.00
47_V184_A1.3231.00
212_E286_T1.3191.00
49_A184_A1.3171.00
105_R135_L1.3021.00
130_V133_T1.2991.00
165_V183_V1.2981.00
94_V145_R1.2961.00
142_Q146_D1.2951.00
225_T266_R1.2911.00
271_Q274_I1.2891.00
86_A151_D1.2881.00
105_R131_L1.2861.00
59_T77_T1.2811.00
60_Q172_T1.2721.00
87_L145_R1.2721.00
76_F157_I1.2641.00
63_V73_Q1.2601.00
112_N124_I1.2511.00
233_V261_V1.2481.00
96_Y100_L1.2441.00
100_L103_E1.2411.00
109_G112_N1.2361.00
168_L171_Y1.2271.00
145_R149_K1.2271.00
167_N184_A1.2271.00
75_L183_V1.2261.00
103_E107_E1.2231.00
68_L188_Q1.2201.00
101_A131_L1.2191.00
25_I29_W1.2131.00
149_K153_E1.2121.00
91_Q145_R1.2091.00
109_G113_R1.2011.00
86_A147_L1.1961.00
211_A265_I1.1901.00
43_F191_F1.1811.00
53_D57_L1.1801.00
214_T221_V1.1771.00
135_L139_A1.1761.00
89_E93_D1.1731.00
113_R116_V1.1691.00
80_Q155_T1.1651.00
190_S266_R1.1631.00
65_D167_N1.1561.00
93_D96_Y1.1541.00
25_I28_A1.1531.00
64_H168_L1.1501.00
212_E284_V1.1481.00
228_S264_R1.1441.00
101_A105_R1.1321.00
24_A28_A1.1241.00
101_A135_L1.1231.00
214_T284_V1.1211.00
130_V134_V1.1111.00
98_Q138_L1.1051.00
133_T137_Q1.0961.00
76_F183_V1.0871.00
38_T284_V1.0821.00
48_V161_A1.0681.00
94_V142_Q1.0661.00
159_A185_L1.0601.00
107_E111_R1.0531.00
108_A131_L1.0511.00
88_E146_D1.0461.00
163_G185_L1.0431.00
52_P157_I1.0371.00
94_V138_L1.0331.00
125_D128_N1.0331.00
97_Y100_L1.0271.00
230_A262_P1.0171.00
102_Q106_Q1.0111.00
106_Q125_D1.0101.00
193_V213_I1.0101.00
110_R125_D1.0081.00
126_Q130_V1.0061.00
101_A138_L1.0051.00
194_L264_R1.0031.00
217_G222_L0.9981.00
93_D144_T0.9981.00
38_T282_T0.9961.00
68_L162_D0.9901.00
55_S177_T0.9851.00
58_I176_I0.9771.00
63_V183_V0.9761.00
80_Q156_V0.9761.00
196_Y262_P0.9731.00
234_T237_S0.9651.00
150_L153_E0.9621.00
140_K144_T0.9611.00
111_R123_E0.9601.00
176_I182_A0.9581.00
117_Q121_R0.9571.00
100_L137_Q0.9561.00
269_N273_N0.9551.00
102_Q105_R0.9531.00
93_D97_Y0.9501.00
63_V168_L0.9431.00
168_L183_V0.9381.00
213_I224_G0.9361.00
206_R209_Y0.9361.00
57_L175_F0.9311.00
61_V76_F0.9301.00
61_V172_T0.9291.00
76_F168_L0.9281.00
23_I27_N0.9281.00
77_T80_Q0.9241.00
148_A151_D0.9161.00
141_A144_T0.9161.00
100_L133_T0.9151.00
76_F182_A0.9111.00
143_A146_D0.9091.00
193_V283_V0.9061.00
144_T147_L0.9031.00
87_L152_L0.8991.00
106_Q109_G0.8981.00
159_A162_D0.8881.00
67_Q73_Q0.8881.00
98_Q101_A0.8851.00
169_N184_A0.8761.00
107_E122_E0.8761.00
97_Y141_A0.8761.00
104_K134_V0.8741.00
102_Q132_Q0.8701.00
39_R195_A0.8701.00
81_P150_L0.8701.00
90_A141_A0.8631.00
137_Q140_K0.8621.00
59_T80_Q0.8551.00
53_D82_R0.8451.00
192_Y227_D0.8381.00
52_P176_I0.8371.00
52_P76_F0.8371.00
29_W33_T0.8351.00
41_A281_A0.8351.00
161_A185_L0.8341.00
201_K204_G0.8331.00
99_V103_E0.8321.00
134_V137_Q0.8311.00
59_T62_N0.8271.00
27_N31_Y0.8271.00
54_V83_Y0.8241.00
43_F275_W0.8231.00
197_M205_V0.8211.00
169_N181_T0.8171.00
29_W32_Y0.8171.00
65_D168_L0.8121.00
22_F26_F0.8111.00
50_I160_P0.8111.00
290_D293_E0.8081.00
286_T289_Q0.8031.00
46_D171_Y0.7991.00
42_R238_S0.7951.00
276_P279_T0.7901.00
55_S175_F0.7881.00
128_N131_L0.7831.00
95_A139_A0.7821.00
85_K150_L0.7781.00
63_V165_V0.7771.00
148_A152_L0.7671.00
214_T219_N0.7661.00
164_W188_Q0.7651.00
28_A32_Y0.7651.00
141_A145_R0.7591.00
217_G220_K0.7561.00
24_A29_W0.7561.00
111_R122_E0.7491.00
90_A93_D0.7411.00
119_M123_E0.7391.00
45_A277_A0.7361.00
137_Q141_A0.7341.00
85_K143_A0.7311.00
47_V186_V0.7291.00
39_R197_M0.7281.00
69_V75_L0.7271.00
211_A224_G0.7271.00
27_N30_V0.7261.00
90_A148_A0.7231.00
82_R151_D0.7171.00
86_A90_A0.7141.00
13_I17_L0.7131.00
214_T282_T0.7071.00
216_L220_K0.7021.00
151_D154_R0.7021.00
93_D140_K0.6961.00
48_V160_P0.6951.00
223_K268_D0.6921.00
93_D137_Q0.6901.00
132_Q136_H0.6891.00
191_F277_A0.6831.00
192_Y266_R0.6821.00
213_I281_A0.6801.00
80_Q152_L0.6791.00
97_Y101_A0.6771.00
23_I26_F0.6751.00
43_F281_A0.6721.00
123_E127_A0.6701.00
82_R86_A0.6701.00
44_S192_Y0.6681.00
49_A174_E0.6651.00
63_V67_Q0.6621.00
142_Q145_R0.6591.00
57_L79_D0.6581.00
50_I183_V0.6571.00
215_P218_S0.6561.00
207_P227_D0.6541.00
107_E110_R0.6531.00
71_K160_P0.6531.00
121_R124_I0.6491.00
97_Y134_V0.6491.00
52_P182_A0.6481.00
28_A31_Y0.6461.00
234_T262_P0.6441.00
99_V102_Q0.6431.00
86_A148_A0.6421.00
87_L148_A0.6401.00
234_T238_S0.6401.00
134_V138_L0.6391.00
213_I267_L0.6361.00
103_E126_Q0.6311.00
131_L134_V0.6311.00
92_A143_A0.6311.00
121_R128_N0.6241.00
210_R286_T0.6241.00
103_E129_N0.6231.00
114_L120_S0.6231.00
107_E127_A0.6221.00
24_A27_N0.6131.00
106_Q129_N0.6121.00
114_L117_Q0.6111.00
21_A24_A0.6091.00
120_S123_E0.6081.00
104_K127_A0.6071.00
207_P229_V0.6071.00
153_E158_R0.6071.00
195_A211_A0.6061.00
90_A94_V0.6051.00
196_Y234_T0.5991.00
46_D172_T0.5971.00
52_P55_S0.5961.00
83_Y148_A0.5961.00
127_A130_V0.5961.00
139_A143_A0.5951.00
208_G225_T0.5941.00
68_L273_N0.5931.00
31_Y34_E0.5921.00
87_L90_A0.5921.00
15_V19_I0.5901.00
205_V285_V0.5881.00
61_V168_L0.5871.00
114_L118_A0.5861.00
33_T36_P0.5861.00
216_L219_N0.5851.00
226_V263_V0.5851.00
110_R114_L0.5821.00
261_V279_T0.5821.00
82_R150_L0.5821.00
91_Q94_V0.5821.00
100_L104_K0.5801.00
52_P78_I0.5791.00
166_T231_A0.5771.00
85_K88_E0.5761.00
197_M285_V0.5731.00
39_R201_K0.5701.00
181_T184_A0.5691.00
104_K107_E0.5691.00
58_I182_A0.5651.00
89_E147_L0.5651.00
19_I23_I0.5641.00
105_R108_A0.5631.00
227_D264_R0.5591.00
83_Y151_D0.5581.00
48_V185_L0.5581.00
54_V155_T0.5581.00
195_A285_V0.5561.00
25_I30_V0.5551.00
103_E106_Q0.5551.00
205_V226_V0.5541.00
147_L150_L0.5531.00
261_V265_I0.5521.00
186_V277_A0.5521.00
51_A175_F0.5521.00
51_A181_T0.5511.00
66_N228_S0.5501.00
129_N133_T0.5501.00
226_V265_I0.5471.00
231_A276_P0.5471.00
100_L130_V0.5401.00
170_V174_E0.5381.00
14_T18_V0.5341.00
92_A95_A0.5321.00
283_V287_G0.5311.00
119_M124_I0.5311.00
122_E125_D0.5311.00
30_V33_T0.5301.00
153_E156_V0.5291.00
233_V238_S0.5261.00
62_N73_Q0.5251.00
17_L24_A0.5241.00
18_V22_F0.5211.00
46_D161_A0.5211.00
216_L222_L0.5211.00
146_D150_L0.5201.00
215_P282_T0.5181.00
213_I283_V0.5171.00
202_L261_V0.5171.00
59_T172_T0.5171.00
45_A192_Y0.5151.00
39_R198_E0.5141.00
174_E180_S0.5141.00
110_R122_E0.5101.00
196_Y237_S0.5081.00
39_R283_V0.5051.00
103_E130_V0.5031.00
235_N238_S0.5021.00
208_G226_V0.5021.00
100_L134_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f1mA 2 0.7419 100 0.315 Contact Map
4dk0A 5 0.8613 100 0.347 Contact Map
3fppA 3 0.7968 100 0.352 Contact Map
3lnnA 6 0.8839 100 0.357 Contact Map
4tkoB 1 0.7484 100 0.367 Contact Map
1vf7A 5 0.7194 100 0.39 Contact Map
4l8jA 2 0.8323 100 0.394 Contact Map
3ne5B 3 0.7516 100 0.394 Contact Map
4kkuA 1 0.6387 100 0.472 Contact Map
2k32A 1 0.3677 99.8 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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