AAEA - ECOLI - GREMLIN Contacts

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AAEA - p-hydroxybenzoic acid efflux pump subunit AaeA

UniProt:	P46482	Sequences: MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQILFTIDQPRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRDDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12823
Length:	310 (263)
Sequences:	29628 (24196)
Seq/√Len:	1492.0

ECOLI - AAEA YDHJ EMRK EMRA YIBH ACRA YIAV ACRE YHII MDTN MDTE MACA MDTA YBHG CUSB
BACSU - YVRP YKNX YHBJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_Q	77_T	3.287	1.00
74_I	156_V	3.204	1.00
70_K	162_D	2.851	1.00
77_T	156_V	2.503	1.00
44_S	194_L	2.435	1.00
62_N	77_T	2.432	1.00
105_R	109_G	2.349	1.00
111_R	119_M	2.344	1.00
210_R	223_K	2.309	1.00
227_D	266_R	2.302	1.00
80_Q	84_Q	2.268	1.00
111_R	127_A	2.238	1.00
70_K	73_Q	2.214	1.00
53_D	154_R	2.213	1.00
74_I	158_R	2.208	1.00
68_L	164_W	2.145	1.00
62_N	74_I	2.024	1.00
212_E	223_K	1.994	1.00
131_L	135_L	1.987	1.00
112_N	115_G	1.954	1.00
166_T	186_V	1.940	1.00
91_Q	149_K	1.903	1.00
112_N	128_N	1.825	1.00
71_K	162_D	1.816	1.00
139_A	142_Q	1.804	1.00
212_E	221_V	1.766	1.00
132_Q	135_L	1.765	1.00
195_A	283_V	1.764	1.00
121_R	125_D	1.758	1.00
128_N	132_Q	1.740	1.00
123_E	126_Q	1.734	1.00
108_A	112_N	1.705	1.00
108_A	124_I	1.684	1.00
43_F	193_V	1.667	1.00
88_E	91_Q	1.648	1.00
64_H	67_Q	1.632	1.00
194_L	262_P	1.619	1.00
26_F	30_V	1.613	1.00
26_F	29_W	1.581	1.00
210_R	225_T	1.571	1.00
138_L	142_Q	1.560	1.00
87_L	149_K	1.559	1.00
95_A	98_Q	1.538	1.00
150_L	154_R	1.488	1.00
46_D	187_K	1.467	1.00
220_K	274_I	1.466	1.00
192_Y	264_R	1.462	1.00
58_I	170_V	1.461	1.00
87_L	91_Q	1.450	1.00
84_Q	88_E	1.449	1.00
83_Y	155_T	1.448	1.00
124_I	128_N	1.448	1.00
59_T	79_D	1.447	1.00
56_G	78_I	1.444	1.00
58_I	76_F	1.438	1.00
177_T	180_S	1.433	1.00
224_G	265_I	1.430	1.00
49_A	181_T	1.421	1.00
187_K	190_S	1.413	1.00
225_T	268_D	1.412	1.00
195_A	265_I	1.405	1.00
147_L	151_D	1.404	1.00
96_Y	137_Q	1.402	1.00
84_Q	152_L	1.401	1.00
74_I	77_T	1.401	1.00
94_V	98_Q	1.377	1.00
98_Q	142_Q	1.356	1.00
198_E	201_K	1.356	1.00
89_E	144_T	1.352	1.00
107_E	126_Q	1.348	1.00
193_V	281_A	1.347	1.00
86_A	89_E	1.344	1.00
146_D	149_K	1.340	1.00
108_A	128_N	1.331	1.00
91_Q	95_A	1.330	1.00
122_E	126_Q	1.330	1.00
98_Q	102_Q	1.329	1.00
55_S	178_R	1.325	1.00
47_V	184_A	1.323	1.00
212_E	286_T	1.319	1.00
49_A	184_A	1.317	1.00
105_R	135_L	1.302	1.00
130_V	133_T	1.299	1.00
165_V	183_V	1.298	1.00
94_V	145_R	1.296	1.00
142_Q	146_D	1.295	1.00
225_T	266_R	1.291	1.00
271_Q	274_I	1.289	1.00
86_A	151_D	1.288	1.00
105_R	131_L	1.286	1.00
59_T	77_T	1.281	1.00
60_Q	172_T	1.272	1.00
87_L	145_R	1.272	1.00
76_F	157_I	1.264	1.00
63_V	73_Q	1.260	1.00
112_N	124_I	1.251	1.00
233_V	261_V	1.248	1.00
96_Y	100_L	1.244	1.00
100_L	103_E	1.241	1.00
109_G	112_N	1.236	1.00
168_L	171_Y	1.227	1.00
145_R	149_K	1.227	1.00
167_N	184_A	1.227	1.00
75_L	183_V	1.226	1.00
103_E	107_E	1.223	1.00
68_L	188_Q	1.220	1.00
101_A	131_L	1.219	1.00
25_I	29_W	1.213	1.00
149_K	153_E	1.212	1.00
91_Q	145_R	1.209	1.00
109_G	113_R	1.201	1.00
86_A	147_L	1.196	1.00
211_A	265_I	1.190	1.00
43_F	191_F	1.181	1.00
53_D	57_L	1.180	1.00
214_T	221_V	1.177	1.00
135_L	139_A	1.176	1.00
89_E	93_D	1.173	1.00
113_R	116_V	1.169	1.00
80_Q	155_T	1.165	1.00
190_S	266_R	1.163	1.00
65_D	167_N	1.156	1.00
93_D	96_Y	1.154	1.00
25_I	28_A	1.153	1.00
64_H	168_L	1.150	1.00
212_E	284_V	1.148	1.00
228_S	264_R	1.144	1.00
101_A	105_R	1.132	1.00
24_A	28_A	1.124	1.00
101_A	135_L	1.123	1.00
214_T	284_V	1.121	1.00
130_V	134_V	1.111	1.00
98_Q	138_L	1.105	1.00
133_T	137_Q	1.096	1.00
76_F	183_V	1.087	1.00
38_T	284_V	1.082	1.00
48_V	161_A	1.068	1.00
94_V	142_Q	1.066	1.00
159_A	185_L	1.060	1.00
107_E	111_R	1.053	1.00
108_A	131_L	1.051	1.00
88_E	146_D	1.046	1.00
163_G	185_L	1.043	1.00
52_P	157_I	1.037	1.00
94_V	138_L	1.033	1.00
125_D	128_N	1.033	1.00
97_Y	100_L	1.027	1.00
230_A	262_P	1.017	1.00
102_Q	106_Q	1.011	1.00
106_Q	125_D	1.010	1.00
193_V	213_I	1.010	1.00
110_R	125_D	1.008	1.00
126_Q	130_V	1.006	1.00
101_A	138_L	1.005	1.00
194_L	264_R	1.003	1.00
217_G	222_L	0.998	1.00
93_D	144_T	0.998	1.00
38_T	282_T	0.996	1.00
68_L	162_D	0.990	1.00
55_S	177_T	0.985	1.00
58_I	176_I	0.977	1.00
63_V	183_V	0.976	1.00
80_Q	156_V	0.976	1.00
196_Y	262_P	0.973	1.00
234_T	237_S	0.965	1.00
150_L	153_E	0.962	1.00
140_K	144_T	0.961	1.00
111_R	123_E	0.960	1.00
176_I	182_A	0.958	1.00
117_Q	121_R	0.957	1.00
100_L	137_Q	0.956	1.00
269_N	273_N	0.955	1.00
102_Q	105_R	0.953	1.00
93_D	97_Y	0.950	1.00
63_V	168_L	0.943	1.00
168_L	183_V	0.938	1.00
213_I	224_G	0.936	1.00
206_R	209_Y	0.936	1.00
57_L	175_F	0.931	1.00
61_V	76_F	0.930	1.00
61_V	172_T	0.929	1.00
76_F	168_L	0.928	1.00
23_I	27_N	0.928	1.00
77_T	80_Q	0.924	1.00
148_A	151_D	0.916	1.00
141_A	144_T	0.916	1.00
100_L	133_T	0.915	1.00
76_F	182_A	0.911	1.00
143_A	146_D	0.909	1.00
193_V	283_V	0.906	1.00
144_T	147_L	0.903	1.00
87_L	152_L	0.899	1.00
106_Q	109_G	0.898	1.00
159_A	162_D	0.888	1.00
67_Q	73_Q	0.888	1.00
98_Q	101_A	0.885	1.00
169_N	184_A	0.876	1.00
107_E	122_E	0.876	1.00
97_Y	141_A	0.876	1.00
104_K	134_V	0.874	1.00
102_Q	132_Q	0.870	1.00
39_R	195_A	0.870	1.00
81_P	150_L	0.870	1.00
90_A	141_A	0.863	1.00
137_Q	140_K	0.862	1.00
59_T	80_Q	0.855	1.00
53_D	82_R	0.845	1.00
192_Y	227_D	0.838	1.00
52_P	176_I	0.837	1.00
52_P	76_F	0.837	1.00
29_W	33_T	0.835	1.00
41_A	281_A	0.835	1.00
161_A	185_L	0.834	1.00
201_K	204_G	0.833	1.00
99_V	103_E	0.832	1.00
134_V	137_Q	0.831	1.00
59_T	62_N	0.827	1.00
27_N	31_Y	0.827	1.00
54_V	83_Y	0.824	1.00
43_F	275_W	0.823	1.00
197_M	205_V	0.821	1.00
169_N	181_T	0.817	1.00
29_W	32_Y	0.817	1.00
65_D	168_L	0.812	1.00
22_F	26_F	0.811	1.00
50_I	160_P	0.811	1.00
290_D	293_E	0.808	1.00
286_T	289_Q	0.803	1.00
46_D	171_Y	0.799	1.00
42_R	238_S	0.795	1.00
276_P	279_T	0.790	1.00
55_S	175_F	0.788	1.00
128_N	131_L	0.783	1.00
95_A	139_A	0.782	1.00
85_K	150_L	0.778	1.00
63_V	165_V	0.777	1.00
148_A	152_L	0.767	1.00
214_T	219_N	0.766	1.00
164_W	188_Q	0.765	1.00
28_A	32_Y	0.765	1.00
141_A	145_R	0.759	1.00
217_G	220_K	0.756	1.00
24_A	29_W	0.756	1.00
111_R	122_E	0.749	1.00
90_A	93_D	0.741	1.00
119_M	123_E	0.739	1.00
45_A	277_A	0.736	1.00
137_Q	141_A	0.734	1.00
85_K	143_A	0.731	1.00
47_V	186_V	0.729	1.00
39_R	197_M	0.728	1.00
69_V	75_L	0.727	1.00
211_A	224_G	0.727	1.00
27_N	30_V	0.726	1.00
90_A	148_A	0.723	1.00
82_R	151_D	0.717	1.00
86_A	90_A	0.714	1.00
13_I	17_L	0.713	1.00
214_T	282_T	0.707	1.00
216_L	220_K	0.702	1.00
151_D	154_R	0.702	1.00
93_D	140_K	0.696	1.00
48_V	160_P	0.695	1.00
223_K	268_D	0.692	1.00
93_D	137_Q	0.690	1.00
132_Q	136_H	0.689	1.00
191_F	277_A	0.683	1.00
192_Y	266_R	0.682	1.00
213_I	281_A	0.680	1.00
80_Q	152_L	0.679	1.00
97_Y	101_A	0.677	1.00
23_I	26_F	0.675	1.00
43_F	281_A	0.672	1.00
123_E	127_A	0.670	1.00
82_R	86_A	0.670	1.00
44_S	192_Y	0.668	1.00
49_A	174_E	0.665	1.00
63_V	67_Q	0.662	1.00
142_Q	145_R	0.659	1.00
57_L	79_D	0.658	1.00
50_I	183_V	0.657	1.00
215_P	218_S	0.656	1.00
207_P	227_D	0.654	1.00
107_E	110_R	0.653	1.00
71_K	160_P	0.653	1.00
121_R	124_I	0.649	1.00
97_Y	134_V	0.649	1.00
52_P	182_A	0.648	1.00
28_A	31_Y	0.646	1.00
234_T	262_P	0.644	1.00
99_V	102_Q	0.643	1.00
86_A	148_A	0.642	1.00
87_L	148_A	0.640	1.00
234_T	238_S	0.640	1.00
134_V	138_L	0.639	1.00
213_I	267_L	0.636	1.00
103_E	126_Q	0.631	1.00
131_L	134_V	0.631	1.00
92_A	143_A	0.631	1.00
121_R	128_N	0.624	1.00
210_R	286_T	0.624	1.00
103_E	129_N	0.623	1.00
114_L	120_S	0.623	1.00
107_E	127_A	0.622	1.00
24_A	27_N	0.613	1.00
106_Q	129_N	0.612	1.00
114_L	117_Q	0.611	1.00
21_A	24_A	0.609	1.00
120_S	123_E	0.608	1.00
104_K	127_A	0.607	1.00
207_P	229_V	0.607	1.00
153_E	158_R	0.607	1.00
195_A	211_A	0.606	1.00
90_A	94_V	0.605	1.00
196_Y	234_T	0.599	1.00
46_D	172_T	0.597	1.00
52_P	55_S	0.596	1.00
83_Y	148_A	0.596	1.00
127_A	130_V	0.596	1.00
139_A	143_A	0.595	1.00
208_G	225_T	0.594	1.00
68_L	273_N	0.593	1.00
31_Y	34_E	0.592	1.00
87_L	90_A	0.592	1.00
15_V	19_I	0.590	1.00
205_V	285_V	0.588	1.00
61_V	168_L	0.587	1.00
114_L	118_A	0.586	1.00
33_T	36_P	0.586	1.00
216_L	219_N	0.585	1.00
226_V	263_V	0.585	1.00
110_R	114_L	0.582	1.00
261_V	279_T	0.582	1.00
82_R	150_L	0.582	1.00
91_Q	94_V	0.582	1.00
100_L	104_K	0.580	1.00
52_P	78_I	0.579	1.00
166_T	231_A	0.577	1.00
85_K	88_E	0.576	1.00
197_M	285_V	0.573	1.00
39_R	201_K	0.570	1.00
181_T	184_A	0.569	1.00
104_K	107_E	0.569	1.00
58_I	182_A	0.565	1.00
89_E	147_L	0.565	1.00
19_I	23_I	0.564	1.00
105_R	108_A	0.563	1.00
227_D	264_R	0.559	1.00
83_Y	151_D	0.558	1.00
48_V	185_L	0.558	1.00
54_V	155_T	0.558	1.00
195_A	285_V	0.556	1.00
25_I	30_V	0.555	1.00
103_E	106_Q	0.555	1.00
205_V	226_V	0.554	1.00
147_L	150_L	0.553	1.00
261_V	265_I	0.552	1.00
186_V	277_A	0.552	1.00
51_A	175_F	0.552	1.00
51_A	181_T	0.551	1.00
66_N	228_S	0.550	1.00
129_N	133_T	0.550	1.00
226_V	265_I	0.547	1.00
231_A	276_P	0.547	1.00
100_L	130_V	0.540	1.00
170_V	174_E	0.538	1.00
14_T	18_V	0.534	1.00
92_A	95_A	0.532	1.00
283_V	287_G	0.531	1.00
119_M	124_I	0.531	1.00
122_E	125_D	0.531	1.00
30_V	33_T	0.530	1.00
153_E	156_V	0.529	1.00
233_V	238_S	0.526	1.00
62_N	73_Q	0.525	1.00
17_L	24_A	0.524	1.00
18_V	22_F	0.521	1.00
46_D	161_A	0.521	1.00
216_L	222_L	0.521	1.00
146_D	150_L	0.520	1.00
215_P	282_T	0.518	1.00
213_I	283_V	0.517	1.00
202_L	261_V	0.517	1.00
59_T	172_T	0.517	1.00
45_A	192_Y	0.515	1.00
39_R	198_E	0.514	1.00
174_E	180_S	0.514	1.00
110_R	122_E	0.510	1.00
196_Y	237_S	0.508	1.00
39_R	283_V	0.505	1.00
103_E	130_V	0.503	1.00
235_N	238_S	0.502	1.00
208_G	226_V	0.502	1.00
100_L	134_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2f1mA	2	0.7419	100	0.315	Contact Map
4dk0A	5	0.8613	100	0.347	Contact Map
3fppA	3	0.7968	100	0.352	Contact Map
3lnnA	6	0.8839	100	0.357	Contact Map
4tkoB	1	0.7484	100	0.367	Contact Map
1vf7A	5	0.7194	100	0.39	Contact Map
4l8jA	2	0.8323	100	0.394	Contact Map
3ne5B	3	0.7516	100	0.394	Contact Map
4kkuA	1	0.6387	100	0.472	Contact Map
2k32A	1	0.3677	99.8	0.651	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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