AAEB - ECOLI - GREMLIN Contacts

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AAEB - p-hydroxybenzoic acid efflux pump subunit AaeB

UniProt:	P46481	Sequences: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGTAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVNRLAGMLHKYQHALTDS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12822
Length:	655 (620)
Sequences:	988 (756)
Seq/√Len:	30.4

ECOLI - AAEB YDHK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
330_I	333_T	4.579	1.00
330_I	337_I	4.190	1.00
104_G	358_F	4.028	1.00
333_T	337_I	3.923	1.00
104_G	362_T	3.833	1.00
26_F	432_S	3.814	1.00
108_W	351_R	3.572	1.00
71_I	154_V	3.337	1.00
319_L	330_I	3.313	1.00
327_N	330_I	3.273	1.00
319_L	322_R	3.261	1.00
327_N	334_E	3.231	1.00
250_T	257_L	3.211	1.00
334_E	337_I	3.207	1.00
100_C	366_I	3.179	1.00
18_A	22_V	3.177	1.00
330_I	334_E	3.123	1.00
291_L	295_I	3.051	1.00
327_N	337_I	3.025	1.00
102_W	106_C	2.926	1.00
251_Q	255_T	2.823	1.00
96_I	369_T	2.808	1.00
592_R	596_D	2.787	1.00
308_Y	312_A	2.781	1.00
250_T	256_Y	2.772	1.00
442_V	446_F	2.657	1.00
312_A	316_R	2.652	1.00
419_L	482_F	2.578	1.00
326_S	330_I	2.578	1.00
250_T	253_C	2.545	0.99
23_L	159_C	2.529	0.99
250_T	255_T	2.526	0.99
316_R	319_L	2.515	0.99
123_L	126_Y	2.488	0.99
88_M	98_V	2.480	0.99
119_Y	123_L	2.454	0.99
27_V	155_I	2.383	0.99
326_S	333_T	2.350	0.99
316_R	327_N	2.343	0.99
568_I	574_R	2.306	0.99
251_Q	257_L	2.302	0.99
310_W	319_L	2.285	0.99
619_E	622_Q	2.279	0.99
326_S	334_E	2.276	0.99
436_L	440_L	2.274	0.99
317_Y	320_L	2.271	0.99
522_A	545_Q	2.262	0.99
614_L	619_E	2.249	0.99
315_T	322_R	2.244	0.99
319_L	327_N	2.216	0.99
154_V	158_V	2.195	0.98
276_T	294_V	2.182	0.98
522_A	541_A	2.166	0.98
587_F	591_M	2.157	0.98
614_L	618_L	2.144	0.98
316_R	330_I	2.122	0.98
618_L	622_Q	2.105	0.98
319_L	324_V	2.103	0.98
429_T	439_S	2.094	0.98
131_I	146_A	2.092	0.98
327_N	333_T	2.077	0.98
308_Y	316_R	2.073	0.98
253_C	256_Y	2.073	0.98
129_L	388_A	2.063	0.98
614_L	621_Y	2.044	0.98
432_S	437_C	2.024	0.97
284_V	287_Q	2.019	0.97
312_A	326_S	2.002	0.97
418_G	482_F	1.995	0.97
316_R	321_K	1.986	0.97
326_S	337_I	1.966	0.97
21_I	44_A	1.925	0.96
130_I	389_V	1.921	0.96
147_V	151_S	1.921	0.96
295_I	299_G	1.920	0.96
133_I	369_T	1.920	0.96
315_T	333_T	1.919	0.96
13_F	451_V	1.914	0.96
16_K	60_S	1.906	0.96
542_L	545_Q	1.880	0.96
350_E	514_V	1.878	0.96
412_L	490_I	1.863	0.96
614_L	622_Q	1.854	0.96
541_A	545_Q	1.846	0.95
541_A	544_Q	1.846	0.95
307_I	310_W	1.834	0.95
312_A	315_T	1.830	0.95
253_C	257_L	1.818	0.95
460_G	526_A	1.817	0.95
102_W	124_A	1.810	0.95
599_I	603_S	1.795	0.95
72_I	75_F	1.789	0.95
614_L	617_E	1.780	0.94
312_A	333_T	1.771	0.94
162_M	166_L	1.767	0.94
22_V	437_C	1.765	0.94
78_C	150_C	1.763	0.94
14_A	44_A	1.762	0.94
93_L	370_L	1.748	0.94
316_R	326_S	1.742	0.94
312_A	319_L	1.737	0.94
309_S	316_R	1.735	0.94
595_A	599_I	1.732	0.94
615_L	622_Q	1.727	0.93
19_T	167_F	1.715	0.93
271_R	275_D	1.715	0.93
540_P	544_Q	1.706	0.93
368_G	387_I	1.696	0.93
306_T	309_S	1.693	0.93
392_S	395_M	1.689	0.93
321_K	327_N	1.688	0.93
320_L	326_S	1.687	0.93
329_K	333_T	1.686	0.93
453_K	456_L	1.684	0.93
78_C	82_L	1.674	0.92
316_R	337_I	1.669	0.92
635_T	638_V	1.657	0.92
309_S	312_A	1.651	0.92
324_V	330_I	1.636	0.91
321_K	337_I	1.631	0.91
284_V	288_L	1.627	0.91
44_A	448_G	1.624	0.91
370_L	374_W	1.614	0.91
615_L	619_E	1.613	0.91
415_L	486_A	1.609	0.91
315_T	319_L	1.608	0.91
316_R	323_G	1.600	0.91
312_A	330_I	1.582	0.90
321_K	324_V	1.581	0.90
436_L	454_R	1.562	0.89
316_R	334_E	1.558	0.89
320_L	323_G	1.552	0.89
618_L	621_Y	1.546	0.89
331_N	334_E	1.546	0.89
309_S	321_K	1.535	0.89
306_T	310_W	1.534	0.89
417_L	461_A	1.534	0.89
321_K	330_I	1.533	0.88
291_L	294_V	1.532	0.88
338_L	342_P	1.529	0.88
45_I	451_V	1.528	0.88
292_R	296_A	1.526	0.88
599_I	606_K	1.513	0.88
308_Y	319_L	1.508	0.88
350_E	545_Q	1.494	0.87
538_H	544_Q	1.476	0.87
276_T	280_T	1.469	0.86
70_R	119_Y	1.457	0.86
312_A	321_K	1.457	0.86
80_A	98_V	1.449	0.85
334_E	338_L	1.432	0.85
385_V	392_S	1.427	0.85
613_Q	617_E	1.425	0.84
180_L	241_I	1.423	0.84
108_W	358_F	1.419	0.84
377_W	380_G	1.417	0.84
252_S	255_T	1.415	0.84
372_W	380_G	1.410	0.84
27_V	159_C	1.409	0.84
326_S	329_K	1.399	0.83
124_A	375_T	1.398	0.83
321_K	326_S	1.393	0.83
574_R	580_V	1.391	0.83
102_W	126_Y	1.390	0.83
45_I	389_V	1.389	0.83
38_W	152_E	1.387	0.83
596_D	599_I	1.383	0.83
319_L	337_I	1.382	0.83
420_L	424_V	1.374	0.82
308_Y	330_I	1.369	0.82
78_C	146_A	1.366	0.82
321_K	333_T	1.362	0.82
351_R	358_F	1.358	0.81
107_T	392_S	1.347	0.81
250_T	254_E	1.338	0.80
313_A	317_Y	1.326	0.80
287_Q	292_R	1.325	0.80
535_K	539_L	1.325	0.80
311_V	315_T	1.323	0.80
72_I	120_A	1.317	0.79
292_R	295_I	1.315	0.79
309_S	330_I	1.314	0.79
95_M	157_I	1.313	0.79
42_T	153_I	1.305	0.79
287_Q	363_L	1.301	0.79
596_D	602_R	1.298	0.78
106_C	128_A	1.288	0.78
121_W	226_M	1.285	0.78
314_A	317_Y	1.271	0.77
111_S	357_N	1.260	0.76
227_E	244_L	1.257	0.76
535_K	538_H	1.257	0.76
619_E	623_E	1.253	0.76
60_S	152_E	1.253	0.76
82_L	146_A	1.252	0.76
99_C	128_A	1.251	0.76
20_A	43_A	1.244	0.75
70_R	126_Y	1.239	0.75
538_H	542_L	1.237	0.75
431_Q	434_L	1.237	0.75
16_K	606_K	1.232	0.75
252_S	256_Y	1.229	0.74
249_I	252_S	1.224	0.74
284_V	292_R	1.222	0.74
135_I	145_F	1.221	0.74
311_V	314_A	1.221	0.74
249_I	257_L	1.216	0.74
125_G	393_L	1.214	0.74
16_K	169_P	1.208	0.73
539_L	543_Y	1.207	0.73
632_P	636_E	1.206	0.73
571_Q	574_R	1.205	0.73
84_I	98_V	1.201	0.73
324_V	327_N	1.197	0.72
65_Y	223_N	1.197	0.72
538_H	545_Q	1.194	0.72
119_Y	126_Y	1.192	0.72
602_R	606_K	1.191	0.72
278_V	281_A	1.188	0.72
611_F	620_I	1.181	0.71
122_G	410_G	1.180	0.71
70_R	74_T	1.178	0.71
266_I	281_A	1.177	0.71
617_E	621_Y	1.177	0.71
45_I	426_I	1.171	0.71
313_A	330_I	1.169	0.71
121_W	152_E	1.164	0.70
152_E	226_M	1.157	0.70
625_L	628_W	1.152	0.69
74_T	119_Y	1.152	0.69
412_L	416_P	1.147	0.69
324_V	333_T	1.147	0.69
24_A	39_A	1.144	0.69
372_W	377_W	1.142	0.69
168_S	173_K	1.138	0.69
634_V	637_P	1.137	0.68
535_K	545_Q	1.137	0.68
617_E	625_L	1.135	0.68
148_E	151_S	1.134	0.68
120_A	131_I	1.126	0.68
597_H	618_L	1.121	0.67
106_C	126_Y	1.115	0.67
101_I	355_M	1.114	0.67
184_L	210_L	1.113	0.67
16_K	167_F	1.107	0.66
155_I	304_P	1.105	0.66
313_A	316_R	1.105	0.66
299_G	302_E	1.104	0.66
15_V	167_F	1.103	0.66
109_I	451_V	1.102	0.66
380_G	400_P	1.096	0.66
164_D	172_I	1.095	0.65
106_C	354_A	1.094	0.65
341_E	344_V	1.094	0.65
70_R	123_L	1.093	0.65
321_K	334_E	1.089	0.65
394_A	496_A	1.089	0.65
620_I	624_K	1.089	0.65
578_I	581_N	1.087	0.65
106_C	124_A	1.087	0.65
221_R	226_M	1.086	0.65
364_S	367_L	1.086	0.65
319_L	323_G	1.084	0.65
534_R	537_N	1.084	0.65
312_A	322_R	1.081	0.64
368_G	495_L	1.079	0.64
598_V	602_R	1.076	0.64
123_L	393_L	1.072	0.64
598_V	605_D	1.068	0.64
100_C	365_C	1.067	0.63
339_Q	343_E	1.066	0.63
28_G	537_N	1.065	0.63
35_T	38_W	1.062	0.63
377_W	484_D	1.059	0.63
254_E	257_L	1.058	0.63
313_A	331_N	1.053	0.62
14_A	38_W	1.051	0.62
598_V	606_K	1.050	0.62
328_T	333_T	1.050	0.62
24_A	156_G	1.050	0.62
43_A	492_G	1.049	0.62
622_Q	625_L	1.046	0.62
371_F	502_L	1.041	0.61
398_P	552_K	1.038	0.61
549_L	567_I	1.036	0.61
12_R	16_K	1.032	0.61
80_A	102_W	1.029	0.61
317_Y	330_I	1.025	0.60
539_L	545_Q	1.024	0.60
31_F	459_M	1.022	0.60
251_Q	256_Y	1.022	0.60
350_E	394_A	1.020	0.60
317_Y	324_V	1.018	0.60
273_F	280_T	1.016	0.60
615_L	618_L	1.015	0.60
38_W	92_P	1.015	0.60
324_V	328_T	1.015	0.60
301_R	304_P	1.007	0.59
62_A	448_G	1.007	0.59
96_I	111_S	1.006	0.59
410_G	447_L	1.004	0.59
322_R	326_S	1.002	0.59
244_L	247_T	0.997	0.58
615_L	621_Y	0.996	0.58
69_L	117_N	0.996	0.58
283_D	290_R	0.994	0.58
345_K	349_A	0.993	0.58
454_R	457_G	0.992	0.58
155_I	282_Q	0.990	0.58
315_T	320_L	0.989	0.57
345_K	350_E	0.987	0.57
123_L	132_V	0.985	0.57
116_E	360_R	0.985	0.57
126_Y	393_L	0.985	0.57
312_A	334_E	0.982	0.57
286_K	597_H	0.982	0.57
590_Q	612_G	0.979	0.57
611_F	615_L	0.979	0.57
44_A	57_E	0.977	0.57
540_P	548_L	0.974	0.56
44_A	152_E	0.974	0.56
287_Q	290_R	0.974	0.56
544_Q	548_L	0.973	0.56
269_T	582_E	0.972	0.56
309_S	314_A	0.968	0.56
299_G	303_T	0.967	0.56
337_I	340_G	0.964	0.56
37_R	223_N	0.963	0.55
14_A	18_A	0.963	0.55
267_T	281_A	0.962	0.55
122_G	393_L	0.961	0.55
587_F	595_A	0.958	0.55
12_R	15_V	0.958	0.55
251_Q	254_E	0.958	0.55
283_D	288_L	0.957	0.55
81_G	130_I	0.953	0.55
368_G	383_A	0.951	0.55
317_Y	333_T	0.947	0.54
107_T	111_S	0.945	0.54
57_E	376_G	0.945	0.54
399_N	505_D	0.941	0.54
597_H	601_A	0.941	0.54
127_T	153_I	0.939	0.54
47_A	160_A	0.936	0.53
380_G	484_D	0.935	0.53
612_G	617_E	0.933	0.53
19_T	441_A	0.931	0.53
267_T	280_T	0.931	0.53
610_Y	619_E	0.931	0.53
406_D	409_Y	0.922	0.52
616_E	620_I	0.921	0.52
32_Q	164_D	0.921	0.52
16_K	121_W	0.919	0.52
40_V	226_M	0.919	0.52
78_C	131_I	0.918	0.52
315_T	321_K	0.916	0.52
535_K	540_P	0.915	0.52
116_E	427_P	0.913	0.51
615_L	631_P	0.910	0.51
329_K	337_I	0.910	0.51
540_P	545_Q	0.904	0.51
65_Y	126_Y	0.904	0.51
86_I	90_R	0.902	0.51
626_R	633_Q	0.901	0.51
42_T	122_G	0.901	0.51
518_Q	545_Q	0.900	0.50
109_I	121_W	0.900	0.50
17_L	164_D	0.900	0.50
21_I	40_V	0.899	0.50
634_V	638_V	0.898	0.50
287_Q	295_I	0.897	0.50
285_H	303_T	0.897	0.50
320_L	327_N	0.897	0.50
423_L	482_F	0.896	0.50
138_E	141_L	0.894	0.50
308_Y	320_L	0.889	0.50
144_Q	348_S	0.887	0.49
408_I	494_V	0.887	0.49
45_I	123_L	0.887	0.49
437_C	444_G	0.886	0.49
271_R	279_E	0.884	0.49
111_S	360_R	0.884	0.49
323_G	330_I	0.882	0.49
417_L	420_L	0.881	0.49
523_A	527_M	0.879	0.49
45_I	436_L	0.877	0.49
314_A	327_N	0.873	0.48
35_T	152_E	0.873	0.48
308_Y	326_S	0.872	0.48
316_R	322_R	0.871	0.48
421_Y	425_I	0.870	0.48
309_S	320_L	0.868	0.48
627_I	635_T	0.867	0.48
632_P	635_T	0.865	0.48
152_E	169_P	0.864	0.48
13_F	25_L	0.862	0.47
609_R	619_E	0.862	0.47
187_Q	195_I	0.862	0.47
309_S	319_L	0.861	0.47
631_P	635_T	0.861	0.47
319_L	326_S	0.860	0.47
324_V	337_I	0.859	0.47
607_R	619_E	0.859	0.47
617_E	622_Q	0.858	0.47
164_D	538_H	0.855	0.47
369_T	384_M	0.853	0.47
74_T	149_R	0.852	0.47
112_L	351_R	0.848	0.46
318_Q	330_I	0.847	0.46
295_I	302_E	0.846	0.46
101_I	417_L	0.846	0.46
290_R	294_V	0.845	0.46
555_G	568_I	0.845	0.46
438_I	627_I	0.845	0.46
482_F	486_A	0.845	0.46
69_L	144_Q	0.841	0.46
591_M	595_A	0.841	0.46
63_I	466_I	0.840	0.46
330_I	336_E	0.838	0.45
69_L	153_I	0.838	0.45
618_L	623_E	0.836	0.45
20_A	106_C	0.830	0.45
92_P	136_Q	0.830	0.45
420_L	616_E	0.829	0.45
316_R	324_V	0.827	0.45
86_I	151_S	0.823	0.44
382_G	467_N	0.823	0.44
333_T	340_G	0.822	0.44
146_A	487_L	0.821	0.44
42_T	139_P	0.820	0.44
312_A	324_V	0.816	0.44
605_D	617_E	0.813	0.44
57_E	69_L	0.812	0.43
382_G	385_V	0.810	0.43
359_W	608_R	0.810	0.43
363_L	416_P	0.806	0.43
598_V	603_S	0.806	0.43
468_I	486_A	0.806	0.43
106_C	360_R	0.805	0.43
88_M	526_A	0.805	0.43
310_W	326_S	0.803	0.43
612_G	615_L	0.802	0.43
319_L	334_E	0.802	0.43
395_M	407_F	0.800	0.43
360_R	473_N	0.800	0.43
79_I	582_E	0.799	0.42
42_T	439_S	0.799	0.42
537_N	540_P	0.799	0.42
593_R	604_D	0.798	0.42
228_S	231_W	0.796	0.42
574_R	581_N	0.791	0.42
231_W	238_L	0.791	0.42
78_C	145_F	0.790	0.42
491_V	613_Q	0.790	0.42
354_A	358_F	0.789	0.42
308_Y	315_T	0.789	0.42
268_D	558_P	0.789	0.42
540_P	546_L	0.788	0.42
66_R	143_P	0.785	0.41
28_G	75_F	0.783	0.41
630_A	635_T	0.782	0.41
320_L	330_I	0.782	0.41
132_V	390_V	0.782	0.41
321_K	342_P	0.781	0.41
618_L	624_K	0.778	0.41
391_T	496_A	0.776	0.41
126_Y	153_I	0.775	0.41
17_L	62_A	0.774	0.40
81_G	498_T	0.774	0.40
625_L	629_Q	0.770	0.40
538_H	541_A	0.770	0.40
611_F	618_L	0.767	0.40
591_M	594_T	0.765	0.40
391_T	468_I	0.765	0.40
272_E	293_R	0.764	0.40
317_Y	328_T	0.764	0.40
574_R	578_I	0.763	0.40
152_E	241_I	0.761	0.39
631_P	638_V	0.760	0.39
27_V	32_Q	0.760	0.39
312_A	320_L	0.760	0.39
289_K	293_R	0.760	0.39
114_R	163_A	0.759	0.39
360_R	500_I	0.758	0.39
193_L	587_F	0.757	0.39
610_Y	622_Q	0.756	0.39
603_S	606_K	0.756	0.39
333_T	336_E	0.756	0.39
306_T	317_Y	0.754	0.39
26_F	30_H	0.749	0.39
87_A	90_R	0.748	0.39
404_A	493_C	0.747	0.38
143_P	147_V	0.747	0.38
464_S	472_D	0.744	0.38
16_K	526_A	0.744	0.38
83_V	597_H	0.743	0.38
268_D	289_K	0.742	0.38
323_G	327_N	0.742	0.38
311_V	321_K	0.742	0.38
625_L	631_P	0.742	0.38
306_T	342_P	0.742	0.38
602_R	605_D	0.741	0.38
389_V	407_F	0.741	0.38
33_L	58_P	0.740	0.38
285_H	289_K	0.739	0.38
617_E	631_P	0.737	0.38
358_F	435_L	0.736	0.38
348_S	545_Q	0.735	0.38
79_I	83_V	0.735	0.38
577_P	599_I	0.735	0.38
272_E	276_T	0.735	0.38
104_G	444_G	0.735	0.38
592_R	632_P	0.734	0.37
445_F	577_P	0.734	0.37
83_V	264_E	0.733	0.37
210_L	393_L	0.732	0.37
24_A	29_F	0.731	0.37
399_N	407_F	0.730	0.37
310_W	330_I	0.729	0.37
601_A	605_D	0.728	0.37
42_T	70_R	0.728	0.37
383_A	492_G	0.727	0.37
545_Q	548_L	0.726	0.37
37_R	92_P	0.726	0.37
535_K	541_A	0.725	0.37
265_L	269_T	0.723	0.37
451_V	457_G	0.722	0.37
62_A	572_R	0.720	0.36
523_A	540_P	0.719	0.36
163_A	390_V	0.719	0.36
79_I	329_K	0.719	0.36
398_P	460_G	0.719	0.36
32_Q	347_E	0.718	0.36
494_V	497_F	0.717	0.36
143_P	432_S	0.716	0.36
584_L	593_R	0.715	0.36
367_L	495_L	0.715	0.36
123_L	153_I	0.715	0.36
593_R	632_P	0.714	0.36
611_F	619_E	0.713	0.36
315_T	330_I	0.712	0.36
407_F	460_G	0.712	0.36
130_I	449_I	0.710	0.36
537_N	541_A	0.709	0.36
112_L	499_V	0.709	0.36
604_D	608_R	0.709	0.36
69_L	116_E	0.707	0.35
537_N	545_Q	0.706	0.35
142_T	385_V	0.706	0.35
99_C	483_L	0.705	0.35
84_I	586_A	0.704	0.35
274_F	278_V	0.704	0.35
268_D	291_L	0.701	0.35
309_S	334_E	0.701	0.35
205_K	209_D	0.700	0.35
313_A	337_I	0.700	0.35
290_R	491_V	0.699	0.35
368_G	371_F	0.699	0.35
319_L	333_T	0.699	0.35
24_A	176_V	0.698	0.35
81_G	132_V	0.696	0.35
611_F	627_I	0.695	0.35
240_A	244_L	0.695	0.35
293_R	298_T	0.694	0.35
610_Y	615_L	0.694	0.35
609_R	613_Q	0.694	0.35
158_V	258_I	0.693	0.34
224_L	421_Y	0.691	0.34
141_L	294_V	0.691	0.34
136_Q	380_G	0.690	0.34
459_M	492_G	0.688	0.34
39_A	75_F	0.688	0.34
589_R	594_T	0.688	0.34
487_L	498_T	0.687	0.34
292_R	302_E	0.686	0.34
269_T	272_E	0.685	0.34
297_W	341_E	0.685	0.34
38_W	389_V	0.683	0.34
227_E	473_N	0.681	0.34
135_I	201_E	0.681	0.34
65_Y	69_L	0.681	0.34
616_E	627_I	0.680	0.34
316_R	320_L	0.679	0.33
83_V	93_L	0.677	0.33
91_A	492_G	0.677	0.33
94_L	358_F	0.675	0.33
88_M	384_M	0.674	0.33
623_E	631_P	0.674	0.33
57_E	106_C	0.673	0.33
290_R	363_L	0.673	0.33
467_N	489_Q	0.672	0.33
535_K	543_Y	0.672	0.33
94_L	431_Q	0.671	0.33
28_G	45_I	0.669	0.33
503_V	528_T	0.669	0.33
187_Q	190_L	0.669	0.33
313_A	335_E	0.668	0.33
88_M	143_P	0.668	0.33
386_M	389_V	0.667	0.33
99_C	356_V	0.667	0.33
598_V	601_A	0.667	0.33
316_R	333_T	0.666	0.33
309_S	324_V	0.665	0.32
538_H	574_R	0.665	0.32
119_Y	132_V	0.665	0.32
25_L	438_I	0.664	0.32
314_A	330_I	0.664	0.32
57_E	172_I	0.663	0.32
18_A	437_C	0.663	0.32
330_I	342_P	0.662	0.32
310_W	315_T	0.662	0.32
14_A	17_L	0.661	0.32
39_A	417_L	0.661	0.32
217_L	411_T	0.659	0.32
400_P	496_A	0.658	0.32
322_R	330_I	0.657	0.32
608_R	619_E	0.655	0.32
111_S	506_K	0.655	0.32
113_V	116_E	0.654	0.32
62_A	538_H	0.654	0.32
483_L	516_L	0.651	0.31
317_Y	331_N	0.648	0.31
16_K	168_S	0.647	0.31
268_D	517_N	0.647	0.31
497_F	501_L	0.647	0.31
23_L	163_A	0.645	0.31
449_I	456_L	0.644	0.31
310_W	313_A	0.644	0.31
313_A	327_N	0.644	0.31
65_Y	123_L	0.644	0.31
328_T	341_E	0.643	0.31
249_I	420_L	0.642	0.31
350_E	518_Q	0.642	0.31
34_E	425_I	0.642	0.31
296_A	300_E	0.642	0.31
633_Q	636_E	0.642	0.31
10_H	449_I	0.641	0.31
319_L	325_I	0.640	0.31
348_S	544_Q	0.639	0.31
360_R	505_D	0.639	0.31
269_T	630_A	0.639	0.31
153_I	421_Y	0.639	0.31
74_T	123_L	0.638	0.31
151_S	360_R	0.637	0.31
42_T	458_S	0.637	0.31
403_V	464_S	0.636	0.30
315_T	324_V	0.636	0.30
259_Q	262_R	0.635	0.30
88_M	114_R	0.633	0.30
371_F	375_T	0.632	0.30
144_Q	148_E	0.632	0.30
464_S	467_N	0.631	0.30
283_D	294_V	0.631	0.30
130_I	444_G	0.631	0.30
610_Y	621_Y	0.630	0.30
364_S	407_F	0.626	0.30
600_S	607_R	0.626	0.30
612_G	627_I	0.626	0.30
382_G	489_Q	0.626	0.30
540_P	543_Y	0.625	0.30
311_V	328_T	0.624	0.30
441_A	445_F	0.623	0.30
297_W	301_R	0.623	0.30
259_Q	263_P	0.622	0.30
288_L	291_L	0.622	0.30
440_L	444_G	0.621	0.29
90_R	360_R	0.621	0.29
23_L	162_M	0.621	0.29
294_V	297_W	0.620	0.29
119_Y	125_G	0.619	0.29
19_T	296_A	0.618	0.29
536_E	540_P	0.618	0.29
613_Q	622_Q	0.618	0.29
394_A	492_G	0.618	0.29
391_T	500_I	0.617	0.29
296_A	303_T	0.615	0.29
437_C	502_L	0.615	0.29
162_M	478_H	0.615	0.29
393_L	463_A	0.612	0.29
611_F	629_Q	0.612	0.29
74_T	127_T	0.611	0.29
152_E	373_L	0.611	0.29
100_C	443_L	0.609	0.29
541_A	548_L	0.608	0.29
336_E	494_V	0.607	0.29
317_Y	321_K	0.607	0.29
258_I	324_V	0.605	0.28
92_P	373_L	0.605	0.28
613_Q	616_E	0.604	0.28
538_H	543_Y	0.603	0.28
141_L	362_T	0.603	0.28
164_D	226_M	0.603	0.28
360_R	375_T	0.603	0.28
499_V	503_V	0.601	0.28
232_A	238_L	0.601	0.28
292_R	325_I	0.600	0.28
412_L	616_E	0.600	0.28
32_Q	463_A	0.600	0.28
80_A	106_C	0.600	0.28
330_I	343_E	0.598	0.28
592_R	599_I	0.597	0.28
118_S	123_L	0.597	0.28
534_R	540_P	0.597	0.28
25_L	29_F	0.596	0.28
289_K	296_A	0.596	0.28
308_Y	311_V	0.596	0.28
596_D	600_S	0.596	0.28
17_L	43_A	0.595	0.28
355_M	359_W	0.595	0.28
593_R	613_Q	0.594	0.28
104_G	402_M	0.594	0.28
630_A	637_P	0.593	0.28
297_W	612_G	0.593	0.28
285_H	288_L	0.593	0.28
275_D	608_R	0.592	0.28
604_D	624_K	0.592	0.28
319_L	336_E	0.589	0.27
134_T	426_I	0.588	0.27
102_W	125_G	0.588	0.27
100_C	104_G	0.588	0.27
43_A	47_A	0.586	0.27
44_A	421_Y	0.586	0.27
626_R	632_P	0.586	0.27
207_W	227_E	0.586	0.27
489_Q	550_M	0.585	0.27
327_N	331_N	0.585	0.27
101_I	135_I	0.585	0.27
83_V	259_Q	0.584	0.27
420_L	428_N	0.584	0.27
25_L	436_L	0.583	0.27
107_T	402_M	0.583	0.27
263_P	608_R	0.583	0.27
81_G	131_I	0.582	0.27
114_R	217_L	0.582	0.27
70_R	427_P	0.582	0.27
283_D	623_E	0.581	0.27
314_A	321_K	0.581	0.27
218_Q	246_L	0.580	0.27
14_A	445_F	0.580	0.27
395_M	505_D	0.579	0.27
605_D	609_R	0.578	0.27
587_F	599_I	0.578	0.27
46_V	133_I	0.577	0.27
121_W	453_K	0.576	0.27
125_G	129_L	0.575	0.26
122_G	504_R	0.575	0.26
292_R	299_G	0.574	0.26
118_S	467_N	0.573	0.26
38_W	449_I	0.573	0.26
168_S	389_V	0.573	0.26
199_D	278_V	0.573	0.26
282_Q	293_R	0.572	0.26
398_P	551_N	0.571	0.26
110_S	376_G	0.571	0.26
366_I	375_T	0.571	0.26
593_R	600_S	0.570	0.26
32_Q	151_S	0.570	0.26
327_N	343_E	0.568	0.26
297_W	304_P	0.568	0.26
181_E	270_F	0.568	0.26
361_T	587_F	0.567	0.26
157_I	427_P	0.566	0.26
129_L	497_F	0.565	0.26
318_Q	322_R	0.564	0.26
110_S	153_I	0.564	0.26
360_R	384_M	0.564	0.26
106_C	129_L	0.564	0.26
426_I	493_C	0.563	0.26
594_T	603_S	0.563	0.26
324_V	334_E	0.563	0.26
593_R	597_H	0.563	0.26
106_C	377_W	0.563	0.26
32_Q	167_F	0.562	0.26
86_I	89_I	0.561	0.26
152_E	160_A	0.561	0.26
189_Q	490_I	0.560	0.26
335_E	587_F	0.559	0.25
240_A	347_E	0.559	0.25
62_A	224_L	0.559	0.25
273_F	276_T	0.558	0.25
286_K	289_K	0.557	0.25
364_S	389_V	0.556	0.25
627_I	636_E	0.556	0.25
313_A	323_G	0.556	0.25
531_V	581_N	0.556	0.25
325_I	342_P	0.556	0.25
425_I	573_L	0.555	0.25
241_I	244_L	0.555	0.25
306_T	314_A	0.554	0.25
310_W	327_N	0.554	0.25
39_A	80_A	0.554	0.25
185_V	341_E	0.554	0.25
597_H	614_L	0.554	0.25
286_K	292_R	0.554	0.25
393_L	496_A	0.554	0.25
360_R	410_G	0.553	0.25
451_V	462_L	0.553	0.25
311_V	337_I	0.553	0.25
309_S	313_A	0.552	0.25
196_K	597_H	0.550	0.25
288_L	302_E	0.550	0.25
421_Y	512_G	0.550	0.25
462_L	465_T	0.549	0.25
265_L	341_E	0.549	0.25
45_I	70_R	0.549	0.25
131_I	142_T	0.549	0.25
248_L	515_L	0.547	0.25
570_H	614_L	0.547	0.25
307_I	316_R	0.547	0.25
157_I	394_A	0.547	0.25
322_R	327_N	0.546	0.25
153_I	441_A	0.546	0.25
596_D	603_S	0.546	0.25
199_D	623_E	0.545	0.25
464_S	489_Q	0.545	0.25
383_A	491_V	0.545	0.25
42_T	134_T	0.545	0.25
267_T	276_T	0.544	0.25
437_C	440_L	0.544	0.25
199_D	275_D	0.544	0.25
271_R	297_W	0.544	0.25
111_S	151_S	0.543	0.25
246_L	485_S	0.542	0.24
258_I	487_L	0.542	0.24
591_M	600_S	0.541	0.24
584_L	625_L	0.540	0.24
86_I	116_E	0.539	0.24
276_T	596_D	0.539	0.24
35_T	62_A	0.539	0.24
122_G	392_S	0.539	0.24
533_R	546_L	0.538	0.24
573_L	607_R	0.538	0.24
47_A	69_L	0.538	0.24
113_V	117_N	0.537	0.24
592_R	620_I	0.537	0.24
17_L	579_P	0.537	0.24
16_K	113_V	0.536	0.24
549_L	571_Q	0.536	0.24
362_T	444_G	0.536	0.24
425_I	587_F	0.536	0.24
93_L	483_L	0.535	0.24
43_A	65_Y	0.535	0.24
127_T	377_W	0.535	0.24
264_E	268_D	0.535	0.24
57_E	220_M	0.535	0.24
341_E	530_N	0.534	0.24
67_G	371_F	0.534	0.24
153_I	161_I	0.534	0.24
44_A	226_M	0.534	0.24
605_D	608_R	0.533	0.24
104_G	435_L	0.532	0.24
340_G	612_G	0.532	0.24
630_A	636_E	0.531	0.24
347_E	403_V	0.531	0.24
569_A	572_R	0.530	0.24
328_T	331_N	0.530	0.24
107_T	391_T	0.530	0.24
447_L	502_L	0.530	0.24
494_V	502_L	0.530	0.24
90_R	116_E	0.530	0.24
85_I	447_L	0.530	0.24
92_P	96_I	0.529	0.24
318_Q	323_G	0.529	0.24
441_A	459_M	0.528	0.24
42_T	74_T	0.527	0.24
86_I	113_V	0.527	0.24
275_D	481_Q	0.527	0.24
160_A	372_W	0.527	0.24
295_I	304_P	0.526	0.24
157_I	426_I	0.525	0.23
405_I	409_Y	0.525	0.23
299_G	309_S	0.525	0.23
627_I	633_Q	0.524	0.23
35_T	221_R	0.524	0.23
276_T	293_R	0.523	0.23
536_E	541_A	0.523	0.23
45_I	126_Y	0.523	0.23
105_F	415_L	0.523	0.23
269_T	276_T	0.522	0.23
293_R	613_Q	0.522	0.23
627_I	630_A	0.522	0.23
516_L	556_D	0.522	0.23
320_L	324_V	0.521	0.23
425_I	480_S	0.521	0.23
613_Q	625_L	0.521	0.23
85_I	307_I	0.521	0.23
16_K	226_M	0.520	0.23
335_E	339_Q	0.519	0.23
291_L	496_A	0.519	0.23
33_L	396_R	0.519	0.23
62_A	207_W	0.518	0.23
590_Q	633_Q	0.516	0.23
312_A	327_N	0.515	0.23
438_I	636_E	0.515	0.23
623_E	629_Q	0.514	0.23
399_N	500_I	0.513	0.23
181_E	362_T	0.513	0.23
60_S	226_M	0.513	0.23
306_T	330_I	0.512	0.23
92_P	377_W	0.512	0.23
28_G	36_P	0.511	0.23
67_G	161_I	0.511	0.23
79_I	173_K	0.510	0.23
106_C	499_V	0.510	0.23
119_Y	156_G	0.510	0.23
314_A	326_S	0.509	0.23
309_S	326_S	0.508	0.23
620_I	631_P	0.508	0.23
265_L	281_A	0.508	0.23
157_I	564_L	0.507	0.22
25_L	546_L	0.507	0.22
102_W	159_C	0.507	0.22
111_S	358_F	0.505	0.22
448_G	466_I	0.505	0.22
622_Q	631_P	0.505	0.22
42_T	377_W	0.505	0.22
277_P	623_E	0.505	0.22
461_A	479_F	0.505	0.22
127_T	515_L	0.504	0.22
293_R	300_E	0.503	0.22
612_G	616_E	0.503	0.22
618_L	628_W	0.502	0.22
329_K	341_E	0.502	0.22
593_R	596_D	0.502	0.22
534_R	542_L	0.501	0.22
543_Y	552_K	0.501	0.22
210_L	495_L	0.501	0.22
169_P	372_W	0.500	0.22
42_T	127_T	0.500	0.22
601_A	612_G	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zz9A	3	0.2412	26	0.979	Contact Map
4k0jA	3	0.2412	17	0.981	Contact Map
3iyzA	3	0.2397	15.4	0.981	Contact Map
3d9sA	3	0.313	14.8	0.981	Contact Map
2zy9A	2	0.2366	14.6	0.981	Contact Map
3effK	4	0.1969	14.1	0.981	Contact Map
3pjsK	4	0.2015	13.2	0.982	Contact Map
4oj2X	3	0.2916	11.8	0.982	Contact Map
3cn5A	3	0.2427	11.3	0.982	Contact Map
3vouA	4	0.2015	11.1	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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