GREMLIN Database
RSEC - Protein RseC
UniProt: P46187 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13178
Length: 159 (142)
Sequences: 667 (538)
Seq/√Len: 45.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_C59_L5.2971.00
117_G121_A4.3411.00
3_K66_E4.2641.00
68_G139_L3.1501.00
92_I96_F3.0251.00
66_E140_S2.8341.00
8_V11_W2.7351.00
6_A20_C2.6881.00
15_Q52_V2.6731.00
104_V108_C2.5811.00
103_D107_L2.5591.00
92_I109_G2.5291.00
75_L79_L2.4621.00
89_L110_A2.3621.00
55_C58_P2.3481.00
63_Q141_V2.3101.00
19_S50_T2.1811.00
113_G117_G1.9410.99
109_G113_G1.9140.99
19_S48_T1.8140.99
80_L84_S1.7460.98
96_F109_G1.7210.98
53_V138_I1.7120.98
17_L52_V1.6760.98
1_M71_E1.5950.97
42_K117_G1.5870.97
92_I113_G1.5730.96
20_C67_L1.5700.96
4_E136_P1.5650.96
7_T63_Q1.5500.96
16_A59_L1.5420.96
16_A55_C1.5270.96
88_G113_G1.5120.96
88_G117_G1.4780.95
40_L43_L1.4390.94
79_L83_M1.4200.94
81_V121_A1.3980.93
11_W61_P1.2870.90
4_E23_K1.2790.90
16_A138_I1.2610.89
8_V59_L1.2480.88
18_V21_D1.2400.88
81_V114_G1.2390.88
86_L136_P1.2070.87
4_E31_S1.2050.87
119_L122_R1.1990.86
10_S61_P1.1780.85
67_L108_C1.1230.83
96_F106_A1.1140.82
20_C49_H1.1120.82
74_L124_Y1.1080.82
6_A67_L1.1030.81
103_D106_A1.0940.81
106_A109_G1.0940.81
38_R44_G1.0930.81
114_G118_F1.0800.80
1_M68_G1.0710.79
108_C116_G1.0660.79
31_S34_G1.0420.78
35_C82_Y1.0300.77
114_G117_G1.0240.76
43_L77_S1.0220.76
53_V127_K1.0010.75
103_D110_A1.0010.75
96_F100_F0.9980.74
61_P84_S0.9900.74
89_L94_S0.9770.73
101_A132_A0.9760.73
110_A138_I0.9690.72
112_L116_G0.9660.72
2_I68_G0.9640.72
112_L115_I0.9500.71
7_T19_S0.9200.68
27_S76_S0.9180.68
95_L98_L0.9090.67
13_N55_C0.8870.65
6_A18_V0.8850.65
68_G137_I0.8820.65
87_V107_L0.8690.64
17_L20_C0.8630.63
5_W89_L0.8590.63
17_L115_I0.8560.63
14_G54_P0.8490.62
22_V34_G0.8480.62
74_L78_A0.8330.60
86_L137_I0.8230.59
14_G55_C0.8200.59
103_D109_G0.8180.59
88_G92_I0.8080.58
94_S107_L0.8060.58
66_E78_A0.7990.57
22_V49_H0.7950.57
7_T64_K0.7940.57
33_A41_N0.7830.56
10_S17_L0.7820.56
90_F123_G0.7810.55
61_P111_I0.7760.55
67_L82_Y0.7720.55
89_L114_G0.7680.54
36_G117_G0.7660.54
89_L117_G0.7640.54
56_D96_F0.7620.54
27_S65_V0.7580.53
31_S71_E0.7570.53
34_G75_L0.7410.52
20_C31_S0.7390.51
21_D37_S0.7370.51
9_V61_P0.7350.51
96_F105_A0.7340.51
70_A116_G0.7330.51
2_I51_I0.7320.51
92_I125_S0.7280.50
130_A135_Q0.7210.50
69_I113_G0.7180.49
13_N114_G0.7120.49
3_K140_S0.7070.48
10_S50_T0.7060.48
107_L111_I0.6950.47
33_A126_R0.6900.47
87_V90_F0.6880.46
99_L124_Y0.6840.46
2_I82_Y0.6800.46
80_L124_Y0.6800.46
17_L50_T0.6800.46
25_S42_K0.6780.45
87_V115_I0.6770.45
5_W22_V0.6720.45
17_L136_P0.6690.45
8_V127_K0.6680.44
71_E139_L0.6670.44
22_V52_V0.6650.44
92_I98_L0.6600.44
42_K81_V0.6570.43
47_T129_A0.6520.43
60_V123_G0.6510.43
40_L44_G0.6500.43
102_S112_L0.6480.43
34_G41_N0.6470.42
19_S25_S0.6450.42
20_C77_S0.6440.42
102_S106_A0.6420.42
42_K75_L0.6410.42
102_S105_A0.6400.42
4_E118_F0.6350.41
47_T79_L0.6350.41
22_V77_S0.6310.41
105_A123_G0.6300.41
83_M89_L0.6290.41
31_S39_V0.6220.40
67_L138_I0.6190.40
32_R41_N0.6190.40
101_A106_A0.6140.39
103_D111_I0.6130.39
12_Q87_V0.6110.39
1_M125_S0.6100.39
113_G122_R0.6090.39
4_E74_L0.6080.39
131_R134_W0.6070.39
112_L119_L0.6020.38
12_Q17_L0.5970.38
61_P102_S0.5910.37
73_S99_L0.5880.37
135_Q138_I0.5830.37
22_V53_V0.5820.36
94_S98_L0.5820.36
8_V61_P0.5770.36
41_N69_I0.5710.35
12_Q52_V0.5680.35
67_L140_S0.5650.35
61_P123_G0.5640.35
71_E109_G0.5640.35
3_K138_I0.5630.35
57_E138_I0.5610.35
25_S70_A0.5600.34
90_F94_S0.5580.34
68_G125_S0.5560.34
130_A133_E0.5510.34
4_E18_V0.5470.33
4_E88_G0.5470.33
91_L99_L0.5450.33
17_L83_M0.5440.33
26_C29_C0.5430.33
14_G109_G0.5410.33
15_Q138_I0.5410.33
31_S36_G0.5400.33
11_W142_A0.5390.33
68_G71_E0.5380.33
36_G122_R0.5380.33
94_S129_A0.5360.32
126_R141_V0.5350.32
5_W78_A0.5340.32
30_A116_G0.5300.32
93_A110_A0.5250.31
16_A129_A0.5240.31
6_A62_G0.5230.31
34_G43_L0.5230.31
10_S133_E0.5200.31
45_P71_E0.5190.31
16_A73_S0.5190.31
7_T21_D0.5160.31
111_I120_I0.5160.31
45_P48_T0.5150.31
31_S37_S0.5150.31
73_S125_S0.5120.30
63_Q106_A0.5120.30
6_A37_S0.5110.30
72_G133_E0.5090.30
5_W18_V0.5080.30
9_V17_L0.5050.30
51_I90_F0.5040.30
45_P63_Q0.5020.30
111_I116_G0.5010.29
37_S71_E0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ql5A 4 0.4151 47.4 0.923 Contact Map
3i4oA 1 0.3962 43.1 0.925 Contact Map
2m5oA 1 0.3836 27.7 0.932 Contact Map
1hr0W 1 0.4088 27.6 0.932 Contact Map
1ah9A 1 0.4151 26.1 0.933 Contact Map
1vehA 1 0.3836 24.2 0.934 Contact Map
1xhjA 1 0.4025 17.7 0.938 Contact Map
4tseA 2 0.6792 13.4 0.941 Contact Map
1fr3A 5 0.3836 10.3 0.944 Contact Map
2dfaA 4 0.3145 9.6 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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