GREMLIN Database
YEDJ - Uncharacterized protein YedJ
UniProt: P46144 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12710
Length: 231 (202)
Sequences: 1508 (1124)
Seq/√Len: 79.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_S170_A4.0701.00
179_L205_M3.2901.00
41_A46_V2.7251.00
44_D189_R2.6561.00
40_L189_R2.6391.00
11_E34_W2.5011.00
10_F53_T2.4931.00
124_Q186_Q2.4691.00
34_W52_L2.3021.00
9_Q88_E2.3001.00
37_A51_I2.2481.00
47_D96_K2.2451.00
189_R192_Q2.2391.00
51_I123_V2.2111.00
138_A141_F2.2081.00
93_P96_K2.1941.00
185_M194_A2.1671.00
171_L205_M2.0721.00
150_A153_D2.0491.00
46_V51_I2.0441.00
200_F207_K2.0421.00
38_Q52_L2.0351.00
159_A162_R2.0211.00
185_M190_G2.0041.00
53_T100_V1.9931.00
186_Q190_G1.9781.00
159_A163_P1.9251.00
149_V170_A1.9231.00
182_P198_A1.9191.00
41_A48_M1.8751.00
34_W38_Q1.8381.00
17_H80_E1.8091.00
196_H207_K1.7991.00
124_Q128_R1.7951.00
208_L212_L1.7921.00
199_H203_E1.7681.00
178_L201_L1.7461.00
43_D192_Q1.7291.00
182_P195_Q1.7181.00
181_L185_M1.7051.00
13_W84_L1.7011.00
118_T121_K1.6851.00
106_A120_A1.6771.00
198_A202_V1.6531.00
195_Q199_H1.6261.00
115_P120_A1.6201.00
200_F203_E1.5811.00
199_H202_V1.5220.99
34_W56_Y1.5160.99
24_A65_K1.4960.99
158_F162_R1.4500.99
141_F145_G1.4320.99
200_F204_F1.4110.99
49_L96_K1.4090.99
158_F163_P1.4030.99
46_V122_I1.3890.99
193_L196_H1.3850.99
107_H120_A1.3840.99
169_Y172_D1.3630.99
171_L208_L1.3620.99
159_A164_L1.3610.99
162_R166_D1.3590.99
53_T92_F1.3590.99
144_S149_V1.3510.99
172_D176_T1.3380.98
10_F84_L1.3380.98
102_H106_A1.3170.98
180_K184_T1.2700.98
203_E207_K1.2670.98
61_V77_A1.2580.98
82_R101_C1.2520.98
202_V206_A1.2500.98
43_D189_R1.2200.97
86_R94_A1.2190.97
36_T193_L1.2100.97
41_A51_I1.2060.97
11_E15_K1.1780.96
22_D65_K1.1770.96
36_T39_K1.1710.96
94_A98_E1.1710.96
201_L205_M1.1400.96
61_V81_T1.1400.96
138_A151_L1.1310.96
188_A191_K1.1000.95
42_A48_M1.0870.94
140_V170_A1.0860.94
121_K186_Q1.0650.94
14_L18_H1.0400.93
179_L198_A1.0400.93
84_L88_E1.0320.93
78_A105_A1.0310.93
162_R165_D1.0270.93
30_F34_W1.0210.92
173_H177_K1.0170.92
21_Q24_A1.0130.92
23_A142_A1.0110.92
46_V118_T1.0020.92
99_A119_E1.0000.92
54_A103_A0.9960.91
39_K43_D0.9950.91
175_Q205_M0.9940.91
92_F96_K0.9940.91
205_M209_S0.9900.91
81_T85_L0.9880.91
163_P166_D0.9770.91
196_H210_A0.9770.91
15_K27_V0.9660.90
82_R97_I0.9620.90
132_L198_A0.9610.90
82_R86_R0.9590.90
106_A116_L0.9490.89
187_T190_G0.9410.89
6_W88_E0.9270.88
81_T104_I0.9250.88
6_W49_L0.9250.88
132_L140_V0.9230.88
171_L175_Q0.9140.87
137_L204_F0.9100.87
37_A123_V0.9020.87
60_I77_A0.9010.87
179_L202_V0.8960.86
40_L193_L0.8860.86
190_G193_L0.8850.86
142_A170_A0.8830.86
49_L53_T0.8800.85
28_C31_R0.8800.85
131_A173_H0.8780.85
149_V167_K0.8740.85
31_R35_A0.8680.85
156_D172_D0.8630.84
30_F130_E0.8610.84
83_R87_E0.8600.84
61_V78_A0.8570.84
106_A113_I0.8550.84
109_F180_K0.8490.83
39_K189_R0.8420.83
203_E206_A0.8400.83
80_E83_R0.8380.82
134_A211_E0.8380.82
143_V147_L0.8360.82
180_K183_Q0.8320.82
14_L27_V0.8270.82
40_L190_G0.8180.81
49_L92_F0.8160.81
10_F57_F0.8140.81
78_A81_T0.8110.80
45_D118_T0.8030.80
103_A107_H0.7980.79
11_E31_R0.7950.79
36_T40_L0.7920.79
54_A107_H0.7910.79
24_A186_Q0.7870.78
175_Q209_S0.7850.78
25_H139_R0.7830.78
57_F81_T0.7770.77
129_L190_G0.7750.77
174_F179_L0.7730.77
173_H181_L0.7690.77
47_D99_A0.7670.76
108_S128_R0.7640.76
109_F181_L0.7580.76
102_H117_T0.7540.75
21_Q65_K0.7510.75
84_L87_E0.7390.74
101_C105_A0.7390.74
141_F193_L0.7380.74
41_A45_D0.7370.74
66_N77_A0.7360.73
179_L194_A0.7350.73
154_G212_L0.7330.73
61_V66_N0.7310.73
97_I101_C0.7300.73
131_A177_K0.7290.73
202_V209_S0.7250.72
39_K193_L0.7200.72
179_L201_L0.7180.72
18_H30_F0.7180.72
31_R34_W0.7170.72
41_A122_I0.7170.72
23_A146_A0.7170.72
124_Q173_H0.7160.71
210_A214_G0.7110.71
116_L121_K0.7070.70
110_S173_H0.7060.70
57_F60_I0.7030.70
50_V99_A0.7010.70
10_F88_E0.7000.70
88_E91_Q0.6990.70
130_E136_G0.6990.70
14_L17_H0.6970.69
112_Q186_Q0.6960.69
62_S176_T0.6960.69
65_K108_S0.6910.69
6_W92_F0.6890.68
108_S173_H0.6810.68
41_A55_C0.6810.68
182_P194_A0.6790.67
82_R98_E0.6730.67
66_N80_E0.6720.67
173_H176_T0.6670.66
10_F13_W0.6630.66
140_V174_F0.6610.65
131_A181_L0.6600.65
62_S123_V0.6600.65
134_A200_F0.6520.64
18_H61_V0.6510.64
136_G185_M0.6510.64
175_Q179_L0.6500.64
110_S124_Q0.6460.64
158_F161_H0.6430.63
28_C154_G0.6400.63
173_H179_L0.6370.62
96_K100_V0.6360.62
140_V181_L0.6360.62
153_D172_D0.6340.62
104_I107_H0.6290.61
197_N207_K0.6290.61
191_K195_Q0.6270.61
103_A106_A0.6260.61
144_S153_D0.6240.61
12_N192_Q0.6240.61
34_W55_C0.6240.61
79_E82_R0.6230.61
168_R172_D0.6230.61
85_L100_V0.6220.61
36_T207_K0.6210.60
160_Q163_P0.6200.60
18_H107_H0.6190.60
7_Q11_E0.6170.60
86_R97_I0.6160.60
177_K181_L0.6160.60
141_F151_L0.6150.60
82_R95_E0.6130.59
120_A186_Q0.6110.59
68_P77_A0.6110.59
25_H177_K0.6090.59
83_R86_R0.6080.59
8_A12_N0.6080.59
62_S128_R0.6080.59
138_A193_L0.6050.58
141_F144_S0.6040.58
107_H123_V0.6030.58
130_E152_F0.6030.58
61_V80_E0.5980.58
8_A31_R0.5960.57
173_H178_L0.5960.57
62_S65_K0.5950.57
32_R130_E0.5900.57
6_W53_T0.5880.56
39_K99_A0.5870.56
64_A176_T0.5850.56
156_D164_L0.5840.56
85_L97_I0.5840.56
87_E91_Q0.5820.56
118_T122_I0.5820.56
149_V169_Y0.5770.55
128_R186_Q0.5760.55
62_S107_H0.5700.54
152_F212_L0.5670.54
27_V148_G0.5650.53
159_A165_D0.5650.53
10_F18_H0.5640.53
6_W10_F0.5640.53
57_F208_L0.5590.53
53_T96_K0.5590.53
54_A123_V0.5580.53
138_A145_G0.5580.53
117_T120_A0.5550.52
60_I80_E0.5510.52
12_N20_H0.5440.51
152_F213_A0.5410.50
86_R93_P0.5390.50
206_A210_A0.5370.50
60_I92_F0.5360.50
210_A213_A0.5350.50
137_L179_L0.5320.49
93_P98_E0.5300.49
161_H168_R0.5270.49
160_Q165_D0.5260.48
132_L182_P0.5250.48
17_H20_H0.5210.48
62_S108_S0.5200.48
22_D142_A0.5180.47
189_R193_L0.5160.47
18_H21_Q0.5150.47
154_G172_D0.5150.47
50_V100_V0.5140.47
77_A80_E0.5140.47
94_A210_A0.5110.46
117_T121_K0.5110.46
7_Q52_L0.5110.46
8_A16_N0.5100.46
45_D189_R0.5080.46
128_R173_H0.5070.46
14_L30_F0.5060.46
130_E135_I0.5030.45
16_N35_A0.5020.45
134_A185_M0.5020.45
120_A142_A0.5020.45
88_E170_A0.5010.45
39_K51_I0.5000.45
16_N20_H0.5000.45
137_L181_L0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gw7A 2 0.8961 100 0.3 Contact Map
2pjqA 2 0.8874 100 0.336 Contact Map
2qgsA 2 0.8831 100 0.338 Contact Map
3dtoA 2 0.8095 100 0.346 Contact Map
3b57A 2 0.7792 100 0.351 Contact Map
3djbA 2 0.8139 100 0.351 Contact Map
2pq7A 2 0.71 100 0.37 Contact Map
2q14A 4 0.9264 99.6 0.778 Contact Map
2cqzA 5 0.697 99.5 0.785 Contact Map
2hekA 4 0.9134 99.5 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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