GREMLIN Database
YFIN - Probable diguanylate cyclase YfiN
UniProt: P46139 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12880
Length: 408 (371)
Sequences: 8101 (7237)
Seq/√Len: 375.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_R251_H4.9611.00
318_G321_H4.7421.00
283_L373_I4.2451.00
289_N403_A4.1941.00
263_F332_A3.8741.00
283_L348_C3.8611.00
281_A377_M3.8391.00
304_R307_I3.2641.00
267_I384_A3.1261.00
258_A262_A3.1221.00
379_I382_A3.0691.00
383_S386_K2.8371.00
257_L310_A2.8331.00
238_L242_N2.7691.00
270_L273_N2.7191.00
356_N404_E2.6001.00
355_F371_L2.5071.00
281_A344_V2.4951.00
382_A390_L2.4881.00
317_G323_A2.3911.00
305_V369_M2.3731.00
313_L323_A2.3151.00
349_S352_T2.2651.00
300_A389_E2.2341.00
215_A218_H2.1501.00
263_F324_Y2.1391.00
335_L347_I2.0931.00
266_G269_T2.0851.00
284_F395_M2.0651.00
398_A405_K2.0631.00
339_Q343_E2.0611.00
389_E393_H2.0511.00
262_A266_G2.0421.00
257_L323_A2.0091.00
231_M234_W1.9801.00
244_Q248_T1.9171.00
246_L250_L1.9151.00
308_E311_K1.9081.00
397_Q401_Q1.9051.00
344_V348_C1.8971.00
242_N245_L1.8921.00
278_K337_D1.8841.00
352_T356_N1.8751.00
312_R358_P1.8681.00
349_S353_Q1.8661.00
288_D372_S1.8471.00
309_I355_F1.8391.00
285_L371_L1.8041.00
326_L332_A1.8031.00
35_L39_V1.7951.00
276_A318_G1.7901.00
352_T406_L1.7731.00
258_A322_K1.7731.00
287_G309_I1.7691.00
317_G333_M1.7461.00
308_E312_R1.7451.00
401_Q405_K1.7401.00
239_Q242_N1.7361.00
266_G322_K1.7341.00
96_D100_N1.7291.00
266_G324_Y1.7261.00
397_Q400_H1.6891.00
234_W238_L1.6841.00
231_M235_Q1.6771.00
370_T404_E1.6751.00
301_T361_L1.6601.00
347_I350_A1.6461.00
348_C375_Y1.6191.00
262_A322_K1.6071.00
311_K314_A1.5931.00
235_Q238_L1.5881.00
280_S378_T1.5881.00
304_R308_E1.5731.00
250_L258_A1.5421.00
345_Q349_S1.5261.00
285_L373_I1.5051.00
293_I305_V1.4971.00
242_N246_L1.4961.00
392_D396_Y1.4911.00
291_K295_D1.4781.00
299_H392_D1.4591.00
352_T373_I1.4481.00
230_E234_W1.4311.00
255_T306_L1.4281.00
188_A192_I1.4261.00
289_N292_Y1.4241.00
42_V46_K1.4231.00
250_L262_A1.4211.00
375_Y406_L1.4181.00
250_L265_S1.4111.00
212_E216_E1.4111.00
270_L336_Y1.4091.00
299_H396_Y1.4091.00
295_D396_Y1.4001.00
310_A323_A1.3841.00
238_L241_K1.3681.00
284_F326_L1.3601.00
213_R218_H1.3581.00
305_V329_D1.3551.00
316_F354_I1.3421.00
193_T197_H1.3401.00
330_E392_D1.3401.00
224_F228_L1.3381.00
348_C373_I1.3241.00
290_F306_L1.3191.00
251_H258_A1.3191.00
344_V375_Y1.3001.00
305_V359_F1.2951.00
287_G371_L1.2881.00
274_S280_S1.2811.00
263_F334_V1.2801.00
185_L188_A1.2801.00
294_N302_G1.2781.00
220_F224_F1.2661.00
378_T387_L1.2611.00
49_A53_L1.2481.00
326_L388_Q1.2461.00
248_T261_A1.2341.00
284_F332_A1.2291.00
376_A391_A1.2201.00
328_G396_Y1.2171.00
286_D396_Y1.2151.00
316_F350_A1.2131.00
294_N328_G1.2121.00
262_A324_Y1.2031.00
283_L335_L1.2021.00
291_K396_Y1.2001.00
287_G306_L1.1981.00
285_L333_M1.1891.00
329_D370_T1.1861.00
196_V199_V1.1831.00
332_A388_Q1.1831.00
132_P136_N1.1781.00
352_T404_E1.1751.00
268_N272_N1.1671.00
210_S221_A1.1651.00
291_K299_H1.1611.00
178_T182_H1.1541.00
265_S269_T1.1531.00
192_I196_V1.1531.00
266_G270_L1.1441.00
295_D392_D1.1421.00
293_I361_L1.1391.00
93_E101_I1.1351.00
182_H186_V1.1341.00
264_R385_E1.1331.00
266_G334_V1.1291.00
239_Q243_A1.1241.00
284_F388_Q1.1131.00
225_N228_L1.1121.00
271_M378_T1.1071.00
281_A375_Y1.1061.00
398_A402_R1.1011.00
376_A387_L1.0981.00
284_F391_A1.0961.00
262_A265_S1.0881.00
136_N141_G1.0881.00
354_I357_L1.0871.00
216_E220_F1.0851.00
53_L57_A1.0841.00
360_D364_G1.0751.00
280_S334_V1.0721.00
317_G351_L1.0711.00
79_T83_L1.0701.00
250_L261_A1.0681.00
301_T304_R1.0671.00
285_L313_L1.0661.00
243_A246_L1.0651.00
241_K244_Q1.0641.00
244_Q247_R1.0581.00
207_R221_A1.0551.00
374_G391_A1.0531.00
72_D75_A1.0491.00
376_A390_L1.0471.00
286_D399_K1.0451.00
251_H262_A1.0421.00
126_P132_P1.0391.00
218_H221_A1.0361.00
321_H350_A1.0321.00
235_Q239_Q1.0311.00
309_I313_L1.0261.00
273_N336_Y1.0221.00
264_R268_N1.0111.00
240_A244_Q1.0091.00
327_G396_Y1.0071.00
338_V343_E1.0061.00
341_E345_Q1.0041.00
283_L333_M1.0021.00
313_L351_L0.9991.00
353_Q356_N0.9991.00
138_E141_G0.9941.00
286_D329_D0.9921.00
381_H390_L0.9891.00
293_I367_T0.9891.00
183_N187_E0.9841.00
360_D366_Q0.9831.00
270_L280_S0.9821.00
312_R359_F0.9781.00
234_W239_Q0.9761.00
318_G347_I0.9711.00
237_R240_A0.9711.00
204_N208_R0.9701.00
188_A193_T0.9651.00
127_A132_P0.9641.00
294_N303_D0.9631.00
267_I334_V0.9561.00
316_F351_L0.9551.00
192_I195_V0.9551.00
292_Y296_T0.9511.00
214_I218_H0.9491.00
295_D299_H0.9441.00
304_R363_N0.9421.00
220_F228_L0.9401.00
252_D325_R0.9401.00
321_H347_I0.9401.00
333_M351_L0.9371.00
317_G347_I0.9331.00
390_L394_N0.9311.00
309_I369_M0.9231.00
324_Y332_A0.9211.00
263_F267_I0.9161.00
311_K315_E0.9061.00
289_N395_M0.9041.00
293_I301_T0.9031.00
343_E346_Q0.9021.00
286_D291_K0.9021.00
346_Q350_A0.9001.00
221_A225_N0.8981.00
263_F388_Q0.8971.00
198_D204_N0.8951.00
318_G350_A0.8941.00
258_A324_Y0.8891.00
216_E221_A0.8881.00
289_N329_D0.8871.00
345_Q406_L0.8841.00
297_W367_T0.8831.00
394_N398_A0.8811.00
299_H330_E0.8751.00
326_L329_D0.8751.00
396_Y399_K0.8731.00
283_L375_Y0.8671.00
317_G321_H0.8671.00
330_E396_Y0.8661.00
308_E359_F0.8631.00
253_P261_A0.8611.00
287_G370_T0.8551.00
286_D295_D0.8511.00
386_K390_L0.8481.00
52_N56_T0.8481.00
46_K50_Q0.8471.00
280_S387_L0.8441.00
95_R101_I0.8411.00
254_L306_L0.8411.00
34_W38_S0.8391.00
310_A313_L0.8321.00
344_V377_M0.8311.00
342_S345_Q0.8311.00
234_W242_N0.8231.00
223_D226_S0.8201.00
45_L49_A0.8191.00
348_C352_T0.8191.00
378_T382_A0.8181.00
359_F369_M0.8161.00
327_G330_E0.8161.00
56_T60_M0.8151.00
260_R264_R0.8121.00
300_A304_R0.8111.00
133_I141_G0.8101.00
279_T380_E0.8101.00
57_A61_T0.8101.00
335_L344_V0.8081.00
91_T104_S0.8051.00
193_T196_V0.8051.00
329_D395_M0.8021.00
209_V230_E0.7911.00
54_A58_A0.7871.00
230_E236_L0.7851.00
247_R256_G0.7851.00
96_D102_L0.7841.00
260_R303_D0.7831.00
376_A382_A0.7801.00
302_G328_G0.7791.00
286_D327_G0.7781.00
305_V361_L0.7771.00
361_L365_H0.7761.00
323_A333_M0.7731.00
307_I311_K0.7691.00
282_L388_Q0.7651.00
258_A266_G0.7641.00
221_A224_F0.7591.00
268_N384_A0.7591.00
341_E380_E0.7581.00
254_L294_N0.7571.00
276_A320_R0.7561.00
241_K248_T0.7551.00
230_E235_Q0.7531.00
341_E377_M0.7521.00
297_W365_H0.7521.00
235_Q242_N0.7491.00
301_T367_T0.7491.00
281_A338_V0.7481.00
175_I179_R0.7421.00
220_F225_N0.7411.00
188_A196_V0.7351.00
271_M384_A0.7351.00
274_S278_K0.7321.00
347_I351_L0.7311.00
182_H185_L0.7291.00
237_R241_K0.7281.00
89_F93_E0.7231.00
129_I132_P0.7191.00
204_N207_R0.7191.00
270_L334_V0.7191.00
93_E104_S0.7181.00
211_E215_A0.7171.00
31_M35_L0.7171.00
286_D330_E0.7151.00
208_R225_N0.7141.00
327_G392_D0.7141.00
129_I133_I0.7111.00
338_V344_V0.7111.00
196_V220_F0.7091.00
286_D290_F0.7071.00
221_A228_L0.7060.99
46_K49_A0.7060.99
335_L338_V0.7050.99
48_Y51_K0.7040.99
373_I406_L0.7040.99
245_L250_L0.7030.99
43_L47_Q0.7030.99
282_L387_L0.7030.99
132_P141_G0.7020.99
248_T251_H0.7010.99
93_E99_Q0.7010.99
217_F221_A0.7000.99
269_T273_N0.6960.99
286_D299_H0.6950.99
157_W161_A0.6940.99
295_D327_G0.6910.99
279_T377_M0.6900.99
315_E354_I0.6890.99
254_L307_I0.6880.99
303_D328_G0.6880.99
41_S45_L0.6860.99
220_F223_D0.6850.99
290_F305_V0.6850.99
220_F227_L0.6830.99
379_I390_L0.6820.99
49_A52_N0.6800.99
291_K329_D0.6800.99
80_L83_L0.6780.99
358_P368_T0.6770.99
358_P361_L0.6770.99
299_H328_G0.6750.99
209_V217_F0.6750.99
232_E236_L0.6750.99
400_H403_A0.6720.99
384_A388_Q0.6670.99
358_P366_Q0.6670.99
382_A386_K0.6670.99
141_G144_R0.6670.99
45_L48_Y0.6660.99
288_D395_M0.6660.99
197_H201_S0.6650.99
270_L276_A0.6640.99
197_H219_R0.6630.99
284_F329_D0.6600.99
301_T365_H0.6600.99
211_E228_L0.6590.99
281_A348_C0.6570.99
60_M64_L0.6560.99
225_N229_D0.6540.99
292_Y329_D0.6530.99
313_L317_G0.6530.99
216_E224_F0.6510.99
213_R216_E0.6490.99
257_L313_L0.6480.99
86_Q89_F0.6470.99
249_A259_N0.6470.99
208_R221_A0.6460.99
291_K392_D0.6440.99
161_A165_G0.6430.99
247_R250_L0.6410.99
270_L274_S0.6400.99
94_V105_W0.6390.99
376_A394_N0.6380.99
222_L226_S0.6380.99
286_D294_N0.6360.99
265_S322_K0.6350.99
271_M280_S0.6320.99
206_S233_E0.6320.99
260_R392_D0.6310.99
224_F227_L0.6300.99
101_I104_S0.6300.99
211_E217_F0.6290.99
91_T105_W0.6290.99
39_V42_V0.6290.99
128_P132_P0.6270.99
355_F359_F0.6260.99
56_T59_T0.6230.99
300_A326_L0.6230.99
106_H109_R0.6220.99
264_R267_I0.6170.99
282_L332_A0.6160.99
291_K330_E0.6160.99
51_K54_A0.6150.99
208_R229_D0.6120.99
286_D392_D0.6120.99
53_L56_T0.6120.99
50_Q54_A0.6080.98
94_V104_S0.6080.98
133_I136_N0.6070.98
196_V223_D0.6070.98
196_V224_F0.6060.98
241_K245_L0.6060.98
93_E105_W0.6050.98
130_I133_I0.6050.98
361_L367_T0.6030.98
290_F398_A0.6020.98
150_S154_H0.6010.98
50_Q53_L0.5990.98
37_L41_S0.5980.98
372_S402_R0.5970.98
196_V200_R0.5970.98
295_D330_E0.5960.98
329_D399_K0.5950.98
291_K372_S0.5940.98
154_H158_F0.5910.98
191_N195_V0.5900.98
228_L232_E0.5890.98
75_A78_E0.5880.98
288_D399_K0.5880.98
219_R222_L0.5880.98
307_I310_A0.5870.98
293_I302_G0.5870.98
256_G307_I0.5870.98
211_E224_F0.5870.98
287_G293_I0.5860.98
30_M33_I0.5850.98
87_G90_S0.5840.98
260_R326_L0.5840.98
299_H302_G0.5840.98
273_N276_A0.5830.98
101_I106_H0.5820.98
215_A221_A0.5820.98
321_H335_L0.5820.98
291_K328_G0.5810.98
245_L248_T0.5810.98
250_L324_Y0.5800.98
43_L46_K0.5790.98
372_S398_A0.5790.98
112_P124_L0.5790.98
390_L393_H0.5780.98
24_T27_F0.5780.98
192_I200_R0.5760.98
328_G392_D0.5750.98
299_H391_A0.5740.98
263_F326_L0.5740.98
312_R354_I0.5740.98
216_E223_D0.5730.98
207_R210_S0.5730.98
294_N329_D0.5720.98
356_N370_T0.5720.98
89_F105_W0.5710.98
372_S399_K0.5700.98
184_G187_E0.5690.98
207_R227_L0.5680.98
210_S224_F0.5660.98
86_Q90_S0.5650.98
209_V221_A0.5640.98
203_R221_A0.5630.98
27_F30_M0.5620.98
156_I160_L0.5610.97
329_D404_E0.5610.97
157_W160_L0.5610.97
338_V377_M0.5600.97
207_R225_N0.5600.97
382_A387_L0.5590.97
265_S268_N0.5590.97
282_L334_V0.5590.97
65_E72_D0.5550.97
395_M403_A0.5550.97
217_F225_N0.5550.97
378_T381_H0.5540.97
101_I105_W0.5530.97
243_A247_R0.5520.97
299_H303_D0.5520.97
288_D330_E0.5520.97
210_S225_N0.5520.97
264_R326_L0.5520.97
81_A84_G0.5490.97
96_D99_Q0.5490.97
53_L59_T0.5490.97
305_V324_Y0.5480.97
314_A323_A0.5480.97
287_G329_D0.5480.97
93_E103_A0.5470.97
329_D403_A0.5470.97
388_Q391_A0.5460.97
132_P137_G0.5460.97
210_S220_F0.5440.97
291_K302_G0.5440.97
190_K194_D0.5410.97
77_T81_A0.5390.97
140_I144_R0.5380.97
264_R384_A0.5380.97
52_N55_L0.5370.97
271_M387_L0.5370.97
267_I388_Q0.5360.97
274_S378_T0.5340.97
370_T402_R0.5340.97
209_V224_F0.5340.97
267_I387_L0.5330.97
57_A60_M0.5320.97
42_V45_L0.5320.97
313_L333_M0.5310.97
158_F162_V0.5300.96
287_G395_M0.5300.96
151_S154_H0.5290.96
312_R361_L0.5280.96
193_T200_R0.5280.96
299_H372_S0.5280.96
44_T47_Q0.5240.96
291_K327_G0.5230.96
236_L239_Q0.5210.96
300_A385_E0.5200.96
142_E146_T0.5200.96
352_T370_T0.5180.96
251_H257_L0.5180.96
126_P141_G0.5170.96
312_R316_F0.5170.96
316_F347_I0.5170.96
136_N140_I0.5160.96
376_A381_H0.5150.96
271_M274_S0.5150.96
178_T181_L0.5150.96
288_D370_T0.5140.96
330_E399_K0.5130.96
293_I358_P0.5130.96
36_L40_T0.5110.96
217_F220_F0.5080.96
341_E344_V0.5080.96
221_A236_L0.5080.96
350_A354_I0.5080.96
297_W329_D0.5070.95
291_K399_K0.5070.95
395_M400_H0.5050.95
308_E358_P0.5050.95
392_D395_M0.5050.95
130_I135_H0.5040.95
60_M63_S0.5030.95
176_T180_H0.5020.95
295_D302_G0.5000.95
198_D201_S0.5000.95
217_F224_F0.5000.95
195_V200_R0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjxA 1 0.4289 100 0.498 Contact Map
1w25A 2 0.8799 100 0.507 Contact Map
4j40A 2 0 100 0.508 Contact Map
3ezuA 2 0.7843 100 0.513 Contact Map
4rnhA 2 0.3775 100 0.517 Contact Map
3ignA 1 0.3946 100 0.529 Contact Map
4h54A 2 0.6324 100 0.53 Contact Map
3mtkA 2 0.3824 100 0.536 Contact Map
3i5cA 2 0.4583 100 0.54 Contact Map
3tvkA 1 0.3922 100 0.542 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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