GREMLIN Database
YDDG - Aromatic amino acid exporter YddG
UniProt: P46136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12713
Length: 293 (272)
Sequences: 35335 (26744)
Seq/√Len: 1621.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_A162_A3.3391.00
9_I235_V2.9721.00
94_E159_Y2.8041.00
235_V239_H2.7471.00
260_A266_A2.6961.00
85_Y161_L2.5441.00
82_S164_I2.4421.00
23_L221_S2.4031.00
125_G282_G2.3451.00
18_S255_L2.3241.00
235_V238_L2.2781.00
96_G256_S2.2661.00
25_R266_A2.2051.00
43_L223_A2.1051.00
24_I84_G2.0751.00
105_L166_A2.0581.00
109_F174_T2.0461.00
10_G236_G2.0141.00
213_T217_I1.9931.00
61_P64_Y1.9901.00
116_Q177_N1.9901.00
82_S161_L1.9771.00
111_I118_T1.8701.00
196_S200_Y1.8691.00
18_S259_L1.8521.00
110_A116_Q1.8321.00
64_Y182_G1.8021.00
223_A227_G1.7991.00
101_L105_L1.7481.00
15_V255_L1.7471.00
106_T246_A1.7461.00
90_H159_Y1.7351.00
107_I126_L1.7221.00
90_H158_S1.7051.00
212_S215_V1.7041.00
160_F164_I1.7031.00
119_N122_I1.6941.00
19_T221_S1.6611.00
89_H157_L1.6481.00
82_S168_I1.6221.00
186_I189_F1.5971.00
241_N244_I1.5961.00
129_A250_Y1.5781.00
31_L215_V1.5621.00
78_C168_I1.5461.00
269_S272_F1.5451.00
95_V162_A1.5271.00
105_L170_A1.5021.00
13_A236_G1.4911.00
284_L288_L1.4671.00
125_G286_C1.4431.00
85_Y89_H1.4251.00
190_V193_T1.4231.00
66_L70_L1.4191.00
110_A114_N1.4191.00
156_P159_Y1.4181.00
38_A199_V1.4161.00
63_G67_A1.4151.00
9_I232_A1.4101.00
176_T234_N1.4081.00
270_F274_Q1.3961.00
200_Y203_L1.3951.00
90_H94_E1.3791.00
255_L259_L1.3751.00
49_I188_V1.3731.00
27_V36_G1.3721.00
105_L167_F1.3531.00
46_L50_F1.3451.00
45_G192_L1.3411.00
109_F113_F1.3361.00
63_G66_L1.3331.00
121_L285_L1.3301.00
92_A260_A1.3301.00
47_L227_G1.3151.00
273_W277_L1.3121.00
30_G215_V1.3121.00
135_W278_M1.3041.00
277_L281_G1.3041.00
36_G222_A1.3011.00
55_P58_R1.2961.00
69_S72_F1.2931.00
67_A71_L1.2791.00
195_A199_V1.2691.00
259_L263_L1.2661.00
120_W124_P1.2651.00
22_G259_L1.2651.00
125_G285_L1.2631.00
123_V127_L1.2621.00
32_G35_G1.2581.00
62_K66_L1.2561.00
251_F255_L1.2551.00
127_L131_V1.2521.00
16_L224_F1.2481.00
93_I257_S1.2481.00
40_I226_L1.2451.00
213_T216_M1.2411.00
214_P217_I1.2371.00
85_Y88_T1.2351.00
62_K65_L1.2331.00
97_M276_A1.2321.00
190_V195_A1.2251.00
66_L69_S1.2221.00
170_A174_T1.2141.00
135_W271_S1.2041.00
68_G71_L1.2011.00
7_T248_G1.1901.00
129_A282_G1.1831.00
19_T259_L1.1751.00
26_G218_K1.1741.00
25_R29_E1.1731.00
67_A70_L1.1691.00
23_L218_K1.1671.00
217_I221_S1.1611.00
116_Q122_I1.1591.00
8_L12_I1.1451.00
13_A232_A1.1411.00
268_L273_W1.1381.00
156_P160_F1.1331.00
178_K181_R1.1331.00
89_H161_L1.1311.00
89_H158_S1.1241.00
132_G275_G1.1191.00
136_V275_G1.1191.00
118_T123_V1.1031.00
189_F193_T1.1021.00
98_V166_A1.1011.00
83_L87_A1.0981.00
38_A42_S1.0941.00
91_Q94_E1.0931.00
106_T242_V1.0891.00
237_I245_M1.0881.00
109_F171_A1.0851.00
196_S199_V1.0811.00
214_P218_K1.0771.00
201_Y205_P1.0771.00
17_W229_A1.0761.00
109_F170_A1.0751.00
13_A17_W1.0751.00
87_A95_V1.0691.00
89_H155_S1.0691.00
177_N241_N1.0521.00
90_H162_A1.0501.00
64_Y67_A1.0501.00
157_L161_L1.0481.00
109_F112_L1.0461.00
120_W123_V1.0421.00
24_I87_A1.0401.00
42_S195_A1.0401.00
30_G212_S1.0361.00
98_V162_A1.0341.00
111_I117_K1.0341.00
178_K182_G1.0281.00
67_A175_V1.0281.00
45_G195_A1.0271.00
92_A264_L1.0181.00
17_W233_W1.0161.00
12_I232_A1.0101.00
37_A84_G1.0021.00
191_L195_A1.0001.00
32_G205_P0.9981.00
33_P37_A0.9981.00
16_L232_A0.9921.00
109_F167_F0.9921.00
106_T173_C0.9911.00
217_I220_I0.9891.00
240_G245_M0.9811.00
53_G56_R0.9781.00
101_L133_V0.9721.00
241_N245_M0.9671.00
158_S162_A0.9641.00
208_E211_F0.9621.00
114_N174_T0.9601.00
220_I223_A0.9601.00
97_M134_C0.9581.00
22_G263_L0.9511.00
138_G269_S0.9501.00
193_T196_S0.9501.00
211_F216_M0.9481.00
193_T197_L0.9461.00
219_L223_A0.9421.00
157_L160_F0.9411.00
254_V276_A0.9341.00
177_N242_V0.9301.00
190_V201_Y0.9261.00
270_F273_W0.9251.00
92_A266_A0.9251.00
237_I241_N0.9241.00
166_A170_A0.9211.00
34_V81_L0.9151.00
194_G198_W0.9141.00
54_F58_R0.9131.00
132_G279_V0.9121.00
11_L255_L0.9111.00
119_N123_V0.9111.00
65_L68_G0.9081.00
121_L288_L0.9081.00
112_L115_G0.9061.00
177_N181_R0.9051.00
216_M220_I0.9001.00
106_T170_A0.8981.00
98_V159_Y0.8941.00
107_I118_T0.8941.00
54_F57_I0.8921.00
27_V215_V0.8771.00
257_S276_A0.8721.00
128_L282_G0.8701.00
131_V135_W0.8611.00
53_G57_I0.8601.00
193_T201_Y0.8581.00
64_Y68_G0.8531.00
257_S268_L0.8511.00
22_G260_A0.8481.00
186_I190_V0.8471.00
189_F195_A0.8361.00
14_I18_S0.8361.00
117_K121_L0.8341.00
14_I255_L0.8301.00
261_A268_L0.8291.00
134_C138_G0.8291.00
48_L227_G0.8291.00
14_I251_F0.8261.00
197_L200_Y0.8221.00
190_V205_P0.8221.00
39_A43_L0.8201.00
67_A179_Y0.8181.00
106_T174_T0.8181.00
190_V194_G0.8151.00
203_L206_Q0.8141.00
117_K120_W0.8141.00
199_V202_F0.8051.00
74_S168_I0.8051.00
240_G244_I0.8051.00
27_V218_K0.8021.00
75_Y172_Y0.8001.00
21_V83_L0.7961.00
42_S46_L0.7911.00
261_A267_P0.7831.00
169_W173_C0.7811.00
70_L175_V0.7801.00
224_F228_F0.7781.00
131_V278_M0.7771.00
155_S159_Y0.7771.00
104_S129_A0.7761.00
47_L50_F0.7761.00
207_P210_I0.7741.00
202_F205_P0.7721.00
69_S193_T0.7661.00
236_G245_M0.7631.00
201_Y204_T0.7621.00
56_R59_Q0.7611.00
22_G92_A0.7601.00
192_L196_S0.7581.00
107_I122_I0.7571.00
111_I115_G0.7551.00
192_L195_A0.7551.00
271_S274_Q0.7541.00
47_L223_A0.7531.00
135_W274_Q0.7521.00
228_F232_A0.7511.00
44_S191_L0.7441.00
65_L69_S0.7431.00
202_F206_Q0.7421.00
68_G72_F0.7411.00
10_G248_G0.7401.00
108_L112_L0.7391.00
218_K221_S0.7391.00
221_S224_F0.7381.00
77_I81_L0.7361.00
274_Q278_M0.7351.00
162_A166_A0.7341.00
133_V137_L0.7311.00
189_F192_L0.7311.00
81_L85_Y0.7301.00
212_S216_M0.7251.00
190_V197_L0.7231.00
45_G49_I0.7221.00
86_A158_S0.7221.00
16_L225_T0.7211.00
124_P128_L0.7191.00
76_E79_L0.7131.00
260_A264_L0.7101.00
251_F254_V0.7091.00
193_T200_Y0.7081.00
276_A280_C0.7061.00
38_A195_A0.7061.00
70_L73_V0.7031.00
90_H95_V0.7021.00
38_A202_F0.6981.00
210_I213_T0.6981.00
86_A95_V0.6951.00
116_Q243_T0.6871.00
105_L163_F0.6861.00
21_V96_G0.6861.00
45_G191_L0.6851.00
31_L36_G0.6811.00
172_Y234_N0.6791.00
153_T156_P0.6791.00
103_P250_Y0.6781.00
7_T244_I0.6741.00
171_A175_V0.6741.00
113_F171_A0.6711.00
64_Y183_F0.6701.00
281_G285_L0.6571.00
45_G188_V0.6561.00
199_V203_L0.6551.00
269_S273_W0.6541.00
70_L74_S0.6541.00
61_P66_L0.6541.00
197_L201_Y0.6541.00
282_G286_C0.6531.00
247_V286_C0.6521.00
31_L35_G0.6491.00
43_L47_L0.6481.00
161_L164_I0.6481.00
78_C82_S0.6461.00
43_L219_L0.6461.00
10_G240_G0.6451.00
39_A219_L0.6421.00
138_G141_N0.6391.00
231_A235_V0.6381.00
200_Y204_T0.6341.00
101_L104_S0.6321.00
118_T122_I0.6311.00
98_V163_F0.6311.00
64_Y70_L0.6301.00
35_G39_A0.6301.00
130_L250_Y0.6291.00
108_L126_L0.6271.00
107_I111_I0.6231.00
97_M137_L0.6211.00
268_L272_F0.6211.00
173_C233_W0.6181.00
169_W233_W0.6171.00
72_F75_Y0.6161.00
100_Y103_P0.6161.00
211_F215_V0.6141.00
61_P67_A0.6121.00
257_S261_A0.6101.00
69_S73_V0.6081.00
64_Y71_L0.6081.00
20_M225_T0.6071.00
191_L194_G0.6071.00
59_Q62_K0.6031.00
83_L95_V0.6001.00
67_A178_K0.5991.00
258_A261_A0.5971.00
132_G282_G0.5961.00
18_S252_T0.5961.00
58_R61_P0.5921.00
66_L71_L0.5911.00
259_L262_V0.5911.00
101_L166_A0.5891.00
215_V218_K0.5841.00
74_S171_A0.5831.00
20_M222_A0.5811.00
167_F171_A0.5801.00
128_L285_L0.5791.00
100_Y133_V0.5781.00
60_I65_L0.5751.00
189_F201_Y0.5751.00
173_C246_A0.5751.00
236_G240_G0.5691.00
122_I241_N0.5651.00
26_G264_L0.5601.00
283_S286_C0.5591.00
189_F197_L0.5591.00
46_L49_I0.5581.00
71_L74_S0.5561.00
195_A201_Y0.5561.00
135_W272_F0.5541.00
62_K68_G0.5531.00
172_Y176_T0.5531.00
272_F276_A0.5511.00
76_E80_A0.5511.00
153_T157_L0.5481.00
24_I28_S0.5481.00
137_L159_Y0.5471.00
57_I60_I0.5441.00
258_A262_V0.5441.00
71_L75_Y0.5411.00
34_V201_Y0.5401.00
16_L229_A0.5371.00
86_A90_H0.5371.00
209_M212_S0.5351.00
267_P271_S0.5351.00
106_T110_A0.5341.00
267_P272_F0.5331.00
44_S223_A0.5301.00
61_P65_L0.5301.00
100_Y166_A0.5301.00
50_F53_G0.5301.00
44_S227_G0.5301.00
262_V265_S0.5301.00
11_L14_I0.5301.00
26_G29_E0.5271.00
212_S217_I0.5241.00
10_G233_W0.5241.00
110_A243_T0.5201.00
187_T191_L0.5161.00
114_N177_N0.5161.00
16_L228_F0.5131.00
104_S126_L0.5131.00
72_F77_I0.5101.00
14_I252_T0.5061.00
82_S165_G0.5061.00
19_T225_T0.5041.00
83_L165_G0.5011.00
131_V134_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2628 98.9 0.751 Contact Map
3b5dA 2 0.3447 98.4 0.788 Contact Map
1pw4A 1 0.9659 20.1 0.936 Contact Map
2gfpA 2 0.959 15.1 0.94 Contact Map
3rkoJ 1 0.5427 11 0.943 Contact Map
3wdoA 1 0.9556 9.1 0.945 Contact Map
2cfqA 1 0.5904 7.9 0.947 Contact Map
4o9uB 2 0.256 7.7 0.947 Contact Map
4o93B 1 0.256 7.1 0.948 Contact Map
3j01B 1 0.1843 6.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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