GREMLIN Database
YBHC - Putative acyl-CoA thioester hydrolase YbhC
UniProt: P46130 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12875
Length: 427 (351)
Sequences: 1093 (674)
Seq/√Len: 36.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_D227_N5.0371.00
149_I213_L4.1251.00
201_F215_I3.4351.00
233_L247_I3.4071.00
216_E248_L3.3631.00
333_F359_I3.3111.00
212_N244_N3.2611.00
311_A341_A3.2471.00
81_D111_K3.2451.00
97_I149_I3.1711.00
56_Q59_F3.1541.00
256_V326_F3.1111.00
295_F298_T3.0291.00
210_L215_I2.8701.00
98_Q102_D2.7421.00
154_D190_S2.7211.00
117_V137_L2.6541.00
369_N372_K2.6431.00
56_Q61_S2.5311.00
310_E375_A2.4911.00
317_A356_Q2.4701.00
279_Y299_E2.4291.00
344_G374_W2.3741.00
341_A364_I2.3741.00
383_P386_G2.3521.00
363_A396_E2.2940.99
85_G89_T2.2800.99
287_V300_F2.2320.99
190_S227_N2.2040.99
94_H103_A2.1940.99
340_V369_N2.1860.99
328_A331_S2.1570.99
125_T153_L2.1460.99
154_D227_N2.1090.99
16_G26_P2.1050.99
150_G218_T2.1040.99
58_Y61_S2.1040.99
237_G240_V2.0760.99
95_T99_A2.0430.99
82_F113_Q2.0070.98
290_R322_I2.0040.98
293_V326_F1.9880.98
116_A140_T1.9670.98
104_A135_I1.9440.98
204_Q236_D1.9390.98
96_T99_A1.9110.98
154_D191_D1.8630.97
67_A70_N1.8450.97
14_A21_A1.8200.97
24_S318_T1.8130.97
242_I247_I1.8080.97
101_V126_V1.7790.97
82_F99_A1.7670.96
22_C29_Q1.7590.96
193_I198_S1.7340.96
228_H308_Q1.7260.96
66_A112_R1.7170.96
359_I364_I1.7080.96
341_A368_F1.7050.96
277_N297_N1.6780.95
357_V388_T1.6770.95
57_H61_S1.6580.95
233_L242_I1.6320.94
349_V384_F1.6160.94
105_I132_P1.6120.94
194_G198_S1.5840.94
214_T248_L1.5750.93
312_Y375_A1.5620.93
61_S66_A1.5600.93
252_N347_L1.5510.93
302_V313_V1.5340.92
128_V137_L1.5320.92
228_H306_R1.5310.92
195_V231_V1.5120.92
137_L201_F1.5100.92
153_L193_I1.5000.91
99_A102_D1.4830.91
384_F407_N1.4780.91
142_E279_Y1.4690.91
382_R386_G1.4380.90
26_P29_Q1.4340.90
83_V93_T1.4250.89
119_P146_D1.4240.89
333_F364_I1.4210.89
256_V293_V1.4150.89
22_C26_P1.4080.89
334_N365_N1.3770.88
143_K246_N1.3710.87
17_V29_Q1.3600.87
87_A90_Q1.3570.87
247_I253_T1.3490.86
53_F319_L1.3480.86
280_I300_F1.3430.86
51_Q54_D1.3410.86
414_N417_V1.3400.86
22_C25_T1.3390.86
238_D272_R1.3390.86
21_A26_P1.3250.85
59_F66_A1.3240.85
47_A53_F1.3220.85
333_F368_F1.2990.84
316_P326_F1.2970.84
349_V381_N1.2890.84
21_A290_R1.2870.84
418_G422_V1.2850.84
25_T29_Q1.2850.84
106_I131_A1.2830.83
86_P123_Q1.2830.83
50_A53_F1.2820.83
21_A25_T1.2800.83
300_F313_V1.2750.83
49_E53_F1.2690.83
235_T240_V1.2680.83
244_N277_N1.2580.82
17_V22_C1.2540.82
23_S26_P1.2500.82
246_N279_Y1.2450.82
361_D392_D1.2370.81
104_A132_P1.2350.81
228_H255_F1.2350.81
25_T28_D1.2330.81
17_V21_A1.2240.80
17_V26_P1.2230.80
297_N330_N1.2230.80
335_A367_G1.2130.80
117_V149_I1.2120.80
14_A323_Y1.2080.80
137_L213_L1.2070.80
236_D240_V1.2000.79
20_T26_P1.2000.79
101_V132_P1.1960.79
310_E340_V1.1820.78
16_G25_T1.1800.78
67_A71_P1.1780.78
196_L202_W1.1600.77
310_E376_D1.1590.77
214_T246_N1.1480.76
418_G421_V1.1460.76
24_S32_S1.1410.76
46_S50_A1.1400.75
106_I132_P1.1390.75
95_T420_K1.1350.75
246_N299_E1.1300.75
59_F62_L1.1300.75
19_L26_P1.1220.74
414_N418_G1.1210.74
226_G306_R1.1210.74
142_E246_N1.1170.74
413_N417_V1.1170.74
22_C52_N1.1170.74
417_V420_K1.1010.73
86_P96_T1.0990.73
190_S226_G1.0820.72
236_D258_N1.0810.71
287_V313_V1.0770.71
125_T152_S1.0590.70
302_V367_G1.0550.70
195_V288_S1.0540.69
14_A26_P1.0520.69
50_A54_D1.0450.69
247_I280_I1.0440.69
24_S28_D1.0390.68
130_A348_D1.0350.68
149_I201_F1.0320.68
38_G42_R1.0320.68
12_A28_D1.0280.68
280_I295_F1.0250.67
49_E54_D1.0250.67
292_A322_I1.0240.67
143_K146_D1.0190.67
17_V324_Y1.0190.67
195_V252_N1.0110.66
294_V325_G1.0090.66
202_W237_G1.0090.66
85_G90_Q1.0080.66
93_T103_A1.0050.66
381_N386_G1.0020.66
209_Q240_V1.0000.65
142_E244_N0.9920.65
79_Q82_F0.9790.64
342_Q369_N0.9780.64
412_Y417_V0.9700.63
14_A25_T0.9640.62
384_F412_Y0.9630.62
82_F93_T0.9620.62
314_F388_T0.9600.62
128_V203_S0.9600.62
110_N331_S0.9570.62
21_A322_I0.9570.62
55_A59_F0.9560.62
210_L242_I0.9550.62
26_P30_R0.9510.61
281_E301_R0.9360.60
133_G206_N0.9330.60
135_I205_N0.9300.60
12_A20_T0.9270.59
16_G20_T0.9240.59
46_S52_N0.9230.59
301_R336_F0.9190.59
17_V25_T0.9180.59
105_I109_T0.9170.59
235_T247_I0.9150.58
151_L218_T0.9130.58
119_P153_L0.9100.58
258_N323_Y0.9090.58
56_Q62_L0.9090.58
299_E332_R0.9080.58
18_T271_P0.8960.57
286_I302_V0.8940.57
62_L241_Q0.8880.56
12_A30_R0.8830.56
48_K52_N0.8820.56
201_F213_L0.8770.55
349_V382_R0.8720.55
117_V201_F0.8710.55
125_T151_L0.8700.55
47_A52_N0.8670.54
47_A54_D0.8670.54
231_V234_R0.8660.54
48_K54_D0.8650.54
370_T402_N0.8620.54
57_H66_A0.8610.54
277_N313_V0.8590.54
209_Q241_Q0.8590.54
355_G388_T0.8560.53
41_S50_A0.8550.53
292_A324_Y0.8460.52
387_N410_W0.8420.52
58_Y62_L0.8410.52
143_K248_L0.8380.52
300_F326_F0.8370.52
420_K423_A0.8350.52
256_V275_V0.8340.51
225_A250_R0.8270.51
194_G202_W0.8260.51
206_N239_Q0.8240.51
85_G88_G0.8220.50
93_T215_I0.8210.50
306_R309_Q0.8180.50
19_L23_S0.8140.50
194_G381_N0.8100.49
68_A72_S0.8090.49
382_R385_A0.8090.49
20_T27_P0.8050.49
48_K51_Q0.8050.49
56_Q60_A0.8030.49
121_E150_G0.8020.49
63_T66_A0.8000.48
293_V419_S0.7990.48
33_D37_P0.7980.48
68_A71_P0.7970.48
359_I362_S0.7960.48
300_F312_Y0.7950.48
21_A28_D0.7940.48
305_S309_Q0.7930.48
143_K214_T0.7930.48
290_R317_A0.7920.48
99_A103_A0.7880.47
107_K130_A0.7850.47
112_R209_Q0.7840.47
17_V23_S0.7830.47
16_G28_D0.7790.47
143_K216_E0.7770.46
44_I48_K0.7740.46
327_L423_A0.7730.46
123_Q150_G0.7720.46
277_N291_G0.7720.46
203_S301_R0.7700.46
105_I113_Q0.7680.46
113_Q235_T0.7680.46
59_F85_G0.7670.46
16_G22_C0.7640.45
195_V229_P0.7610.45
301_R334_N0.7600.45
252_N377_A0.7600.45
196_L321_N0.7580.45
121_E407_N0.7500.44
280_I287_V0.7480.44
326_F335_A0.7480.44
192_S227_N0.7480.44
59_F70_N0.7470.44
248_L281_E0.7420.43
240_V275_V0.7350.43
300_F331_S0.7330.43
372_K402_N0.7300.42
189_R284_V0.7280.42
15_F26_P0.7260.42
235_T242_I0.7260.42
415_R418_G0.7250.42
16_G29_Q0.7250.42
203_S236_D0.7240.42
127_Y331_S0.7230.42
154_D193_I0.7210.42
19_L30_R0.7180.41
18_T26_P0.7160.41
18_T333_F0.7130.41
17_V28_D0.7080.41
94_H135_I0.7080.41
228_H377_A0.7050.40
293_V327_L0.7050.40
14_A19_L0.7050.40
358_V389_G0.7020.40
300_F308_Q0.7000.40
125_T336_F0.6980.40
37_P42_R0.6960.40
304_N339_G0.6950.40
376_D379_I0.6900.39
132_P365_N0.6900.39
14_A17_V0.6890.39
205_N237_G0.6880.39
28_D31_P0.6870.39
252_N288_S0.6860.39
41_S54_D0.6850.39
65_G277_N0.6810.38
32_S37_P0.6800.38
79_Q95_T0.6790.38
16_G23_S0.6780.38
206_N237_G0.6780.38
290_R316_P0.6760.38
33_D36_A0.6760.38
290_R324_Y0.6760.38
302_V341_A0.6730.38
205_N290_R0.6720.38
418_G423_A0.6720.38
49_E52_N0.6700.37
20_T29_Q0.6700.37
284_V364_I0.6700.37
82_F405_N0.6700.37
14_A18_T0.6700.37
111_K121_E0.6690.37
405_N411_E0.6680.37
277_N327_L0.6660.37
16_G19_L0.6630.37
13_L35_T0.6610.37
40_S47_A0.6610.37
31_P39_T0.6570.36
211_Q244_N0.6570.36
281_E336_F0.6530.36
19_L22_C0.6530.36
284_V308_Q0.6530.36
356_Q386_G0.6520.36
196_L255_F0.6510.36
379_I382_R0.6510.36
142_E235_T0.6500.36
203_S278_S0.6480.36
21_A29_Q0.6470.36
104_A109_T0.6420.35
16_G21_A0.6420.35
21_A24_S0.6410.35
13_L410_W0.6390.35
123_Q152_S0.6380.35
304_N307_T0.6380.35
85_G118_M0.6380.35
242_I278_S0.6360.35
302_V311_A0.6350.35
399_R402_N0.6350.35
25_T30_R0.6340.35
362_S399_R0.6320.34
20_T25_T0.6320.34
111_K248_L0.6310.34
17_V20_T0.6290.34
246_N281_E0.6270.34
150_G216_E0.6260.34
15_F20_T0.6260.34
215_I247_I0.6250.34
199_A202_W0.6230.34
14_A292_A0.6230.34
326_F409_M0.6220.34
280_I367_G0.6210.34
288_S347_L0.6190.33
386_G409_M0.6190.33
135_I335_A0.6180.33
215_I245_V0.6160.33
359_I410_W0.6150.33
252_N286_I0.6120.33
65_G300_F0.6120.33
18_T23_S0.6110.33
300_F328_A0.6100.33
35_T52_N0.6090.33
19_L52_N0.6090.33
295_F326_F0.6090.33
132_P331_S0.6090.33
22_C258_N0.6080.33
281_E295_F0.6070.32
359_I374_W0.6050.32
331_S362_S0.6050.32
99_A407_N0.6050.32
117_V306_R0.6030.32
417_V421_V0.6020.32
12_A15_F0.6000.32
19_L35_T0.5990.32
254_F275_V0.5980.32
413_N418_G0.5980.32
229_P385_A0.5980.32
136_T209_Q0.5970.32
117_V358_V0.5960.32
197_C202_W0.5950.32
359_I375_A0.5950.32
123_Q216_E0.5950.32
271_P323_Y0.5930.31
255_F396_E0.5920.31
61_S85_G0.5910.31
101_V248_L0.5910.31
12_A34_Q0.5900.31
247_I278_S0.5880.31
360_R393_D0.5880.31
25_T32_S0.5870.31
338_D402_N0.5860.31
24_S31_P0.5860.31
389_G413_N0.5850.31
115_I135_I0.5840.31
198_S284_V0.5840.31
189_R193_I0.5830.31
328_A359_I0.5830.31
195_V255_F0.5820.31
272_R288_S0.5820.31
295_F394_N0.5780.30
76_L101_V0.5770.30
249_G409_M0.5770.30
40_S46_S0.5750.30
142_E214_T0.5740.30
316_P382_R0.5740.30
287_V333_F0.5730.30
45_L49_E0.5720.30
385_A388_T0.5720.30
12_A27_P0.5720.30
194_G197_C0.5700.30
15_F52_N0.5700.30
274_L296_D0.5690.30
364_I367_G0.5690.30
229_P347_L0.5680.30
104_A115_I0.5660.29
38_G300_F0.5660.29
101_V136_T0.5650.29
189_R198_S0.5650.29
251_Q345_R0.5650.29
314_F344_G0.5650.29
196_L295_F0.5650.29
45_L50_A0.5630.29
35_T40_S0.5600.29
13_L27_P0.5580.29
335_A341_A0.5560.29
251_Q347_L0.5530.28
23_S291_G0.5530.28
315_A345_R0.5520.28
350_D385_A0.5510.28
380_S405_N0.5510.28
126_V203_S0.5510.28
94_H271_P0.5490.28
21_A257_T0.5490.28
27_P128_V0.5490.28
276_T297_N0.5480.28
23_S210_L0.5470.28
45_L62_L0.5470.28
30_R33_D0.5460.28
379_I383_P0.5450.28
285_D345_R0.5430.28
235_T312_Y0.5420.28
12_A19_L0.5420.28
128_V143_K0.5420.28
366_E402_N0.5410.28
64_P99_A0.5410.28
227_N309_Q0.5410.28
43_P101_V0.5410.28
134_G212_N0.5390.28
355_G386_G0.5390.28
61_S70_N0.5390.28
23_S30_R0.5380.27
28_D32_S0.5380.27
356_Q387_N0.5370.27
240_V258_N0.5370.27
252_N388_T0.5360.27
86_P93_T0.5350.27
15_F23_S0.5350.27
14_A366_E0.5350.27
22_C28_D0.5340.27
141_G272_R0.5320.27
104_A411_E0.5320.27
20_T290_R0.5320.27
243_N246_N0.5320.27
65_G71_P0.5300.27
344_G404_T0.5280.27
93_T420_K0.5280.27
88_G390_S0.5280.27
239_Q402_N0.5280.27
342_Q387_N0.5270.27
211_Q243_N0.5270.27
34_Q39_T0.5270.27
333_F366_E0.5250.27
15_F32_S0.5250.27
15_F80_P0.5210.26
203_S208_L0.5210.26
104_A138_Y0.5200.26
45_L52_N0.5200.26
97_I125_T0.5200.26
271_P275_V0.5200.26
410_W417_V0.5200.26
277_N281_E0.5200.26
335_A409_M0.5180.26
119_P241_Q0.5170.26
48_K53_F0.5170.26
356_Q383_P0.5150.26
283_D309_Q0.5150.26
308_Q318_T0.5130.26
387_N417_V0.5120.26
333_F398_Q0.5120.26
50_A101_V0.5110.26
225_A310_E0.5110.26
137_L242_I0.5110.26
378_V383_P0.5110.26
142_E153_L0.5100.26
80_P138_Y0.5100.26
390_S393_D0.5090.25
372_K376_D0.5070.25
42_R48_K0.5060.25
104_A128_V0.5050.25
55_A64_P0.5040.25
55_A61_S0.5040.25
204_Q255_F0.5030.25
229_P377_A0.5030.25
58_Y67_A0.5030.25
23_S27_P0.5030.25
282_G289_G0.5020.25
34_Q40_S0.5010.25
121_E218_T0.5000.25
128_V207_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3grhA 1 0.8759 100 0.354 Contact Map
1gq8A 1 0.6885 100 0.355 Contact Map
1xg2A 1 0.6792 100 0.359 Contact Map
4pmhA 1 0.7869 100 0.381 Contact Map
2nspA 1 0.6885 100 0.416 Contact Map
5c1eA 1 0.6464 100 0.418 Contact Map
3uw0A 1 0.6534 100 0.434 Contact Map
1ru4A 1 0.6511 99.7 0.871 Contact Map
1dbgA 1 0.6042 99.5 0.891 Contact Map
2inuA 3 0.6815 98.9 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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