GREMLIN Database
YEDI - Inner membrane protein YedI
UniProt: P46125 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12709
Length: 305 (287)
Sequences: 1132 (733)
Seq/√Len: 43.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_A235_V7.6851.00
257_H260_E5.2301.00
94_M251_G4.5851.00
61_W65_K3.8971.00
171_L175_V3.6211.00
68_L72_V3.3241.00
248_V286_I3.2221.00
98_A290_V3.0321.00
6_S10_T2.9301.00
68_L183_L2.8731.00
91_P94_M2.8031.00
256_H260_E2.7981.00
223_I227_W2.6611.00
213_L217_L2.4061.00
253_A257_H2.3861.00
65_K69_I2.3821.00
109_L113_E2.3581.00
202_L217_L2.3411.00
105_V288_G2.2901.00
98_A286_I2.2861.00
172_L176_L2.2081.00
285_I289_I2.1881.00
136_P139_F2.1471.00
260_E264_G2.1331.00
246_G250_H2.1311.00
256_H259_I2.1280.99
62_G141_K2.1150.99
90_T251_G2.0940.99
5_G10_T2.0710.99
72_V179_S2.0460.99
181_I185_V1.9580.99
211_S215_Q1.9410.99
87_W91_P1.9210.99
212_A215_Q1.8970.99
184_V188_G1.8850.99
246_G279_N1.8760.99
279_N287_G1.8680.99
196_I232_L1.8520.99
68_L187_V1.8410.99
249_V259_I1.8280.98
115_R118_K1.8240.98
257_H261_H1.8070.98
92_L152_F1.7980.98
108_V284_F1.7970.98
270_V274_L1.7840.98
41_L192_L1.7810.98
281_I285_I1.7520.98
83_A174_Q1.7470.98
105_V284_F1.7440.98
290_V294_V1.7390.98
108_V112_L1.7260.98
166_V177_V1.7120.98
165_I177_V1.6930.97
209_K214_M1.6830.97
69_I145_K1.6470.97
75_V182_A1.6110.97
72_V183_L1.5920.96
216_A219_K1.5900.96
135_D138_K1.5740.96
220_G224_I1.5480.96
202_L206_L1.5190.95
277_V281_I1.5170.95
215_Q219_K1.5130.95
91_P251_G1.5100.95
176_L180_G1.5040.95
102_F106_E1.4890.95
199_I221_L1.4770.94
183_L187_V1.4770.94
204_Y222_L1.4760.94
292_L296_A1.4720.94
30_A181_I1.4660.94
82_S174_Q1.4600.94
199_I228_L1.4580.94
173_N177_V1.4510.94
211_S214_M1.4420.94
249_V282_L1.4290.93
51_V143_K1.4250.93
195_V202_L1.4220.93
23_S26_G1.4140.93
238_L280_L1.4120.93
205_W209_K1.3460.91
93_L161_I1.3320.90
217_L285_I1.2980.89
110_H295_K1.2890.89
92_L229_M1.2880.89
242_L280_L1.2820.89
188_G192_L1.2750.88
213_L216_A1.2560.88
288_G292_L1.2370.87
98_A101_C1.2280.86
214_M217_L1.2260.86
261_H264_G1.2220.86
83_A171_L1.2060.85
295_K298_E1.2050.85
194_G202_L1.2030.85
115_R119_E1.1970.85
94_M98_A1.1910.85
145_K149_R1.1740.84
7_S18_L1.1730.84
73_I77_L1.1670.84
109_L291_V1.1610.83
221_L227_W1.1500.83
179_S183_L1.1480.83
276_T279_N1.1390.82
204_Y208_E1.1370.82
79_L175_V1.1250.81
291_V294_V1.1160.81
26_G180_G1.1130.80
24_V28_L1.1080.80
89_I235_V1.1030.80
262_F265_Q1.0960.79
119_E122_A1.0930.79
8_L11_L1.0900.79
146_G156_A1.0860.79
57_L202_L1.0850.79
33_T37_L1.0810.79
49_S160_A1.0720.78
242_L276_T1.0690.78
46_Q237_T1.0630.77
75_V79_L1.0470.76
90_T248_V1.0290.75
61_W64_A1.0210.74
169_A174_Q1.0190.74
43_L47_Q1.0180.74
98_A105_V1.0180.74
293_G297_V1.0160.74
259_I263_A1.0120.74
80_I273_I1.0100.74
227_W231_A1.0070.73
89_I221_L1.0010.73
78_A206_L0.9970.73
69_I77_L0.9710.71
291_V295_K0.9700.71
63_V241_F0.9670.70
289_I293_G0.9660.70
260_E263_A0.9660.70
160_A164_G0.9640.70
30_A184_V0.9600.70
51_V232_L0.9500.69
102_F171_L0.9470.69
15_I18_L0.9440.68
143_K250_H0.9430.68
272_M276_T0.9420.68
101_C244_G0.9320.67
275_P279_N0.9290.67
110_H117_H0.9250.67
234_I237_T0.9230.67
284_F287_G0.9190.66
54_N57_L0.9130.66
209_K215_Q0.9130.66
31_K38_G0.9120.66
210_S215_Q0.9110.66
204_Y207_A0.9070.65
258_A262_F0.9070.65
240_M244_G0.8950.64
169_A173_N0.8940.64
141_K145_K0.8920.64
143_K246_G0.8900.64
112_L141_K0.8880.64
84_F99_F0.8840.63
110_H115_R0.8830.63
37_L225_A0.8830.63
252_I282_L0.8830.63
74_L143_K0.8770.63
199_I202_L0.8760.63
34_A188_G0.8740.62
43_L46_Q0.8740.62
59_V81_I0.8720.62
62_G144_I0.8650.62
108_V288_G0.8650.62
47_Q63_V0.8610.61
153_I294_V0.8590.61
202_L221_L0.8590.61
59_V148_I0.8530.60
267_S270_V0.8520.60
90_T94_M0.8480.60
138_K142_D0.8480.60
212_A216_A0.8440.60
177_V180_G0.8430.60
207_A219_K0.8280.58
266_Q270_V0.8250.58
259_I262_F0.8210.58
161_I165_I0.8180.57
17_T22_I0.8170.57
287_G294_V0.8140.57
99_F153_I0.8120.57
287_G291_V0.8060.56
111_M271_A0.8040.56
255_L278_L0.8030.56
162_T181_I0.8010.56
210_S214_M0.8010.56
217_L221_L0.8000.56
65_K182_A0.7960.55
152_F232_L0.7960.55
51_V148_I0.7960.55
109_L288_G0.7930.55
99_F298_E0.7920.55
294_V298_E0.7920.55
182_A221_L0.7910.55
77_L81_I0.7870.54
263_A271_A0.7850.54
162_T180_G0.7830.54
9_L237_T0.7800.54
238_L284_F0.7780.53
49_S233_S0.7770.53
110_H145_K0.7760.53
60_V64_A0.7750.53
46_Q49_S0.7720.53
64_A68_L0.7710.53
89_I196_I0.7700.53
152_F182_A0.7700.53
80_I84_F0.7670.52
109_L112_L0.7650.52
44_N47_Q0.7630.52
38_G45_A0.7620.52
160_A246_G0.7610.52
89_I250_H0.7580.52
256_H263_A0.7580.52
99_F152_F0.7560.51
111_M234_I0.7530.51
41_L45_A0.7520.51
278_L282_L0.7520.51
18_L54_N0.7500.51
207_A222_L0.7500.51
105_V108_V0.7500.51
95_I144_I0.7440.50
199_I224_I0.7400.50
27_K41_L0.7390.50
38_G166_V0.7390.50
142_D208_E0.7340.49
43_L63_V0.7340.49
95_I273_I0.7340.49
234_I238_L0.7310.49
28_L44_N0.7240.48
27_K38_G0.7230.48
17_T84_F0.7220.48
180_G184_V0.7200.48
7_S10_T0.7170.48
182_A207_A0.7160.48
242_L270_V0.7100.47
248_V251_G0.7080.47
74_L246_G0.7080.47
105_V280_L0.7070.47
219_K223_I0.7030.46
183_L289_I0.7020.46
269_V277_V0.7010.46
57_L60_V0.7010.46
29_A149_R0.7010.46
78_A163_L0.6990.46
81_I225_A0.6950.46
27_K45_A0.6910.45
87_W98_A0.6900.45
153_I290_V0.6900.45
173_N282_L0.6890.45
256_H264_G0.6890.45
272_M275_P0.6880.45
225_A228_L0.6870.45
45_A242_L0.6820.44
85_I91_P0.6790.44
132_A135_D0.6750.44
85_I88_A0.6740.44
148_I207_A0.6740.44
48_V51_V0.6740.44
199_I227_W0.6720.43
209_K224_I0.6700.43
7_S63_V0.6700.43
195_V199_I0.6690.43
164_G250_H0.6660.43
115_R291_V0.6650.43
89_I194_G0.6650.43
43_L241_F0.6620.42
184_V292_L0.6590.42
173_N176_L0.6590.42
73_I273_I0.6570.42
9_L224_I0.6560.42
177_V253_A0.6560.42
29_A177_V0.6530.42
63_V75_V0.6530.42
5_G25_M0.6510.41
162_T178_L0.6510.41
188_G202_L0.6500.41
134_Q137_L0.6490.41
38_G44_N0.6490.41
172_L175_V0.6480.41
10_T279_N0.6470.41
113_E117_H0.6470.41
214_M270_V0.6460.41
47_Q241_F0.6450.41
73_I132_A0.6440.41
231_A234_I0.6430.41
74_L250_H0.6430.41
143_K148_I0.6430.41
60_V68_L0.6410.41
82_S161_I0.6360.40
116_K122_A0.6340.40
59_V199_I0.6320.40
196_I241_F0.6320.40
24_V30_A0.6320.40
34_A229_M0.6310.40
78_A164_G0.6310.40
47_Q51_V0.6300.40
26_G42_S0.6280.39
284_F288_G0.6270.39
28_L249_V0.6260.39
41_L44_N0.6250.39
227_W230_K0.6250.39
99_F160_A0.6240.39
249_V278_L0.6240.39
170_P173_N0.6230.39
148_I152_F0.6220.39
28_L45_A0.6220.39
11_L14_D0.6160.38
74_L160_A0.6150.38
48_V101_C0.6130.38
28_L47_Q0.6130.38
160_A251_G0.6110.38
74_L89_I0.6090.38
89_I233_S0.6070.37
152_F196_I0.6060.37
202_L215_Q0.6060.37
256_H265_Q0.6060.37
68_L89_I0.6060.37
19_L23_S0.6060.37
196_I228_L0.6050.37
175_V179_S0.6050.37
187_V194_G0.6040.37
289_I296_A0.6030.37
16_A266_Q0.6020.37
242_L249_V0.6000.37
161_I179_S0.5970.37
265_Q293_G0.5970.37
83_A246_G0.5960.36
22_I188_G0.5960.36
249_V279_N0.5950.36
89_I143_K0.5950.36
280_L284_F0.5930.36
276_T280_L0.5920.36
141_K144_I0.5890.36
214_M222_L0.5890.36
27_K44_N0.5880.36
199_I225_A0.5880.36
262_F273_I0.5880.36
80_I269_V0.5880.36
238_L268_A0.5870.36
37_L59_V0.5850.36
242_L282_L0.5830.35
74_L276_T0.5810.35
165_I229_M0.5790.35
249_V252_I0.5740.35
282_L289_I0.5740.35
120_D289_I0.5740.35
246_G275_P0.5740.35
59_V229_M0.5730.34
11_L260_E0.5730.34
131_L137_L0.5720.34
280_L287_G0.5710.34
9_L51_V0.5690.34
174_Q253_A0.5680.34
166_V184_V0.5650.34
272_M281_I0.5640.34
9_L110_H0.5630.34
109_L180_G0.5630.34
176_L281_I0.5630.34
102_F271_A0.5610.33
108_V238_L0.5590.33
87_W251_G0.5580.33
80_I122_A0.5560.33
8_L12_L0.5550.33
267_S271_A0.5540.33
94_M101_C0.5530.33
162_T185_V0.5530.33
57_L94_M0.5530.33
131_L134_Q0.5520.33
31_K45_A0.5510.33
165_I174_Q0.5510.33
6_S9_L0.5510.33
59_V194_G0.5510.33
277_V297_V0.5490.32
22_I42_S0.5470.32
160_A279_N0.5470.32
202_L205_W0.5470.32
94_M248_V0.5440.32
89_I253_A0.5440.32
215_Q222_L0.5440.32
25_M199_I0.5420.32
247_I250_H0.5410.32
28_L38_G0.5400.32
27_K31_K0.5380.32
121_P168_E0.5370.31
99_F290_V0.5360.31
69_I142_D0.5360.31
260_E271_A0.5350.31
52_R204_Y0.5320.31
68_L179_S0.5310.31
224_I228_L0.5280.31
9_L60_V0.5280.31
38_G47_Q0.5280.31
262_F271_A0.5270.31
17_T143_K0.5240.30
90_T160_A0.5230.30
137_L141_K0.5230.30
44_N242_L0.5210.30
283_G287_G0.5200.30
117_H132_A0.5200.30
5_G53_A0.5200.30
146_G229_M0.5190.30
27_K33_T0.5190.30
292_L297_V0.5180.30
72_V75_V0.5170.30
19_L26_G0.5160.30
143_K152_F0.5160.30
29_A196_I0.5160.30
161_I267_S0.5160.30
81_I92_L0.5150.30
171_L244_G0.5150.30
74_L251_G0.5140.30
198_K229_M0.5120.29
29_A54_N0.5110.29
207_A215_Q0.5090.29
57_L68_L0.5060.29
33_T38_G0.5050.29
31_K41_L0.5050.29
110_H291_V0.5030.29
146_G233_S0.5030.29
59_V217_L0.5030.29
53_A69_I0.5020.29
162_T205_W0.5020.29
262_F269_V0.5010.29
160_A249_V0.5000.28
99_F249_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oarA 7 0.3311 12.5 0.979 Contact Map
3tx3A 2 0.2295 12.4 0.979 Contact Map
2kluA 1 0.1213 10.6 0.98 Contact Map
4c7rA 3 0.3738 9 0.981 Contact Map
3j2wE 1 0.1508 6.5 0.982 Contact Map
1mhmB 1 0.1639 5.8 0.982 Contact Map
3bz1X 1 0.0984 5.3 0.983 Contact Map
2m20A 2 0.1082 3.9 0.984 Contact Map
2l2tA 2 0.1246 3.8 0.984 Contact Map
2jwaA 2 0.1377 3.8 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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