GREMLIN Database
HEXR - HTH-type transcriptional regulator HexR
UniProt: P46118 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12860
Length: 289 (258)
Sequences: 9118 (6366)
Seq/√Len: 396.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_K176_G4.5091.00
207_A219_A3.7031.00
196_Q218_E2.9531.00
181_L195_A2.7261.00
124_L204_M2.7181.00
11_L23_E2.6951.00
133_F143_A2.6581.00
187_R214_P2.6421.00
129_K174_S2.4141.00
38_A57_S2.3971.00
121_A206_I2.3231.00
104_A108_H2.3071.00
199_R220_T2.2871.00
121_A221_L2.2711.00
195_A205_V2.2601.00
130_K156_P2.2481.00
60_T69_H2.2211.00
10_Q13_H2.1261.00
129_K177_D2.1131.00
28_S31_N2.0771.00
122_V253_G2.0551.00
146_A150_F2.0461.00
236_P239_S2.0371.00
179_V198_A2.0341.00
123_D257_R1.9731.00
197_L200_E1.9611.00
173_C203_A1.9551.00
103_M107_D1.9331.00
174_S177_D1.9141.00
23_E27_A1.8821.00
24_V28_S1.8391.00
182_I247_I1.8071.00
114_D117_A1.7931.00
130_K158_V1.7931.00
126_T257_R1.7901.00
204_M220_T1.7851.00
143_A182_I1.7581.00
178_V206_I1.7551.00
133_F146_A1.7471.00
195_A215_L1.7191.00
181_L191_L1.7191.00
124_L221_L1.7161.00
182_I208_L1.6951.00
128_A178_V1.6921.00
150_F254_F1.6411.00
198_A203_A1.6371.00
133_F180_V1.6201.00
18_E57_S1.5951.00
22_A54_F1.5771.00
204_M221_L1.5641.00
65_D68_L1.5641.00
40_M53_R1.5471.00
183_S215_L1.5331.00
35_S43_E1.5321.00
68_L71_A1.5121.00
123_D127_Q1.5071.00
160_S169_S1.5041.00
117_A120_R1.4981.00
223_I246_V1.4731.00
146_A247_I1.4621.00
142_V247_I1.4531.00
55_C66_F1.4441.00
207_A215_L1.4381.00
120_R221_L1.4241.00
179_V203_A1.4131.00
147_M158_V1.4131.00
21_V54_F1.4121.00
55_C73_S1.4081.00
253_G257_R1.4041.00
124_L178_V1.3831.00
207_A222_A1.3821.00
99_F106_L1.3741.00
11_L19_R1.3691.00
40_M56_R1.3691.00
205_V219_A1.3661.00
180_V208_L1.3661.00
40_M57_S1.3551.00
106_L245_T1.3541.00
109_V226_D1.3451.00
216_A222_A1.3401.00
258_R261_K1.3371.00
181_L205_V1.3361.00
126_T254_F1.3291.00
265_N268_R1.2911.00
134_F179_V1.2881.00
90_S93_S1.2871.00
130_K177_D1.2651.00
89_D97_K1.2641.00
121_A124_L1.2511.00
189_K193_E1.2441.00
67_K71_A1.2431.00
199_R218_E1.2351.00
51_V77_G1.2341.00
60_T63_F1.2161.00
126_T258_R1.2121.00
19_R23_E1.2091.00
125_L178_V1.2081.00
17_S20_K1.2051.00
58_M76_N1.2011.00
225_L243_Q1.1961.00
17_S50_T1.1801.00
193_E196_Q1.1801.00
181_L198_A1.1651.00
125_L128_A1.1511.00
256_L266_L1.1461.00
140_A144_H1.1311.00
144_H161_D1.1171.00
66_F70_L1.1121.00
37_I52_N1.1051.00
147_M157_V1.0861.00
105_T242_A1.0821.00
120_R124_L1.0811.00
149_K248_D1.0801.00
31_N43_E1.0681.00
61_R65_D1.0611.00
115_K119_N1.0591.00
150_F157_V1.0571.00
138_S236_P1.0561.00
133_F150_F1.0401.00
24_V44_A1.0361.00
253_G256_L1.0351.00
262_F265_N1.0261.00
252_T269_V1.0241.00
117_A221_L1.0221.00
177_D203_A1.0201.00
31_N35_S1.0181.00
146_A180_V1.0171.00
122_V257_R1.0111.00
173_C177_D1.0091.00
132_A177_D1.0061.00
150_F251_A1.0061.00
35_S39_A1.0001.00
127_Q204_M0.9951.00
11_L22_A0.9921.00
21_V44_A0.9821.00
69_H72_Q0.9811.00
14_L40_M0.9751.00
197_L201_N0.9741.00
37_I41_A0.9731.00
29_P33_I0.9681.00
265_N269_V0.9681.00
132_A173_C0.9671.00
141_A144_H0.9641.00
263_R267_K0.9611.00
63_F67_K0.9601.00
92_E96_G0.9471.00
96_G110_R0.9461.00
147_M151_F0.9341.00
72_Q75_A0.9341.00
216_A224_T0.9321.00
125_L254_F0.9311.00
125_L180_V0.9301.00
109_V225_L0.9271.00
20_K52_N0.9251.00
132_A158_V0.9211.00
131_I178_V0.9171.00
124_L127_Q0.9121.00
25_I66_F0.9091.00
173_C179_V0.9041.00
107_D111_H0.9041.00
96_G100_E0.9001.00
122_V126_T0.8971.00
120_R123_D0.8971.00
24_V43_E0.8951.00
52_N62_G0.8941.00
18_E66_F0.8911.00
24_V35_S0.8911.00
145_D149_K0.8901.00
83_R86_N0.8871.00
156_P160_S0.8871.00
196_Q200_E0.8821.00
192_V214_P0.8801.00
103_M106_L0.8771.00
123_D126_T0.8741.00
119_N257_R0.8741.00
59_D62_G0.8681.00
152_R170_C0.8611.00
104_A107_D0.8601.00
40_M63_F0.8591.00
264_D267_K0.8591.00
125_L131_I0.8591.00
198_A205_V0.8561.00
133_F147_M0.8551.00
68_L72_Q0.8501.00
121_A223_I0.8471.00
32_A70_L0.8431.00
147_M159_Y0.8391.00
167_R193_E0.8391.00
15_S18_E0.8381.00
140_A159_Y0.8371.00
108_H111_H0.8351.00
24_V31_N0.8341.00
140_A161_D0.8311.00
14_L56_R0.8281.00
142_V182_I0.8211.00
109_V242_A0.8171.00
145_D240_R0.8151.00
36_S39_A0.8131.00
10_Q14_L0.8121.00
116_S119_N0.8101.00
33_I36_S0.8091.00
208_L247_I0.8061.00
60_T66_F0.8021.00
209_T216_A0.8001.00
14_L57_S0.8001.00
117_A121_A0.7991.00
201_N268_R0.7961.00
38_A48_E0.7941.00
30_D34_H0.7911.00
211_A224_T0.7881.00
55_C62_G0.7851.00
20_K45_N0.7851.00
178_V204_M0.7851.00
130_K174_S0.7801.00
49_P52_N0.7781.00
221_L224_T0.7751.00
133_F157_V0.7741.00
55_C70_L0.7731.00
17_S56_R0.7721.00
95_T115_K0.7691.00
50_T53_R0.7631.00
192_V196_Q0.7621.00
40_M51_V0.7611.00
261_K266_L0.7601.00
183_S186_G0.7581.00
53_R57_S0.7581.00
128_A177_D0.7561.00
149_K251_A0.7531.00
164_V190_N0.7511.00
240_R243_Q0.7431.00
91_V100_E0.7421.00
34_H37_I0.7391.00
74_L77_G0.7371.00
124_L128_A0.7361.00
33_I71_A0.7361.00
69_H73_S0.7351.00
132_A179_V0.7341.00
131_I180_V0.7321.00
15_S57_S0.7311.00
129_K156_P0.7301.00
180_V206_I0.7281.00
264_D268_R0.7201.00
181_L194_L0.7201.00
127_Q176_G0.7201.00
259_G262_F0.7151.00
155_V258_R0.7081.00
92_E115_K0.7051.00
21_V51_V0.7041.00
119_N253_G0.7041.00
21_V50_T0.7041.00
65_D69_H0.6961.00
153_F251_A0.6931.00
237_M240_R0.6921.00
146_A149_K0.6911.00
121_A250_L0.6901.00
150_F250_L0.6891.00
102_A245_T0.6891.00
167_R197_L0.6860.99
176_G204_M0.6840.99
99_F245_T0.6800.99
252_T266_L0.6800.99
32_A35_S0.6790.99
225_L246_V0.6780.99
136_L188_T0.6750.99
39_A42_L0.6750.99
155_V159_Y0.6750.99
54_F58_M0.6740.99
144_H147_M0.6730.99
135_G139_S0.6710.99
93_S96_G0.6630.99
192_V215_L0.6620.99
195_A218_E0.6620.99
25_I54_F0.6540.99
187_R210_S0.6500.99
261_K265_N0.6440.99
263_R266_L0.6420.99
157_V160_S0.6420.99
251_A255_T0.6410.99
58_M72_Q0.6390.99
245_T248_D0.6390.99
151_F169_S0.6380.99
170_C201_N0.6360.99
256_L263_R0.6350.99
36_S41_A0.6350.99
64_P67_K0.6340.99
53_R56_R0.6330.99
142_V243_Q0.6270.99
108_H112_S0.6250.99
112_S226_D0.6230.99
142_V244_L0.6200.99
48_E52_N0.6140.99
136_L190_N0.6140.99
131_I155_V0.6130.99
213_T216_A0.6120.99
207_A213_T0.6110.99
225_L242_A0.6110.99
209_T222_A0.6110.99
242_A245_T0.6100.99
209_T213_T0.6100.99
135_G140_A0.6090.99
22_A26_L0.6090.99
102_A248_D0.6050.99
113_L118_I0.6050.99
94_Y97_K0.6030.99
240_R244_L0.6020.99
35_S40_M0.6000.99
103_M110_R0.6000.99
134_F194_L0.5990.99
109_V112_S0.5940.99
170_C197_L0.5910.98
192_V218_E0.5900.98
29_P32_A0.5900.98
12_E19_R0.5890.98
214_P218_E0.5840.98
20_K51_V0.5830.98
98_I102_A0.5790.98
25_I32_A0.5790.98
99_F102_A0.5780.98
155_V254_F0.5780.98
118_I249_V0.5780.98
100_E103_M0.5780.98
185_T188_T0.5770.98
73_S77_G0.5770.98
109_V246_V0.5750.98
181_L207_A0.5750.98
39_A43_E0.5750.98
133_F182_I0.5750.98
255_T266_L0.5740.98
193_E197_L0.5730.98
100_E107_D0.5680.98
171_M197_L0.5640.98
21_V46_V0.5640.98
31_N78_T0.5640.98
135_G190_N0.5620.98
132_A160_S0.5620.98
99_F249_V0.5600.98
206_I221_L0.5590.98
219_A222_A0.5590.98
20_K48_E0.5580.98
102_A241_L0.5560.98
43_E53_R0.5560.98
132_A170_C0.5540.98
118_I250_L0.5520.98
38_A42_L0.5480.98
58_M62_G0.5480.98
71_A75_A0.5480.98
175_D202_D0.5480.98
134_F181_L0.5480.98
70_L73_S0.5470.98
216_A219_A0.5460.97
91_V119_N0.5450.97
116_S120_R0.5450.97
118_I253_G0.5430.97
72_Q76_N0.5420.97
146_A251_A0.5400.97
144_H159_Y0.5390.97
44_A51_V0.5370.97
14_L22_A0.5350.97
259_G263_R0.5340.97
98_I245_T0.5330.97
258_R262_F0.5300.97
95_T249_V0.5280.97
131_I150_F0.5270.97
142_V225_L0.5270.97
199_R205_V0.5240.97
252_T255_T0.5230.97
128_A204_M0.5210.97
60_T65_D0.5200.97
114_D118_I0.5190.97
133_F247_I0.5170.97
108_H226_D0.5160.96
122_V125_L0.5160.96
122_V254_F0.5130.96
14_L53_R0.5120.96
260_A264_D0.5120.96
260_A263_R0.5110.96
262_F266_L0.5100.96
55_C60_T0.5100.96
183_S207_A0.5090.96
170_C173_C0.5080.96
93_S115_K0.5070.96
129_K175_D0.5060.96
170_C203_A0.5060.96
243_Q247_I0.5060.96
110_R245_T0.5060.96
18_E21_V0.5050.96
20_K46_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ivnA 2 0.91 100 0.213 Contact Map
3shoA 4 0.6401 100 0.558 Contact Map
2xhzA 4 0.5882 100 0.574 Contact Map
3fxaA 4 0.654 100 0.583 Contact Map
2pocA 4 0.6851 100 0.587 Contact Map
3etnA 4 0.6505 99.9 0.589 Contact Map
3tbfA 2 0.7024 99.9 0.596 Contact Map
1moqA 2 0.6955 99.9 0.597 Contact Map
1jeoA 4 0.5917 99.9 0.602 Contact Map
1m3sA 4 0.6125 99.9 0.602 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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