GREMLIN Database
DSDC - HTH-type transcriptional regulator DsdC
UniProt: P46068 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13161
Length: 311 (286)
Sequences: 79490 (57660)
Seq/√Len: 3409.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_S88_T3.7311.00
29_H38_E3.4121.00
25_V38_E2.6851.00
167_H304_R2.6131.00
81_A95_D2.6071.00
168_F281_Q2.4881.00
108_Y150_I2.3771.00
59_I74_E2.3381.00
24_E83_K2.3021.00
175_L256_K2.2411.00
171_D281_Q2.2291.00
104_T135_T2.2061.00
168_F171_D2.2001.00
24_E28_R2.1931.00
81_A88_T2.1591.00
22_T49_R2.1391.00
25_V29_H2.1381.00
182_Y198_C2.0431.00
104_T133_S2.0411.00
124_D302_W2.0161.00
245_A252_A2.0101.00
106_T135_T1.9951.00
173_E256_K1.9951.00
27_A71_L1.9621.00
171_D279_C1.9611.00
85_S89_L1.9341.00
191_T194_N1.9081.00
175_L270_A1.8991.00
79_Y83_K1.8821.00
25_V28_R1.8741.00
22_T46_V1.8681.00
246_M267_E1.8591.00
242_V262_R1.8521.00
28_R83_K1.8431.00
27_A79_Y1.8411.00
34_L37_E1.8331.00
24_E79_Y1.8171.00
246_M262_R1.8141.00
199_T232_G1.7741.00
166_H283_Y1.7491.00
81_A84_S1.7481.00
201_L250_G1.7331.00
77_R95_D1.7251.00
29_H34_L1.6851.00
63_V70_E1.6571.00
31_S34_L1.6331.00
144_N149_G1.6181.00
178_C271_P1.6141.00
167_H286_T1.5721.00
78_V92_E1.5651.00
19_K56_E1.5511.00
165_T288_L1.5341.00
24_E82_L1.5291.00
115_Q239_D1.5071.00
286_T300_I1.5041.00
81_A91_Q1.5041.00
65_S70_E1.4971.00
88_T91_Q1.4961.00
19_K52_Q1.4951.00
32_F50_I1.4881.00
128_R302_W1.4861.00
28_R38_E1.4791.00
42_S45_A1.4701.00
300_I304_R1.4661.00
165_T286_T1.4541.00
25_V39_L1.4431.00
19_K49_R1.4381.00
144_N150_I1.4371.00
155_Y285_I1.4301.00
60_Q63_V1.3871.00
106_T137_L1.3801.00
125_F132_I1.3771.00
80_W84_S1.3771.00
125_F299_F1.3751.00
85_S92_E1.3741.00
157_D283_Y1.3741.00
292_Q296_I1.3711.00
284_Y300_I1.3511.00
168_F283_Y1.3491.00
145_L153_A1.3451.00
33_A43_P1.3421.00
81_A92_E1.3371.00
16_Q19_K1.3361.00
243_I246_M1.3241.00
298_A301_I1.3211.00
23_F79_Y1.3151.00
213_T217_H1.3121.00
24_E86_L1.3021.00
17_L89_L1.3001.00
41_L45_A1.2991.00
102_S131_S1.2991.00
241_A252_A1.2981.00
172_E257_R1.2941.00
78_V93_I1.2911.00
73_H76_K1.2901.00
152_L284_Y1.2891.00
187_A194_N1.2881.00
124_D128_R1.2811.00
77_R81_A1.2731.00
123_G247_N1.2711.00
262_R267_E1.2701.00
48_H52_Q1.2621.00
22_T41_L1.2601.00
100_E131_S1.2471.00
126_T232_G1.2461.00
152_L296_I1.2341.00
178_C251_V1.2321.00
198_C251_V1.2311.00
214_D218_S1.2201.00
146_Q163_Q1.2191.00
77_R80_W1.2161.00
126_T199_T1.2081.00
84_S91_Q1.2001.00
123_G127_R1.1991.00
120_P247_N1.1961.00
270_A273_G1.1831.00
180_P267_E1.1821.00
256_K260_Q1.1801.00
76_K80_W1.1651.00
23_F27_A1.1641.00
183_A198_C1.1621.00
20_M82_L1.1611.00
180_P269_V1.1571.00
166_H285_I1.1491.00
48_H51_N1.1391.00
243_I247_N1.1371.00
188_L269_V1.1361.00
139_G144_N1.1301.00
167_H300_I1.1291.00
23_F62_F1.1271.00
256_K270_A1.1221.00
129_Y298_A1.1191.00
199_T230_S1.1131.00
25_V35_A1.1011.00
189_T274_D1.0981.00
85_S88_T1.0941.00
49_R52_Q1.0821.00
137_L144_N1.0781.00
242_V246_M1.0701.00
51_N55_E1.0691.00
214_D217_H1.0691.00
173_E279_C1.0671.00
302_W305_E1.0651.00
32_F69_V1.0571.00
56_E93_I1.0551.00
105_L299_F1.0491.00
135_T234_G1.0451.00
89_L93_I1.0441.00
93_I97_K1.0391.00
190_N194_N1.0381.00
179_S248_H1.0341.00
297_E301_I1.0261.00
201_L241_A1.0241.00
261_K265_S1.0241.00
202_H231_S1.0211.00
87_D91_Q1.0161.00
260_Q264_A1.0121.00
146_Q161_S1.0101.00
47_S51_N1.0051.00
114_A138_T1.0041.00
124_D127_R0.9891.00
301_I304_R0.9871.00
26_A35_A0.9821.00
121_A303_L0.9801.00
125_F302_W0.9791.00
78_V82_L0.9761.00
125_F129_Y0.9721.00
21_H90_N0.9691.00
220_A225_V0.9611.00
84_S87_D0.9591.00
74_E77_R0.9541.00
27_A62_F0.9481.00
35_A46_V0.9481.00
23_F61_L0.9451.00
52_Q55_E0.9411.00
18_S21_H0.9411.00
123_G249_I0.9401.00
71_L75_G0.9371.00
26_A32_F0.9351.00
30_Q70_E0.9341.00
165_T168_F0.9251.00
182_Y185_R0.9251.00
294_P298_A0.9181.00
177_V259_V0.9171.00
235_F241_A0.9151.00
176_P251_V0.9151.00
90_N93_I0.9141.00
34_L38_E0.9131.00
128_R305_E0.9131.00
192_V275_M0.9101.00
89_L92_E0.9061.00
177_V270_A0.8991.00
23_F53_L0.8981.00
121_A302_W0.8941.00
59_I96_I0.8881.00
144_N147_R0.8881.00
41_L46_V0.8861.00
91_Q95_D0.8851.00
293_W296_I0.8841.00
178_C182_Y0.8821.00
22_T39_L0.8771.00
33_A37_E0.8751.00
111_P237_R0.8721.00
88_T92_E0.8721.00
80_W83_K0.8711.00
21_H25_V0.8701.00
29_H35_A0.8671.00
18_S49_R0.8651.00
126_T249_I0.8631.00
65_S68_K0.8631.00
15_W56_E0.8621.00
157_D281_Q0.8621.00
23_F71_L0.8611.00
28_R79_Y0.8601.00
219_W223_Y0.8511.00
27_A30_Q0.8471.00
26_A62_F0.8441.00
235_F244_A0.8421.00
74_E96_I0.8421.00
262_R265_S0.8401.00
181_E248_H0.8401.00
76_K79_Y0.8381.00
184_Q198_C0.8371.00
62_F69_V0.8341.00
103_G295_K0.8341.00
21_H24_E0.8331.00
30_Q68_K0.8331.00
200_L229_T0.8301.00
287_T290_G0.8281.00
90_N94_L0.8271.00
92_E96_I0.8191.00
26_A50_I0.8151.00
183_A188_L0.8151.00
107_L152_L0.8141.00
292_Q297_E0.8141.00
263_L266_G0.8131.00
108_Y153_A0.8111.00
199_T231_S0.8071.00
244_A249_I0.8061.00
237_R240_L0.8001.00
193_I196_C0.7991.00
267_E270_A0.7991.00
218_S222_H0.7971.00
215_E218_S0.7921.00
43_P47_S0.7921.00
298_A302_W0.7901.00
26_A46_V0.7901.00
137_L150_I0.7901.00
215_E219_W0.7891.00
83_K87_D0.7851.00
39_L46_V0.7801.00
132_I295_K0.7791.00
182_Y186_H0.7771.00
173_E277_V0.7761.00
150_I153_A0.7761.00
82_L85_S0.7701.00
32_F46_V0.7671.00
109_S114_A0.7661.00
194_N197_H0.7581.00
178_C183_A0.7561.00
108_Y155_Y0.7541.00
17_L86_L0.7501.00
125_F298_A0.7501.00
133_S230_S0.7501.00
148_A287_T0.7471.00
115_Q243_I0.7431.00
51_N60_Q0.7421.00
71_L76_K0.7401.00
179_S249_I0.7371.00
73_H77_R0.7371.00
21_H86_L0.7371.00
23_F78_V0.7341.00
81_A85_S0.7331.00
164_L285_I0.7291.00
186_H199_T0.7271.00
204_R234_G0.7271.00
177_V254_G0.7261.00
23_F75_G0.7251.00
19_K22_T0.7241.00
63_V72_T0.7231.00
120_P123_G0.7231.00
179_S182_Y0.7211.00
219_W222_H0.7211.00
259_V262_R0.7171.00
151_D296_I0.7171.00
27_A75_G0.7131.00
101_L129_Y0.7101.00
30_Q76_K0.7081.00
146_Q164_L0.7071.00
185_R269_V0.7071.00
216_W219_W0.7071.00
152_L299_F0.7021.00
27_A76_K0.7011.00
191_T274_D0.7001.00
176_P253_M0.7001.00
128_R298_A0.6961.00
106_T151_D0.6951.00
178_C269_V0.6911.00
163_Q288_L0.6871.00
301_I305_E0.6851.00
266_G270_A0.6841.00
177_V252_A0.6831.00
37_E40_S0.6751.00
139_G143_V0.6731.00
255_R258_L0.6691.00
203_D241_A0.6681.00
220_A223_Y0.6651.00
45_A49_R0.6651.00
246_M265_S0.6641.00
74_E78_V0.6611.00
63_V68_K0.6591.00
181_E185_R0.6591.00
78_V96_I0.6581.00
18_S52_Q0.6581.00
216_W220_A0.6581.00
133_S234_G0.6561.00
86_L90_N0.6551.00
103_G132_I0.6531.00
200_L251_V0.6461.00
177_V263_L0.6411.00
156_F280_H0.6411.00
118_L121_A0.6411.00
70_E76_K0.6401.00
294_P297_E0.6371.00
290_G293_W0.6351.00
233_I244_A0.6341.00
106_T150_I0.6331.00
178_C184_Q0.6321.00
91_Q94_L0.6321.00
57_L78_V0.6291.00
204_R236_D0.6251.00
263_L270_A0.6191.00
218_S221_Q0.6151.00
212_G216_W0.6131.00
191_T275_M0.6121.00
213_T234_G0.6111.00
235_F240_L0.6091.00
213_T219_W0.6071.00
217_H221_Q0.6021.00
299_F303_L0.6001.00
196_C225_V0.6001.00
189_T272_F0.5991.00
145_L164_L0.5991.00
181_E184_Q0.5981.00
152_L300_I0.5971.00
119_V123_G0.5951.00
15_W93_I0.5931.00
105_L152_L0.5931.00
259_V263_L0.5921.00
54_E64_R0.5911.00
77_R96_I0.5911.00
173_E272_F0.5891.00
180_P266_G0.5881.00
26_A31_S0.5851.00
261_K264_A0.5831.00
138_T236_D0.5831.00
57_L60_Q0.5821.00
59_I63_V0.5791.00
18_S22_T0.5751.00
35_A39_L0.5741.00
146_Q149_G0.5721.00
123_G126_T0.5691.00
211_S214_D0.5691.00
145_L285_I0.5681.00
174_I253_M0.5681.00
87_D90_N0.5681.00
295_K298_A0.5671.00
176_P195_L0.5661.00
129_Y132_I0.5651.00
220_A229_T0.5641.00
32_F43_P0.5621.00
286_T297_E0.5621.00
94_L98_N0.5621.00
182_Y199_T0.5611.00
95_D98_N0.5601.00
120_P124_D0.5601.00
286_T292_Q0.5601.00
102_S133_S0.5591.00
117_W121_A0.5571.00
183_A186_H0.5551.00
62_F71_L0.5511.00
169_L284_Y0.5471.00
30_Q69_V0.5461.00
176_P200_L0.5461.00
182_Y251_V0.5451.00
183_A187_A0.5451.00
57_L96_I0.5451.00
60_Q74_E0.5441.00
197_H230_S0.5431.00
109_S118_L0.5431.00
16_Q56_E0.5431.00
45_A48_H0.5381.00
297_E300_I0.5361.00
239_D243_I0.5351.00
20_M78_V0.5341.00
157_D166_H0.5341.00
92_E95_D0.5341.00
111_P140_N0.5341.00
108_Y137_L0.5341.00
133_S232_G0.5311.00
254_G259_V0.5311.00
124_D305_E0.5311.00
296_I300_I0.5261.00
217_H220_A0.5261.00
184_Q190_N0.5241.00
44_S48_H0.5241.00
193_I225_V0.5241.00
103_G131_S0.5221.00
16_Q52_Q0.5211.00
241_A245_A0.5201.00
172_E280_H0.5191.00
154_I303_L0.5181.00
109_S136_V0.5171.00
101_L131_S0.5161.00
120_P243_I0.5161.00
44_S47_S0.5141.00
82_L86_L0.5141.00
41_L49_R0.5131.00
24_E90_N0.5111.00
110_R113_I0.5101.00
115_Q237_R0.5081.00
213_T216_W0.5081.00
50_I54_E0.5071.00
203_D238_S0.5071.00
98_N101_L0.5061.00
71_L79_Y0.5051.00
94_L97_K0.5051.00
218_S223_Y0.5001.00
212_G215_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7074 100 0.12 Contact Map
2esnA 3 0.9453 100 0.129 Contact Map
3szpA 3 0.926 100 0.138 Contact Map
3fzvA 4 0.9132 100 0.139 Contact Map
1ixcA 4 0.9293 100 0.14 Contact Map
4x6gA 4 0.9518 100 0.141 Contact Map
3fxqA 3 0.9293 100 0.141 Contact Map
1al3A 1 0.6624 100 0.146 Contact Map
2h98A 2 0.6559 100 0.151 Contact Map
2h9bA 2 0.6559 100 0.155 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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