GREMLIN Database
MTGA - Monofunctional biosynthetic peptidoglycan transglycosylase
UniProt: P46022 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12808
Length: 242 (226)
Sequences: 9449 (6554)
Seq/√Len: 435.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_K193_E4.1071.00
228_Y238_Q3.7631.00
175_E185_P3.6641.00
235_F239_H3.2581.00
234_P237_Q3.1221.00
76_M174_V2.7671.00
175_E186_A2.7331.00
74_P78_L2.6411.00
228_Y235_F2.6301.00
171_V180_R2.5401.00
98_S101_K2.4491.00
153_S156_R2.3781.00
74_P77_G2.3461.00
217_R221_A2.3291.00
69_M77_G2.3221.00
87_K95_D2.2811.00
105_H114_R2.1881.00
86_Q226_Q2.1631.00
69_M159_T2.1601.00
78_L232_G2.1371.00
89_P155_K2.1091.00
203_N206_R2.0631.00
83_A222_W2.0081.00
86_Q230_L1.9961.00
68_S71_Q1.9761.00
55_H59_R1.9521.00
80_V167_F1.9321.00
226_Q230_L1.9291.00
124_A148_I1.8841.00
152_W160_V1.8791.00
75_W194_A1.8731.00
80_V198_A1.8561.00
77_G155_K1.8061.00
91_H149_E1.8011.00
75_W78_L1.7761.00
191_R233_E1.7701.00
83_A226_Q1.7681.00
76_M194_A1.7521.00
73_S186_A1.7361.00
226_Q229_Q1.7161.00
101_K114_R1.7031.00
225_R238_Q1.7011.00
71_Q187_S1.6811.00
123_T160_V1.6401.00
82_A232_G1.6341.00
81_I89_P1.6331.00
69_M155_K1.6291.00
196_L216_V1.6011.00
185_P188_K1.5741.00
167_F174_V1.5521.00
87_K90_E1.5121.00
165_A201_L1.5041.00
212_P215_Y1.4891.00
80_V201_L1.4681.00
76_M80_V1.4631.00
224_L238_Q1.4531.00
79_A227_M1.4131.00
233_E238_Q1.3841.00
75_W191_R1.3401.00
109_N113_I1.3391.00
69_M72_I1.3041.00
82_A230_L1.2981.00
217_R220_Q1.2861.00
76_M162_L1.2681.00
95_D98_S1.2681.00
166_E170_G1.2601.00
225_R229_Q1.2471.00
156_R159_T1.2461.00
169_D208_K1.2361.00
120_S145_T1.2301.00
120_S149_E1.2181.00
106_N112_R1.2031.00
87_K97_A1.2031.00
100_E103_L1.1941.00
179_Q183_H1.1911.00
235_F238_Q1.1911.00
72_I77_G1.1751.00
79_A198_A1.1731.00
189_L194_A1.1711.00
29_G33_L1.1691.00
213_S217_R1.1671.00
87_K91_H1.1601.00
30_G34_F1.1591.00
228_Y233_E1.1551.00
77_G158_L1.1551.00
67_V186_A1.1461.00
175_E179_Q1.1451.00
124_A128_F1.1291.00
135_W139_G1.1271.00
147_G151_V1.1261.00
214_G218_S1.1251.00
72_I76_M1.1221.00
67_V72_I1.1171.00
103_L106_N1.1101.00
184_K188_K1.1091.00
206_R215_Y1.1081.00
225_R228_Y1.1041.00
215_Y218_S1.0971.00
162_L174_V1.0911.00
112_R135_W1.0911.00
99_I121_Q1.0901.00
136_V140_L1.0821.00
166_E172_F1.0751.00
68_S159_T1.0731.00
104_A108_R1.0641.00
85_D91_H1.0631.00
66_W159_T1.0471.00
77_G89_P1.0421.00
83_A202_P1.0401.00
94_F142_A1.0381.00
37_A40_P1.0341.00
179_Q185_P1.0341.00
100_E104_A1.0321.00
196_L220_Q1.0301.00
81_I158_L1.0261.00
192_S220_Q1.0241.00
112_R133_R1.0241.00
126_N165_A1.0151.00
18_R22_V1.0071.00
149_E157_I0.9951.00
149_E154_K0.9881.00
92_W96_V0.9881.00
186_A189_L0.9861.00
222_W226_Q0.9691.00
75_W237_Q0.9641.00
178_A189_L0.9611.00
73_S194_A0.9571.00
96_V100_E0.9511.00
129_L144_L0.9501.00
169_D180_R0.9461.00
105_H113_I0.9391.00
109_N112_R0.9351.00
98_S114_R0.9351.00
42_S45_M0.9351.00
126_N164_I0.9261.00
81_I232_G0.9251.00
67_V175_E0.9191.00
65_D179_Q0.9181.00
99_I142_A0.9121.00
94_F99_I0.9111.00
124_A144_L0.9051.00
31_I34_F0.8981.00
41_F44_V0.8911.00
69_M89_P0.8851.00
106_N135_W0.8841.00
96_V146_L0.8821.00
55_H58_F0.8821.00
78_L89_P0.8761.00
129_L137_R0.8651.00
96_V99_I0.8561.00
169_D210_S0.8531.00
125_K131_D0.8511.00
147_G150_T0.8501.00
196_L199_A0.8501.00
125_K137_R0.8491.00
202_P207_F0.8471.00
80_V174_V0.8461.00
106_N114_R0.8431.00
199_A216_V0.8401.00
106_N109_N0.8401.00
121_Q141_E0.8391.00
191_R224_L0.8381.00
233_E237_Q0.8331.00
40_P43_A0.8281.00
152_W156_R0.8281.00
102_A106_N0.8271.00
94_F146_L0.8211.00
116_A125_K0.8181.00
236_M239_H0.8051.00
28_G32_A0.8051.00
113_I133_R0.7931.00
167_F201_L0.7921.00
136_V139_G0.7921.00
14_R17_L0.7881.00
195_A224_L0.7871.00
127_L160_V0.7831.00
21_V25_V0.7821.00
80_V162_L0.7781.00
49_Q66_W0.7771.00
143_G147_G0.7741.00
132_G137_R0.7731.00
77_G81_I0.7691.00
35_S38_P0.7621.00
65_D175_E0.7611.00
86_Q229_Q0.7611.00
83_A219_R0.7601.00
32_A36_V0.7601.00
186_A194_A0.7521.00
203_N207_F0.7511.00
83_A223_I0.7491.00
80_V119_I0.7451.00
199_A223_I0.7371.00
31_I35_S0.7351.00
166_E171_V0.7291.00
105_H109_N0.7271.00
139_G143_G0.7261.00
92_W146_L0.7251.00
167_F177_A0.7241.00
22_V26_F0.7231.00
73_S76_M0.7231.00
192_S196_L0.7211.00
76_M189_L0.7191.00
214_G217_R0.7191.00
106_N116_A0.7151.00
30_G33_L0.7111.00
128_F144_L0.7071.00
119_I165_A0.7001.00
105_H108_R0.6981.00
29_G34_F0.6961.00
124_A127_L0.6921.00
99_I116_A0.6901.00
222_W225_R0.6891.00
108_R112_R0.6761.00
103_L107_E0.6741.00
202_P206_R0.6731.00
65_D176_A0.6731.00
69_M158_L0.6721.00
26_F30_G0.6701.00
198_A201_L0.6701.00
182_F196_L0.6691.00
51_S54_L0.6671.00
82_A227_M0.6671.00
156_R160_V0.6671.00
29_G32_A0.6621.00
196_L209_V0.6611.00
135_W142_A0.6581.00
38_P42_S0.6571.00
158_L162_L0.6500.99
27_W31_I0.6480.99
213_S216_V0.6410.99
220_Q224_L0.6400.99
47_E50_V0.6390.99
190_T194_A0.6350.99
123_T127_L0.6350.99
14_R18_R0.6290.99
174_V197_L0.6270.99
72_I174_V0.6260.99
97_A100_E0.6240.99
80_V165_A0.6230.99
202_P222_W0.6210.99
184_K190_T0.6210.99
167_F200_V0.6180.99
15_F18_R0.6180.99
121_Q125_K0.6180.99
144_L147_G0.6160.99
228_Y239_H0.6150.99
180_R210_S0.6120.99
94_F145_T0.6120.99
195_A220_Q0.6110.99
24_A28_G0.6090.99
49_Q52_A0.6080.99
63_H176_A0.6080.99
166_E205_L0.6070.99
208_K211_S0.6050.99
142_A146_L0.6030.99
46_V49_Q0.5980.99
16_L23_L0.5970.99
159_T163_N0.5960.99
21_V28_G0.5950.99
113_I116_A0.5950.99
83_A230_L0.5950.99
67_V174_V0.5940.99
50_V63_H0.5920.99
48_R62_A0.5910.99
191_R227_M0.5880.99
64_S164_I0.5880.99
178_A186_A0.5860.99
168_G181_Y0.5850.99
25_V29_G0.5780.99
35_S39_V0.5760.99
83_A198_A0.5730.99
18_R21_V0.5670.99
146_L150_T0.5670.99
131_D134_S0.5670.99
63_H180_R0.5660.99
167_F202_P0.5650.99
30_G38_P0.5650.99
72_I162_L0.5640.99
99_I103_L0.5630.98
51_S64_S0.5630.98
194_A201_L0.5620.98
207_F215_Y0.5600.98
83_A201_L0.5600.98
200_V216_V0.5600.98
177_A181_Y0.5600.98
137_R141_E0.5590.98
92_W150_T0.5580.98
95_D116_A0.5570.98
16_L19_L0.5540.98
166_E204_P0.5520.98
54_L58_F0.5490.98
70_D155_K0.5480.98
75_W79_A0.5440.98
20_M26_F0.5440.98
140_L143_G0.5410.98
121_Q129_L0.5390.98
67_V71_Q0.5380.98
178_A184_K0.5380.98
174_V186_A0.5380.98
16_L20_M0.5380.98
76_M186_A0.5370.98
106_N111_N0.5360.98
20_M23_L0.5360.98
196_L200_V0.5340.98
106_N142_A0.5320.98
177_A197_L0.5320.98
130_W144_L0.5310.98
17_L26_F0.5310.98
105_H112_R0.5310.98
134_S137_R0.5280.98
166_E169_D0.5270.98
227_M233_E0.5260.98
36_V39_V0.5250.98
200_V207_F0.5250.98
167_F181_Y0.5240.98
202_P223_I0.5230.98
189_L197_L0.5220.98
148_I157_I0.5210.98
105_H111_N0.5200.97
18_R25_V0.5200.97
83_A199_A0.5200.97
167_F197_L0.5190.97
38_P41_F0.5180.97
17_L24_A0.5180.97
234_P238_Q0.5160.97
181_Y200_V0.5160.97
82_A223_I0.5120.97
89_P158_L0.5090.97
228_Y234_P0.5080.97
216_V220_Q0.5070.97
37_A42_S0.5050.97
47_E164_I0.5040.97
218_S222_W0.5040.97
202_P219_R0.5030.97
41_F45_M0.5020.97
228_Y231_G0.5010.97
24_A30_G0.5010.97
28_G34_F0.5010.97
121_Q142_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jchA 1 0.0413 100 0.09 Contact Map
4oonA 1 0.0537 100 0.096 Contact Map
3vmtA 1 0.8678 100 0.123 Contact Map
3vmaA 1 0.843 100 0.13 Contact Map
3udfA 2 0.5496 100 0.135 Contact Map
2olvA 1 0.7934 100 0.15 Contact Map
2oqoA 2 0.7273 100 0.154 Contact Map
3hzsA 3 0.8182 100 0.183 Contact Map
3zg9B 1 0.3678 100 0.572 Contact Map
3zg9A 1 0.1488 98.3 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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