GREMLIN Database
CAS2 - CRISPR-associated endoribonuclease Cas2
UniProt: P45956 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12845
Length: 94 (87)
Sequences: 364 (201)
Seq/√Len: 21.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_V57_V2.8230.99
47_I56_V2.6830.99
26_V70_F2.5010.98
34_D67_G2.0700.94
18_R46_Q2.0460.93
7_V31_Y2.0070.93
14_R78_R1.9670.92
10_N28_A1.9050.90
62_T69_E1.8960.90
41_E71_Q1.8560.89
23_L35_V1.8480.89
18_R21_I1.7960.88
6_V47_I1.7870.87
32_V59_A1.7870.87
15_L26_V1.7640.87
68_F78_R1.6650.83
21_I39_I1.6470.82
69_E87_R1.6260.82
4_L23_L1.6030.81
45_E49_G1.5950.80
48_A73_F1.5920.80
14_R31_Y1.5880.80
64_T67_G1.5220.77
11_V78_R1.4770.75
43_I60_W1.4600.74
41_E61_A1.4340.73
7_V30_V1.4230.72
39_I68_F1.3530.68
7_V27_R1.3460.68
34_D72_T1.3450.68
3_M22_W1.2350.61
21_I43_I1.2150.59
80_P89_V1.1830.57
9_E55_N1.1750.57
6_V71_Q1.1520.55
21_I66_T1.1500.55
18_R26_V1.0730.50
43_I65_E1.0670.50
25_E29_G1.0240.47
46_Q70_F1.0200.46
18_R74_G1.0060.46
39_I65_E0.9740.43
67_G72_T0.9550.42
28_A55_N0.9540.42
22_W56_V0.9330.41
13_P31_Y0.9140.39
11_V58_M0.9130.39
28_A35_V0.9090.39
9_E38_K0.9070.39
14_R27_R0.9020.39
8_T56_V0.8990.39
60_W69_E0.8910.38
15_L19_L0.8820.37
45_E48_A0.8760.37
31_Y35_V0.8670.37
55_N78_R0.8650.36
66_T87_R0.8590.36
71_Q84_D0.8540.36
13_P74_G0.8540.36
38_K80_P0.8510.36
11_V14_R0.8450.35
36_S84_D0.8410.35
15_L67_G0.8330.34
44_W58_M0.8320.34
79_T90_S0.8300.34
12_P15_L0.8270.34
63_N67_G0.8220.34
53_E62_T0.8220.34
67_G90_S0.8190.34
45_E71_Q0.8030.33
84_D90_S0.7980.32
27_R55_N0.7950.32
14_R18_R0.7910.32
7_V14_R0.7840.32
51_A56_V0.7790.31
64_T89_V0.7790.31
21_I65_E0.7760.31
36_S86_L0.7730.31
66_T86_L0.7610.30
22_W33_G0.7590.30
24_L68_F0.7480.29
49_G68_F0.7480.29
8_T51_A0.7460.29
35_V47_I0.7420.29
6_V72_T0.7410.29
81_V90_S0.7380.29
41_E74_G0.7250.28
59_A66_T0.7230.28
71_Q81_V0.7090.27
26_V86_L0.6970.27
36_S66_T0.6900.26
78_R89_V0.6820.26
13_P28_A0.6770.26
31_Y45_E0.6750.26
43_I84_D0.6740.25
69_E82_D0.6660.25
24_L89_V0.6490.24
20_A87_R0.6480.24
46_Q72_T0.6440.24
57_V75_L0.6410.24
21_I82_D0.6400.24
55_N66_T0.6390.24
9_E59_A0.6390.24
76_N79_T0.6360.24
42_M73_F0.6160.23
41_E79_T0.6140.23
51_A73_F0.6100.22
23_L89_V0.6030.22
8_T11_V0.5990.22
62_T67_G0.5960.22
4_L35_V0.5940.22
32_V48_A0.5930.22
52_E73_F0.5840.21
22_W54_G0.5820.21
62_T65_E0.5810.21
20_A27_R0.5780.21
72_T88_L0.5630.20
19_L31_Y0.5570.20
41_E76_N0.5490.20
80_P87_R0.5470.20
7_V72_T0.5410.19
27_R76_N0.5360.19
27_R78_R0.5350.19
18_R42_M0.5350.19
47_I50_L0.5340.19
68_F90_S0.5320.19
48_A53_E0.5290.19
55_N68_F0.5260.19
45_E52_E0.5080.18
6_V41_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4makA 2 0.8085 100 0.097 Contact Map
4es1A 2 0.8723 58.2 0.913 Contact Map
1zpwX 2 0.7979 57.4 0.913 Contact Map
3oq2A 3 0.9255 55.8 0.914 Contact Map
4qr2A 2 0.766 48.7 0.918 Contact Map
2r0bA 1 0.7021 22.9 0.931 Contact Map
2ivyA 2 0.7979 21.4 0.932 Contact Map
4tnoA 2 0.8404 16.1 0.936 Contact Map
3excX 2 0.7553 11.8 0.939 Contact Map
1udgA 1 0.9043 8.3 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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