GREMLIN Database
IGAA - Putative membrane protein IgaA homolog
UniProt: P45800 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12927
Length: 711 (693)
Sequences: 105 (73)
Seq/√Len: 2.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
412_W418_S4.9970.85
390_V628_V4.9390.85
111_Y217_F4.0930.71
491_V598_L3.8070.65
100_I471_S3.4340.56
100_I467_R3.2670.52
406_I628_V3.2110.51
195_Y627_I3.0140.46
100_I412_W3.0120.46
329_V580_I2.9910.46
111_Y347_S2.9630.45
257_I317_V2.9610.45
265_R470_A2.9130.44
215_M582_S2.8460.42
568_Q599_Y2.7890.41
326_H490_I2.7120.39
9_A13_A2.7020.39
210_V346_G2.6760.38
231_A361_D2.6430.37
25_R28_R2.6050.37
308_I419_P2.5610.36
367_T618_M2.5570.36
217_F347_S2.5380.35
9_A111_Y2.5340.35
362_M405_N2.5290.35
101_S398_I2.5190.35
55_N347_S2.4950.34
257_I304_Q2.4740.34
241_G274_D2.4500.33
366_F469_S2.3990.32
41_Q454_V2.3860.32
330_K648_D2.3790.32
117_V372_K2.3370.31
362_M676_A2.3320.31
129_D408_T2.3220.31
70_T77_I2.2940.30
99_G147_L2.2790.30
376_T659_T2.2680.29
437_P573_P2.2480.29
431_N510_A2.2470.29
340_S445_N2.2460.29
407_R429_I2.2270.29
431_N573_P2.2230.29
429_I574_A2.2190.28
123_W578_F2.1850.28
442_E684_R2.1780.28
442_E519_D2.1550.27
245_L342_I2.1550.27
6_I115_V2.1240.27
336_H667_G2.0500.25
189_K517_S2.0350.25
357_W362_M2.0240.25
50_R580_I2.0210.25
241_G671_Y1.9990.24
510_A550_L1.9920.24
117_V209_I1.9900.24
339_R488_G1.9690.24
197_L266_R1.9580.24
11_L495_A1.9510.23
308_I490_I1.9390.23
348_L597_S1.9250.23
489_D639_Q1.9030.23
267_W697_C1.9000.23
139_D444_V1.8880.22
376_T524_V1.8770.22
209_I679_R1.8630.22
53_V121_P1.8620.22
44_K317_V1.8610.22
491_V563_T1.8590.22
332_F337_W1.8560.22
316_V430_W1.8200.21
72_A77_I1.8180.21
316_V622_F1.8120.21
282_S420_F1.8020.21
4_I26_S1.7870.21
15_S25_R1.7870.21
459_H548_D1.7730.21
437_P572_S1.7690.20
102_T155_Y1.7600.20
431_N572_S1.7590.20
73_S605_E1.7550.20
101_S128_N1.7510.20
7_F16_L1.7500.20
289_V386_A1.7360.20
26_S36_A1.7340.20
377_I667_G1.7240.20
101_S357_W1.7210.20
386_A645_P1.7180.20
282_S490_I1.7110.20
27_R133_V1.7100.20
429_I610_F1.6990.19
43_R49_E1.6910.19
90_M151_T1.6850.19
444_V618_M1.6850.19
420_F584_E1.6780.19
217_F397_R1.6740.19
309_D490_I1.6690.19
240_A627_I1.6620.19
192_H390_V1.6580.19
407_R610_F1.6570.19
9_A548_D1.6510.19
527_A532_L1.6480.19
340_S398_I1.6470.19
316_V333_P1.6460.19
261_R679_R1.6290.18
271_G426_S1.6190.18
11_L18_A1.6080.18
266_R697_C1.6060.18
31_L117_V1.6060.18
100_I469_S1.6050.18
94_A470_A1.6050.18
431_N571_N1.5990.18
100_I273_N1.5910.18
303_G332_F1.5860.18
74_A701_Q1.5850.18
112_L475_A1.5830.18
15_S20_W1.5810.18
366_F559_I1.5780.18
657_S677_W1.5590.17
341_T364_L1.5580.17
151_T219_C1.5560.17
357_W405_N1.5500.17
8_L16_L1.5410.17
384_Q678_R1.5380.17
98_Y332_F1.5340.17
212_S489_D1.5310.17
342_I417_N1.5230.17
70_T73_S1.5220.17
339_R602_P1.5180.17
444_V669_A1.5040.17
153_Q398_I1.5000.17
210_V227_V1.4990.17
430_W622_F1.4940.16
19_G125_Q1.4900.16
265_R697_C1.4890.16
338_L533_D1.4820.16
219_C681_Q1.4730.16
505_V700_P1.4690.16
406_I614_A1.4620.16
510_A571_N1.4530.16
298_I642_G1.4500.16
122_F140_S1.4360.16
54_E648_D1.4350.16
212_S641_I1.4340.16
47_P70_T1.4190.15
182_I595_S1.4160.15
73_S102_T1.4120.15
347_S392_V1.4120.15
273_N366_F1.4060.15
91_L353_M1.3960.15
12_L19_G1.3900.15
330_K334_L1.3900.15
46_T257_I1.3890.15
185_L519_D1.3820.15
71_G115_V1.3810.15
48_E399_S1.3740.15
476_I562_E1.3730.15
108_W573_P1.3710.15
14_C19_G1.3680.15
70_T619_H1.3650.15
142_P311_Y1.3630.15
98_Y123_W1.3620.15
507_L634_D1.3620.15
231_A347_S1.3590.15
367_T444_V1.3570.15
83_A86_N1.3560.15
501_K663_L1.3550.15
112_L130_E1.3430.15
112_L209_I1.3350.14
216_F618_M1.3340.14
210_V615_Q1.3330.14
399_S580_I1.3300.14
333_P430_W1.3280.14
333_P622_F1.3250.14
10_A20_W1.3230.14
581_V656_L1.3180.14
341_T535_V1.3160.14
37_F569_S1.3140.14
32_P36_A1.3110.14
214_L579_L1.3070.14
364_L432_D1.3070.14
35_N347_S1.3040.14
437_P571_N1.3040.14
293_H354_L1.3030.14
50_R260_L1.3020.14
74_A126_Y1.2980.14
158_E182_I1.2980.14
247_A369_S1.2970.14
204_R561_H1.2950.14
336_H451_T1.2920.14
341_T469_S1.2880.14
313_D610_F1.2870.14
228_P645_P1.2830.14
8_L168_P1.2820.14
387_D628_V1.2800.14
510_A573_P1.2790.14
436_L573_P1.2750.14
252_S666_L1.2690.14
144_V173_S1.2680.14
286_I368_L1.2680.14
100_I366_F1.2640.14
507_L607_W1.2630.14
289_V455_N1.2610.14
352_F371_M1.2600.14
301_D449_A1.2560.14
471_S559_I1.2550.14
94_A286_I1.2520.13
227_V674_V1.2510.13
193_E330_K1.2490.13
128_N471_S1.2460.13
437_P440_E1.2450.13
340_S379_A1.2440.13
42_T242_L1.2420.13
519_D614_A1.2410.13
84_E200_P1.2370.13
216_F367_T1.2350.13
358_I546_S1.2320.13
113_D246_F1.2310.13
292_A684_R1.2300.13
15_S130_E1.2250.13
248_P605_E1.2170.13
443_L462_P1.2160.13
590_D595_S1.2150.13
31_L496_D1.2140.13
76_P339_R1.2140.13
249_P254_L1.2120.13
443_L666_L1.2100.13
628_V692_A1.2100.13
129_D456_R1.2100.13
431_N555_T1.2060.13
190_E393_G1.2030.13
154_E192_H1.2020.13
226_F391_R1.1990.13
182_I448_T1.1980.13
17_L412_W1.1980.13
374_A395_T1.1950.13
154_E376_T1.1930.13
295_Q653_W1.1930.13
257_I597_S1.1900.13
415_K604_Q1.1890.13
120_P637_G1.1880.13
472_L480_G1.1850.13
671_Y675_Q1.1840.13
35_N531_K1.1830.13
257_I391_R1.1820.13
22_I91_L1.1810.13
16_L210_V1.1700.13
340_S367_T1.1680.13
514_L520_W1.1660.13
175_R256_E1.1650.13
276_E556_A1.1650.13
267_W538_L1.1640.13
406_I587_D1.1630.13
453_A500_A1.1600.12
220_L293_H1.1580.12
431_N459_H1.1530.12
481_M540_R1.1520.12
460_P542_V1.1510.12
478_K537_V1.1470.12
7_F10_A1.1430.12
332_F624_A1.1420.12
369_S656_L1.1410.12
108_W431_N1.1400.12
346_G377_I1.1400.12
369_S646_I1.1400.12
267_W470_A1.1390.12
485_D538_L1.1390.12
8_L46_T1.1390.12
123_W337_W1.1370.12
443_L603_P1.1370.12
31_L304_Q1.1350.12
21_L667_G1.1330.12
510_A555_T1.1310.12
340_S672_N1.1300.12
453_A489_D1.1260.12
128_N398_I1.1210.12
675_Q683_H1.1200.12
50_R275_Q1.1160.12
151_T677_W1.1160.12
91_L563_T1.1160.12
99_G337_W1.1150.12
324_S626_G1.1130.12
20_W23_K1.1130.12
416_T442_E1.1120.12
72_A75_A1.1110.12
230_L675_Q1.1080.12
308_I444_V1.1070.12
384_Q474_S1.0950.12
21_L33_W1.0950.12
12_L614_A1.0920.12
519_D538_L1.0900.12
74_A667_G1.0890.12
257_I697_C1.0880.12
210_V675_Q1.0870.12
129_D216_F1.0870.12
346_G668_S1.0860.12
11_L83_A1.0860.12
117_V317_V1.0850.12
192_H603_P1.0820.12
445_N467_R1.0820.12
43_R144_V1.0800.12
487_F540_R1.0790.12
21_L28_R1.0770.12
405_N408_T1.0760.12
273_N559_I1.0760.12
44_K81_L1.0750.12
531_K554_S1.0740.12
364_L580_I1.0720.12
472_L494_T1.0720.12
570_L624_A1.0720.12
334_L578_F1.0700.12
227_V341_T1.0700.12
121_P179_S1.0700.12
618_M628_V1.0690.12
135_L206_A1.0680.12
48_E252_S1.0670.12
339_R546_S1.0670.12
295_Q337_W1.0610.11
59_S657_S1.0600.11
260_L364_L1.0590.11
170_T208_L1.0590.11
590_D687_M1.0590.11
189_K609_A1.0580.11
340_S366_F1.0570.11
39_D213_F1.0560.11
524_V659_T1.0550.11
398_I488_G1.0550.11
286_I677_W1.0540.11
89_M654_R1.0520.11
462_P628_V1.0500.11
37_F679_R1.0490.11
89_M503_D1.0480.11
310_I609_A1.0450.11
71_G372_K1.0450.11
187_I612_K1.0430.11
260_L580_I1.0420.11
519_D550_L1.0400.11
480_G494_T1.0380.11
189_K256_E1.0350.11
26_S90_M1.0340.11
470_A679_R1.0310.11
62_Q464_D1.0300.11
245_L501_K1.0280.11
357_W684_R1.0220.11
354_L684_R1.0210.11
104_D298_I1.0210.11
361_D698_L1.0210.11
369_S444_V1.0200.11
338_L519_D1.0180.11
357_W469_S1.0150.11
224_D432_D1.0120.11
178_E627_I1.0110.11
136_I616_M1.0110.11
199_R688_M1.0100.11
473_R559_I1.0100.11
196_A664_T1.0090.11
630_K642_G1.0070.11
52_A654_R1.0060.11
28_R154_E1.0060.11
101_S412_W1.0050.11
63_V73_S1.0050.11
387_D398_I1.0030.11
349_L698_L1.0030.11
122_F256_E1.0030.11
405_N440_E1.0020.11
4_I371_M1.0010.11
309_D687_M0.9990.11
339_R604_Q0.9990.11
264_P403_M0.9980.11
538_L588_F0.9950.11
155_Y342_I0.9940.11
17_L216_F0.9940.11
237_L374_A0.9930.11
197_L697_C0.9920.11
171_Q313_D0.9920.11
609_A612_K0.9910.11
111_Y231_A0.9890.11
108_W510_A0.9880.11
138_T679_R0.9880.11
614_A628_V0.9860.11
7_F218_F0.9850.11
112_L563_T0.9840.11
364_L411_T0.9830.11
127_I223_P0.9820.11
343_I398_I0.9800.11
262_G400_G0.9780.11
64_L680_Y0.9760.11
556_A587_D0.9720.11
60_L129_D0.9700.11
178_E395_T0.9700.11
18_A495_A0.9670.11
21_L24_V0.9670.11
219_C231_A0.9650.11
134_E385_L0.9650.11
108_W555_T0.9590.11
138_T311_Y0.9580.10
111_Y418_S0.9550.10
256_E702_L0.9520.10
74_A442_E0.9510.10
303_G491_V0.9480.10
131_N148_N0.9470.10
131_N188_R0.9470.10
131_N194_E0.9470.10
131_N291_P0.9470.10
131_N294_W0.9470.10
131_N404_C0.9470.10
131_N498_C0.9470.10
131_N504_C0.9470.10
148_N188_R0.9470.10
148_N194_E0.9470.10
148_N291_P0.9470.10
148_N294_W0.9470.10
148_N404_C0.9470.10
148_N498_C0.9470.10
148_N504_C0.9470.10
188_R194_E0.9470.10
188_R291_P0.9470.10
188_R294_W0.9470.10
188_R404_C0.9470.10
188_R498_C0.9470.10
188_R504_C0.9470.10
194_E291_P0.9470.10
194_E294_W0.9470.10
194_E404_C0.9470.10
194_E498_C0.9470.10
194_E504_C0.9470.10
291_P294_W0.9470.10
291_P404_C0.9470.10
291_P498_C0.9470.10
291_P504_C0.9470.10
294_W404_C0.9470.10
294_W498_C0.9470.10
294_W504_C0.9470.10
404_C498_C0.9470.10
404_C504_C0.9470.10
498_C504_C0.9470.10
495_A687_M0.9450.10
527_A629_T0.9440.10
75_A86_N0.9430.10
103_D312_L0.9420.10
123_W363_P0.9410.10
447_A570_L0.9410.10
530_G637_G0.9390.10
284_G523_L0.9380.10
322_Y563_T0.9380.10
618_M662_L0.9370.10
193_E539_L0.9360.10
293_H567_A0.9350.10
141_L695_E0.9320.10
248_P308_I0.9320.10
350_V633_T0.9290.10
99_G275_Q0.9280.10
405_N429_I0.9280.10
97_R373_G0.9270.10
336_H546_S0.9270.10
313_D650_S0.9250.10
187_I236_L0.9240.10
13_A19_G0.9240.10
298_I443_L0.9240.10
241_G695_E0.9230.10
343_I369_S0.9220.10
313_D587_D0.9210.10
618_M651_G0.9210.10
231_A650_S0.9180.10
392_V581_V0.9150.10
94_A656_L0.9130.10
195_Y236_L0.9120.10
204_R682_R0.9120.10
276_E384_Q0.9110.10
376_T471_S0.9100.10
119_L424_D0.9080.10
141_L241_G0.9080.10
412_W467_R0.9080.10
190_E523_L0.9070.10
393_G523_L0.9070.10
685_T689_E0.9060.10
374_A569_S0.9050.10
74_A417_N0.9030.10
295_Q354_L0.9030.10
383_K670_I0.9030.10
118_H268_G0.9020.10
52_A95_I0.9020.10
170_T474_S0.9010.10
78_S139_D0.9010.10
276_E321_R0.9010.10
297_Y695_E0.8990.10
339_R407_R0.8990.10
367_T445_N0.8980.10
29_R344_A0.8970.10
325_L643_L0.8960.10
473_R574_A0.8950.10
16_L57_L0.8940.10
58_E71_G0.8910.10
358_I395_T0.8900.10
137_H645_P0.8880.10
91_L352_F0.8870.10
156_M673_G0.8870.10
268_G319_Q0.8860.10
113_D544_A0.8850.10
112_L256_E0.8840.10
417_N700_P0.8820.10
582_S663_L0.8810.10
214_L659_T0.8790.10
100_I351_L0.8770.10
238_L664_T0.8770.10
321_R538_L0.8770.10
149_G223_P0.8760.10
40_A556_A0.8750.10
4_I28_R0.8740.10
234_A525_K0.8740.10
85_S378_E0.8740.10
17_L628_V0.8720.10
476_I513_N0.8720.10
147_L302_L0.8700.10
317_V352_F0.8690.10
167_V670_I0.8670.10
341_T384_Q0.8660.10
534_G589_V0.8630.10
247_A429_I0.8620.10
439_P570_L0.8620.10
24_V36_A0.8620.10
133_V205_E0.8610.10
338_L614_A0.8610.10
369_S407_R0.8600.10
451_T610_F0.8600.10
187_I310_I0.8580.10
398_I442_E0.8560.10
427_Q552_A0.8550.10
446_K561_H0.8540.10
437_P550_L0.8540.10
108_W437_P0.8530.10
377_I466_S0.8530.10
587_D614_A0.8530.10
184_L258_H0.8510.10
335_Q640_H0.8500.10
272_E655_Y0.8490.10
398_I529_A0.8490.10
12_L474_S0.8480.10
32_P35_N0.8480.10
491_V503_D0.8480.10
297_Y429_I0.8480.10
187_I248_P0.8460.10
354_L661_L0.8450.10
11_L28_R0.8430.09
690_I694_Y0.8410.09
330_K651_G0.8390.09
91_L679_R0.8380.09
197_L265_R0.8370.09
227_V675_Q0.8360.09
240_A338_L0.8360.09
454_V534_G0.8360.09
123_W334_L0.8340.09
11_L94_A0.8330.09
422_P490_I0.8330.09
608_N700_P0.8330.09
489_D541_P0.8330.09
423_F577_G0.8310.09
174_I532_L0.8300.09
406_I554_S0.8290.09
519_D687_M0.8270.09
316_V576_G0.8260.09
47_P347_S0.8250.09
485_D512_V0.8240.09
482_V564_A0.8230.09
104_D233_G0.8220.09
341_T677_W0.8220.09
242_L531_K0.8200.09
468_V488_G0.8200.09
279_N665_M0.8190.09
217_F381_S0.8180.09
337_W360_L0.8180.09
366_F471_S0.8170.09
92_T475_A0.8160.09
21_L145_I0.8150.09
166_P454_V0.8130.09
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441_S458_L0.5260.07
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176_G247_A0.5260.07
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380_T612_K0.5240.07
176_G568_Q0.5230.07
336_H398_I0.5230.07
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339_R554_S0.5230.07
464_D695_E0.5230.07
366_F507_L0.5230.07
151_T488_G0.5220.07
206_A652_L0.5220.07
587_D610_F0.5210.07
117_V563_T0.5210.07
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38_A219_C0.5170.07
23_K26_S0.5170.07
38_A519_D0.5150.07
200_P702_L0.5140.07
326_H454_V0.5140.07
308_I627_I0.5130.07
427_Q604_Q0.5130.07
182_I313_D0.5120.07
181_Q339_R0.5120.07
486_D563_T0.5110.07
383_K443_L0.5100.07
83_A700_P0.5100.07
300_Q343_I0.5100.07
330_K440_E0.5100.07
71_G76_P0.5100.07
268_G506_R0.5090.07
25_R675_Q0.5080.07
207_L667_G0.5070.07
336_H700_P0.5070.07
266_R588_F0.5060.07
332_F653_W0.5050.07
339_R676_A0.5050.07
237_L293_H0.5050.07
130_E469_S0.5050.07
185_L682_R0.5040.07
208_L222_T0.5030.07
59_S443_L0.5020.07
89_M421_L0.5020.07
355_L399_S0.5000.07
93_H376_T0.5000.07
324_S328_E0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uzmA 1 0.1674 100 0.841 Contact Map
1s7qA 1 0 28.5 0.989 Contact Map
2jwaA 2 0.0436 25.8 0.99 Contact Map
2mfrA 1 0.0563 24.6 0.99 Contact Map
2l2tA 2 0.0464 24.3 0.99 Contact Map
2ks1B 1 0.045 23.8 0.99 Contact Map
4b2nA 1 0.0844 22.2 0.99 Contact Map
4um9B 2 0 22.2 0.99 Contact Map
4aybH 1 0.1069 21.8 0.99 Contact Map
2x3dA 5 0.1238 18.8 0.99 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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