GREMLIN Database
NUDE - ADP compounds hydrolase NudE
UniProt: P45799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12926
Length: 186 (169)
Sequences: 5914 (4214)
Seq/√Len: 324.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_T30_E2.9621.00
51_M77_F2.7891.00
89_Y93_N2.4721.00
14_E26_S2.3941.00
106_D130_Q2.3581.00
18_R23_T2.3441.00
56_V59_H2.3181.00
97_K103_G2.3031.00
155_M173_L2.2011.00
59_H151_P2.1901.00
156_M177_R2.1861.00
59_H149_R2.1831.00
12_N28_D2.1501.00
75_L148_V2.1271.00
13_V25_E2.0711.00
15_T18_R2.0391.00
87_S90_E2.0001.00
109_F125_N1.9941.00
157_D161_D1.9931.00
26_S38_V1.9761.00
108_T130_Q1.9731.00
28_D36_R1.9711.00
61_I149_R1.9681.00
112_K123_K1.9391.00
56_V149_R1.9361.00
64_R146_P1.9031.00
105_N131_D1.7981.00
43_R121_S1.7971.00
25_E43_R1.7971.00
105_N133_Y1.7881.00
82_I91_A1.7581.00
158_L163_D1.7311.00
109_F112_K1.7191.00
86_E94_R1.7081.00
93_N107_L1.7011.00
64_R148_V1.6951.00
13_V27_V1.6901.00
30_E36_R1.6771.00
65_E76_G1.6471.00
88_V125_N1.6461.00
52_I92_A1.6101.00
150_W158_L1.6031.00
19_S40_E1.5471.00
151_P154_H1.5391.00
112_K125_N1.5371.00
174_F178_E1.5291.00
11_L30_E1.5071.00
27_V68_V1.4951.00
96_L104_A1.4821.00
103_G133_Y1.4741.00
10_I68_V1.4571.00
28_D38_V1.4481.00
53_V172_A1.4361.00
90_E93_N1.4131.00
154_H157_D1.4111.00
77_F172_A1.4031.00
114_S165_N1.3671.00
89_Y107_L1.3611.00
72_S165_N1.3221.00
106_D131_D1.3221.00
61_I102_F1.3181.00
82_I88_V1.3141.00
26_S40_E1.2931.00
91_A94_R1.2711.00
11_L36_R1.2341.00
53_V176_V1.2121.00
15_T25_E1.2081.00
113_L171_S1.1871.00
97_K138_E1.1871.00
93_N97_K1.1711.00
15_T23_T1.1391.00
88_V127_V1.1381.00
97_K135_E1.1371.00
78_S100_V1.1311.00
70_T74_E1.1191.00
150_W155_M1.1161.00
14_E28_D1.1141.00
102_F134_P1.0951.00
70_T114_S1.0841.00
113_L126_I1.0821.00
61_I147_Q1.0791.00
156_M160_E1.0661.00
116_A122_S1.0661.00
54_P96_L1.0641.00
154_H158_L1.0481.00
160_E178_E1.0471.00
68_V71_E1.0461.00
109_F127_V1.0461.00
157_D160_E1.0191.00
48_E82_I0.9821.00
86_E91_A0.9791.00
64_R73_Y0.9711.00
32_S144_P0.9601.00
126_I172_A0.9601.00
110_L128_V0.9551.00
159_L170_V0.9551.00
138_E143_E0.9421.00
66_Y71_E0.9271.00
50_V92_A0.9271.00
171_S174_F0.9121.00
49_A124_M0.8931.00
16_V24_V0.8861.00
107_L129_A0.8701.00
74_E117_P0.8651.00
89_Y109_F0.8571.00
27_V41_R0.8541.00
67_A76_G0.8481.00
55_I128_V0.8471.00
166_E169_N0.8471.00
58_D152_L0.8471.00
16_V26_S0.8471.00
48_E123_K0.8431.00
10_I27_V0.8421.00
92_A107_L0.8381.00
56_V102_F0.8321.00
53_V60_L0.8321.00
44_P122_S0.8291.00
156_M173_L0.8281.00
57_D131_D0.8281.00
107_L127_V0.8201.00
22_F42_M0.8201.00
104_A107_L0.8191.00
77_F173_L0.8161.00
60_L173_L0.8151.00
53_V77_F0.8071.00
52_I129_A0.8041.00
51_M126_I0.7971.00
62_L150_W0.7881.00
60_L77_F0.7831.00
139_G145_L0.7781.00
115_M119_Y0.7641.00
17_A24_V0.7540.99
42_M119_Y0.7530.99
55_I152_L0.7520.99
139_G143_E0.7520.99
51_M124_M0.7490.99
114_S123_K0.7440.99
62_L75_L0.7370.99
10_I71_E0.7320.99
97_K136_S0.7300.99
93_N103_G0.7230.99
48_E125_N0.7210.99
62_L148_V0.7190.99
57_D130_Q0.7180.99
113_L167_A0.7060.99
124_M168_R0.7050.99
64_R75_L0.7020.99
108_T128_V0.7010.99
111_K171_S0.7000.99
159_L164_F0.6990.99
54_P128_V0.6980.99
158_L161_D0.6930.99
75_L150_W0.6910.99
104_A129_A0.6870.99
60_L176_V0.6850.99
23_T43_R0.6830.99
51_M168_R0.6820.99
113_L170_V0.6800.99
55_I60_L0.6790.99
50_V88_V0.6790.99
41_R68_V0.6750.99
73_Y144_P0.6720.99
139_G142_P0.6690.99
116_A120_F0.6660.99
44_P48_E0.6630.99
63_I145_L0.6570.99
78_S96_L0.6570.99
13_V43_R0.6490.98
57_D133_Y0.6480.98
89_Y127_V0.6450.98
112_K165_N0.6450.98
62_L155_M0.6440.98
55_I130_Q0.6380.98
111_K175_L0.6380.98
55_I58_D0.6370.98
140_D143_E0.6300.98
152_L177_R0.6260.98
55_I176_V0.6260.98
151_P156_M0.6240.98
54_P104_A0.6200.98
155_M159_L0.6200.98
24_V42_M0.6160.98
137_L147_Q0.6160.98
54_P77_F0.6160.98
11_L28_D0.6090.98
115_M167_A0.6090.98
60_L152_L0.6080.98
54_P63_I0.6060.98
49_A81_L0.6060.98
123_K165_N0.6030.97
106_D109_F0.5950.97
154_H163_D0.5900.97
152_L156_M0.5880.97
82_I125_N0.5860.97
92_A127_V0.5860.97
174_F177_R0.5850.97
44_P119_Y0.5820.97
14_E38_V0.5810.97
33_N144_P0.5810.97
52_I78_S0.5770.97
136_S139_G0.5730.97
92_A96_L0.5730.97
19_S26_S0.5730.97
8_P29_L0.5720.96
56_V61_I0.5690.96
171_S175_L0.5670.96
27_V71_E0.5660.96
75_L158_L0.5660.96
135_E138_E0.5650.96
47_R81_L0.5650.96
74_E114_S0.5640.96
131_D134_P0.5620.96
12_N15_T0.5620.96
153_A156_M0.5600.96
52_I96_L0.5580.96
159_L173_L0.5570.96
51_M79_K0.5510.96
148_V158_L0.5510.96
110_L176_V0.5500.96
60_L155_M0.5490.96
104_A132_L0.5450.95
167_A171_S0.5450.95
108_T111_K0.5420.95
8_P32_S0.5410.95
83_D91_A0.5410.95
10_I13_V0.5400.95
150_W154_H0.5400.95
164_F169_N0.5360.95
111_K162_P0.5360.95
31_F35_V0.5360.95
48_E81_L0.5320.95
115_M120_F0.5300.95
79_K168_R0.5280.95
173_L177_R0.5260.94
111_K170_V0.5260.94
29_L37_R0.5260.94
87_S127_V0.5250.94
79_K118_S0.5250.94
59_H154_H0.5220.94
41_R44_P0.5190.94
39_Y44_P0.5190.94
128_V175_L0.5190.94
29_L68_V0.5180.94
158_L164_F0.5180.94
30_E34_G0.5160.94
67_A118_S0.5140.94
155_M177_R0.5110.94
170_V174_F0.5100.93
104_A131_D0.5080.93
52_I107_L0.5070.93
31_F37_R0.5040.93
79_K116_A0.5040.93
44_P120_F0.5010.93
103_G135_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhzA 2 1 100 0.287 Contact Map
1g0sA 2 0.9839 100 0.309 Contact Map
2dscA 2 0.9355 100 0.324 Contact Map
1mk1A 2 0.8817 100 0.377 Contact Map
2yvpA 2 0.9516 100 0.407 Contact Map
3o6zA 2 0.9355 100 0.417 Contact Map
1v8yA 2 0.8011 100 0.44 Contact Map
3q91A 2 0.6989 100 0.482 Contact Map
2w4eA 2 0.7312 99.9 0.526 Contact Map
2fvvA 1 0.7151 99.9 0.572 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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