GREMLIN Database
YHDX - Putative amino-acid ABC transporter permease protein YhdX
UniProt: P45767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12835
Length: 393 (379)
Sequences: 771 (536)
Seq/√Len: 27.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_L373_I5.5911.00
157_A167_S4.6751.00
98_C329_I4.1681.00
112_A124_S4.0271.00
109_I273_S3.7021.00
101_F265_T3.6601.00
140_I267_A3.6041.00
71_L93_L3.5611.00
380_L383_I3.3941.00
286_A317_V3.3111.00
105_L109_I3.3021.00
75_Q78_D3.2011.00
169_R250_N2.9011.00
107_F311_I2.8191.00
202_F214_R2.7071.00
69_Q258_I2.6780.99
66_G76_Q2.6740.99
62_G77_G2.6570.99
97_L265_T2.5930.99
330_V377_I2.5910.99
246_L250_N2.5560.99
202_F206_Y2.5470.99
349_A366_T2.5410.99
206_Y214_R2.4950.99
139_Q143_W2.4830.99
141_F145_F2.4530.99
214_R219_I2.4360.99
196_S224_I2.4350.99
54_S358_Q2.4230.99
301_P304_V2.4170.99
375_L379_L2.3740.99
196_S220_A2.3680.99
36_V40_F2.3280.99
118_W122_K2.3240.99
246_L251_F2.3040.98
95_S330_V2.2400.98
333_S336_A2.2240.98
103_S326_Y2.1590.98
102_A276_I2.1590.98
69_Q93_L2.1320.97
176_P241_W2.1160.97
94_V264_L2.1160.97
192_A196_S2.1060.97
387_R391_V2.0940.97
96_A100_V2.0560.97
105_L269_S2.0460.97
323_T381_M2.0170.96
248_G251_F1.9440.95
296_R305_T1.8970.95
242_D245_A1.8220.94
45_T49_N1.7920.93
337_A346_S1.7840.93
156_Q246_L1.7630.92
39_L43_T1.7430.92
144_Y260_E1.7410.92
353_L362_T1.7340.92
72_I82_R1.7270.92
22_W26_I1.7080.91
56_F364_A1.7020.91
296_R302_N1.7020.91
192_A224_I1.6870.91
154_P168_N1.6790.90
52_I358_Q1.6750.90
169_R248_G1.6700.90
72_I89_L1.6540.90
374_S384_Y1.6470.90
159_S162_D1.6380.89
271_Y275_F1.6200.89
108_F112_A1.6180.89
177_Q242_D1.6040.88
272_T328_N1.5950.88
373_I377_I1.5740.87
104_V212_Q1.5600.87
336_A343_D1.5530.87
41_H45_T1.5440.86
173_I255_M1.5410.86
137_L338_A1.5220.85
186_I190_V1.5210.85
126_I130_I1.5120.85
166_L171_L1.4930.84
201_R205_T1.4790.84
193_I197_V1.4540.83
258_I267_A1.4540.83
83_V337_A1.4500.82
188_A231_A1.4490.82
95_S101_F1.4420.82
304_V308_Q1.4310.82
84_F369_V1.4170.81
234_L360_I1.4000.80
97_L261_L1.3990.80
188_A227_L1.3970.80
154_P169_R1.3910.80
163_L243_V1.3750.79
102_A269_S1.3740.79
154_P250_N1.3690.79
199_L214_R1.3580.78
114_L327_L1.3540.78
94_V333_S1.3390.77
145_F149_R1.3350.77
93_L261_L1.3320.77
157_A250_N1.3300.77
305_T309_V1.3260.76
53_T358_Q1.3160.76
352_V362_T1.3090.75
165_F251_F1.3060.75
65_F342_P1.3040.75
207_Q213_L1.3010.75
289_Y292_H1.2900.74
173_I257_L1.2880.74
111_L280_I1.2720.73
327_L374_S1.2600.72
169_R251_F1.2580.72
319_I388_I1.2580.72
334_S345_V1.2340.71
272_T332_N1.2210.70
101_F269_S1.2140.70
268_L327_L1.2130.70
267_A340_G1.2130.70
138_L339_I1.2040.69
175_S242_D1.1900.68
88_L369_V1.1750.67
110_G280_I1.1730.67
302_N305_T1.1680.67
98_C330_V1.1500.65
223_L226_G1.1490.65
315_L343_D1.1440.65
55_G358_Q1.1430.65
274_A282_A1.1370.64
382_N385_N1.1370.64
34_G38_W1.1340.64
157_A246_L1.1270.64
151_L166_L1.1240.64
31_A35_I1.1230.63
160_A163_L1.1200.63
14_F23_L1.1200.63
272_T325_Q1.1170.63
72_I86_V1.1130.63
23_L310_I1.1040.62
325_Q328_N1.1020.62
167_S172_Y1.1010.62
104_V108_F1.0890.61
136_P139_Q1.0850.61
306_L311_I1.0790.60
245_A252_R1.0780.60
182_F239_L1.0780.60
71_L89_L1.0770.60
84_F270_V1.0760.60
34_G190_V1.0740.60
142_F147_V1.0690.60
232_Q267_A1.0690.60
337_A377_I1.0680.59
323_T345_V1.0660.59
47_L360_I1.0580.59
288_P292_H1.0500.58
323_T327_L1.0490.58
78_D82_R1.0460.58
185_F235_F1.0450.58
131_F139_Q1.0420.58
83_V365_M1.0420.58
26_I191_M1.0400.57
66_G347_L1.0380.57
49_N309_V1.0380.57
84_F366_T1.0370.57
183_I187_L1.0350.57
247_R252_R1.0320.57
114_L285_Q1.0280.57
40_F44_V1.0270.56
172_Y256_V1.0240.56
69_Q350_G1.0220.56
131_F140_I1.0220.56
121_R285_Q1.0160.56
291_Q313_Q1.0130.55
169_R246_L1.0100.55
52_I359_A1.0090.55
279_I324_S1.0040.55
180_D238_A1.0010.55
206_Y212_Q0.9970.54
78_D95_S0.9960.54
73_D78_D0.9940.54
187_L190_V0.9930.54
83_V349_A0.9920.54
192_A227_L0.9790.53
350_G366_T0.9790.53
203_N216_T0.9720.52
110_G276_I0.9690.52
178_L182_F0.9660.52
268_L272_T0.9620.52
305_T310_I0.9610.51
232_Q237_A0.9600.51
86_V347_L0.9570.51
362_T366_T0.9560.51
54_S366_T0.9560.51
181_G236_G0.9480.50
276_I329_I0.9420.50
93_L350_G0.9420.50
155_R248_G0.9400.50
322_L344_M0.9400.50
97_L375_L0.9380.50
247_R251_F0.9370.50
272_T275_F0.9370.50
19_V380_L0.9350.49
69_Q267_A0.9310.49
154_P247_R0.9310.49
283_G318_I0.9280.49
83_V352_V0.9280.49
19_V23_L0.9250.49
65_F351_T0.9070.47
181_G238_A0.9000.47
40_F108_F0.8990.47
160_A164_A0.8990.47
258_I342_P0.8970.47
217_W221_A0.8950.46
188_A228_P0.8950.46
282_A367_M0.8940.46
274_A279_I0.8920.46
321_P328_N0.8900.46
376_T380_L0.8880.46
139_Q146_A0.8840.46
93_L258_I0.8830.46
121_R218_P0.8830.46
267_A337_A0.8820.45
131_F388_I0.8780.45
102_A329_I0.8780.45
355_Q374_S0.8750.45
155_R250_N0.8750.45
28_A136_P0.8710.45
53_T57_A0.8710.45
57_A79_T0.8700.45
199_L219_I0.8690.44
30_V235_F0.8690.44
153_G156_Q0.8680.44
43_T50_R0.8670.44
81_G85_I0.8610.44
107_F147_V0.8610.44
224_I376_T0.8600.44
362_T365_M0.8590.44
110_G385_N0.8570.44
26_I187_L0.8560.44
99_I124_S0.8560.44
372_I376_T0.8550.43
131_F134_I0.8540.43
155_R249_F0.8530.43
206_Y219_I0.8510.43
245_A248_G0.8480.43
16_N19_V0.8410.42
148_L366_T0.8380.42
258_I366_T0.8320.42
268_L332_N0.8300.42
131_F270_V0.8300.42
351_T355_Q0.8270.41
194_V198_G0.8260.41
318_I381_M0.8260.41
32_V36_V0.8240.41
74_Y83_V0.8210.41
192_A248_G0.8160.41
48_N336_A0.8140.40
108_F120_L0.8110.40
21_A95_S0.8100.40
328_N375_L0.8070.40
275_F325_Q0.8070.40
65_F347_L0.8070.40
353_L366_T0.8050.40
32_V360_I0.8040.40
57_A61_R0.8040.40
191_M195_L0.8020.40
68_V324_S0.8010.39
267_A350_G0.8000.39
167_S262_A0.7960.39
366_T369_V0.7940.39
232_Q239_L0.7920.39
155_R252_R0.7880.39
39_L80_Y0.7880.39
201_R310_I0.7870.38
130_I134_I0.7870.38
287_V310_I0.7860.38
250_N340_G0.7860.38
124_S306_L0.7840.38
266_L270_V0.7840.38
128_I134_I0.7830.38
91_T95_S0.7810.38
57_A60_D0.7800.38
19_V79_T0.7800.38
378_S382_N0.7800.38
195_L223_L0.7790.38
141_F391_V0.7790.38
35_I39_L0.7780.38
319_I324_S0.7770.38
74_Y186_I0.7720.37
272_T329_I0.7710.37
202_F224_I0.7710.37
23_L341_Y0.7710.37
209_K222_V0.7640.37
321_P374_S0.7610.37
109_I128_I0.7580.36
318_I384_Y0.7540.36
52_I55_G0.7530.36
80_Y351_T0.7510.36
50_R54_S0.7490.36
83_V140_I0.7470.36
282_A285_Q0.7450.35
232_Q238_A0.7440.35
84_F365_M0.7440.35
383_I386_R0.7430.35
383_I391_V0.7410.35
134_I358_Q0.7390.35
260_E323_T0.7380.35
336_A341_Y0.7370.35
107_F315_L0.7360.35
127_Y131_F0.7350.35
344_M366_T0.7350.35
92_L96_A0.7350.35
150_N257_L0.7350.35
29_V33_V0.7340.35
104_V221_A0.7340.35
31_A36_V0.7330.35
189_V224_I0.7320.35
39_L197_V0.7310.34
72_I78_D0.7270.34
214_R217_W0.7260.34
55_G361_E0.7260.34
350_G353_L0.7260.34
134_I148_L0.7240.34
140_I265_T0.7240.34
250_N283_G0.7220.34
30_V34_G0.7210.34
280_I308_Q0.7190.34
379_L383_I0.7190.34
141_F339_I0.7190.34
50_R53_T0.7160.33
186_I386_R0.7150.33
109_I362_T0.7140.33
247_R250_N0.7120.33
296_R324_S0.7110.33
99_I343_D0.7100.33
195_L225_I0.7080.33
199_L216_T0.7070.33
32_V39_L0.7070.33
317_V371_L0.7050.33
220_A224_I0.7030.33
250_N253_G0.7030.33
327_L335_L0.7010.32
79_T245_A0.7010.32
50_R341_Y0.6990.32
33_V37_G0.6980.32
297_S300_L0.6980.32
271_Y325_Q0.6980.32
83_V347_L0.6980.32
31_A245_A0.6970.32
324_S382_N0.6970.32
144_Y259_P0.6940.32
194_V252_R0.6890.32
45_T221_A0.6880.32
193_I241_W0.6880.32
187_L191_M0.6850.31
89_L93_L0.6840.31
118_W375_L0.6840.31
27_L225_I0.6830.31
88_L368_S0.6830.31
92_L380_L0.6820.31
197_V201_R0.6800.31
342_P351_T0.6800.31
102_A328_N0.6800.31
61_R380_L0.6790.31
83_V163_L0.6770.31
367_M391_V0.6730.31
113_R374_S0.6720.31
337_A363_I0.6710.30
193_I224_I0.6710.30
65_F80_Y0.6690.30
96_A330_V0.6680.30
63_A67_I0.6670.30
35_I187_L0.6670.30
295_A305_T0.6660.30
68_V258_I0.6650.30
364_A368_S0.6630.30
67_I83_V0.6610.30
98_C272_T0.6600.30
57_A72_I0.6590.30
384_Y388_I0.6590.30
297_S360_I0.6580.30
314_A327_L0.6570.30
33_V116_D0.6560.30
137_L268_L0.6560.30
226_G229_L0.6550.29
337_A343_D0.6520.29
22_W195_L0.6510.29
325_Q371_L0.6500.29
37_G41_H0.6480.29
28_A369_V0.6480.29
353_L360_I0.6470.29
147_V167_S0.6460.29
64_G144_Y0.6450.29
136_P347_L0.6430.29
189_V193_I0.6410.29
190_V194_V0.6410.29
304_V330_V0.6400.29
121_R209_K0.6390.28
20_R24_F0.6380.28
93_L311_I0.6360.28
68_V337_A0.6360.28
69_Q366_T0.6350.28
134_I388_I0.6350.28
88_L376_T0.6330.28
67_I74_Y0.6330.28
157_A251_F0.6310.28
44_V48_N0.6280.28
159_S167_S0.6270.28
283_G287_V0.6260.28
128_I138_L0.6240.28
78_D376_T0.6240.28
117_N295_A0.6230.27
374_S377_I0.6220.27
318_I323_T0.6220.27
132_R174_P0.6210.27
321_P325_Q0.6210.27
99_I311_I0.6200.27
19_V352_V0.6200.27
347_L362_T0.6190.27
100_V187_L0.6170.27
288_P392_E0.6170.27
62_G324_S0.6150.27
71_L273_S0.6140.27
229_L379_L0.6140.27
146_A311_I0.6130.27
311_I362_T0.6130.27
136_P265_T0.6120.27
131_F273_S0.6120.27
69_Q78_D0.6090.27
273_S350_G0.6080.27
191_M226_G0.6080.27
157_A362_T0.6080.27
81_G84_F0.6070.27
128_I280_I0.6060.26
85_I197_V0.6060.26
166_L264_L0.6050.26
233_W237_A0.6040.26
33_V187_L0.6000.26
114_L272_T0.6000.26
271_Y321_P0.5990.26
246_L340_G0.5980.26
349_A363_I0.5980.26
50_R168_N0.5980.26
24_F352_V0.5970.26
110_G382_N0.5950.26
96_A373_I0.5950.26
93_L267_A0.5920.26
190_V212_Q0.5920.26
61_R157_A0.5910.26
100_V173_I0.5900.26
206_Y209_K0.5900.26
15_A315_L0.5900.26
50_R306_L0.5900.26
111_L359_A0.5870.25
80_Y355_Q0.5850.25
68_V267_A0.5850.25
192_A225_I0.5850.25
259_P323_T0.5830.25
205_T209_K0.5820.25
273_S276_I0.5810.25
22_W28_A0.5790.25
83_V267_A0.5770.25
268_L328_N0.5760.25
277_A282_A0.5760.25
107_F306_L0.5750.25
122_K336_A0.5750.25
346_S391_V0.5750.25
192_A223_L0.5750.25
99_I330_V0.5740.25
200_F204_K0.5730.25
109_I391_V0.5730.25
321_P371_L0.5720.24
44_V54_S0.5720.24
100_V104_V0.5720.24
337_A365_M0.5720.24
116_D310_I0.5710.24
237_A282_A0.5680.24
311_I315_L0.5670.24
202_F219_I0.5650.24
88_L260_E0.5640.24
15_A270_V0.5630.24
209_K243_V0.5610.24
340_G352_V0.5610.24
69_Q76_Q0.5600.24
110_G295_A0.5600.24
195_L227_L0.5590.24
105_L234_L0.5580.24
47_L51_G0.5570.24
126_I372_I0.5570.24
51_G134_I0.5570.24
349_A370_Y0.5570.24
323_T360_I0.5560.24
36_V198_G0.5550.24
127_Y283_G0.5540.24
27_L30_V0.5540.24
132_R326_Y0.5530.23
206_Y210_T0.5520.23
157_A169_R0.5490.23
193_I326_Y0.5470.23
207_Q210_T0.5460.23
168_N334_S0.5450.23
199_L257_L0.5440.23
295_A354_N0.5440.23
80_Y346_S0.5430.23
199_L224_I0.5420.23
274_A340_G0.5410.23
131_F267_A0.5390.23
96_A307_R0.5390.23
214_R383_I0.5380.23
107_F322_L0.5350.22
99_I107_F0.5330.22
292_H296_R0.5320.22
153_G179_G0.5320.22
341_Y369_V0.5300.22
79_T198_G0.5300.22
165_F358_Q0.5300.22
53_T173_I0.5290.22
306_L325_Q0.5280.22
84_F88_L0.5260.22
266_L322_L0.5250.22
107_F276_I0.5250.22
186_I289_Y0.5250.22
369_V393_R0.5240.22
131_F274_A0.5240.22
379_L386_R0.5240.22
202_F213_L0.5230.22
30_V56_F0.5220.22
201_R204_K0.5220.22
332_N336_A0.5220.22
137_L339_I0.5220.22
179_G240_H0.5210.22
50_R377_I0.5190.22
175_S185_F0.5190.22
39_L78_D0.5190.22
191_M227_L0.5180.22
198_G229_L0.5170.22
45_T60_D0.5170.22
165_F245_A0.5170.22
251_F256_V0.5170.22
252_R344_M0.5150.21
315_L336_A0.5140.21
255_M352_V0.5140.21
30_V96_A0.5140.21
96_A266_L0.5130.21
43_T384_Y0.5130.21
271_Y328_N0.5120.21
261_L321_P0.5120.21
164_A241_W0.5120.21
159_S163_L0.5120.21
95_S368_S0.5120.21
129_E343_D0.5110.21
261_L265_T0.5110.21
85_I303_P0.5100.21
311_I350_G0.5100.21
46_N271_Y0.5080.21
286_A318_I0.5080.21
369_V373_I0.5080.21
323_T384_Y0.5080.21
253_G340_G0.5070.21
64_G298_L0.5070.21
79_T193_I0.5070.21
146_A223_L0.5050.21
148_L362_T0.5040.21
323_T377_I0.5030.21
139_Q258_I0.5030.21
109_I277_A0.5030.21
302_N343_D0.5020.21
332_N341_Y0.5010.21
20_R46_N0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.5471 99.8 0.865 Contact Map
3tuiA 2 0.5318 99.8 0.877 Contact Map
2onkC 2 0.626 99.7 0.88 Contact Map
3rlfF 1 0.7226 99.7 0.883 Contact Map
3d31C 2 0.6234 99.7 0.888 Contact Map
3rlfG 1 0.6947 99.6 0.891 Contact Map
4tquM 1 0.6896 99.6 0.897 Contact Map
4tquN 1 0.6718 99.5 0.902 Contact Map
2l2tA 2 0.112 12.3 0.983 Contact Map
2mmuA 1 0.1145 9.5 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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