GREMLIN Database
GSPL - Putative type II secretion system protein L
UniProt: P45763 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12895
Length: 387 (359)
Sequences: 835 (706)
Seq/√Len: 37.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_T227_H7.2181.00
114_S230_F4.5271.00
139_C160_R4.4661.00
295_H300_Y4.2921.00
302_K306_A4.2121.00
281_Q285_Q4.0321.00
294_T300_Y3.9691.00
59_E156_S3.7561.00
54_L124_L3.3381.00
138_G166_F3.2921.00
136_P139_C3.0511.00
159_I167_N3.0291.00
54_L134_V2.9601.00
114_S229_I2.9211.00
284_W291_I2.8571.00
291_I304_Q2.7711.00
56_I120_Y2.7521.00
359_C363_Q2.7271.00
280_Q297_F2.7021.00
352_E356_D2.6761.00
304_Q307_Q2.5711.00
57_P120_Y2.5431.00
20_W32_H2.4431.00
124_L131_V2.4181.00
362_T368_M2.4101.00
304_Q308_Q2.3941.00
90_D113_Q2.3871.00
293_R296_N2.3571.00
71_A79_T2.3171.00
273_E280_Q2.3061.00
269_T273_E2.2950.99
352_E380_W2.2810.99
296_N299_F2.2370.99
82_W85_E2.2300.99
160_R166_F2.2040.99
63_Y110_I2.1990.99
58_P138_G2.1480.99
96_H225_M1.9860.99
92_T95_W1.9300.98
96_H117_L1.9230.98
117_L134_V1.9050.98
56_I84_A1.8380.98
226_L232_K1.8120.97
142_P160_R1.7760.97
96_H228_G1.7750.97
81_Q97_W1.7710.97
82_W287_Y1.7590.97
113_Q116_K1.7520.97
251_L341_K1.7440.97
52_V124_L1.7400.97
279_Q282_E1.7320.96
118_S122_E1.7200.96
121_L131_V1.7050.96
84_A312_A1.6890.96
61_L110_I1.6740.96
97_W111_G1.6730.96
354_N357_R1.6640.95
116_K120_Y1.6540.95
117_L120_Y1.6390.95
284_W288_F1.6350.95
312_A336_Y1.6200.95
351_S354_N1.6100.95
263_S267_W1.6010.94
342_S352_E1.5550.93
96_H227_H1.5480.93
139_C166_F1.5350.93
64_R111_G1.5330.93
56_I117_L1.5280.93
347_M355_I1.5240.93
52_V129_L1.5110.92
348_S379_V1.5030.92
255_I362_T1.5010.92
122_E126_T1.4880.92
356_D359_C1.4770.92
152_N157_W1.4760.92
54_L140_Y1.4720.91
228_G284_W1.4430.91
319_L345_L1.4420.91
210_S214_Y1.4380.90
99_V227_H1.4200.90
370_K373_K1.4050.89
323_L358_F1.3970.89
118_S229_I1.3880.89
352_E370_K1.3800.89
250_C309_Y1.3790.89
265_A269_T1.3740.88
40_L46_Q1.3650.88
11_S16_K1.3600.88
227_H230_F1.3490.87
63_Y138_G1.3460.87
136_P160_R1.3380.87
56_I77_A1.3310.87
97_W140_Y1.3240.86
24_S27_S1.3140.86
277_Q285_Q1.3100.86
86_E349_A1.2980.85
88_L111_G1.2830.85
44_A47_P1.2770.84
84_A97_W1.2690.84
112_I116_K1.2660.84
66_L109_V1.2600.83
68_L296_N1.2600.83
117_L229_I1.2420.83
347_M382_V1.2390.82
86_E89_P1.2330.82
54_L82_W1.2200.81
355_I382_V1.2130.81
121_L226_L1.2100.81
284_W300_Y1.2100.81
226_L231_R1.2010.80
296_N300_Y1.1950.80
56_I230_F1.1870.80
300_Y305_L1.1850.79
75_L166_F1.1790.79
91_N364_S1.1760.79
245_R249_S1.1710.79
374_D379_V1.1680.78
55_L140_Y1.1590.78
319_L366_L1.1560.78
284_W304_Q1.1460.77
32_H74_K1.1460.77
63_Y139_C1.1390.77
66_L257_S1.1380.77
356_D378_G1.1380.77
121_L224_D1.1380.77
243_L336_Y1.1310.76
299_F303_Q1.1250.76
264_I268_H1.1220.76
55_L138_G1.1220.76
368_M380_W1.1220.76
248_V252_V1.1210.76
371_T382_V1.1180.75
88_L331_L1.1150.75
272_I276_L1.1100.75
142_P162_A1.1050.74
57_P232_K1.1000.74
172_H182_P1.1000.74
111_G326_H1.1000.74
293_R300_Y1.0960.74
64_R87_T1.0920.74
312_A334_A1.0900.73
77_A227_H1.0850.73
154_Q251_L1.0740.72
319_L343_L1.0720.72
21_M24_S1.0660.72
51_N132_T1.0650.72
58_P137_D1.0650.72
81_Q240_G1.0550.71
115_E118_S1.0530.71
60_G116_K1.0520.71
266_L270_L1.0500.71
197_A200_N1.0470.70
258_F365_W1.0420.70
240_G343_L1.0420.70
356_D380_W1.0410.70
195_G198_A1.0320.69
79_T372_E1.0230.69
120_Y137_D1.0220.69
107_V129_L1.0170.68
146_D149_T1.0150.68
266_L288_F1.0150.68
284_W295_H1.0140.68
85_E88_L1.0140.68
98_T226_L1.0120.68
65_S106_S1.0120.68
91_N272_I1.0110.68
259_V334_A1.0110.68
244_A248_V1.0070.67
38_L43_L1.0000.67
245_R248_V0.9980.67
78_Q370_K0.9960.67
97_W148_W0.9960.67
182_P185_N0.9930.66
165_A168_E0.9930.66
284_W305_L0.9810.65
150_L159_I0.9780.65
19_E23_F0.9780.65
136_P268_H0.9740.65
24_S29_S0.9730.65
175_Q305_L0.9730.65
75_L273_E0.9700.64
63_Y81_Q0.9690.64
288_F292_K0.9660.64
194_H278_Q0.9650.64
53_H124_L0.9640.64
288_F301_F0.9640.64
12_S60_G0.9640.64
226_L323_L0.9610.64
18_W25_A0.9600.64
171_E175_Q0.9490.63
104_N271_K0.9420.62
358_F362_T0.9380.62
132_T322_L0.9320.61
366_L372_E0.9310.61
140_Y166_F0.9310.61
70_N76_T0.9270.61
178_A181_F0.9230.61
65_S136_P0.9210.60
18_W22_T0.9010.59
83_L90_D0.8980.58
95_W111_G0.8970.58
281_Q294_T0.8970.58
373_K382_V0.8950.58
258_F261_S0.8950.58
48_G297_F0.8890.58
83_L86_E0.8840.57
55_L136_P0.8810.57
243_L378_G0.8730.56
246_L280_Q0.8720.56
152_N155_T0.8710.56
31_V347_M0.8710.56
277_Q281_Q0.8640.55
83_L96_H0.8630.55
140_Y366_L0.8610.55
86_E243_L0.8570.55
56_I136_P0.8550.55
93_Q356_D0.8530.54
23_F29_S0.8500.54
75_L160_R0.8480.54
54_L117_L0.8480.54
247_A251_L0.8420.54
150_L356_D0.8410.53
166_F336_Y0.8410.53
64_R70_N0.8400.53
93_Q212_S0.8370.53
193_P198_A0.8330.53
110_I131_V0.8320.53
264_I329_L0.8320.53
100_V193_P0.8310.53
84_A230_F0.8280.52
137_D343_L0.8240.52
48_G175_Q0.8230.52
72_K347_M0.8230.52
75_L139_C0.8220.52
317_Y356_D0.8180.51
130_N226_L0.8180.51
95_W147_S0.8170.51
68_L102_K0.8140.51
294_T303_Q0.8090.51
81_Q284_W0.8090.51
107_V345_L0.8060.50
196_V235_T0.8050.50
111_G124_L0.8040.50
232_K316_L0.8040.50
250_C308_Q0.7990.50
170_D198_A0.7970.50
80_L97_W0.7970.50
161_S165_A0.7950.49
114_S117_L0.7930.49
86_E140_Y0.7920.49
82_W300_Y0.7910.49
52_V130_N0.7910.49
46_Q249_S0.7910.49
109_V225_M0.7900.49
98_T117_L0.7870.49
242_W246_L0.7850.48
79_T98_T0.7840.48
299_F316_L0.7840.48
240_G265_A0.7840.48
273_E276_L0.7840.48
61_L136_P0.7830.48
69_P75_L0.7830.48
67_T178_A0.7820.48
55_L135_L0.7800.48
163_A197_A0.7790.48
55_L319_L0.7780.48
347_M353_A0.7760.48
96_H230_F0.7740.47
211_L284_W0.7690.47
81_Q272_I0.7690.47
117_L230_F0.7680.47
371_T383_R0.7670.47
288_F291_I0.7670.47
143_W146_D0.7640.47
177_L250_C0.7630.47
69_P362_T0.7610.46
353_A356_D0.7610.46
89_P230_F0.7590.46
370_K382_V0.7590.46
63_Y166_F0.7590.46
74_K349_A0.7560.46
20_W25_A0.7560.46
316_L355_I0.7530.46
293_R303_Q0.7520.46
161_S166_F0.7510.45
141_L167_N0.7500.45
159_I163_A0.7500.45
352_E373_K0.7500.45
209_P335_N0.7480.45
66_L84_A0.7480.45
287_Y301_F0.7480.45
109_V333_E0.7400.45
83_L139_C0.7400.45
142_P148_W0.7360.44
291_I296_N0.7360.44
186_M195_G0.7360.44
54_L210_S0.7330.44
112_I226_L0.7330.44
174_L320_Q0.7310.44
61_L307_Q0.7290.44
284_W297_F0.7290.44
18_W28_V0.7270.43
287_Y291_I0.7250.43
20_W26_D0.7230.43
26_D256_L0.7220.43
75_L382_V0.7220.43
329_L358_F0.7210.43
74_K329_L0.7210.43
280_Q283_T0.7180.43
194_H203_I0.7170.43
250_C286_R0.7160.42
55_L137_D0.7080.42
88_L95_W0.7040.41
299_F355_I0.7030.41
42_S45_D0.7010.41
66_L311_E0.7010.41
271_K283_T0.7000.41
379_V383_R0.6960.41
333_E346_K0.6960.41
146_D162_A0.6960.41
78_Q86_E0.6950.41
96_H347_M0.6950.41
72_K284_W0.6950.41
59_E92_T0.6930.40
355_I373_K0.6930.40
148_W196_V0.6920.40
213_L319_L0.6920.40
83_L323_L0.6910.40
226_L293_R0.6890.40
252_V274_D0.6890.40
92_T308_Q0.6890.40
69_P79_T0.6880.40
156_S359_C0.6880.40
107_V273_E0.6870.40
291_I301_F0.6850.40
169_L172_H0.6830.40
58_P160_R0.6810.39
133_R219_A0.6810.39
280_Q286_R0.6790.39
113_Q230_F0.6790.39
110_I311_E0.6790.39
316_L349_A0.6780.39
145_V327_P0.6770.39
22_T50_G0.6770.39
192_V197_A0.6720.39
134_V226_L0.6720.39
86_E301_F0.6710.39
93_Q137_D0.6710.39
266_L343_L0.6700.38
104_N207_E0.6690.38
70_N100_V0.6690.38
64_R97_W0.6680.38
79_T100_V0.6670.38
87_T111_G0.6660.38
245_R267_W0.6640.38
23_F248_V0.6610.38
252_V257_S0.6610.38
110_I120_Y0.6570.37
121_L134_V0.6560.37
99_V244_A0.6530.37
22_T29_S0.6530.37
207_E253_L0.6510.37
103_Q109_V0.6500.37
75_L226_L0.6500.37
298_R302_K0.6490.37
101_D112_I0.6460.37
275_Q286_R0.6460.37
271_K274_D0.6460.37
243_L294_T0.6450.36
29_S32_H0.6440.36
123_R336_Y0.6440.36
66_L83_L0.6430.36
89_P261_S0.6420.36
113_Q318_H0.6390.36
109_V175_Q0.6390.36
103_Q229_I0.6370.36
291_I300_Y0.6360.36
63_Y136_P0.6350.36
137_D352_E0.6350.36
105_E358_F0.6340.36
143_W357_R0.6340.36
261_S300_Y0.6330.35
80_L316_L0.6320.35
74_K280_Q0.6320.35
68_L257_S0.6320.35
337_S342_S0.6310.35
70_N382_V0.6310.35
359_C369_E0.6290.35
173_W190_G0.6280.35
115_E276_L0.6280.35
72_K83_L0.6270.35
123_R127_A0.6200.34
192_V345_L0.6180.34
16_K331_L0.6170.34
89_P382_V0.6160.34
82_W137_D0.6150.34
69_P370_K0.6140.34
19_E24_S0.6110.34
83_L135_L0.6090.34
122_E309_Y0.6090.34
191_V306_A0.6090.34
162_A252_V0.6090.34
118_S230_F0.6080.33
98_T365_W0.6070.33
15_R44_A0.6050.33
67_T155_T0.6050.33
111_G310_P0.6040.33
75_L362_T0.6020.33
92_T284_W0.6020.33
224_D331_L0.6010.33
156_S169_L0.5990.33
284_W301_F0.5980.33
92_T105_E0.5980.33
139_C164_H0.5970.33
68_L382_V0.5970.33
316_L345_L0.5960.33
368_M374_D0.5950.32
94_D143_W0.5940.32
56_I289_P0.5940.32
66_L111_G0.5930.32
126_T241_K0.5930.32
211_L276_L0.5930.32
198_A238_K0.5910.32
372_E375_P0.5910.32
274_D277_Q0.5900.32
100_V283_T0.5900.32
12_S21_M0.5900.32
248_V251_L0.5890.32
305_L349_A0.5860.32
58_P111_G0.5850.32
296_N303_Q0.5850.32
23_F28_V0.5850.32
20_W134_V0.5840.32
266_L273_E0.5830.32
173_W179_A0.5800.31
352_E359_C0.5770.31
100_V249_S0.5760.31
286_R316_L0.5750.31
372_E383_R0.5740.31
347_M380_W0.5740.31
67_T88_L0.5730.31
161_S230_F0.5720.31
137_D298_R0.5720.31
266_L280_Q0.5720.31
135_L161_S0.5720.31
231_R265_A0.5710.31
68_L371_T0.5700.31
39_P252_V0.5690.30
54_L242_W0.5690.30
218_I366_L0.5680.30
178_A183_P0.5670.30
136_P144_E0.5670.30
103_Q236_V0.5660.30
82_W95_W0.5640.30
310_P366_L0.5630.30
299_F302_K0.5620.30
16_K65_S0.5610.30
145_V194_H0.5610.30
209_P347_M0.5600.30
288_F382_V0.5570.30
69_P382_V0.5550.29
113_Q350_K0.5550.29
192_V363_Q0.5540.29
126_T364_S0.5540.29
112_I117_L0.5540.29
72_K79_T0.5540.29
114_S271_K0.5530.29
136_P158_L0.5530.29
297_F380_W0.5520.29
263_S335_N0.5520.29
328_E358_F0.5520.29
264_I278_Q0.5480.29
168_E226_L0.5470.29
119_R336_Y0.5470.29
69_P72_K0.5460.29
265_A268_H0.5440.29
54_L141_L0.5440.29
167_N301_F0.5420.28
157_W213_L0.5410.28
251_L348_S0.5410.28
281_Q356_D0.5390.28
70_N379_V0.5370.28
71_A250_C0.5370.28
68_L140_Y0.5370.28
15_R29_S0.5360.28
97_W159_I0.5350.28
24_S30_S0.5350.28
251_L271_K0.5350.28
123_R259_V0.5350.28
270_L296_N0.5350.28
25_A67_T0.5340.28
69_P301_F0.5340.28
208_I214_Y0.5330.28
42_S48_G0.5330.28
22_T30_S0.5330.28
346_K383_R0.5320.28
178_A182_P0.5320.28
143_W160_R0.5320.28
22_T347_M0.5310.28
101_D264_I0.5310.28
192_V205_H0.5300.28
186_M272_I0.5300.28
241_K260_G0.5290.28
53_H193_P0.5280.27
111_G269_T0.5280.27
58_P61_L0.5250.27
344_T347_M0.5250.27
58_P66_L0.5240.27
81_Q85_E0.5240.27
88_L334_A0.5190.27
78_Q275_Q0.5190.27
72_K368_M0.5180.27
312_A357_R0.5180.27
89_P92_T0.5160.27
98_T113_Q0.5160.27
23_F27_S0.5160.27
182_P290_Q0.5160.27
40_L52_V0.5150.27
44_A251_L0.5150.27
92_T296_N0.5150.27
68_L288_F0.5140.26
280_Q320_Q0.5140.26
134_V165_A0.5110.26
241_K313_V0.5090.26
211_L214_Y0.5090.26
287_Y333_E0.5080.26
259_V263_S0.5080.26
70_N341_K0.5070.26
88_L251_L0.5060.26
61_L82_W0.5050.26
72_K346_K0.5050.26
319_L332_M0.5050.26
287_Y366_L0.5030.26
58_P246_L0.5020.26
205_H208_I0.5020.26
83_L227_H0.5010.26
204_Q235_T0.5000.26
118_S241_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bh1A 1 0.5891 100 0.484 Contact Map
4phtX 1 0.5788 100 0.517 Contact Map
2w7vA 2 0.2067 99.4 0.81 Contact Map
4bhqA 2 0.199 95.8 0.917 Contact Map
2ychA 1 0.7287 84.6 0.939 Contact Map
1uv7A 2 0.1757 71.8 0.946 Contact Map
4pwuA 4 0.199 14 0.964 Contact Map
2rjzA 2 0.2997 13.6 0.965 Contact Map
2l26A 1 0.1576 11.8 0.966 Contact Map
2lc0A 1 0.2739 7.5 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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