GREMLIN Database
GSPK - Putative type II secretion system protein K
UniProt: P45762 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12894
Length: 327 (301)
Sequences: 980 (787)
Seq/√Len: 45.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_D164_E4.6021.00
73_T77_Q4.2451.00
144_I194_I3.7811.00
97_L291_L3.5621.00
103_C207_C3.4671.00
150_D153_D3.4621.00
127_F194_I3.3721.00
153_D179_N3.1781.00
65_D77_Q3.0401.00
155_D164_E2.9031.00
164_E179_N2.7581.00
167_F171_Q2.7161.00
150_D179_N2.6801.00
99_D220_M2.6761.00
65_D73_T2.6761.00
150_D164_E2.5371.00
65_D310_F2.4861.00
256_T259_A2.4761.00
55_E306_S2.3411.00
100_A290_T2.2671.00
73_T310_F2.2141.00
150_D155_D2.2121.00
153_D162_G2.2101.00
106_L206_V2.1801.00
100_A103_C2.1301.00
238_T241_D2.1281.00
79_W289_F2.1261.00
194_I199_Y2.0550.99
155_D179_N2.0070.99
106_L208_V2.0010.99
182_L191_I2.0000.99
164_E168_Y1.9950.99
221_L228_L1.9910.99
148_I194_I1.9840.99
167_F192_K1.9610.99
185_T206_V1.9480.99
168_Y175_R1.9300.99
148_I182_L1.9150.99
102_H221_L1.9120.99
151_Y168_Y1.9070.99
130_L231_A1.8690.99
216_I228_L1.8460.99
150_D162_G1.7670.98
103_C221_L1.7660.98
100_A307_H1.7420.98
147_S192_K1.7380.98
124_A145_V1.7350.98
75_L220_M1.7190.98
151_Y175_R1.7180.98
108_A214_L1.7170.98
195_T198_I1.7020.98
7_G10_L1.6970.98
242_A246_L1.6820.98
218_L260_F1.6650.98
146_Q161_H1.6290.97
209_L307_H1.6150.97
290_T305_Q1.5920.97
100_A207_C1.5890.97
230_R239_D1.5790.97
77_Q80_A1.5680.96
109_L152_I1.5490.96
65_D79_W1.5230.96
207_C221_L1.5200.96
149_A159_R1.5170.96
167_F170_S1.5090.96
153_D168_Y1.5070.96
54_A58_A1.5050.96
306_S319_I1.5040.95
207_C250_P1.4960.95
257_T284_P1.4740.95
189_R199_Y1.4720.95
291_L308_I1.4580.95
221_L250_P1.4390.94
206_V242_A1.4270.94
74_T77_Q1.4120.94
215_S283_F1.4040.93
151_Y187_E1.3980.93
317_A321_R1.3930.93
102_H222_T1.3920.93
53_L294_E1.3790.93
162_G179_N1.3740.93
171_Q174_P1.3530.92
155_D162_G1.3440.92
250_P253_G1.3400.92
98_R292_S1.3360.92
175_R190_Q1.3320.92
131_L136_I1.3280.91
143_E147_S1.3250.91
104_F131_L1.3170.91
51_I304_W1.3140.91
147_S191_I1.3130.91
258_D279_K1.3000.91
86_Q91_N1.2950.90
165_D177_S1.2950.90
73_T79_W1.2900.90
148_I188_L1.2870.90
221_L254_W1.2840.90
220_M286_S1.2720.90
289_F310_F1.2680.89
103_C250_P1.2160.87
18_A21_A1.2140.87
33_S40_Q1.2020.87
5_Q9_A1.2010.87
7_G217_N1.1930.86
101_Q288_Y1.1830.86
134_A204_P1.1790.86
178_A183_F1.1670.85
218_L266_Q1.1650.85
237_I242_A1.1640.85
46_Q254_W1.1640.85
210_P288_Y1.1560.84
47_R51_I1.1490.84
240_A243_R1.1490.84
140_N195_T1.1440.84
226_I239_D1.1330.83
150_D163_A1.1320.83
107_N208_V1.1260.83
27_M34_Q1.1180.82
152_I182_L1.1150.82
209_L214_L1.1120.82
153_D163_A1.1030.82
165_D176_H1.1010.81
266_Q269_S1.0980.81
16_L54_A1.0960.81
98_R102_H1.0940.81
134_A205_Y1.0890.81
75_L80_A1.0870.81
73_T103_C1.0860.81
217_N289_F1.0640.79
175_R187_E1.0600.79
202_L206_V1.0560.79
155_D168_Y1.0530.78
105_N210_P1.0520.78
99_D217_N1.0510.78
126_V231_A1.0510.78
62_L310_F1.0490.78
79_W99_D1.0360.77
51_I295_S1.0330.77
126_V281_H1.0300.77
191_I194_I1.0230.76
292_S305_Q1.0180.76
99_D289_F1.0180.76
11_L14_L1.0050.75
219_N289_F1.0030.75
129_A221_L1.0020.75
150_D168_Y0.9930.74
315_Q321_R0.9930.74
20_M254_W0.9860.74
147_S193_G0.9790.73
163_A179_N0.9780.73
15_M36_Q0.9770.73
167_F174_P0.9690.72
201_R204_P0.9650.72
188_L191_I0.9650.72
201_R205_Y0.9620.72
317_A320_Y0.9620.72
4_E7_G0.9600.72
74_T80_A0.9600.72
49_Y254_W0.9600.72
136_I144_I0.9550.71
143_E192_K0.9490.71
25_A37_R0.9440.70
21_A51_I0.9420.70
11_L296_I0.9400.70
62_L80_A0.9400.70
315_Q318_Q0.9340.70
170_S173_P0.9220.69
105_N109_L0.9140.68
170_S228_L0.9130.68
11_L20_M0.9130.68
15_M127_F0.9110.68
144_I147_S0.9080.67
316_S320_Y0.9070.67
21_A24_A0.9060.67
95_W293_T0.9060.67
104_F127_F0.9050.67
109_L148_I0.8960.66
221_L227_P0.8940.66
64_Q68_D0.8930.66
311_N316_S0.8920.66
22_A35_L0.8890.66
257_T261_L0.8850.65
297_S300_Q0.8810.65
72_Q76_Q0.8790.65
194_I198_I0.8770.65
107_N152_I0.8760.65
15_M109_L0.8740.64
65_D289_F0.8730.64
226_I230_R0.8730.64
103_C228_L0.8730.64
163_A168_Y0.8710.64
66_V69_N0.8690.64
101_Q209_L0.8670.64
311_N318_Q0.8640.63
54_A304_W0.8640.63
106_L148_I0.8630.63
129_A235_N0.8540.63
219_N284_P0.8510.62
23_L194_I0.8450.62
36_Q40_Q0.8440.62
109_L219_N0.8430.62
242_A249_R0.8430.62
98_R290_T0.8430.62
246_L249_R0.8420.61
33_S37_R0.8380.61
171_Q175_R0.8360.61
5_Q96_Q0.8340.61
25_A284_P0.8300.60
105_N219_N0.8300.60
250_P254_W0.8300.60
232_L282_L0.8260.60
5_Q8_V0.8260.60
39_R43_H0.8260.60
12_I15_M0.8230.60
168_Y187_E0.8220.60
255_L259_A0.8210.59
27_M31_F0.8200.59
78_Y242_A0.8190.59
93_V295_S0.8160.59
210_P214_L0.8160.59
13_V95_W0.8150.59
69_N77_Q0.8130.59
214_L221_L0.8130.59
92_T201_R0.8090.58
106_L248_K0.8020.58
151_Y190_Q0.7960.57
24_A28_T0.7910.57
19_L93_V0.7900.57
44_H314_Q0.7900.57
211_T288_Y0.7890.56
147_S198_I0.7810.56
216_I314_Q0.7770.55
185_T208_V0.7740.55
13_V127_F0.7730.55
169_Q176_H0.7730.55
205_Y222_T0.7730.55
43_H299_E0.7700.55
13_V45_L0.7680.54
28_T195_T0.7670.54
130_L204_P0.7650.54
148_I152_I0.7620.54
107_N168_Y0.7610.54
78_Y81_Q0.7600.54
50_D93_V0.7580.53
217_N220_M0.7560.53
79_W220_M0.7560.53
148_I199_Y0.7540.53
73_T289_F0.7510.53
40_Q44_H0.7510.53
284_P289_F0.7490.53
244_V280_R0.7450.52
123_P126_V0.7440.52
39_R138_R0.7400.52
99_D286_S0.7390.52
168_Y179_N0.7350.51
47_R302_Q0.7350.51
219_N286_S0.7320.51
17_L45_L0.7310.51
162_G168_Y0.7300.51
106_L252_E0.7280.50
43_H298_D0.7230.50
16_L20_M0.7200.50
37_R101_Q0.7170.49
50_D55_E0.7160.49
11_L180_Q0.7140.49
15_M202_L0.7100.49
192_K197_N0.7100.49
128_S146_Q0.7080.49
163_A167_F0.7070.48
73_T80_A0.7060.48
153_D187_E0.7060.48
144_I198_I0.7050.48
134_A206_V0.7010.48
40_Q300_Q0.7010.48
179_N188_L0.6990.48
166_S169_Q0.6980.48
188_L206_V0.6970.47
183_F241_D0.6970.47
156_D179_N0.6970.47
122_F125_Q0.6910.47
95_W291_L0.6910.47
288_Y307_H0.6890.47
229_F321_R0.6890.47
22_A95_W0.6840.46
216_I319_I0.6840.46
33_S148_I0.6830.46
37_R53_L0.6830.46
135_G138_R0.6820.46
9_A105_N0.6780.46
75_L79_W0.6770.46
102_H207_C0.6740.45
77_Q310_F0.6700.45
40_Q53_L0.6690.45
100_A209_L0.6680.45
41_V216_I0.6670.45
53_L145_V0.6670.45
73_T207_C0.6640.44
245_L305_Q0.6640.44
184_L201_R0.6630.44
132_I256_T0.6630.44
130_L134_A0.6620.44
131_L222_T0.6610.44
229_F303_G0.6610.44
158_P167_F0.6590.44
286_S289_F0.6590.44
51_I300_Q0.6550.43
89_D303_G0.6520.43
261_L279_K0.6520.43
216_I221_L0.6470.43
10_L37_R0.6450.42
87_L295_S0.6440.42
126_V235_N0.6420.42
91_N177_S0.6420.42
51_I175_R0.6410.42
122_F126_V0.6390.42
107_N179_N0.6380.42
57_L61_S0.6360.42
294_E301_S0.6330.41
43_H216_I0.6300.41
54_A295_S0.6280.41
207_C254_W0.6240.40
50_D91_N0.6230.40
76_Q191_I0.6190.40
219_N259_A0.6190.40
242_A307_H0.6180.40
14_L268_F0.6170.40
254_W260_F0.6160.40
126_V186_G0.6160.40
206_V247_Q0.6150.40
102_H228_L0.6130.39
130_L165_D0.6120.39
47_R277_Q0.6080.39
257_T262_Y0.6020.38
132_I279_K0.6010.38
83_Q308_I0.6010.38
39_R299_E0.5990.38
50_D54_A0.5990.38
259_A262_Y0.5950.38
46_Q286_S0.5940.38
10_L14_L0.5930.38
110_A149_A0.5930.38
31_F214_L0.5920.37
155_D163_A0.5910.37
180_Q190_Q0.5910.37
186_G203_I0.5900.37
168_Y191_I0.5890.37
104_F228_L0.5880.37
221_L246_L0.5880.37
191_I262_Y0.5880.37
182_L284_P0.5850.37
32_H35_L0.5850.37
207_C253_G0.5840.37
75_L249_R0.5820.37
109_L281_H0.5810.36
22_A25_A0.5810.36
203_I208_V0.5810.36
314_Q317_A0.5800.36
10_L39_R0.5780.36
144_I153_D0.5760.36
66_V73_T0.5720.36
185_T199_Y0.5710.36
105_N254_W0.5700.35
14_L131_L0.5660.35
94_K161_H0.5650.35
147_S163_A0.5630.35
59_L222_T0.5630.35
20_M33_S0.5620.35
200_Q203_I0.5610.35
141_T198_I0.5610.35
10_L267_D0.5600.35
18_A91_N0.5600.35
48_Q52_E0.5580.34
304_W307_H0.5570.34
233_F237_I0.5570.34
102_H229_F0.5570.34
74_T79_W0.5560.34
54_A293_T0.5560.34
96_Q294_E0.5560.34
11_L309_F0.5550.34
189_R196_E0.5540.34
94_K316_S0.5530.34
97_L308_I0.5520.34
170_S191_I0.5520.34
34_Q108_A0.5520.34
49_Y79_W0.5520.34
216_I232_L0.5510.34
103_C310_F0.5510.34
182_L208_V0.5510.34
47_R300_Q0.5510.34
65_D80_A0.5500.34
148_I284_P0.5490.34
226_I241_D0.5490.34
106_L182_L0.5490.34
31_F51_I0.5480.34
37_R55_E0.5470.33
95_W220_M0.5450.33
165_D168_Y0.5410.33
62_L65_D0.5410.33
248_K251_R0.5400.33
110_A120_P0.5400.33
55_E58_A0.5380.33
127_F183_F0.5360.33
15_M28_T0.5350.32
269_S306_S0.5350.32
103_C253_G0.5340.32
296_I299_E0.5340.32
105_N214_L0.5340.32
32_H290_T0.5340.32
293_T303_G0.5330.32
54_A106_L0.5320.32
219_N242_A0.5320.32
238_T305_Q0.5310.32
272_K275_V0.5310.32
299_E321_R0.5290.32
128_S141_T0.5270.32
21_A211_T0.5270.32
83_Q194_I0.5260.32
168_Y192_K0.5250.32
20_M29_L0.5240.31
143_E291_L0.5240.31
17_L21_A0.5210.31
146_Q154_V0.5210.31
109_L210_P0.5200.31
185_T193_G0.5200.31
207_C228_L0.5180.31
82_P231_A0.5180.31
8_V56_K0.5180.31
179_N187_E0.5170.31
230_R235_N0.5160.31
205_Y227_P0.5160.31
154_V228_L0.5150.31
110_A118_A0.5140.31
30_S209_L0.5130.31
146_Q162_G0.5110.30
12_I245_L0.5110.30
167_F246_L0.5100.30
46_Q50_D0.5090.30
49_Y102_H0.5080.30
152_I178_A0.5080.30
280_R283_F0.5070.30
31_F103_C0.5050.30
86_Q190_Q0.5050.30
100_A221_L0.5050.30
13_V78_Y0.5030.30
4_E25_A0.5030.30
21_A204_P0.5030.30
133_N242_A0.5030.30
237_I268_F0.5020.30
47_R297_S0.5010.30
48_Q102_H0.5010.30
154_V299_E0.5010.30
163_A174_P0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ci0K 1 0.8471 100 0.272 Contact Map
2duyA 1 0.1957 93.9 0.922 Contact Map
3wu2U 1 0.2905 92.6 0.926 Contact Map
4pj0U 1 0.2813 92.3 0.927 Contact Map
2eduA 1 0.2966 90.9 0.929 Contact Map
2i5hA 1 0.422 83.2 0.937 Contact Map
3psiA 1 0.8563 36 0.955 Contact Map
2kp7A 1 0.2446 29.4 0.957 Contact Map
1wcnA 1 0.2141 26.7 0.958 Contact Map
2pmyA 4 0.2141 20.2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.