GSPK - ECOLI - GREMLIN Contacts

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GSPK - Putative type II secretion system protein K

UniProt:	P45762	Sequences: MNNEQRGVALLIVLMLLALMAALAADMTLSFHSQLQRTRQVNHHLQRQYDIELAEKLALASLTQDVKDNDRQTTLQQYWAQPQQLQLEDGNTVKWQLRDAQHCFNLNALAKISDDPLASPDFPAQVFSALLINAGIDRGNTDEIVQSIADYIDVDDSPRFHGAEDSFYQSQTPPRHSANQMLFLTGELRQIKGITENIYQRLIPYVCVLPTTELSINLNMLTENDIPLFRALFLNNITDADARVLLQKRPREGWLTTDAFLYWAQQDFSGVKPLVAQVKRHLFPYSRYFTLSTESISDEQSQGWQSHIFFNRKQQSAQIYRRTLQLY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12894
Length:	327 (301)
Sequences:	980 (787)
Seq/√Len:	45.4

ECOLI - GSPK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
153_D	164_E	4.602	1.00
73_T	77_Q	4.245	1.00
144_I	194_I	3.781	1.00
97_L	291_L	3.562	1.00
103_C	207_C	3.467	1.00
150_D	153_D	3.462	1.00
127_F	194_I	3.372	1.00
153_D	179_N	3.178	1.00
65_D	77_Q	3.040	1.00
155_D	164_E	2.903	1.00
164_E	179_N	2.758	1.00
167_F	171_Q	2.716	1.00
150_D	179_N	2.680	1.00
99_D	220_M	2.676	1.00
65_D	73_T	2.676	1.00
150_D	164_E	2.537	1.00
65_D	310_F	2.486	1.00
256_T	259_A	2.476	1.00
55_E	306_S	2.341	1.00
100_A	290_T	2.267	1.00
73_T	310_F	2.214	1.00
150_D	155_D	2.212	1.00
153_D	162_G	2.210	1.00
106_L	206_V	2.180	1.00
100_A	103_C	2.130	1.00
238_T	241_D	2.128	1.00
79_W	289_F	2.126	1.00
194_I	199_Y	2.055	0.99
155_D	179_N	2.007	0.99
106_L	208_V	2.001	0.99
182_L	191_I	2.000	0.99
164_E	168_Y	1.995	0.99
221_L	228_L	1.991	0.99
148_I	194_I	1.984	0.99
167_F	192_K	1.961	0.99
185_T	206_V	1.948	0.99
168_Y	175_R	1.930	0.99
148_I	182_L	1.915	0.99
102_H	221_L	1.912	0.99
151_Y	168_Y	1.907	0.99
130_L	231_A	1.869	0.99
216_I	228_L	1.846	0.99
150_D	162_G	1.767	0.98
103_C	221_L	1.766	0.98
100_A	307_H	1.742	0.98
147_S	192_K	1.738	0.98
124_A	145_V	1.735	0.98
75_L	220_M	1.719	0.98
151_Y	175_R	1.718	0.98
108_A	214_L	1.717	0.98
195_T	198_I	1.702	0.98
7_G	10_L	1.697	0.98
242_A	246_L	1.682	0.98
218_L	260_F	1.665	0.98
146_Q	161_H	1.629	0.97
209_L	307_H	1.615	0.97
290_T	305_Q	1.592	0.97
100_A	207_C	1.589	0.97
230_R	239_D	1.579	0.97
77_Q	80_A	1.568	0.96
109_L	152_I	1.549	0.96
65_D	79_W	1.523	0.96
207_C	221_L	1.520	0.96
149_A	159_R	1.517	0.96
167_F	170_S	1.509	0.96
153_D	168_Y	1.507	0.96
54_A	58_A	1.505	0.96
306_S	319_I	1.504	0.95
207_C	250_P	1.496	0.95
257_T	284_P	1.474	0.95
189_R	199_Y	1.472	0.95
291_L	308_I	1.458	0.95
221_L	250_P	1.439	0.94
206_V	242_A	1.427	0.94
74_T	77_Q	1.412	0.94
215_S	283_F	1.404	0.93
151_Y	187_E	1.398	0.93
317_A	321_R	1.393	0.93
102_H	222_T	1.392	0.93
53_L	294_E	1.379	0.93
162_G	179_N	1.374	0.93
171_Q	174_P	1.353	0.92
155_D	162_G	1.344	0.92
250_P	253_G	1.340	0.92
98_R	292_S	1.336	0.92
175_R	190_Q	1.332	0.92
131_L	136_I	1.328	0.91
143_E	147_S	1.325	0.91
104_F	131_L	1.317	0.91
51_I	304_W	1.314	0.91
147_S	191_I	1.313	0.91
258_D	279_K	1.300	0.91
86_Q	91_N	1.295	0.90
165_D	177_S	1.295	0.90
73_T	79_W	1.290	0.90
148_I	188_L	1.287	0.90
221_L	254_W	1.284	0.90
220_M	286_S	1.272	0.90
289_F	310_F	1.268	0.89
103_C	250_P	1.216	0.87
18_A	21_A	1.214	0.87
33_S	40_Q	1.202	0.87
5_Q	9_A	1.201	0.87
7_G	217_N	1.193	0.86
101_Q	288_Y	1.183	0.86
134_A	204_P	1.179	0.86
178_A	183_F	1.167	0.85
218_L	266_Q	1.165	0.85
237_I	242_A	1.164	0.85
46_Q	254_W	1.164	0.85
210_P	288_Y	1.156	0.84
47_R	51_I	1.149	0.84
240_A	243_R	1.149	0.84
140_N	195_T	1.144	0.84
226_I	239_D	1.133	0.83
150_D	163_A	1.132	0.83
107_N	208_V	1.126	0.83
27_M	34_Q	1.118	0.82
152_I	182_L	1.115	0.82
209_L	214_L	1.112	0.82
153_D	163_A	1.103	0.82
165_D	176_H	1.101	0.81
266_Q	269_S	1.098	0.81
16_L	54_A	1.096	0.81
98_R	102_H	1.094	0.81
134_A	205_Y	1.089	0.81
75_L	80_A	1.087	0.81
73_T	103_C	1.086	0.81
217_N	289_F	1.064	0.79
175_R	187_E	1.060	0.79
202_L	206_V	1.056	0.79
155_D	168_Y	1.053	0.78
105_N	210_P	1.052	0.78
99_D	217_N	1.051	0.78
126_V	231_A	1.051	0.78
62_L	310_F	1.049	0.78
79_W	99_D	1.036	0.77
51_I	295_S	1.033	0.77
126_V	281_H	1.030	0.77
191_I	194_I	1.023	0.76
292_S	305_Q	1.018	0.76
99_D	289_F	1.018	0.76
11_L	14_L	1.005	0.75
219_N	289_F	1.003	0.75
129_A	221_L	1.002	0.75
150_D	168_Y	0.993	0.74
315_Q	321_R	0.993	0.74
20_M	254_W	0.986	0.74
147_S	193_G	0.979	0.73
163_A	179_N	0.978	0.73
15_M	36_Q	0.977	0.73
167_F	174_P	0.969	0.72
201_R	204_P	0.965	0.72
188_L	191_I	0.965	0.72
201_R	205_Y	0.962	0.72
317_A	320_Y	0.962	0.72
4_E	7_G	0.960	0.72
74_T	80_A	0.960	0.72
49_Y	254_W	0.960	0.72
136_I	144_I	0.955	0.71
143_E	192_K	0.949	0.71
25_A	37_R	0.944	0.70
21_A	51_I	0.942	0.70
11_L	296_I	0.940	0.70
62_L	80_A	0.940	0.70
315_Q	318_Q	0.934	0.70
170_S	173_P	0.922	0.69
105_N	109_L	0.914	0.68
170_S	228_L	0.913	0.68
11_L	20_M	0.913	0.68
15_M	127_F	0.911	0.68
144_I	147_S	0.908	0.67
316_S	320_Y	0.907	0.67
21_A	24_A	0.906	0.67
95_W	293_T	0.906	0.67
104_F	127_F	0.905	0.67
109_L	148_I	0.896	0.66
221_L	227_P	0.894	0.66
64_Q	68_D	0.893	0.66
311_N	316_S	0.892	0.66
22_A	35_L	0.889	0.66
257_T	261_L	0.885	0.65
297_S	300_Q	0.881	0.65
72_Q	76_Q	0.879	0.65
194_I	198_I	0.877	0.65
107_N	152_I	0.876	0.65
15_M	109_L	0.874	0.64
65_D	289_F	0.873	0.64
226_I	230_R	0.873	0.64
103_C	228_L	0.873	0.64
163_A	168_Y	0.871	0.64
66_V	69_N	0.869	0.64
101_Q	209_L	0.867	0.64
311_N	318_Q	0.864	0.63
54_A	304_W	0.864	0.63
106_L	148_I	0.863	0.63
129_A	235_N	0.854	0.63
219_N	284_P	0.851	0.62
23_L	194_I	0.845	0.62
36_Q	40_Q	0.844	0.62
109_L	219_N	0.843	0.62
242_A	249_R	0.843	0.62
98_R	290_T	0.843	0.62
246_L	249_R	0.842	0.61
33_S	37_R	0.838	0.61
171_Q	175_R	0.836	0.61
5_Q	96_Q	0.834	0.61
25_A	284_P	0.830	0.60
105_N	219_N	0.830	0.60
250_P	254_W	0.830	0.60
232_L	282_L	0.826	0.60
5_Q	8_V	0.826	0.60
39_R	43_H	0.826	0.60
12_I	15_M	0.823	0.60
168_Y	187_E	0.822	0.60
255_L	259_A	0.821	0.59
27_M	31_F	0.820	0.59
78_Y	242_A	0.819	0.59
93_V	295_S	0.816	0.59
210_P	214_L	0.816	0.59
13_V	95_W	0.815	0.59
69_N	77_Q	0.813	0.59
214_L	221_L	0.813	0.59
92_T	201_R	0.809	0.58
106_L	248_K	0.802	0.58
151_Y	190_Q	0.796	0.57
24_A	28_T	0.791	0.57
19_L	93_V	0.790	0.57
44_H	314_Q	0.790	0.57
211_T	288_Y	0.789	0.56
147_S	198_I	0.781	0.56
216_I	314_Q	0.777	0.55
185_T	208_V	0.774	0.55
13_V	127_F	0.773	0.55
169_Q	176_H	0.773	0.55
205_Y	222_T	0.773	0.55
43_H	299_E	0.770	0.55
13_V	45_L	0.768	0.54
28_T	195_T	0.767	0.54
130_L	204_P	0.765	0.54
148_I	152_I	0.762	0.54
107_N	168_Y	0.761	0.54
78_Y	81_Q	0.760	0.54
50_D	93_V	0.758	0.53
217_N	220_M	0.756	0.53
79_W	220_M	0.756	0.53
148_I	199_Y	0.754	0.53
73_T	289_F	0.751	0.53
40_Q	44_H	0.751	0.53
284_P	289_F	0.749	0.53
244_V	280_R	0.745	0.52
123_P	126_V	0.744	0.52
39_R	138_R	0.740	0.52
99_D	286_S	0.739	0.52
168_Y	179_N	0.735	0.51
47_R	302_Q	0.735	0.51
219_N	286_S	0.732	0.51
17_L	45_L	0.731	0.51
162_G	168_Y	0.730	0.51
106_L	252_E	0.728	0.50
43_H	298_D	0.723	0.50
16_L	20_M	0.720	0.50
37_R	101_Q	0.717	0.49
50_D	55_E	0.716	0.49
11_L	180_Q	0.714	0.49
15_M	202_L	0.710	0.49
192_K	197_N	0.710	0.49
128_S	146_Q	0.708	0.49
163_A	167_F	0.707	0.48
73_T	80_A	0.706	0.48
153_D	187_E	0.706	0.48
144_I	198_I	0.705	0.48
134_A	206_V	0.701	0.48
40_Q	300_Q	0.701	0.48
179_N	188_L	0.699	0.48
166_S	169_Q	0.698	0.48
188_L	206_V	0.697	0.47
183_F	241_D	0.697	0.47
156_D	179_N	0.697	0.47
122_F	125_Q	0.691	0.47
95_W	291_L	0.691	0.47
288_Y	307_H	0.689	0.47
229_F	321_R	0.689	0.47
22_A	95_W	0.684	0.46
216_I	319_I	0.684	0.46
33_S	148_I	0.683	0.46
37_R	53_L	0.683	0.46
135_G	138_R	0.682	0.46
9_A	105_N	0.678	0.46
75_L	79_W	0.677	0.46
102_H	207_C	0.674	0.45
77_Q	310_F	0.670	0.45
40_Q	53_L	0.669	0.45
100_A	209_L	0.668	0.45
41_V	216_I	0.667	0.45
53_L	145_V	0.667	0.45
73_T	207_C	0.664	0.44
245_L	305_Q	0.664	0.44
184_L	201_R	0.663	0.44
132_I	256_T	0.663	0.44
130_L	134_A	0.662	0.44
131_L	222_T	0.661	0.44
229_F	303_G	0.661	0.44
158_P	167_F	0.659	0.44
286_S	289_F	0.659	0.44
51_I	300_Q	0.655	0.43
89_D	303_G	0.652	0.43
261_L	279_K	0.652	0.43
216_I	221_L	0.647	0.43
10_L	37_R	0.645	0.42
87_L	295_S	0.644	0.42
126_V	235_N	0.642	0.42
91_N	177_S	0.642	0.42
51_I	175_R	0.641	0.42
122_F	126_V	0.639	0.42
107_N	179_N	0.638	0.42
57_L	61_S	0.636	0.42
294_E	301_S	0.633	0.41
43_H	216_I	0.630	0.41
54_A	295_S	0.628	0.41
207_C	254_W	0.624	0.40
50_D	91_N	0.623	0.40
76_Q	191_I	0.619	0.40
219_N	259_A	0.619	0.40
242_A	307_H	0.618	0.40
14_L	268_F	0.617	0.40
254_W	260_F	0.616	0.40
126_V	186_G	0.616	0.40
206_V	247_Q	0.615	0.40
102_H	228_L	0.613	0.39
130_L	165_D	0.612	0.39
47_R	277_Q	0.608	0.39
257_T	262_Y	0.602	0.38
132_I	279_K	0.601	0.38
83_Q	308_I	0.601	0.38
39_R	299_E	0.599	0.38
50_D	54_A	0.599	0.38
259_A	262_Y	0.595	0.38
46_Q	286_S	0.594	0.38
10_L	14_L	0.593	0.38
110_A	149_A	0.593	0.38
31_F	214_L	0.592	0.37
155_D	163_A	0.591	0.37
180_Q	190_Q	0.591	0.37
186_G	203_I	0.590	0.37
168_Y	191_I	0.589	0.37
104_F	228_L	0.588	0.37
221_L	246_L	0.588	0.37
191_I	262_Y	0.588	0.37
182_L	284_P	0.585	0.37
32_H	35_L	0.585	0.37
207_C	253_G	0.584	0.37
75_L	249_R	0.582	0.37
109_L	281_H	0.581	0.36
22_A	25_A	0.581	0.36
203_I	208_V	0.581	0.36
314_Q	317_A	0.580	0.36
10_L	39_R	0.578	0.36
144_I	153_D	0.576	0.36
66_V	73_T	0.572	0.36
185_T	199_Y	0.571	0.36
105_N	254_W	0.570	0.35
14_L	131_L	0.566	0.35
94_K	161_H	0.565	0.35
147_S	163_A	0.563	0.35
59_L	222_T	0.563	0.35
20_M	33_S	0.562	0.35
200_Q	203_I	0.561	0.35
141_T	198_I	0.561	0.35
10_L	267_D	0.560	0.35
18_A	91_N	0.560	0.35
48_Q	52_E	0.558	0.34
304_W	307_H	0.557	0.34
233_F	237_I	0.557	0.34
102_H	229_F	0.557	0.34
74_T	79_W	0.556	0.34
54_A	293_T	0.556	0.34
96_Q	294_E	0.556	0.34
11_L	309_F	0.555	0.34
189_R	196_E	0.554	0.34
94_K	316_S	0.553	0.34
97_L	308_I	0.552	0.34
170_S	191_I	0.552	0.34
34_Q	108_A	0.552	0.34
49_Y	79_W	0.552	0.34
216_I	232_L	0.551	0.34
103_C	310_F	0.551	0.34
182_L	208_V	0.551	0.34
47_R	300_Q	0.551	0.34
65_D	80_A	0.550	0.34
148_I	284_P	0.549	0.34
226_I	241_D	0.549	0.34
106_L	182_L	0.549	0.34
31_F	51_I	0.548	0.34
37_R	55_E	0.547	0.33
95_W	220_M	0.545	0.33
165_D	168_Y	0.541	0.33
62_L	65_D	0.541	0.33
248_K	251_R	0.540	0.33
110_A	120_P	0.540	0.33
55_E	58_A	0.538	0.33
127_F	183_F	0.536	0.33
15_M	28_T	0.535	0.32
269_S	306_S	0.535	0.32
103_C	253_G	0.534	0.32
296_I	299_E	0.534	0.32
105_N	214_L	0.534	0.32
32_H	290_T	0.534	0.32
293_T	303_G	0.533	0.32
54_A	106_L	0.532	0.32
219_N	242_A	0.532	0.32
238_T	305_Q	0.531	0.32
272_K	275_V	0.531	0.32
299_E	321_R	0.529	0.32
128_S	141_T	0.527	0.32
21_A	211_T	0.527	0.32
83_Q	194_I	0.526	0.32
168_Y	192_K	0.525	0.32
20_M	29_L	0.524	0.31
143_E	291_L	0.524	0.31
17_L	21_A	0.521	0.31
146_Q	154_V	0.521	0.31
109_L	210_P	0.520	0.31
185_T	193_G	0.520	0.31
207_C	228_L	0.518	0.31
82_P	231_A	0.518	0.31
8_V	56_K	0.518	0.31
179_N	187_E	0.517	0.31
230_R	235_N	0.516	0.31
205_Y	227_P	0.516	0.31
154_V	228_L	0.515	0.31
110_A	118_A	0.514	0.31
30_S	209_L	0.513	0.31
146_Q	162_G	0.511	0.30
12_I	245_L	0.511	0.30
167_F	246_L	0.510	0.30
46_Q	50_D	0.509	0.30
49_Y	102_H	0.508	0.30
152_I	178_A	0.508	0.30
280_R	283_F	0.507	0.30
31_F	103_C	0.505	0.30
86_Q	190_Q	0.505	0.30
100_A	221_L	0.505	0.30
13_V	78_Y	0.503	0.30
4_E	25_A	0.503	0.30
21_A	204_P	0.503	0.30
133_N	242_A	0.503	0.30
237_I	268_F	0.502	0.30
47_R	297_S	0.501	0.30
48_Q	102_H	0.501	0.30
154_V	299_E	0.501	0.30
163_A	174_P	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ci0K	1	0.8471	100	0.272	Contact Map
2duyA	1	0.1957	93.9	0.922	Contact Map
3wu2U	1	0.2905	92.6	0.926	Contact Map
4pj0U	1	0.2813	92.3	0.927	Contact Map
2eduA	1	0.2966	90.9	0.929	Contact Map
2i5hA	1	0.422	83.2	0.937	Contact Map
3psiA	1	0.8563	36	0.955	Contact Map
2kp7A	1	0.2446	29.4	0.957	Contact Map
1wcnA	1	0.2141	26.7	0.958	Contact Map
2pmyA	4	0.2141	20.2	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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