GREMLIN Database
GSPC - Putative type II secretion system protein C
UniProt: P45757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12889
Length: 271 (238)
Sequences: 994 (878)
Seq/√Len: 56.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_I252_I4.8081.00
214_R242_T4.7461.00
132_I135_I4.6071.00
140_V144_T3.5041.00
148_Y152_T3.0521.00
216_N233_L3.0161.00
213_L249_P2.5571.00
140_V145_H2.5011.00
119_S122_E2.4741.00
89_L149_E2.4211.00
134_K139_S2.2781.00
192_L212_A2.2291.00
222_H225_E2.2181.00
176_I254_V2.2171.00
142_F145_H2.2021.00
136_N139_S2.1721.00
104_T107_V2.1721.00
148_Y151_V2.1661.00
214_R217_N2.1401.00
144_T149_E2.0411.00
213_L242_T2.0081.00
94_N97_V2.0011.00
119_S123_A1.9611.00
120_L123_A1.9141.00
198_L202_T1.8831.00
99_T105_S1.8801.00
242_T249_P1.8741.00
29_G32_I1.8010.99
116_K120_L1.7830.99
140_V148_Y1.7680.99
91_I151_V1.7670.99
202_T207_Q1.7660.99
102_D107_V1.7510.99
134_K140_V1.7510.99
117_R122_E1.7330.99
65_L68_N1.7100.99
142_F151_V1.6770.99
240_Q251_L1.6740.99
87_P149_E1.6650.99
142_F148_Y1.6530.99
206_L252_I1.6180.99
155_P158_P1.6020.99
116_K122_E1.5930.98
241_F252_I1.5890.98
23_I27_S1.5610.98
93_L96_I1.5590.98
147_H152_T1.5450.98
117_R123_A1.5420.98
144_T152_T1.5340.98
134_K137_K1.5290.98
31_I35_V1.5240.98
173_A177_I1.5160.98
146_G152_T1.5140.98
103_E107_V1.5120.98
104_T108_L1.5070.98
102_D105_S1.5000.98
130_T134_K1.4700.97
148_Y153_L1.4600.97
134_K144_T1.4530.97
107_V135_I1.4490.97
116_K119_S1.4300.97
171_V177_I1.4290.97
134_K138_T1.4060.97
117_R120_L1.3920.96
158_P200_A1.3880.96
218_L229_A1.3830.96
87_P151_V1.3740.96
45_N49_I1.3710.96
221_T225_E1.3690.96
135_I140_V1.3660.96
149_E153_L1.3440.96
244_R247_G1.2980.95
109_I151_V1.2920.95
133_R143_E1.2890.94
206_L241_F1.2810.94
189_G211_I1.2800.94
118_Y122_E1.2720.94
133_R148_Y1.2700.94
93_L109_I1.2620.94
240_Q253_N1.2480.93
63_A67_R1.2480.93
66_W135_I1.2480.93
132_I155_P1.2480.93
174_D235_T1.2400.93
153_L217_N1.2390.93
226_V255_S1.2390.93
139_S150_K1.2320.93
132_I138_T1.2240.93
141_V150_K1.2050.92
138_T144_T1.2030.92
210_D245_R1.2010.92
145_H151_V1.1970.92
233_L237_Q1.1800.91
117_R127_A1.1640.91
165_D169_Q1.1520.90
162_K166_S1.1490.90
204_S254_V1.1380.90
83_N93_L1.1340.90
171_V178_A1.1270.89
225_E228_Q1.1240.89
44_K57_Q1.1210.89
32_I35_V1.1150.89
23_I26_I1.1010.88
103_E106_F1.0950.88
146_G151_V1.0920.88
103_E112_G1.0890.88
47_Q51_Q1.0880.88
140_V153_L1.0830.87
173_A201_F1.0720.87
87_P91_I1.0710.87
64_A68_N1.0690.87
123_A127_A1.0670.87
131_F142_F1.0610.86
228_Q231_S1.0600.86
176_I201_F1.0600.86
228_Q232_L1.0460.85
165_D174_D1.0360.85
177_I204_S1.0140.84
126_S131_F1.0050.83
88_K93_L1.0020.83
132_I140_V0.9960.83
132_I137_K0.9900.82
140_V143_E0.9900.82
140_V151_V0.9850.82
204_S236_Q0.9820.82
224_D254_V0.9780.81
160_I163_Q0.9710.81
32_I39_H0.9630.80
95_G108_L0.9580.80
64_A88_K0.9560.80
177_I192_L0.9530.80
131_F143_E0.9410.79
86_T89_L0.9410.79
215_I253_N0.9370.79
183_D188_Y0.9350.78
132_I141_V0.9260.78
62_L66_W0.9170.77
89_L93_L0.9130.77
143_E148_Y0.9130.77
116_K121_N0.9110.77
191_R209_G0.9100.76
42_I48_I0.9050.76
20_N24_I0.9010.76
192_L206_L0.9000.76
101_N104_T0.8990.76
60_F64_A0.8980.75
144_T206_L0.8930.75
174_D201_F0.8890.75
242_T250_R0.8830.74
60_F70_N0.8830.74
78_N81_A0.8790.74
21_I53_T0.8790.74
61_S66_W0.8760.74
201_F226_V0.8680.73
84_Q91_I0.8650.73
130_T138_T0.8600.72
157_L161_I0.8560.72
40_T51_Q0.8520.72
106_F117_R0.8430.71
18_A47_Q0.8400.70
193_N209_G0.8380.70
131_F137_K0.8360.70
86_T91_I0.8360.70
61_S64_A0.8310.70
206_L216_N0.8310.70
126_S134_K0.8290.69
90_S93_L0.8270.69
77_A80_V0.8260.69
24_I28_I0.8230.69
23_I65_L0.8190.69
140_V149_E0.8190.69
107_V191_R0.8170.68
159_D163_Q0.8150.68
158_P165_D0.8150.68
64_A67_R0.8110.68
173_A190_L0.7990.67
183_D190_L0.7970.66
157_L199_N0.7950.66
90_S95_G0.7890.66
195_R201_F0.7890.66
165_D211_I0.7870.65
114_E167_E0.7870.65
116_K124_L0.7870.65
238_S253_N0.7860.65
84_Q150_K0.7800.65
164_P207_Q0.7780.65
165_D176_I0.7750.64
21_I113_S0.7710.64
106_F119_S0.7690.64
65_L69_E0.7690.64
209_G244_R0.7680.64
236_Q255_S0.7660.63
168_S171_V0.7660.63
241_F254_V0.7580.63
242_T251_L0.7580.63
89_L95_G0.7560.62
47_Q58_S0.7550.62
195_R241_F0.7450.61
101_N105_S0.7430.61
87_P90_S0.7350.60
194_P201_F0.7350.60
215_I241_F0.7350.60
109_I140_V0.7350.60
142_F152_T0.7330.60
86_T152_T0.7330.60
146_G153_L0.7320.60
179_T252_I0.7240.59
140_V152_T0.7200.59
31_I230_L0.7170.58
51_Q167_E0.7150.58
95_G189_G0.7130.58
169_Q201_F0.7100.57
140_V150_K0.7080.57
176_I256_V0.7040.57
17_A36_N0.7010.57
195_R198_L0.7010.57
220_L244_R0.6980.56
171_V174_D0.6950.56
180_P226_V0.6940.56
105_S119_S0.6930.56
105_S120_L0.6920.56
131_F134_K0.6910.55
153_L201_F0.6910.55
203_T237_Q0.6860.55
60_F92_A0.6840.55
117_R121_N0.6800.54
154_H177_I0.6790.54
174_D177_I0.6740.54
150_K153_L0.6680.53
230_L233_L0.6640.53
120_L154_H0.6630.52
184_G191_R0.6610.52
164_P256_V0.6590.52
52_P58_S0.6580.52
22_L26_I0.6570.52
243_I250_R0.6560.52
217_N220_L0.6560.52
85_E88_K0.6490.51
173_A176_I0.6480.51
41_T45_N0.6480.51
212_A236_Q0.6460.51
27_S32_I0.6450.50
195_R199_N0.6430.50
119_S124_L0.6430.50
91_I215_I0.6420.50
106_F113_S0.6420.50
168_S172_L0.6390.50
155_P159_D0.6380.50
64_A69_E0.6380.50
109_I115_Q0.6370.50
37_Y40_T0.6370.50
28_I32_I0.6360.49
16_D19_I0.6340.49
187_I190_L0.6330.49
89_L92_A0.6280.49
27_S39_H0.6270.48
108_L115_Q0.6270.48
22_L112_G0.6260.48
111_E127_A0.6250.48
242_T248_V0.6230.48
98_L109_I0.6220.48
239_A256_V0.6200.48
50_N54_N0.6180.47
56_F71_H0.6160.47
53_T56_F0.6160.47
195_R220_L0.6150.47
41_T44_K0.6120.47
105_S127_A0.6110.47
27_S31_I0.6110.47
72_A76_D0.6100.47
178_A232_L0.6100.47
98_L105_S0.6090.47
154_H169_Q0.6030.46
158_P162_K0.6020.46
116_K123_A0.6010.46
212_A215_I0.6000.46
183_D203_T0.6000.46
107_V118_Y0.5990.45
31_I38_F0.5990.45
162_K256_V0.5900.44
85_E96_I0.5900.44
141_V148_Y0.5880.44
124_L144_T0.5850.44
161_I254_V0.5830.44
183_D209_G0.5820.44
63_A69_E0.5810.43
193_N231_S0.5810.43
96_I99_T0.5800.43
145_H148_Y0.5790.43
154_H171_V0.5780.43
130_T142_F0.5780.43
26_I31_I0.5780.43
163_Q168_S0.5770.43
135_I138_T0.5750.43
204_S235_T0.5730.43
133_R140_V0.5730.43
108_L117_R0.5700.42
220_L226_V0.5690.42
213_L251_L0.5670.42
153_L220_L0.5660.42
172_L202_T0.5650.42
133_R153_L0.5630.42
55_A67_R0.5620.41
178_A190_L0.5600.41
181_I191_R0.5590.41
217_N256_V0.5560.41
179_T194_P0.5540.41
19_I43_V0.5540.41
180_P230_L0.5540.41
120_L124_L0.5540.41
22_L32_I0.5510.40
227_S231_S0.5510.40
122_E127_A0.5510.40
139_S146_G0.5500.40
115_Q201_F0.5500.40
242_T254_V0.5500.40
98_L140_V0.5490.40
173_A230_L0.5480.40
93_L151_V0.5470.40
178_A230_L0.5460.40
164_P168_S0.5450.40
19_I29_G0.5420.39
38_F81_A0.5410.39
18_A26_I0.5410.39
139_S152_T0.5400.39
177_I180_P0.5390.39
98_L194_P0.5390.39
26_I29_G0.5380.39
127_A130_T0.5350.39
27_S33_F0.5350.39
192_L252_I0.5340.39
38_F49_I0.5320.38
120_L127_A0.5310.38
144_T151_V0.5310.38
96_I208_P0.5310.38
34_N130_T0.5300.38
169_Q174_D0.5300.38
54_N72_A0.5300.38
87_P93_L0.5270.38
214_R219_S0.5250.38
160_I164_P0.5250.38
67_R71_H0.5240.37
124_L127_A0.5230.37
138_T142_F0.5190.37
123_A126_S0.5180.37
165_D195_R0.5180.37
28_I33_F0.5180.37
144_T147_H0.5180.37
177_I226_V0.5140.36
158_P220_L0.5140.36
223_P227_S0.5130.36
43_V211_I0.5090.36
149_E152_T0.5080.36
166_S227_S0.5040.35
25_F31_I0.5040.35
130_T136_N0.5000.35
135_I192_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i4sA 1 0.3875 99.8 0.657 Contact Map
2l97A 1 0.417 99.7 0.68 Contact Map
2i6vA 1 0.321 99.6 0.697 Contact Map
3stjA 6 0.893 99.6 0.706 Contact Map
3pv2A 6 0.8376 99.5 0.716 Contact Map
1ky9A 5 0.9041 99.5 0.718 Contact Map
1te0A 6 0.8413 99.5 0.722 Contact Map
3qo6A 5 0.8598 99.5 0.725 Contact Map
4ic6A 4 0.893 99.5 0.726 Contact Map
1y8tA 3 0.7601 99.4 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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