GREMLIN Database
TSAC - Threonylcarbamoyl-AMP synthase
UniProt: P45748 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12840
Length: 190 (180)
Sequences: 5993 (3979)
Seq/√Len: 296.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_V21_R4.8621.00
25_Y34_G4.1631.00
21_R163_P3.3601.00
36_D39_S3.0701.00
63_A67_Q2.8101.00
11_A130_A2.6731.00
69_K82_R2.3701.00
15_D19_E2.2821.00
37_P60_L2.2421.00
64_N129_Q2.1711.00
36_D133_K2.1401.00
20_E39_S2.1131.00
155_R159_G2.0471.00
25_Y124_V2.0461.00
24_A162_F1.9491.00
56_K143_S1.9341.00
35_C42_A1.9031.00
142_L157_Q1.8821.00
44_M48_E1.8461.00
17_L131_Y1.8231.00
150_T153_E1.8211.00
85_I95_F1.7911.00
126_A129_Q1.7681.00
22_V49_L1.7571.00
180_D183_T1.7311.00
21_R45_R1.7261.00
65_Y86_F1.7001.00
63_A129_Q1.6891.00
40_E106_W1.6841.00
72_I97_F1.6741.00
78_T81_Q1.6471.00
180_D185_E1.6161.00
63_A128_C1.5981.00
67_Q70_P1.5961.00
40_E104_P1.5471.00
45_R48_E1.5351.00
14_I130_A1.5291.00
126_A130_A1.5211.00
94_T115_A1.5191.00
99_A108_T1.4861.00
62_A68_L1.4841.00
142_L161_A1.4741.00
155_R164_V1.4661.00
14_I131_Y1.4561.00
82_R86_F1.4521.00
38_D133_K1.4331.00
62_A118_V1.4321.00
10_I130_A1.4281.00
96_V187_F1.4271.00
24_A154_V1.4001.00
96_V113_S1.3851.00
71_Y116_V1.3651.00
64_N67_Q1.3541.00
145_L157_Q1.3441.00
73_D100_P1.3341.00
65_Y118_V1.3211.00
44_M106_W1.3001.00
118_V125_V1.2961.00
14_I18_N1.2951.00
99_A105_R1.2871.00
12_A15_D1.2801.00
25_Y137_S1.2681.00
25_Y127_L1.2581.00
73_D98_P1.2441.00
98_P112_D1.2361.00
44_M54_V1.2291.00
39_S42_A1.2121.00
45_R163_P1.2051.00
72_I100_P1.1981.00
65_Y82_R1.1821.00
40_E44_M1.1691.00
70_P102_T1.1591.00
125_V129_Q1.1581.00
10_I127_L1.1541.00
15_D18_N1.1531.00
29_A176_S1.1511.00
73_D101_A1.1471.00
49_L161_A1.1321.00
152_D156_A1.1281.00
113_S182_L1.1271.00
47_L54_V1.1121.00
77_L85_I1.1071.00
16_V163_P1.0981.00
120_D125_V1.0921.00
34_G135_L1.0801.00
11_A15_D1.0781.00
72_I116_V1.0771.00
61_I137_S1.0691.00
17_L135_L1.0671.00
122_P126_A1.0631.00
81_Q181_A1.0521.00
150_T169_T1.0451.00
66_E69_K1.0321.00
51_Q142_L1.0271.00
95_F179_R1.0241.00
35_C46_L1.0201.00
123_L167_G1.0101.00
127_L165_V1.0031.00
81_Q85_I0.9961.00
89_W93_V0.9761.00
119_T124_V0.9631.00
68_L77_L0.9631.00
59_I115_A0.9591.00
38_D104_P0.9581.00
151_V166_P0.9501.00
46_L136_V0.9461.00
148_C154_V0.9401.00
65_Y85_I0.9391.00
119_T125_V0.9291.00
43_V106_W0.9271.00
24_A151_V0.9201.00
84_T93_V0.9181.00
17_L127_L0.9151.00
49_L158_F0.9071.00
93_V179_R0.9071.00
80_V83_E0.8951.00
68_L116_V0.8921.00
72_I114_L0.8861.00
28_E119_T0.8861.00
120_D171_G0.8801.00
123_L165_V0.8741.00
36_D131_Y0.8661.00
51_Q161_A0.8621.00
52_R141_N0.8421.00
121_H124_V0.8321.00
22_V45_R0.8291.00
147_P175_P0.8261.00
17_L133_K0.8261.00
20_E36_D0.8241.00
80_V181_A0.8101.00
79_D82_R0.8061.00
83_E87_S0.8051.00
154_V164_V0.8001.00
67_Q128_C0.7981.00
18_N133_K0.7981.00
99_A112_D0.7920.99
61_I128_C0.7880.99
85_I89_W0.7790.99
62_A67_Q0.7780.99
22_V163_P0.7750.99
103_T114_L0.7710.99
151_V154_V0.7700.99
89_W95_F0.7690.99
93_V177_E0.7670.99
85_I118_V0.7620.99
60_L71_Y0.7610.99
68_L97_F0.7610.99
38_D71_Y0.7600.99
81_Q97_F0.7570.99
30_V141_N0.7520.99
56_K109_G0.7500.99
153_E157_Q0.7450.99
9_A12_A0.7410.99
97_F181_A0.7400.99
34_G124_V0.7390.99
81_Q95_F0.7380.99
12_A16_V0.7360.99
124_V137_S0.7340.99
88_R93_V0.7290.99
148_C157_Q0.7280.99
16_V19_E0.7220.99
13_A127_L0.7210.99
113_S180_D0.7180.99
151_V164_V0.7060.99
24_A33_V0.7020.99
140_A154_V0.6960.99
77_L97_F0.6880.99
60_L107_L0.6850.98
84_T88_R0.6840.98
148_C153_E0.6820.98
69_K73_D0.6730.98
128_C135_L0.6710.98
70_P100_P0.6710.98
77_L82_R0.6690.98
9_A165_V0.6690.98
59_I137_S0.6640.98
89_W118_V0.6610.98
30_V175_P0.6610.98
28_E92_P0.6600.98
142_L145_L0.6590.98
186_L189_Q0.6570.98
34_G137_S0.6550.98
122_P125_V0.6500.98
26_P167_G0.6490.98
72_I77_L0.6480.98
84_T181_A0.6440.98
60_L114_L0.6440.98
30_V139_S0.6430.98
20_E41_T0.6390.98
158_F163_P0.6370.98
47_L58_L0.6320.97
67_Q134_P0.6240.97
62_A71_Y0.6240.97
38_D102_T0.6230.97
80_V184_G0.6220.97
13_A16_V0.6220.97
127_L135_L0.6190.97
41_T44_M0.6130.97
78_T184_G0.6090.97
34_G127_L0.6090.97
79_D83_E0.6080.97
155_R160_A0.6080.97
63_A125_V0.6060.97
10_I123_L0.6050.97
138_T141_N0.6030.97
115_A178_I0.6010.97
24_A164_V0.5960.96
30_V147_P0.5960.96
50_K138_T0.5960.96
131_Y134_P0.5910.96
98_P182_L0.5910.96
177_E190_G0.5900.96
85_I181_A0.5880.96
17_L36_D0.5870.96
131_Y135_L0.5820.96
159_G162_F0.5800.96
83_E86_F0.5800.96
46_L137_S0.5780.96
123_L126_A0.5780.96
32_G52_R0.5720.95
148_C158_F0.5720.95
27_T34_G0.5700.95
50_K141_N0.5690.95
12_A19_E0.5670.95
60_L103_T0.5660.95
48_E161_A0.5640.95
65_Y69_K0.5630.95
99_A103_T0.5590.95
64_N125_V0.5570.95
31_F168_E0.5570.95
40_E105_R0.5550.95
37_P43_V0.5540.95
55_D106_W0.5540.95
119_T128_C0.5540.95
97_F116_V0.5540.95
107_L114_L0.5520.95
43_V107_L0.5520.95
11_A14_I0.5510.94
95_F181_A0.5490.94
25_Y61_I0.5480.94
49_L163_P0.5460.94
22_V35_C0.5430.94
35_C136_V0.5410.94
152_D155_R0.5400.94
38_D134_P0.5390.94
67_Q118_V0.5380.94
47_L52_R0.5370.94
91_G177_E0.5360.94
128_C131_Y0.5350.94
23_I34_G0.5310.93
45_R49_L0.5310.93
29_A32_G0.5300.93
156_A159_G0.5290.93
8_D11_A0.5290.93
28_E61_I0.5280.93
52_R143_S0.5200.93
71_Y103_T0.5200.93
105_R112_D0.5190.93
52_R139_S0.5190.93
77_L81_Q0.5150.92
96_V115_A0.5130.92
122_P129_Q0.5100.92
84_T95_F0.5100.92
50_K56_K0.5100.92
118_V128_C0.5080.92
124_V128_C0.5050.91
141_N144_G0.5050.91
47_L56_K0.5050.91
180_D187_F0.5030.91
69_K77_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eqaA 1 0.9895 100 0.098 Contact Map
1hruA 2 0.9789 100 0.151 Contact Map
1k7jA 1 0.9789 100 0.156 Contact Map
3l7vA 1 0.9474 100 0.164 Contact Map
1jcuA 1 0.9684 100 0.169 Contact Map
3vthA 1 0.9684 100 0.201 Contact Map
4g9iA 1 0.9737 100 0.213 Contact Map
3ttcA 1 0.9368 100 0.276 Contact Map
3venA 1 0.8579 96.9 0.874 Contact Map
1tksA 2 0.7895 27.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.